Article
Biology
Samy Gauthier, Alexy Tran-Dinh, Ian Morilla
Summary: Efforts to understand COVID-19's molecular mechanisms have identified ACE2 as the main receptor for SARS-CoV-2 spike protein. However, the role of other proteins remains unclear. To address this, we modeled the plasma proteome of 384 COVID-19 patients, accurately assessing illness severity and constructing a dynamic model to learn molecular interactions and identify potential treatments.
LIFE SCIENCE ALLIANCE
(2023)
Article
Biochemistry & Molecular Biology
Riadh Badraoui, Mousa M. Alrashedi, Michele Veronique El-May, Fevzi Bardakci
Summary: ARDS is a severe form of respiratory failure that can be induced by SARS-CoV-2 infection, particularly in COVID-19 cases. Understanding the pathophysiological mechanisms of ARDS, learned from past coronavirus outbreaks and ongoing research on SARS-CoV-2, can provide insight into managing severe cases and improving prognosis.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Biology
Stefanie Deinhardt-Emmer, Daniel Wittschieber, Juliane Sanft, Sandra Kleemann, Stefan Elschner, Karoline Frieda Haupt, Vanessa Vau, Clio Haering, Jurgen Roedel, Andreas Henke, Christina Ehrhardt, Michael Bauer, Mike Philipp, Nikolaus Gassler, Sandor Nietzsche, Bettina Loeffler, Gita Mall
Summary: COVID-19 is a systemic disease, and viral RNA distribution was found in both pulmonary and extrapulmonary tissues and organs, with high viral loads in the lungs. This supports the hypothesis of maladaptive host response with viremia and multiorgan dysfunction.
Review
Biochemistry & Molecular Biology
Arif Jamal Siddiqui, Sadaf Jahan, Syed Amir Ashraf, Mousa Alreshidi, Mohammad Saquib Ashraf, Mitesh Patel, Mejdi Snoussi, Ritu Singh, Mohd Adnan
Summary: The global spread of the new coronavirus infection, identified as novel SARS-CoV-2 and causing COVID-19, has resulted in over 8,807,398 confirmed cases and 464,483 deaths as of June 21, 2020. Currently, there is no specific drug therapy available for COVID-19. Potential antimalarial and antiviral drugs are being tested worldwide, with some showing promising effects against the virus.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Review
Biochemistry & Molecular Biology
Mohammad Mahdi Nejadi Babadaei, Anwarul Hasan, Samir Haj Bloukh, Zehra Edis, Majid Sharifi, Ehsan Kachooei, Mojtaba Falahati
Summary: Researchers have reported useful information about SARS-CoV-2 leading to COVID-19, including the development of antiviral drugs and diagnostic tests. The distribution of ACE2 on the surface of host cells may play a key role in exploring the pathogenesis of SARS-COV-2. Acute and chronic cardiovascular diseases may be associated with the clinical severity of COVID-19.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Virology
Hasan Oncul, Fatma Y. Oncul, Mehmet F. Alakus, Mehtap Caglayan, Umut Dag
Summary: This study investigated ocular findings in patients with COVID-19 and found that ocular diseases are uncommon but may occur during the early stages of the disease or follow-up. Ocular diseases could be the initial or only sign of COVID-19 infection.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Review
Microbiology
Ahmed O. Kaseb, Yehia Mohamed, Alexandre E. Malek, Issam I. Raad, Lina Altameemi, Dan Li, Omar A. Kaseb, Safa A. Kaseb, Abdelhafez Selim, Qing Ma
Summary: The COVID-19 pandemic poses an unprecedented threat to the international community and is largely mediated by the interaction between viral spike protein and ACE2. Variations in ACE2 expression in different demographic groups may explain differences in infection rates and mortality, making it a potential therapeutic target.
Review
Pathology
Stefania Caramaschi, Meghan E. Kapp, Sara E. Miller, Rosana Eisenberg, Joyce Johnson, Garretson Epperly, Antonino Maiorana, Guido Silvestri, Giovanna A. Giannico
Summary: Pathological findings from autopsy and biopsy studies of COVID-19 patients reveal main features of diffuse alveolar damage, thromboembolism, and nonspecific shock injury in multiple organs. Additionally, it suggests a unifying pathogenic mechanism for COVID-19 as ARDS with inflammatory response, cytokine release, fever, inflammation, and generalized endothelial disturbance.
Review
Medicine, General & Internal
Caroline Hirsch, Yun Soo Park, Vanessa Piechotta, Khai Li Chai, Lise J. Estcourt, Ina Monsef, Susanne Salomon, Erica M. Wood, Cynthia So-Osman, Zoe McQuilten, Christoph D. Spinner, Jakob J. Malin, Miriam Stegemann, Nicole Skoetz, Nina Kreuzberger
Summary: This study evaluated the effects of SARS-CoV-2-neutralising mAbs for preventing COVID-19, using a living systematic review approach. It included randomised controlled trials assessing mAbs for pre-exposure prophylaxis (PrEP) and postexposure prophylaxis (PEP) of COVID-19.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2022)
Article
Cell Biology
Rocio Diaz Escarcega, Pedram Honarpisheh, Gabriela Delevati Colpo, Hilda W. Ahnstedt, Lucy Couture, Shivanki Juneja, Glenda Torres, Guadalupe J. Ortiz, James Sollome, Natalie Tabor, Bhanu P. Ganesh, H. Alex Choi, Fudong Liu, Louise D. McCullough, Andrey S. Tsvetkov
Summary: The study finds sex differences in metabolism and sexual dimorphism in the correlations between clinical parameters and metabolic profiles in severe COVID-19 patients, providing important knowledge for the development of sex-associated biomarkers and druggable targets for COVID-19 patients.
CELL DEATH & DISEASE
(2022)
Article
Medicine, General & Internal
Miguel Angel Sanchez-Tena, Clara Martinez-Perez, Cesar Villa-Collar, Cristina Alvarez-Peregrina
Summary: This study used citation networks to analyze the relationship between different publications on the impact of COVID-19 at an ocular level and their authors, identifying three different research areas and determining the most cited publication.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cell Biology
Thankamani Karthika, Jeswin Joseph, V. R. Akshay Das, Niranjana Nair, Packirisamy Charulekha, Melvin Daniel Roji, V. Stalin Raj
Summary: The cytoplasmic tail of ACE2 is not essential for the entry of SARS-CoV-1 and -2, suggesting that their entry may be mediated via known or unknown host factors. Inhibition of pseudotyped SARS-CoVs entry into cells was observed when treated with a dynamin inhibitor and an endosomal acidification inhibitor. Antibodies against SARS-CoV and soluble ACE2 were unable to enter cells expressing wtACE2 and increment cytACE2.
Review
Medicine, General & Internal
Mitra Akbari, Maryam Dourandeesh
Summary: COVID-19 can have ocular manifestations and complications. Conjunctivitis is the most common presentation, and the eye involvement is attributed to the direct effect of the virus, inflammation-induced tissue damage, underlying diseases, and adverse effects of medications. There are also reports of life-threatening complications, such as rhino-orbital cerebral mucormycosis.
FRONTIERS IN MEDICINE
(2022)
Review
Cell Biology
Koji Kitazawa, Stefanie Deinhardt-Emmer, Takenori Inomata, Sharvari Deshpande, Chie Sotozono
Summary: This review highlights the potential of SARS-CoV-2 to use the ocular surface as a route for transmission, and recommends eye protection for ophthalmologists and at-risk patients.
Review
Medicine, Research & Experimental
Farnaz Farshidfar, Navid Koleini, Hossein Ardehali
Summary: The emergence of SARS-CoV-2 has led to a global pandemic with a high impact on public health. Apart from lung involvement, COVID-19 also affects the cardiovascular system, with preexisting cardiovascular disease increasing mortality in patients with the virus. Potential mechanisms for cardiovascular complications include direct viral infection and cytokine storm-induced myocarditis.
Review
Ophthalmology
Karen Walsh, Lyndon Jones, Kurt Moody
Summary: Advancements in contact lens technology over the past 50 years have been significant, with changes in materials, replacement frequency, care systems, and designs. Despite the widespread availability of contact lenses, the usage rates for vision correction remain low and many practitioners still hold on to outdated beliefs.
CLINICAL AND EXPERIMENTAL OPTOMETRY
(2022)
Article
Ophthalmology
Safal Khanal, Yuqiang Bai, William Ngo, Kelly K. Nichols, Landon Wilson, Stephen Barnes, Jason J. Nichols
Summary: The study evaluated the presence and roles of cholesteryl esters (CEs) and wax esters (WEs) from human tear film and meibum in meibomian gland dysfunction (MGD). Results showed that the abundances of CEs and WEs from human precorneal tear film and meibum were independent of MGD disease status and tear film thinning rates. Changes in CEs and WEs do not contribute to alterations in tear film dynamics in MGD.
Article
Ophthalmology
Nathan Efron, Lyndon W. Jones, Phillip B. Morgan, Jason J. Nichols
Summary: Publication metrics were derived for silicone hydrogel (SH) and daily disposable (DD) contact lenses fields, identifying the most impactful authors, institutions, countries, and journals in each category. The study found that the impact of SH field is significantly higher than that of the DD field.
JOURNAL OF OPTOMETRY
(2022)
Article
Cell & Tissue Engineering
Jasmin Taubenschmid-Stowers, Maria Rostovskaya, Fatima Santos, Sebastian Ljung, Ricard Argelaguet, Felix Krueger, Jennifer Nichols, Wolf Reik
Summary: This study discovered human 8-cell-like cells (8CLCs) among naive embryonic stem cells, which transcriptionally resemble the 8-cell human embryo. These cells express markers and elements associated with embryonic development, providing important insights into early events in human embryogenesis.
Article
Ophthalmology
Eugene Appenteng Osae, Lyndon Jones, Jason J. Nichols
Summary: This review summarizes the evidence on how contact lens wear affects the morphology and secretion of the meibomian glands, with key factors such as duration, type, design, and material of the lenses influencing the extent of these changes.
Review
Ophthalmology
Nathan Efron, Philip B. Morgan, Jason J. Nichols, Karen Walsh, Mark D. Willcox, James S. Wolffsohn, Lyndon W. Jones
Summary: This article discusses the implications of inappropriately substituting different types of soft contact lenses, including lens properties and usage, as well as potential patient dissatisfaction and adverse events. It emphasizes that contact lenses are medical devices that require prescription and fitting, and different lens types have differences, so substitution may lead to undesirable consequences.
CONTACT LENS & ANTERIOR EYE
(2022)
Article
Biology
Sophie Kraunsoe, Takuya Azami, Yihan Pei, Graziano Martello, Kenneth Jones, Thorsten Boroviak, Jennifer Nichols
Summary: We investigated the roles of STAT3 and TFCP2L1 in maintaining naive pluripotency and found that their protein levels decline during blastocyst expansion but increase in the embryonic region after diapause induction. Embryos lacking STAT3 or TFCP2L1 showed catastrophic loss of the inner cell mass during diapause, indicating additional signals are required for sustaining pluripotency. Blocking MEK/ERK signaling allowed efficient derivation of embryonic stem cells from STAT3 null embryos, highlighting an unknown role of TFCP2L1 in the transition to embryonic stem cells in vitro.
Article
Instruments & Instrumentation
Ana F. F. Pereira-da-Mota, Maria Vivero-Lopez, Piyush Garg, Chau-Minh Phan, Angel Concheiro, Lyndon Jones, Carmen Alvarez-Lorenzo
Summary: This study aimed to evaluate the release profiles of two drug-loaded contact lenses (CLs) in a 3D in vitro eye blink model and compare them with in vivo profiles. The results showed that the release of both drugs was more sustained and lower in the 3D eye model compared to in vitro release in vials. The findings suggest that the current 3D printed eye blink model could be a useful tool to measure the release of ophthalmic drugs from medicated CLs, but further optimization is needed.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Ophthalmology
Marcella McParland, Karen Walsh, Daniel Comoroda, Anna Sulley
Summary: This study aimed to determine the effectiveness of stenfilcon A multifocal soft contact lenses in real-world settings. The results showed that these lenses were easy to fit and had a high success rate, with patients reporting high levels of satisfaction with comfort, vision, satisfaction, and handling.
CLINICAL OPTOMETRY
(2022)
Article
Developmental Biology
Elena Corujo-Simon, Arthur H. Radley, Jennifer Nichols
Summary: The rapid establishment of three founder lineages, namely trophectoderm, epiblast and hypoblast, is crucial for successful human pregnancy. Different models have been proposed to explain the lineage segregation. This study investigates the expression order of genes associated with hypoblast emergence and supports the model of sequential segregation of founder lineages. Specifically, PDGFRA is the first marker identifying presumptive hypoblast, followed by SOX17, FOXA2, and GATA4.
Editorial Material
Ophthalmology
Kwaku A. Osei, Champion Deivanayagam, Jason J. Nichols
Article
Ophthalmology
Jason J. Nichols, Philip B. Morgan, Lyndon W. Jones, Nathan Efron
Summary: This study conducted a bibliometric analysis of ophthalmic journals and identified the most highly cited articles, leading journals, authors, institutions, and countries. It provides guidance for individuals or institutions regarding their contributions to the field of ophthalmology.
JAMA OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Nathan Efron, Philip B. Morgan, Lyndon W. Jones, Jason J. Nichols
Summary: This study identifies the most impactful journals, papers, authors, institutions, and countries that cite optometry journal articles, confirming the utility and influence of optometry journals.
JOURNAL OF OPTOMETRY
(2023)
Article
Ophthalmology
Lyndon Jones, Nathan Efron, Kalika Bandamwar, Melissa Barnett, Deborah S. Jacobs, Isabelle Jalbert, Heiko Pult, Michelle K. Rhee, Heather Sheardown, Joseph P. Shovlin, Ulli Stahl, Adriana Stanila, Jacqueline Tan, Silvia Tavazzi, Omur O. Ucakhan, Mark D. P. Willcox, Laura E. Downie
Summary: The lifestyle choices of contact lens wearers can have negative impacts on eye health, such as poor adherence to care, sleeping in lenses, inappropriate purchases, lack of regular aftercare visits, wearing lenses while feeling unwell, wearing lenses too soon after surgery, and wearing lenses during risky behaviors. However, contact lenses can also provide therapeutic benefits. The COVID-19 pandemic introduced new challenges for contact lens wearers, including mask-associated dry eye, increased discomfort from digital device use, accidental exposure to hand sanitizers, and reduced lens usage.