Esculetin Ameliorates Lipopolysaccharide-Induced Acute Lung Injury in Mice Via Modulation of the AKT/ERK/NF-κB and RORγt/IL-17 Pathways

Acute Lung Injury: IL-17A-Mediated Inflammatory Pathway and Its Regulation by Curcumin

(2019) Mahesh Manjunath Gouda et al.   INFLAMMATION

New thiazolidinedione LPSF/GQ-2 inhibits NFκB and MAPK activation in LPS-induced acute lung inflammation

(2018) Laise Aline Martins dos Santos et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Use of cilomilast-loaded phosphatiosomes to suppress neutrophilic inflammation for attenuating acute lung injury: the effect of nanovesicular surface charge

(2018) Fu-Chao Liu et al.   JOURNAL OF NANOBIOTECHNOLOGY

Barbaloin protects against lipopolysaccharide (LPS)-induced acute lung injury by inhibiting the ROS-mediated PI3K/AKT/NF-κB pathway

(2018) Kangfeng Jiang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Magnoflorine Ameliorates Lipopolysaccharide-Induced Acute Lung Injury via Suppressing NF-κB and MAPK Activation

(2018) Shuai Guo et al.   Frontiers in Pharmacology

Protective Effects of Anti-IL17 on Acute Lung Injury Induced by LPS in Mice

(2018) Renato Fraga Righetti et al.   Frontiers in Pharmacology

Inhibition of neutrophil elastase contributes to attenuation of lipopolysaccharide-induced acute lung injury during neutropenia recovery in mice

(2017) Jong Min Lee et al.   Journal of Anesthesia

Naringenin ameliorates LPS-induced acute lung injury through its anti-oxidative and anti-inflammatory activity and by inhibition of the PI3K/AKT pathway

(2017) Minghong Zhao et al.   Experimental and Therapeutic Medicine

Role of IL-17 in LPS-induced acute lung injury: an in vivo study

(2017) Qi Ding et al.   Oncotarget

Nuciferine Ameliorates Inflammatory Responses by Inhibiting the TLR4-Mediated Pathway in Lipopolysaccharide-Induced Acute Lung Injury

(2017) Haichong Wu et al.   Frontiers in Pharmacology

HMGB1-TLR4-IL23-IL17A axis promotes paraquat-induced acute lung injury by mediating neutrophil infiltration in mice

(2017) Bailing Yan et al.   Scientific Reports

Blockade of IL-23 ameliorates allergic lung inflammation via decreasing the infiltration of Tc17 cells

(2016) Sheng Cheng et al.   Archives of Medical Science

Esculetin Attenuates Th2 and Th17 Responses in an Ovalbumin-Induced Asthmatic Mouse Model

(2016) Long Hongyan   INFLAMMATION

Phloretin attenuates LPS-induced acute lung injury in mice via modulation of the NF-κB and MAPK pathways

(2016) Wen-Chung Huang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

PI3k/Akt signalling pathway plays a crucial role in the anti-inflammatory effects of curcumin in LPS-activated microglia

(2016) Antonia Cianciulli et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Isovitexin Exerts Anti-Inflammatory and Anti-Oxidant Activities on Lipopolysaccharide-Induced Acute Lung Injury by Inhibiting MAPK and NF-κB and Activating HO-1/Nrf2 Pathways

(2016) Hongming Lv et al.   International Journal of Biological Sciences

Cytoprotective effects of esculetin against oxidative stress are associated with the upregulation of Nrf2-mediated NQO1 expression via the activation of the ERK pathway

(2016) Min Ho Han et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Epidemiology, Patterns of Care, and Mortality for Patients With Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries

(2016) Giacomo Bellani et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Discovery of new MD2 inhibitor from chalcone derivatives with anti-inflammatory effects in LPS-induced acute lung injury

(2016) Yali Zhang et al.   Scientific Reports

Overexpression of RORγt Enhances Pulmonary Inflammation after Infection with Mycobacterium Avium

(2016) Masashi Matsuyama et al.   PLoS One

Effects of esculetin on lipopolysaccharide (LPS)-induced acute lung injury via regulation of RhoA/Rho Kinase/NF-кB pathways in vivo and in vitro

(2015) Tong Chen et al.   FREE RADICAL RESEARCH

Fisetin Alleviates Lipopolysaccharide-Induced Acute Lung Injury via TLR4-Mediated NF-κB Signaling Pathway in Rats

(2015) Guang Feng et al.   INFLAMMATION

Innate-like function of memory Th17 cells for enhancing endotoxin-induced acute lung inflammation through IL-22

(2015) Ryota Sakaguchi et al.   INTERNATIONAL IMMUNOLOGY

Biomarkers in acute lung injury

(2015) Daniela Mokra et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

The effects of corticosteroids on cytokine production from asthma lung lymphocytes

(2014) Manminder Kaur et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The thymoquinone-induced production of reactive oxygen species promotes dedifferentiation through the ERK pathway and inflammation through the p38 and PI3K pathways in rabbit articular chondrocytes

(2014) SEON-MI YU et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Neutrophils Counteract Autophagy-Mediated Anti-Inflammatory Mechanisms in Alveolar Macrophage: Role in Posthemorrhagic Shock Acute Lung Inflammation

(2014) Zongmei Wen et al.   JOURNAL OF IMMUNOLOGY

Elevated Expression of IL-23/IL-17 Pathway–Related Mediators Correlates With Exacerbation of Pulmonary Inflammation During Polymicrobial Sepsis

(2014) David M. Cauvi et al.   SHOCK

Role of PI3K/Akt and mTOR complexes in Th17 cell differentiation

(2013) Shigenori Nagai et al.   Annals of the New York Academy of Sciences

IL-17A and Th17 Cells in Lung Inflammation: An Update on the Role of Th17 Cell Differentiation and IL-17R Signaling in Host Defense against Infection

(2013) Hsing-Chuan Tsai et al.   Clinical & Developmental Immunology

Arctigenin ameliorates inflammation in vitro and in vivo by inhibiting the PI3K/AKT pathway and polarizing M1 macrophages to M2-like macrophages

(2013) Supriya R. Hyam et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

A natural coumarin derivative esculetin offers neuroprotection on cerebral ischemia/reperfusion injury in mice

(2012) Chen Wang et al.   JOURNAL OF NEUROCHEMISTRY

RORγt-dependent IL-17A-producing cells in the pathogenesis of intestinal inflammation

(2012) T Kanai et al.   Mucosal Immunology

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(2011) Jochen Grommes et al.   MOLECULAR MEDICINE

Preventive Effects of Valnemulin on Lipopolysaccharide-Induced Acute Lung Injury in Mice

(2010) Zhibao Chen et al.   INFLAMMATION

Inhibition of the MAP kinase ERK protects from lipopolysaccharide-induced lung injury

(2009) Katrin Schuh et al.   BIOCHEMICAL PHARMACOLOGY

Shared Principles in NF-κB Signaling

(2008) Matthew S. Hayden et al.   CELL

Role of corticosteroids in the management of acute respiratory distress syndrome

(2008) Eli N. Deal et al.   CLINICAL THERAPEUTICS

Ozone exposure in a mouse model induces airway hyperreactivity that requires the presence of natural killer T cells and IL-17

(2008) Muriel Pichavant et al.   JOURNAL OF EXPERIMENTAL MEDICINE