A natural coumarin derivative esculetin offers neuroprotection on cerebral ischemia/reperfusion injury in mice

Death and survival of neuronal and astrocytic cells in ischemic brain injury: a role of autophagy

(2011) Min Xu et al.   ACTA PHARMACOLOGICA SINICA

Inhibition of 5-lipoxygenase and skin inflammation by the aerial parts of Artemisia capillaris and its constituents

(2011) Oh Song Kwon et al.   ARCHIVES OF PHARMACAL RESEARCH

Heart Disease and Stroke Statistics—2012 Update

(2011) et al.   CIRCULATION

Plasminogen Activation-Based Thrombolysis for Ischaemic Stroke: The Diversity of Targets may Demand New Approaches

(2011) Robert L. Medcalf   CURRENT DRUG TARGETS

Esculetin Ameliorates Carbon Tetrachloride-Mediated Hepatic Apoptosis in Rats

(2011) Yun-Chen Tien et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Prostate Apoptosis Response 4 (Par-4), a Novel Substrate of Caspase-3 during Apoptosis Activation

(2011) P. Chaudhry et al.   MOLECULAR AND CELLULAR BIOLOGY

Stroke research at a crossroad: asking the brain for directions

(2011) Costantino Iadecola et al.   NATURE NEUROSCIENCE

Emerging mechanisms of disrupted cellular signaling in brain ischemia

(2011) Michael Tymianski   NATURE NEUROSCIENCE

Investigational Therapies for Ischemic Stroke: Neuroprotection and Neurorecovery

(2011) Preeti Sahota et al.   Neurotherapeutics

p38 MAPK activation is required for esculetin-induced inhibition of vascular smooth muscle cells proliferation

(2011) Eun-Sun Yun et al.   TOXICOLOGY IN VITRO

Natural compounds from traditional medicinal herbs in the treatment of cerebral ischemia/reperfusion injury

(2010) Peng-fei Wu et al.   ACTA PHARMACOLOGICA SINICA

Synergistic protective effects of humanin and necrostatin-1 on hypoxia and ischemia/reperfusion injury

(2010) Xingshun Xu et al.   BRAIN RESEARCH

Intestinal anti-inflammatory activity of esculetin and 4-methylesculetin in the trinitrobenzenesulphonic acid model of rat colitis

(2010) Aline Witaicenis et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Aesculetin-induced apoptosis through a ROS-mediated mitochondrial dysfunction pathway in human cervical cancer cells

(2010) Jin Yang et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

Characterisation of neuronal cell death in acute and delayed in vitro ischemia (oxygen–glucose deprivation) models

(2010) Bruno P. Meloni et al.   JOURNAL OF NEUROSCIENCE METHODS

Protective effect of esculetin against oxidative stress-induced cell damage via scavenging reactive oxygen species

(2009) So-hyung Kim et al.   ACTA PHARMACOLOGICA SINICA

Enhancement of esculetin on arsenic trioxide-provoked apoptosis in human leukemia U937 cells

(2009) Tseng-Hsi Lin et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Esculetin enhances TRAIL-induced apoptosis through DR5 upregulation in human oral cancer SAS cells

(2009) Sang-Heng Kok et al.   ORAL ONCOLOGY

Apoptotic Mechanisms After Cerebral Ischemia

(2009) Brad R.S. Broughton et al.   STROKE

Neuroprotective effect of humanin on cerebral ischemia/reperfusion injury is mediated by a PI3K/Akt pathway

(2008) Xingshun Xu et al.   BRAIN RESEARCH

Induction of apoptosis by esculetin in human leukemia U937 cells through activation of JNK and ERK

(2007) Cheol Park et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY