Article
Clinical Neurology
H. J. Kim, H. Cho, M. Park, J. W. Kim, S. J. Ahn, C. H. Lyoo, S. H. Suh, Y. H. Ryu
Summary: The presence of perivascular spaces in the centrum semiovale is independently associated with β-amyloid positivity in patients with Alzheimer's disease-related cognitive impairment, serving as an indirect imaging marker of amyloid pathology in the brain.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2021)
Article
Multidisciplinary Sciences
Kathleen E. Hupfeld, Sutton B. Richmond, Heather R. McGregor, Daniel L. Schwartz, Madison N. Luther, Nichole E. Beltran, Igor S. Kofman, Yiri E. De Dios, Roy F. Riascos, Scott J. Wood, Jacob J. Bloomberg, Ajitkumar P. Mulavara, Lisa C. Silbert, Jeffrey J. Iliff, Rachael D. Seidler, Juan Piantino
Summary: The study found that spaceflight can lead to changes in perivascular spaces (PVSs) in the brain, with novice astronauts showing an increase in total PVS volume post-flight while experienced crewmembers did not. The findings suggest that prior spaceflight experience may play a role in determining PVS characteristics.
SCIENTIFIC REPORTS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hyun Gi Kim, Na-Young Shin, Yoonho Nam, Eunkyeong Yun, Uicheul Yoon, Hye Sun Lee, Kook Jin Ahn
Summary: This study found that the volume of dilated perivascular spaces (dPVS) in brain MRI showed a biphasic pattern with age, with lower volumes before the mid-30s and higher volumes thereafter. Additionally, dPVS could be classified into different grades based on age, with a grade of 3 or higher in basal ganglia indicating pathology, and a grade of 4 or higher in white matter indicating pathology.
Article
Neurosciences
Kirsten M. Lynch, Farshid Sepehrband, Arthur W. Toga, Jeiran Choupan
Summary: Enlarged perivascular spaces (PVS) are biomarkers for vascular pathology and their changes with age, sex, and cognitive performance were characterized in a large cohort using MRI data. Age was found to be associated with wider and more numerous PVS, with different spatial patterns of enlargement. Males had higher PVS burden than females, with differing morphological changes over time. These findings contribute to our understanding of perivascular physiology and serve as a reference for pathological alterations.
Article
Clinical Neurology
Young Min Choe, Hyewon Baek, Hyo Jung Choi, Min Soo Byun, Dahyun Yi, Bo Kyung Sohn, Chul-Ho Sohn, Dong Young Lee
Summary: This study examines the relationship between enlarged perivascular spaces (EPVS) in different brain regions and cognitive impairment in a memory clinic population. The findings suggest that EPVS may not be a specific marker for cognitive impairment, although there is an association between a high degree of EPVS in the basal ganglia and executive dysfunction. Controlling for other markers of small vessel disease weakened this association.
Article
Behavioral Sciences
Merel M. van der Thiel, Walter H. Backes, Inez H. G. B. Ramakers, Jacobus F. A. Jansen
Summary: The waste clearance system in the brain plays a role in Alzheimer's disease through the aggregation of Amyloid-beta. MRI techniques have potential for studying this system, especially non-contrast enhanced techniques. This review discusses recent advancements in non-CE MRI techniques and their application in studying the physiological aspects of the clearance system and its dysfunction in cognitive decline and AD.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Geriatrics & Gerontology
Farshid Sepehrband, Giuseppe Barisano, Nasim Sheikh-Bahaei, Jeiran Choupan, Ryan P. Cabeen, Kirsten M. Lynch, Malcolm S. Crawford, Haoyu Lan, Wendy J. Mack, Helena C. Chui, John M. Ringman, Arthur W. Toga
Summary: Early cognitive dysfunction is associated with altered presence and distribution of perivascular spaces (PVS) in the brain, particularly in the anterosuperior medial temporal lobe. These changes are linked to neurofibrillary tau tangle deposition, a hallmark of early Alzheimer's disease pathology. (English Summary)
NEUROBIOLOGY OF AGING
(2021)
Article
Neurosciences
Xiao Zhang, Paul O'Callaghan, Honglian Li, Yingxia Tan, Ganlin Zhang, Uri Barash, Xiaomin Wang, Lars Lannfelt, Israel Vlodavsky, Ulf Lindahl, Jin-Ping Li
Summary: Defective clearance of amyloid-beta in the brain, caused by elevated levels of heparanase, results in impaired perivascular drainage and accumulation of A beta, contributing to the pathogenesis of Alzheimer's disease. This study highlights the potential role of heparanase in altering the blood-brain barrier and promoting amyloid-beta accumulation in the brain.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2021)
Article
Neurosciences
Arunima Kapoor, Belinda Yew, Jung Yun Jang, Shubir Dutt, Yanrong Li, John Paul M. Alitin, Aimee Gaubert, Jean K. Ho, Anna E. Blanken, Isabel J. Sible, Anisa Marshall, Xingfeng Shao, Mara Mather, Danny J. J. Wang, Daniel A. Nation
Summary: In this study, pathological widening of perivascular spaces in older adults was significantly associated with deficits in global cerebrovascular reactivity to hypercapnia, but not to hypocapnia. The findings suggest that perivascular spaces may impact cerebrovascular vasodilatory response, highlighting the importance of further longitudinal studies in understanding the relationship between cerebrovascular function and perivascular space enlargement.
Review
Physiology
Kathleen B. Miller, Kaitlyn L. Mi, Gregory A. Nelson, Ryan B. Norman, Zarana S. Patel, Janice L. Huff
Summary: This study examines the impact of space radiation on the vascular and nervous systems, indicating potential risks for cerebrovascular diseases and cognitive impairments. Due to the complexity and gaps in research, further exploration of the long-term effects of ionizing radiation on brain health is needed.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Clinical Neurology
Audrey Low, Maria A. Prats-Sedano, James D. Stefaniak, Elizabeth Frances McKiernan, Stephen F. Carter, Maria-Eleni Douvani, Elijah Mak, Li Su, Olivia Stupart, Graciela Muniz, Karen Ritchie, Craig W. Ritchie, Hugh S. Markus, John Tiernan O'Brien
Summary: Markers of cerebrovascular disease are common in midlife adults, but their clinical relevance in predicting future dementia remains unclear. This study found that the Cardiovascular Risk Factors, Ageing and Dementia (CAIDE) risk score is associated with markers of cerebral small vessel disease (SVD) and predicts the progression of SVD in midlife adults. The study also highlighted the potential of the CAIDE score as a prognostic and predictive marker for managing modifiable risk factors in cerebrovascular disease.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Veterinary Sciences
Carolin Fischer, Sebastian Schaub, Kathrin Buettner, Katinka Hartmann, Martin Juergen Schmidt
Summary: This study evaluated the occurrence and MRI morphology of VRS in structurally normal canine and feline brains, as well as physiological cerebrospinal fluid analysis. The results showed that 57% of patients presented dilated VRS, which was related to magnetic field strength, gender, and body weight.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Clinical Neurology
Matthew Paradise, John D. Crawford, Ben C. P. Lam, Wei Wen, Nicole A. Kochan, Steve Makkar, Laughlin Dawes, Julian Trollor, Brian Draper, Henry Brodaty, Perminder S. Sachdev
Summary: Severe perivascular space dilation is associated with cognitive decline and dementia risk over a period of 8 years. The presence of severe PVS pathology, particularly in both regions, is an independent predictor of dementia. Differential cognitive associations between BG and CSO PVS may indicate underlying pathological differences.
Article
Clinical Neurology
Zachary L. Adirim, Chinthaka Heyn, Brian J. Murray
Summary: This case report highlights the complex association between sleep disorders, the development of VRS, and impaired sleep, suggesting that the development of this perivascular abnormality may contribute to subsequent sleep disorders.
Article
Clinical Neurology
Benjamin S. Aribisala, Maria del C. Valdes Hernandez, Judith A. Okely, Simon R. Cox, Lucia Ballerini, David Alexander Dickie, Stewart J. Wiseman, Renata L. Riha, Susana Munoz Maniega, Ratko Radakovic, Adele Taylor, Alison Pattie, Janie Corley, Paul Redmond, Mark E. Bastin, Ian Deary, Joanna M. Wardlaw
Summary: Poor sleep quality and impaired waste clearance are associated with deteriorating brain health. The study found that decreased sleep efficiency and increased white matter damage were related to reductions in normal-appearing white matter and increased white matter hyperintensities. Additionally, increased burden of perivascular spaces was associated with worse brain health.
Article
Radiology, Nuclear Medicine & Medical Imaging
Simon Duchesne, Isabelle Chouinard, Olivier Potvin, Vladimir S. Fonov, April Khademi, Robert Bartha, Pierre Bellec, D. Louis Collins, Maxime Descoteaux, Rick Hoge, Cheryl R. McCreary, Joel Ramirez, Christopher J. M. Scott, Eric E. Smith, Stephen C. Strother, Sandra E. Black
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2019)
Article
Clinical Neurology
Yana Yunusova, Jamal Ansari, Joel Ramirez, Sanjana Shellikeri, Greg J. Stanisz, Sandra E. Black, Susan M. Gillingham, Alex Kiss, Donald T. Stuss, Lorne Zinman
BEHAVIOURAL NEUROLOGY
(2019)
Review
Clinical Neurology
Joanna M. Wardlaw, Helene Benveniste, Maiken Nedergaard, Berislav V. Zlokovic, Humberto Mestre, Hedok Lee, Fergus N. Doubal, Rosalind Brown, Joel Ramirez, Bradley J. MacIntosh, Allen Tannenbaum, Lucia Ballerini, Ravi L. Rungta, Davide Boido, Melanie Sweeney, Axel Montagne, Serge Charpak, Anne Joutel, Kenneth J. Smith, Sandra E. Black
NATURE REVIEWS NEUROLOGY
(2020)
Article
Clinical Neurology
Joel Ramirez, Allison A. Dilliott, Malcolm A. Binns, David P. Breen, Emily C. Evans, Derek Beaton, Paula M. McLaughlin, Donna Kwan, Melissa F. Holmes, Miracle Ozzoude, Christopher J. M. Scott, Stephen C. Strother, Sean Symons, Richard H. Swartz, David Grimes, Mandar Jog, Mario Masellis, Sandra E. Black, Anne Joutel, Connie Marras, Ekaterina Rogaeva, Robert A. Hegele, Anthony E. Lang
MOVEMENT DISORDERS
(2020)
Article
Neurosciences
Miracle Ozzoude, Joel Ramirez, Pradeep Reddy Raamana, Melissa F. Holmes, Kirstin Walker, Christopher J. M. Scott, Fuqiang Gao, Maged Goubran, Donna Kwan, Maria C. Tartaglia, Derek Beaton, Gustavo Saposnik, Ayman Hassan, Jane Lawrence-Dewars, Dariush Dowlatshahi, Stephen C. Strother, Sean Symons, Robert Bertha, Richard H. Swartz, Sandra E. Black
FRONTIERS IN NEUROSCIENCE
(2020)
Article
Geriatrics & Gerontology
Michael Ouk, Che-Yuan Wu, Jennifer S. Rabin, Jodi D. Edwards, Joel Ramirez, Mario Masellis, Richard H. Swartz, Nathan Herrmann, Krista L. Lanctot, Sandra E. Black, Walter Swardfager
Summary: This study suggests that ARBs may be more effective than ACE-Is in protecting against memory decline by slowing amyloid-beta accumulation in certain brain regions. Differences in amyloid-beta accumulation rates between ARB and ACE-I users may be influenced by apolipoprotein E epsilon 4 carrier status. Further studies and clinical trials are needed to confirm the potential benefits of ARBs in Alzheimer's disease prevention and treatment.
NEUROBIOLOGY OF AGING
(2021)
Article
Clinical Neurology
Joel Ramirez, Melissa F. Holmes, Courtney Berezuk, Donna Kwan, Brian Tan, Derek Beaton, Christopher J. M. Scott, Miracle Ozzoude, Fuqiang Gao, Di Yu, Walter Swardfager, Jane Lawrence-Dewar, Dar Dowlatshahi, Gustavo Saposnik, Mark Boulos, Brian J. Murray, Sean Symons, Robert Bartha, Sandra E. Black, Richard H. Swartz, Andrew Lim
Summary: Individuals with greater PVS volumes spend more time in bed, leading to longer total sleep times; however, individuals with greater basal ganglia PVS volumes are more likely to report daytime dysfunction despite longer total sleep times.
Article
Clinical Neurology
Kelly M. Sunderland, Derek Beaton, Stephen R. Arnott, Peter Kleinstiver, Donna Kwan, Jane M. Lawrence-Dewar, Joel Ramirez, Brian Tan, Robert Bartha, Sandra E. Black, Michael Borrie, Donald Brien, Leanne K. Casaubon, Brian C. Coe, Benjamin Cornish, Allison A. Dilliott, Dar Dowlatshahi, Elizabeth Finger, Corinne Fischer, Andrew Frank, Julia Fraser, Morris Freedman, Barry Greenberg, David A. Grimes, Ayman Hassan, Wendy Hatch, Robert A. Hegele, Christopher Hudson, Mandar Jog, Sanjeev Kumar, Anthony Lang, Brian Levine, Wendy Lou, Jennifer Mandzia, Connie Marras, William McIlroy, Manuel Montero-Odasso, David G. Munoz, Douglas P. Munoz, Joseph B. Orange, David S. Park, Stephen H. Pasternak, Frederico Pieruccini-Faria, Tarek K. Rajji, Angela C. Roberts, John F. Robinson, Ekaterina Rogaeva, Demetrios J. Sahlas, Gustavo Saposnik, Christopher J. M. Scott, Dallas Seitz, Christen Shoesmith, Thomas D. L. Steeves, Michael J. Strong, Stephen C. Strother, Richard H. Swartz, Sean Symons, David F. Tang-Wai, Maria Carmela Tartaglia, Angela K. Troyer, John Turnbull, Lorne Zinman, Paula M. McLaughlin, Mario Masellis, Malcolm A. Binns
Summary: This is a multi-site, longitudinal, observational cohort study that aims to understand the impact of neurodegenerative and cerebrovascular diseases on dementia presentation. The study recruited 520 participants with prevalent neurodegenerative and cerebrovascular diseases and comprehensively assessed them. Results showed that the participants were predominantly White males with higher education levels. The data will be shared with the global scientific community to identify markers of disease severity, progression, and therapy targets.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Joel Ramirez, Stephanie A. Berberian, David P. Breen, Fuqiang Gao, Miracle Ozzoude, Sabrina Adamo, Christopher J. M. Scott, Courtney Berezuk, Vanessa Yhap, Tiago A. Mestre, Connie Marras, Maria C. Tartaglia, David Grimes, Mandar Jog, Donna Kwan, Brian Tan, Malcolm A. Binns, Stephen R. Arnott, Robert Bartha, Sean Symons, Mario Masellis, Sandra E. Black, Anthony E. Lang
Summary: This study showed that small BG-PVS are associated with motor and nonmotor aspects of experiences in daily living, while large BG-PVS are associated with motor symptoms and motor complications.
MOVEMENT DISORDERS
(2022)
Article
Clinical Neurology
Julie Ottoy, Miracle Ozzoude, Katherine Zukotynski, Sabrina Adamo, Christopher Scott, Vincent Gaudet, Joel Ramirez, Walter Swardfager, Hugo Cogo-Moreira, Benjamin Lam, Aparna Bhan, Parisa Mojiri, Min Su Kang, Jennifer S. Rabin, Alex Kiss, Stephen Strother, Christian Bocti, Michael Borrie, Howard Chertkow, Richard Frayne, Robin Hsiung, Robert Laforce, Michael D. Noseworthy, Frank S. Prato, Demetrios J. Sahlas, Eric E. Smith, Phillip H. Kuo, Vesna Sossi, Alexander Thiel, Jean-Paul Soucy, Jean-Claude Tardif, Sandra E. Black, Maged Goubran
Summary: This study investigated the association between cerebrovascular burden and cognitive function, and found that the relationship was mainly mediated by localized neurodegeneration rather than amyloid beta deposition. The results suggest an amyloid-independent pathway through which vascular burden affects cognitive function.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
David Lahna, Daniel L. Schwartz, Randy Woltjer, Sandra E. Black, Natalie Roese, Hiroko Dodge, Erin L. Boespflug, Julia Keith, Fuqiang Gao, Joel Ramirez, Lisa C. Silbert
Summary: The study indicates that venous collagenosis is associated with periventricular white matter hyperintensities (pvWMHs), while arterial collagenosis is not. This suggests the importance of changes in the venous system in the commonly observed MRI white matter lesions in older individuals.
ANNALS OF NEUROLOGY
(2022)
Article
Endocrinology & Metabolism
Julie Ottoy, Miracle Ozzoude, Katherine Zukotynski, Min Su Kang, Sabrina Adamo, Christopher Scott, Joel Ramirez, Walter Swardfager, Benjamin Lam, Aparna Bhan, Parisa Mojiri, Alex Kiss, Stephen Strother, Christian Bocti, Michael Borrie, Howard Chertkow, Richard Frayne, Robin Hsiung, Robert Laforce, Michael D. Noseworthy, Frank S. Prato, Demetrios J. Sahlas, Eric E. Smith, Phillip H. Kuo, Jordan A. Chad, Ofer Pasternak, Vesna Sossi, Alexander Thiel, Jean-Paul Soucy, Jean-Claude Tardif, Sandra E. Black, Maged Goubran
Summary: This study investigated the relationship between A beta-PET signal in white matter (WM) regions and diffusion MRI-based microstructural alterations. The results showed that decreased A beta-PET signal in WMH regions was closely associated with higher free water and higher WMH volume, while increased A beta-PET signal in normal-appearing WM was closely associated with higher cortical A beta and lower free water-adjusted FA. Furthermore, cognitive impairment was more closely related to higher free water than to either free water-adjusted FA or WM PET.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Cardiac & Cardiovascular Systems
Di Yu, Nuanyi Liang, Julia Zebarth, Qing Shen, Miracle Ozzoude, Maged Goubran, Jennifer S. Rabin, Joel Ramirez, Christopher J. M. Scott, Fuqiang Gao, Robert Bartha, Sean Symons, Seyyed Mohammad Hassan Haddad, Courtney Berezuk, Brian Tan, Donna Kwan, Robert A. Hegele, Allison A. Dilliott, Nuwan D. Nanayakkara, Malcolm A. Binns, Derek Beaton, Stephen R. Arnott, Jane M. Lawrence-Dewar, Ayman Hassan, Dar Dowlatshahi, Jennifer Mandzia, Demetrios Sahlas, Leanne Casaubon, Gustavo Saposnik, Yurika Otoki, Krista L. Lanctot, Mario Masellis, Sandra E. Black, Richard H. Swartz, Ameer Y. Taha, Walter Swardfager
Summary: A study found that cerebral small vessel disease is associated with the ratio of certain fatty acid metabolites, and this association has not been examined in stroke patients before. The study analyzed clinical and imaging data of stroke patients and found that the ratio of these fatty acid metabolites is related to small vessel stroke, white matter hyperintensities, and temporal lobe atrophy.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Neuroimaging
Olivier Potvin, Isabelle Chouinard, Louis Dieumegarde, Robert Bartha, Pierre Bellec, D. Louis Collins, Maxime Descoteaux, Rick Hoge, Joel Ramirez, Christopher J. M. Scott, Eric E. Smith, Stephen C. Strother, Sandra E. Black, Simon Duchesne
NEUROIMAGE-CLINICAL
(2019)
Article
Clinical Neurology
Eric E. Smith, Geert Jan Biessels, Francois De Guio, Frank Erik de Leeuw, Simon Duchesne, Marco Duering, Richard Frayne, M. Arfan Ikram, Eric Jouvent, Bradley J. MacIntosh, Michael J. Thrippleton, Meike W. Vernooij, Hieab Adams, Walter H. Backes, Lucia Ballerini, Sandra E. Black, Christopher Chen, Rod Corriveau, Charles DeCarli, Steven M. Greenberg, M. Edip Gurol, Michael Ingrisch, Dominic Job, Bonnie Y. K. Lam, Lenore J. Launer, Jennifer Linn, Cheryl R. McCreary, Vincent C. T. Mok, Leonardo Pantoni, G. Bruce Pike, Joel Ramirez, Yael D. Reijmer, Jose Rafael Romero, Stefan Ropele, Natalia S. Rost, Perminder S. Sachdev, Christopher J. M. Scott, Sudha Seshadri, Mukul Sharma, Steven Sourbron, Rebecca M. E. Steketee, Richard H. Swartz, Robert van Oostenbrugge, Matthias van Osch, Sanneke van Rooden, Anand Viswanathan, David Werring, Martin Dichgans, Joanna M. Wardlaw
ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING
(2019)