Targeting TLR4-dependent inflammation in post-hemorrhagic brain injury

Modulation of brain cation-Cl− cotransport via the SPAK kinase inhibitor ZT-1a

(2020) Jinwei Zhang et al.   Nature Communications

Toll-like Receptors and the Control of Immunity

(2020) Katherine A. Fitzgerald et al.   CELL

Inflammation in acquired hydrocephalus: pathogenic mechanisms and therapeutic targets

(2020) Jason K. Karimy et al.   Nature Reviews Neurology

Dehydroabietic Acid Suppresses Inflammatory Response Via Suppression of Src-, Syk-, and TAK1-Mediated Pathways

(2019) Eunji Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ciprofloxacin and levofloxacin attenuate microglia inflammatory response via TLR4/NF-kB pathway

(2019) Morena Zusso et al.   Journal of Neuroinflammation

Microglia-derived TNF-α mediates endothelial necroptosis aggravating blood brain–barrier disruption after ischemic stroke

(2019) An-Qi Chen et al.   Cell Death & Disease

Dasatinib regulates LPS-induced microglial and astrocytic neuroinflammatory responses by inhibiting AKT/STAT3 signaling

(2019) Ka-Young Ryu et al.   Journal of Neuroinflammation

Biodegradable PEG-poly(ω-pentadecalactone- co - p -dioxanone) nanoparticles for enhanced and sustained drug delivery to treat brain tumors

(2018) Evan M. Chen et al.   BIOMATERIALS

Anti-Inflammatory Effects of Resveratrol: Mechanistic Insights

(2018) Diego de Sá Coutinho et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

TLR4-Binding DNA Aptamers Show a Protective Effect against Acute Stroke in Animal Models

(2018) Gerónimo Fernández et al.   MOLECULAR THERAPY

Identifying the inhibition of TIR proteins involved in TLR signalling as an anti-inflammatory strategy

(2018) U. Saqib et al.   SAR AND QSAR IN ENVIRONMENTAL RESEARCH

Heparin: The Silver Bullet of Aneurysmal Subarachnoid Hemorrhage?

(2018) Nicolas K. Khattar et al.   Frontiers in Neurology

Suppression of TLR4 activation by resveratrol is associated with STAT3 and Akt inhibition in oxidized low-density lipoprotein-activated platelets

(2018) Jie Sun et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Fluoxetine attenuates neuroinflammation in early brain injury after subarachnoid hemorrhage: a possible role for the regulation of TLR4/MyD88/NF-κB signaling pathway

(2018) Fu-yi Liu et al.   Journal of Neuroinflammation

Bimodal Distribution of Nuclear Factor-κB Activation and Expression of Subunits in Experimental Models of Intracerebral Hemorrhage In Vivo

(2018) Ze-Li Zhang et al.   Journal of Stroke & Cerebrovascular Diseases

Thrombin-induced, TNFR-dependent miR-181c downregulation promotes MLL1 and NF-κB target gene expression in human microglia

(2017) Min Yin et al.   Journal of Neuroinflammation

All-Trans Retinoic Acid Modulates TLR4/NF-κB Signaling Pathway Targeting TNF-αand Nitric Oxide Synthase 2 Expression in Colonic Mucosa during Ulcerative Colitis and Colitis Associated Cancer

(2017) Hayet Rafa et al.   MEDIATORS OF INFLAMMATION

Heparin and Heparin-Derivatives in Post-Subarachnoid Hemorrhage Brain Injury: A Multimodal Therapy for a Multimodal Disease

(2017) Erik Hayman et al.   MOLECULES

Inflammation-dependent cerebrospinal fluid hypersecretion by the choroid plexus epithelium in posthemorrhagic hydrocephalus

(2017) Jason K Karimy et al.   NATURE MEDICINE

Toll-like receptor 4 as a possible therapeutic target for delayed brain injuries after aneurysmal subarachnoid hemorrhage

(2017) Hidenori Suzuki et al.   Neural Regeneration Research

Human Endothelial Cell Activation byEscherichia coliandStaphylococcus aureusIs Mediated by TNF and IL-1β Secondarily to Activation of C5 and CD14 in Whole Blood

(2016) Stig Nymo et al.   JOURNAL OF IMMUNOLOGY

The Formation of Microthrombi in Parenchymal Microvessels after Traumatic Brain Injury Is Independent of Coagulation Factor XI

(2016) Susanne M. Schwarzmaier et al.   JOURNAL OF NEUROTRAUMA

The effect of lysophosphatidic acid on Toll-like receptor 4 expression and the nuclear factor-κB signaling pathway in THP-1 cells

(2016) Bo Yang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Heparin inhibits the inflammation and proliferation of human rheumatoid arthritis fibroblast-like synoviocytes through the NF-κB pathway

(2016) Li Qi et al.   Molecular Medicine Reports

Effects of Toll-Like Receptor 4 Antagonists Against Cerebral Vasospasm After Experimental Subarachnoid Hemorrhage in Mice

(2016) Fumihiro Kawakita et al.   MOLECULAR NEUROBIOLOGY

Methemoglobin Is an Endogenous Toll-Like Receptor 4 Ligand—Relevance to Subarachnoid Hemorrhage

(2015) Min Kwon et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Inflammation drives thrombosis after Salmonella infection via CLEC-2 on platelets

(2015) Jessica R. Hitchcock et al.   JOURNAL OF CLINICAL INVESTIGATION

Guidelines for the Management of Spontaneous Intracerebral Hemorrhage

(2015) J. Claude Hemphill et al.   STROKE

Polyubiquitination of Transforming Growth Factor β-activated Kinase 1 (TAK1) at Lysine 562 Residue Regulates TLR4-mediated JNK and p38 MAPK Activation

(2015) I-Ting Chen et al.   Scientific Reports

Discovery of small molecule inhibitors of MyD88-dependent signaling pathways using a computational screen

(2015) Mark A. Olson et al.   Scientific Reports

Toll-Like Receptor 4 Regulates Platelet Function and Contributes to Coagulation Abnormality and Organ Injury in Hemorrhagic Shock and Resuscitation

(2014) N. Ding et al.   Circulation-Cardiovascular Genetics

Identification of dehydroabietc acid from Boswellia thurifera resin as a positive GABAA receptor modulator

(2014) Diana C. Rueda et al.   FITOTERAPIA

Curcumin attenuates acute inflammatory injury by inhibiting the TLR4/MyD88/NF-κB signaling pathway in experimental traumatic brain injury

(2014) Hai-tao Zhu et al.   Journal of Neuroinflammation

Fibrinogen, an endogenous ligand of Toll-like receptor 4, activates monocytes in pre-eclamptic patients

(2014) Ebtisam Al-ofi et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease

(2013) J. D. Belcher et al.   BLOOD

The role of microglia and the TLR4 pathway in neuronal apoptosis and vasospasm after subarachnoid hemorrhage

(2013) Khalid A Hanafy   Journal of Neuroinflammation

Hemoglobin induces inflammation after preterm intraventricular hemorrhage by methemoglobin formation

(2013) Magnus Gram et al.   Journal of Neuroinflammation

Tenascin-C induces prolonged constriction of cerebral arteries in rats

(2013) Masashi Fujimoto et al.   NEUROBIOLOGY OF DISEASE

Intracranial Hemorrhage

(2012) J. Alfredo Caceres et al.   EMERGENCY MEDICINE CLINICS OF NORTH AMERICA

TRAF6 is functional in inhibition of TLR4-mediated NF-κB activation by resveratrol

(2012) Peter B. Jakus et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Toll-like Receptor 4 (TLR4) Is Essential for Hsp70-like Protein 1 (HSP70L1) to Activate Dendritic Cells and Induce Th1 Response

(2011) Hongliang Fang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Resveratrol mitigates lipopolysaccharide- and Aβ-mediated microglial inflammation by inhibiting the TLR4/NF-κB/STAT signaling cascade

(2011) Hemachander Capiralla et al.   JOURNAL OF NEUROCHEMISTRY

Inflammation of the Choroid Plexus and Ependymal Layer of the Ventricle Following Intraventricular Hemorrhage

(2011) Philippe F. Simard et al.   Translational Stroke Research

The Acute Management of Intracerebral Hemorrhage

(2010) Justine Elliott et al.   ANESTHESIA AND ANALGESIA

Quercetin regulates oxidized LDL induced inflammatory changes in human PBMCs by modulating the TLR-NF-κB signaling pathway

(2010) Shobha Bhaskar et al.   IMMUNOBIOLOGY

Hemin and a metabolic derivative coprohemin modulate the TLR4 pathway differently through different molecular targets

(2010) Matteo Piazza et al.   Innate Immunity

Endogenous ligands of TLR2 and TLR4: agonists or assistants?

(2010) Clett Erridge   JOURNAL OF LEUKOCYTE BIOLOGY

TAK-242 (Resatorvid), a Small-Molecule Inhibitor of Toll-Like Receptor (TLR) 4 Signaling, Binds Selectively to TLR4 and Interferes with Interactions between TLR4 and Its Adaptor Molecules

(2010) N. Matsunaga et al.   MOLECULAR PHARMACOLOGY

The endogenous Toll-like receptor 4 agonist S100A8/S100A9 (calprotectin) as innate amplifier of infection, autoimmunity, and cancer

(2009) Jan M. Ehrchen et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Cerebral vasospasm following subarachnoid hemorrhage: time for a new world of thought

(2009) Ryszard M. Pluta et al.   NEUROLOGICAL RESEARCH

LPS/TLR4 signal transduction pathway

(2008) Yong-Chen Lu et al.   CYTOKINE