Identification of Tri- and Tetracyclic Pyrimidinediones as Sirtuin Inhibitors

Histone Deacetylase Inhibitors and Neurodegenerative Disorders: Holding the Promise

(2009) Antonello Mai et al.   CURRENT PHARMACEUTICAL DESIGN

Novel Cambinol Analogs as Sirtuin Inhibitors: Synthesis, Biological Evaluation, and Rationalization of Activity

(2009) Federico Medda et al.   JOURNAL OF MEDICINAL CHEMISTRY

Study of 1,4-Dihydropyridine Structural Scaffold: Discovery of Novel Sirtuin Activators and Inhibitors

(2009) Antonello Mai et al.   JOURNAL OF MEDICINAL CHEMISTRY

SIRTUIN 1: Regulating the regulator

(2008) Barbara Zschoernig et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Therapeutic role of sirtuins in neurodegenerative disease

(2008) Tiago Fleming Outeiro et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Discovery, In Vivo Activity, and Mechanism of Action of a Small-Molecule p53 Activator

(2008) Sonia Lain et al.   CANCER CELL

Biological and Potential Therapeutic Roles of Sirtuin Deacetylases

(2008) D. M. Taylor et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Thiobarbiturates as Sirtuin Inhibitors: Virtual Screening, Free-Energy Calculations, and Biological Testing

(2008) Urszula Uciechowska et al.   ChemMedChem

The Sirtuin family: therapeutic targets to treat diseases of aging

(2008) Jill C Milne et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Epigenetic Multiple Ligands: Mixed Histone/Protein Methyltransferase, Acetyltransferase, and Class III Deacetylase (Sirtuin) Inhibitors

(2008) Antonello Mai et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure–Activity Studies on Splitomicin Derivatives as Sirtuin Inhibitors and Computational Prediction of Binding Mode

(2008) Robert C. Neugebauer et al.   JOURNAL OF MEDICINAL CHEMISTRY

Negative regulation of the deacetylase SIRT1 by DBC1

(2008) Wenhui Zhao et al.   NATURE

Sirtuins — novel therapeutic targets to treat age-associated diseases

(2008) Siva Lavu et al.   NATURE REVIEWS DRUG DISCOVERY

Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect

(2008) E Lara et al.   ONCOGENE

SIRT1 and neuronal diseases

(2007) Bor Luen Tang et al.   MOLECULAR ASPECTS OF MEDICINE