Dasatinib regulates LPS-induced microglial and astrocytic neuroinflammatory responses by inhibiting AKT/STAT3 signaling

The Role of Neuroinflammation in Postoperative Cognitive Dysfunction: Moving From Hypothesis to Treatment

(2019) Seyed A. Safavynia et al.   Frontiers in Psychiatry

c-Abl kinase regulates neutrophil extracellular trap formation, inflammation, and tissue damage in severe acute pancreatitis

(2019) Raed Madhi et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Sinomenine regulates CD14/TLR4, JAK2/STAT3 pathway and calcium signal via α7nAChR to inhibit inflammation in LPS-stimulated macrophages

(2019) Rui-Li Zhu et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Dasatinib can enhance paclitaxel and gemcitabine inhibitory activity in human pancreatic cancer cells

(2019) Ling Ma et al.   CANCER BIOLOGY & THERAPY

Src family kinases, HCK and FGR, associate with local inflammation and tumour progression in colorectal cancer

(2019) Antonia K. Roseweir et al.   CELLULAR SIGNALLING

Microglia-mediated neuroinflammation in neurodegenerative diseases

(2019) Charannya Sozheesvari Subhramanyam et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Src family kinase tyrosine phosphorylates Toll-like receptor 4 to dissociate MyD88 and Mal/Tirap, suppressing LPS-induced inflammatory responses

(2018) Jonathon Mitchell et al.   BIOCHEMICAL PHARMACOLOGY

Syk and Src-targeted anti-inflammatory activity of aripiprazole, an atypical antipsychotic

(2018) Sulgi Yoo et al.   BIOCHEMICAL PHARMACOLOGY

Echinacoside alleviated LPS-induced cell apoptosis and inflammation in rat intestine epithelial cells by inhibiting the mTOR/STAT3 pathway

(2018) Lei Li et al.   BIOMEDICINE & PHARMACOTHERAPY

Senolytics improve physical function and increase lifespan in old age

(2018) Ming Xu et al.   NATURE MEDICINE

Ibrutinib suppresses LPS-induced neuroinflammatory responses in BV2 microglial cells and wild-type mice

(2018) Hye Yeon Nam et al.   Journal of Neuroinflammation

Mechanisms, monitoring, and management of tyrosine kinase inhibitors-associated cardiovascular toxicities

(2018) Maher Chaar et al.   OncoTargets and Therapy

M2b macrophage polarization and its roles in diseases

(2018) Le-xun Wang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The small molecule CA140 inhibits the neuroinflammatory response in wild-type mice and a mouse model of AD

(2018) Ju-Young Lee et al.   Journal of Neuroinflammation

Ponatinib Inhibits Multiple Signaling Pathways Involved in STAT3 Signaling and Attenuates Colorectal Tumor Growth

(2018) Fiona Tan et al.   Cancers

A Mercaptoacetamide-Based Class II Histone Deacetylase Inhibitor Suppresses Cell Migration and Invasion in Monomorphic Malignant Human Glioma Cells by Inhibiting FAK/STAT3 Signaling

(2017) Jin Han Nam et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Involvement of c-Abl Kinase in Microglial Activation of NLRP3 Inflammasome and Impairment in Autolysosomal System

(2017) Vivek Lawana et al.   Journal of Neuroimmune Pharmacology

Microglia amplify inflammatory activation of astrocytes in manganese neurotoxicity

(2017) Kelly S. Kirkley et al.   Journal of Neuroinflammation

Pinus densiflora needle supercritical fluid extract suppresses the expression of pro-inflammatory mediators iNOS, IL-6 and IL-1β, and activation of inflammatory STAT1 and STAT3 signaling proteins in bacterial lipopolysaccharide-challenged murine macrophages

(2017) Thamizhiniyan Venkatesan et al.   DARU-Journal of Pharmaceutical Sciences

Lipopolysaccharide potentiates platelet responses via toll-like receptor 4-stimulated Akt-Erk-PLA2 signalling

(2017) Maria E. Lopes Pires et al.   PLoS One

Neuroinflammation in Alzheimer's disease: Current evidence and future directions

(2016) Valeria Calsolaro et al.   Alzheimers & Dementia

The tyrosine kinase inhibitor dasatinib reduces lung inflammation and remodelling in experimental allergic asthma

(2016) AL da Silva et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Bruton Tyrosine Kinase (BTK) Inhibitor Acalabrutinib Demonstrates Potent On-Target Effects and Efficacy in Two Mouse Models of Chronic Lymphocytic Leukemia

(2016) Sarah E.M. Herman et al.   CLINICAL CANCER RESEARCH

Upregulation of Akt/NF-κB-regulated inflammation and Akt/Bad-related apoptosis signaling pathway involved in hepatic carcinoma process: suppression by carnosic acid nanoparticle

(2016) Bo Tang et al.   International Journal of Nanomedicine

Role of neuroinflammation in neurodegenerative diseases (Review)

(2016) WEI-WEI CHEN et al.   Molecular Medicine Reports

The emerging role of Toll-like receptor 4 in myocardial inflammation

(2016) Y Yang et al.   Cell Death & Disease

Dasatinib Reduces Lung Inflammation and Fibrosis in Acute Experimental Silicosis

(2016) Fernanda Ferreira Cruz et al.   PLoS One

The Effects of Dasatinib in Experimental Acute Respiratory Distress Syndrome Depend on Dose and Etiology

(2015) Gisele P. Oliveira et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Therapeutic effects of dasatinib in mouse model of multiple sclerosis

(2015) Gholamreza Azizi et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Phlorofucofuroeckol B suppresses inflammatory responses by down-regulating nuclear factor κB activation via Akt, ERK, and JNK in LPS-stimulated microglial cells

(2015) Dong-Kyung Yu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Bruton’s tyrosine kinase is essential for NLRP3 inflammasome activation and contributes to ischaemic brain injury

(2015) Minako Ito et al.   Nature Communications

Quantitative Analysis of Histological Staining and Fluorescence Using ImageJ

(2014) Ellen C. Jensen   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Janus kinase inhibition by ruxolitinib extends dasatinib- and dexamethasone-induced remissions in a mouse model of Ph+ ALL

(2014) I. Appelmann et al.   BLOOD

LPS and IL-1 differentially activate mouse and human astrocytes: Role of CD14

(2014) Leonid Tarassishin et al.   GLIA

Btk Regulates Macrophage Polarization in Response to Lipopolysaccharide

(2014) Joan Ní Gabhann et al.   PLoS One

Modeling chronic myeloid leukemia in immunodeficient mice reveals expansion of aberrant mast cells and accumulation of pre-B cells

(2014) M Askmyr et al.   Blood Cancer Journal

Toll-Like Receptors in Antiviral Innate Immunity

(2013) Sandra N. Lester et al.   JOURNAL OF MOLECULAR BIOLOGY

Prevention of LPS-Induced Microglia Activation, Cytokine Production and Sickness Behavior with TLR4 Receptor Interfering Peptides

(2013) Dustin J. Hines et al.   PLoS One

Dasatinib inhibits proinflammatory functions of mature human neutrophils

(2012) K. Futosi et al.   BLOOD

Caffeine suppresses lipopolysaccharide-stimulated BV2 microglial cells by suppressing Akt-mediated NF-κB activation and ERK phosphorylation

(2012) Chang-Hee Kang et al.   FOOD AND CHEMICAL TOXICOLOGY

The PI3K/Akt pathway is required for LPS activation of microglial cells

(2012) Concetta Saponaro et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Inhibition of Src kinase activity attenuates amyloid associated microgliosis in a murine model of Alzheimer’s disease

(2012) Gunjan Dhawan et al.   Journal of Neuroinflammation

Leukocyte rolling and adhesion both contribute to regulation of microvascular permeability to albumin via ligation of ICAM-1

(2011) Ronen Sumagin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Central Nervous System Blast Crisis in Chronic Myeloid Leukemia on Imatinib Mesylate Therapy: Report of Two Cases

(2011) Narayan Radhika et al.   INDIAN JOURNAL OF HEMATOLOGY AND BLOOD TRANSFUSION

TIRAP, an Adaptor Protein for TLR2/4, Transduces a Signal from RAGE Phosphorylated upon Ligand Binding

(2011) Masakiyo Sakaguchi et al.   PLoS One

Dasatinib: A potent SRC inhibitor in clinical development for the treatment of solid tumors

(2010) John Araujo et al.   CANCER TREATMENT REVIEWS

IL-6 Trans-Signaling Modulates TLR4-Dependent Inflammatory Responses via STAT3

(2010) C. J. Greenhill et al.   JOURNAL OF IMMUNOLOGY

Increase in the density of resting microglia precedes neuritic plaque formation and microglial activation in a transgenic model of Alzheimer's disease

(2010) J J Rodríguez et al.   Cell Death & Disease

Targeting extracellular signal-regulated kinase (ERK) signaling has therapeutic implications for inflammatory osteolysis

(2009) Sung Wook Seo et al.   BONE

Tec kinases regulate actin assembly and cytokine expression in LPS-stimulated human neutrophils via JNK activation

(2009) Rachel L. Zemans et al.   CELLULAR IMMUNOLOGY

Dasatinib inhibits the secretion of TNF-α following TLR stimulation in vitro and in vivo

(2009) Cara K. Fraser et al.   EXPERIMENTAL HEMATOLOGY

Role of Endothelial TLR4 for Neutrophil Recruitment into Central Nervous System Microvessels in Systemic Inflammation

(2009) H. Zhou et al.   JOURNAL OF IMMUNOLOGY

Leptin regulates leukocyte recruitment into the brain following systemic LPS-induced inflammation

(2009) C Rummel et al.   MOLECULAR PSYCHIATRY