Evaluation of subchronic administration of antiseizure drugs in spontaneously seizing rats

The impact of nonadherence to antiseizure drugs on seizure outcomes in an animal model of epilepsy

(2017) Kyle E. Thomson et al.   EPILEPSIA

Development and pharmacologic characterization of the rat 6 Hz model of partial seizures

(2017) Cameron S. Metcalf et al.   EPILEPSIA

Common data elements and data management: Remedy to cure underpowered preclinical studies

(2017) Niina Lapinlampi et al.   EPILEPSY RESEARCH

The National Institute of Neurological Disorders and Stroke (NINDS) Epilepsy Therapy Screening Program (ETSP)

(2017) John H. Kehne et al.   NEUROCHEMICAL RESEARCH

Profile of retigabine-induced neuronal apoptosis in the developing rat brain

(2016) Lindsay Brown et al.   EPILEPSIA

An Updated Overview on Therapeutic Drug Monitoring of Recent Antiepileptic Drugs

(2016) Shery Jacob et al.   Drugs in research & development

The AMPA receptor antagonist NBQX exerts anti-seizure but not antiepileptogenic effects in the intrahippocampal kainate mouse model of mesial temporal lobe epilepsy

(2015) Friederike Twele et al.   NEUROPHARMACOLOGY

Functional Characterization of the 1,5-Benzodiazepine Clobazam and Its Major Active Metabolite N-Desmethylclobazam at Human GABAA Receptors Expressed in Xenopus laevis Oocytes

(2015) Harriet Hammer et al.   PLoS One

Antiepileptic efficacy of lamotrigine in phenobarbital-resistant and -responsive epileptic rats: A pilot study

(2014) Claudia Brandt et al.   EPILEPSY RESEARCH

A novel open-source drug-delivery system that allows for first-of-kind simulation of nonadherence to pharmacological interventions in animal disease models

(2014) Kyle E. Thomson et al.   JOURNAL OF NEUROSCIENCE METHODS

Rapid loss of efficacy to the antiseizure drugs lamotrigine and carbamazepine: A novel experimental model of pharmacoresistant epilepsy

(2013) Ajay K. Srivastava et al.   EPILEPSIA

Issues related to development of new antiseizure treatments

(2013) Karen S. Wilcox et al.   EPILEPSIA

New avenues for anti-epileptic drug discovery and development

(2013) Wolfgang Löscher et al.   NATURE REVIEWS DRUG DISCOVERY

Carbamazepine, but not valproate, displays pharmacoresistance in lamotrigine-resistant amygdala kindled rats

(2012) Ajay K. Srivastava et al.   EPILEPSY RESEARCH

Pharmacokinetics, brain distribution, and plasma protein binding of the antiepileptic drug lacosamide in rats

(2011) Tae-Sung Koo et al.   ARCHIVES OF PHARMACAL RESEARCH

Modern antiepileptic drug development has failed to deliver: Ways out of the current dilemma

(2011) Wolfgang Löscher et al.   EPILEPSIA

Perampanel: A novel, orally active, noncompetitive AMPA-receptor antagonist that reduces seizure activity in rodent models of epilepsy

(2011) Takahisa Hanada et al.   EPILEPSIA

Critical review of current animal models of seizures and epilepsy used in the discovery and development of new antiepileptic drugs

(2011) Wolfgang Löscher   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Comparative pharmacokinetics of RAD001 (everolimus) in normal and tumor-bearing rodents

(2009) Terence O’Reilly et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Drug treatment of epilepsy in the century of the ILAE: The second 50 years, 1959-2009

(2009) Simon D. Shorvon   EPILEPSIA

Development of Spontaneous Recurrent Seizures after Kainate-Induced Status Epilepticus

(2009) P. A. Williams et al.   JOURNAL OF NEUROSCIENCE

Antiepileptogenic and antiictogenic effects of retigabine under conditions of rapid kindling: An ontogenic study

(2008) Andréy Mazarati et al.   EPILEPSIA

A new potential AED, carisbamate, substantially reduces spontaneous motor seizures in rats with kainate-induced epilepsy

(2008) Heidi L. Grabenstatter et al.   EPILEPSIA

Development of tolerance to levetiracetam in rats with chronic epilepsy

(2008) Erwin A. van Vliet et al.   EPILEPSIA