Article
Biology
Stefanie Deinhardt-Emmer, Daniel Wittschieber, Juliane Sanft, Sandra Kleemann, Stefan Elschner, Karoline Frieda Haupt, Vanessa Vau, Clio Haering, Jurgen Roedel, Andreas Henke, Christina Ehrhardt, Michael Bauer, Mike Philipp, Nikolaus Gassler, Sandor Nietzsche, Bettina Loeffler, Gita Mall
Summary: COVID-19 is a systemic disease, and viral RNA distribution was found in both pulmonary and extrapulmonary tissues and organs, with high viral loads in the lungs. This supports the hypothesis of maladaptive host response with viremia and multiorgan dysfunction.
Article
Biology
Samy Gauthier, Alexy Tran-Dinh, Ian Morilla
Summary: Efforts to understand COVID-19's molecular mechanisms have identified ACE2 as the main receptor for SARS-CoV-2 spike protein. However, the role of other proteins remains unclear. To address this, we modeled the plasma proteome of 384 COVID-19 patients, accurately assessing illness severity and constructing a dynamic model to learn molecular interactions and identify potential treatments.
LIFE SCIENCE ALLIANCE
(2023)
Article
Multidisciplinary Sciences
Atish Gheware, Animesh Ray, Deeksha Rana, Prashant Bajpai, Aruna Nambirajan, S. Arulselvi, Purva Mathur, Anjan Trikha, Sudheer Arava, Prasenjit Das, Asit Ranjan Mridha, Geetika Singh, Manish Soneja, Neeraj Nischal, Sanjeev Lalwani, Naveet Wig, Chitra Sarkar, Deepali Jain
Summary: This study found significantly higher ACE2 protein expression in the lung tissues of deceased COVID-19 patients, which correlated with pathological changes and disease severity.
SCIENTIFIC REPORTS
(2022)
Review
Medicine, Research & Experimental
Farnaz Farshidfar, Navid Koleini, Hossein Ardehali
Summary: The emergence of SARS-CoV-2 has led to a global pandemic with a high impact on public health. Apart from lung involvement, COVID-19 also affects the cardiovascular system, with preexisting cardiovascular disease increasing mortality in patients with the virus. Potential mechanisms for cardiovascular complications include direct viral infection and cytokine storm-induced myocarditis.
Article
Biochemistry & Molecular Biology
Riadh Badraoui, Mousa M. Alrashedi, Michele Veronique El-May, Fevzi Bardakci
Summary: ARDS is a severe form of respiratory failure that can be induced by SARS-CoV-2 infection, particularly in COVID-19 cases. Understanding the pathophysiological mechanisms of ARDS, learned from past coronavirus outbreaks and ongoing research on SARS-CoV-2, can provide insight into managing severe cases and improving prognosis.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Multidisciplinary Sciences
Fei Xia, Mingwei Zhang, Bo Cui, Wei An, Min Chen, Ping Yang, Tao Qin, Xiaoyang Zhou, Yaling Liao, Xin Xu, Shiguo Liu, Kuangyu Li, Qin Zhou, Keke Wang, Guangxu Hu, Ming Du, Songrui Chen, Yafang Zhang, Wei Wei, Ming Xiang, Jianjun Zhang
Summary: This retrospective study analyzed data from 82 patients diagnosed with COVID-19, finding hypertension to be the most common comorbidity in these patients. Compared to non-hypertensive patients, those with hypertension had a higher risk of severe inflammatory reactions, organ injury, and disease progression.
SCIENTIFIC REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Mohammad Mahdi Nejadi Babadaei, Anwarul Hasan, Samir Haj Bloukh, Zehra Edis, Majid Sharifi, Ehsan Kachooei, Mojtaba Falahati
Summary: Researchers have reported useful information about SARS-CoV-2 leading to COVID-19, including the development of antiviral drugs and diagnostic tests. The distribution of ACE2 on the surface of host cells may play a key role in exploring the pathogenesis of SARS-COV-2. Acute and chronic cardiovascular diseases may be associated with the clinical severity of COVID-19.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Review
Microbiology
Ahmed O. Kaseb, Yehia Mohamed, Alexandre E. Malek, Issam I. Raad, Lina Altameemi, Dan Li, Omar A. Kaseb, Safa A. Kaseb, Abdelhafez Selim, Qing Ma
Summary: The COVID-19 pandemic poses an unprecedented threat to the international community and is largely mediated by the interaction between viral spike protein and ACE2. Variations in ACE2 expression in different demographic groups may explain differences in infection rates and mortality, making it a potential therapeutic target.
Review
Pathology
Stefania Caramaschi, Meghan E. Kapp, Sara E. Miller, Rosana Eisenberg, Joyce Johnson, Garretson Epperly, Antonino Maiorana, Guido Silvestri, Giovanna A. Giannico
Summary: Pathological findings from autopsy and biopsy studies of COVID-19 patients reveal main features of diffuse alveolar damage, thromboembolism, and nonspecific shock injury in multiple organs. Additionally, it suggests a unifying pathogenic mechanism for COVID-19 as ARDS with inflammatory response, cytokine release, fever, inflammation, and generalized endothelial disturbance.
Review
Medicine, General & Internal
Caroline Hirsch, Yun Soo Park, Vanessa Piechotta, Khai Li Chai, Lise J. Estcourt, Ina Monsef, Susanne Salomon, Erica M. Wood, Cynthia So-Osman, Zoe McQuilten, Christoph D. Spinner, Jakob J. Malin, Miriam Stegemann, Nicole Skoetz, Nina Kreuzberger
Summary: This study evaluated the effects of SARS-CoV-2-neutralising mAbs for preventing COVID-19, using a living systematic review approach. It included randomised controlled trials assessing mAbs for pre-exposure prophylaxis (PrEP) and postexposure prophylaxis (PEP) of COVID-19.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2022)
Article
Cell Biology
Rocio Diaz Escarcega, Pedram Honarpisheh, Gabriela Delevati Colpo, Hilda W. Ahnstedt, Lucy Couture, Shivanki Juneja, Glenda Torres, Guadalupe J. Ortiz, James Sollome, Natalie Tabor, Bhanu P. Ganesh, H. Alex Choi, Fudong Liu, Louise D. McCullough, Andrey S. Tsvetkov
Summary: The study finds sex differences in metabolism and sexual dimorphism in the correlations between clinical parameters and metabolic profiles in severe COVID-19 patients, providing important knowledge for the development of sex-associated biomarkers and druggable targets for COVID-19 patients.
CELL DEATH & DISEASE
(2022)
Article
Cell Biology
Thankamani Karthika, Jeswin Joseph, V. R. Akshay Das, Niranjana Nair, Packirisamy Charulekha, Melvin Daniel Roji, V. Stalin Raj
Summary: The cytoplasmic tail of ACE2 is not essential for the entry of SARS-CoV-1 and -2, suggesting that their entry may be mediated via known or unknown host factors. Inhibition of pseudotyped SARS-CoVs entry into cells was observed when treated with a dynamin inhibitor and an endosomal acidification inhibitor. Antibodies against SARS-CoV and soluble ACE2 were unable to enter cells expressing wtACE2 and increment cytACE2.
Article
Multidisciplinary Sciences
Viviane Fongaro Botosso, Soraia Attie Calil Jorge, Renato Mancini Astray, Ana Marcia de Sa Guimaraes, Monica Beatriz Mathor, Patricia dos Santos de Carneiro, Edison Luiz Durigon, Dimas Covas, Danielle Bruna Leal de Oliveira, Ricardo das Neves Oliveira, Durvanei Augusto Maria, Silas Fernandes Eto, Neuza Maria Frazatti Gallina, Giselle Pidde, Carla Cristina Squaiella-Baptistao, Dilza Trevisan Silva, Isadora Maria Villas-Boas, Dayanne Carla Fernandes, Aline Vivian Vatti Auada, Alexandre Campos Banari, Antonio Francisco de Souza Filho, Camila Bianconi, Carla Lilian de Agostini Utescher, Denise Cristina Andre Oliveira, Douglas Oscar Ceolin Mariano, Flavia Ferreira Barbosa, Giuliana Rondon, Josana Kapronezai, Juliana Galvao da Silva, Mauricio Barbugiani Goldfeder, Priscila Comone, Regis Edgar Castilho Junior, Taiana Taina Silva Pereira, Fan Hui Wen, Denise Tambourgi, Ana Marisa Chudzinski-Tavassi
Summary: The new outbreak of COVID-19 has caused millions of deaths worldwide. Efforts are being made to find effective treatments, such as using immunoglobulin from immunized animals or plasma from convalescent patients. Clinical trials using anti-SARS-CoV-2 immunoglobulins from horses immunized with spike protein are underway. Researchers have developed an anti-SARS-CoV-2 equine F(ab ')(2) immunoglobulin that successfully neutralizes the virus, is safe in animal models, and reduces the severity of the disease in a hamster model of SARS-CoV-2 infection.
SCIENTIFIC REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Pawan Kumar Raghav, Keerthana Kalyanaraman, Dinesh Kumar
Summary: The research is divided into three main categories, focusing on the overview of SARS-CoV-2, human cell receptors interacting with it, and current available approaches for COVID-19 treatment.
Article
Medicine, Research & Experimental
Huai-Chia Chuang, Chia-Hsin Hsueh, Pu-Ming Hsu, Rou-Huei Huang, Ching-Yi Tsai, Nai-Hsiang Chung, Yen-Hung Chow, Tse-Hua Tan
Summary: Overexpression of GLK leads to stabilization of ACE2, promoting the invasion and infection of SARS-CoV-2. These findings may help to explain the pathogenesis of COVID-19.
EMBO MOLECULAR MEDICINE
(2022)
Article
Food Science & Technology
Ishrat Majid, Shafat Khan, Alanoud Aladel, Aamir Hussain Dar, Mohd Adnan, Mohammad Idreesh Khan, Amir Mahgoub Awadelkareem, Syed Amir Ashraf
Summary: The extraction of bioactive compounds from natural food sources using non-conventional methods, particularly green extraction techniques, is gaining popularity due to their advantages over conventional methods. Hybrid extraction techniques have been found to be effective and novel methods for extraction. Bioactive compounds extracted through these novel techniques have great potential in the functional food market as they are considered safer and have less chemical interference. Further research is needed to validate the safety, consumer acceptability, challenges, and legal feasibility of these green extraction techniques.
CYTA-JOURNAL OF FOOD
(2023)
Article
Biotechnology & Applied Microbiology
Mousa Alreshidi, Riadh Badraoui, Mohd Adnan, Mitesh Patel, Ahmed Alotaibi, Mohd Saeed, Mohammed Ghandourah, Khalid A. Al-Motair, Ibrahim A. Arif, Yazeed Albulaihed, Mejdi Snoussi
Summary: This study aimed to investigate the phytochemical composition of the methanol/water extract from Sargassum sp. collected from the Red sea. The dominant compounds were identified as 2-pentadecanone, 6,10,14-trimethyl-, hexadecenoic acid, methyl ester, n-hexadecanoic acid, 1,2-benzenedicarboxylic acid, and mono(2-ethylhexyl) ester. The extract showed effective antimicrobial and antibiofilm activities against various microorganisms.
ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS
(2023)
Article
Infectious Diseases
Mohd Adnan, Arif Jamal Siddiqui, Emira Noumi, Sami Hannachi, Syed Amir Ashraf, Amir Mahgoub Awadelkareem, Mejdi Snoussi, Riadh Badraoui, Fevzi Bardakci, Manojkumar Sachidanandan, Mirav Patel, Mitesh Patel
Summary: This study used a network pharmacology approach to investigate the anti-listeriosis properties of biosurfactants and their mechanisms of action. It identified certain biosurfactants with potential therapeutic effects against L. monocytogenes infection and explored their pharmacological mechanisms, providing a foundation for further research and development.
Article
Biochemistry & Molecular Biology
Nuzhat Ahsan, Mohammad Imran, Yousuf Mohammed, Fatme Al Anouti, Mohammad Idreesh Khan, Tanushree Banerjee, Mohd Adnan, Fauzia Ashfaq, Marek Kieliszek, Syed Amir Ashraf, Afrozul Haq
Summary: The pathophysiology of COVID-19 involves inflammation, weakened immunity, immune cell infiltration, necrosis, lung hyperplasia, severe pneumonia, and potential mortality due to septic shock and organ failure. Vitamin D, zinc, and magnesium have been reported to improve the immune system against respiratory illnesses. This comprehensive review focuses on the mechanistic details of these micronutrients as immunomodulators and their potential role in preventing and treating respiratory illnesses.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Nouha Bouali, Iqrar Ahmad, Harun Patel, Elham Bader Alhejaili, Walid Sabri Hamadou, Riadh Badraoui, Ramzi Hadj Lajimi, Mousa Alreshidi, Arif Jamal Siddiqui, Mohd Adnan, Mohammad A. Abdulhakeem, Abdulrahman S. Bazaid, Mitesh Patel, Mohd Saeed, Mejdi Snoussi, Emira Noumi
Summary: This study aimed to investigate the antimicrobial potential of Ziziphus honey (ZH) against clinical bacterial strains and yeasts and molds. The results showed that ZH was able to inhibit the growth of both Gram-positive and Gram-negative bacteria. Computational simulations revealed that certain compounds in ZH had good affinity for targeted receptors. These findings highlight the potential pharmacological applications of ZH and its identified compounds.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Review
Virology
Bharti Datten, Anis Ahmad Chaudhary, Shalini Sharma, Lokender Singh, Krishna Dutta Rawat, Mohammad Saquib Ashraf, Lina M. Alneghery, Malak O. Aladwani, Hassan Ahmad Rudayni, Deen Dayal, Sanjay Kumar, Kundan Kumar Chaubey
Summary: The lumpy skin disease virus (LSDV) infects cattle and buffalo, causing lumpy skin disease (LSD) characterized by enlarged lymph nodes and the formation of cutaneous nodules. Symptoms include high temperature, drop in milk supply, discharge from the eyes and nose, salivation, loss of appetite, depression, damaged hides, and emaciation.
Article
Biology
Alam Jamal, Mahmood Hassan Dalhat, Sadaf Jahan, Hani Choudhry, Mohammad Imran Khan
Summary: This study evaluated the effect of BTYNB on leukemic cells and found that BTYNB inhibited the function of IGF2BP1, promoting cell differentiation in leukemia.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Arif Jamal Siddiqui, Riadh Badraoui, Sadaf Jahan, Mohammed Merae Alshahrani, Maqsood Ahmed Siddiqui, Andleeb Khan, Mohd Adnan
Summary: NMDARs are important for brain function and NMDAR over activation is involved in many diseases. In this study, potential Gly/NMDA receptor antagonists were discovered using computational methods. Six molecules with high binding affinity were identified as potential new perspectives for therapeutic strategies.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Reyaz Hassan Mir, Prince Ahad Mir, Jasreen Uppal, Apporva Chawla, Mitesh Patel, Fevzi Bardakci, Mohd Adnan, Roohi Mohi-ud-din
Summary: Homeostasis between protein synthesis and degradation is critical in biological functions. The ubiquitin-proteasome pathway (UPP) plays a major role in cellular protein degradation. UPP inhibition has been used as an anticancer therapy to shift the balance towards cell death. Natural products have been found to be involved in UPP engagement. The discovery of natural compounds targeting UPP pathway could lead to new anticancer medications.
Article
Biochemistry & Molecular Biology
Mohamed Ali Boujbiha, Hassiba Chahdoura, Khaoula Adouni, Borhane Eddine Cherif Ziani, Mejdi Snoussi, Yasmine Chakroun, Maria Ciudad-Mulero, Virginia Fernandez-Ruiz, Lotfi Achour, Boulbaba Selmi, Patricia Morales, Guido Flamini, Habib Mosbah
Summary: This study validates the beneficial use of Vitex agnus-castus (VAC) fruits and fruit decoctions (VFDs) through in vitro and in vivo experiments. VFDs exhibit antioxidant, antimicrobial, analgesic, and gastroprotective activities. This work supports the traditional use of VAC in treating pain, inflammation, and gastric disorders, and encourages further investigation of pharmacological compounds from this species.
Article
Infectious Diseases
Mohd Adnan, Arif Jamal Siddiqui, Syed Amir Ashraf, Mohammad Saquib Ashraf, Sarah Owdah Alomrani, Mousa Alreshidi, Bektas Tepe, Manojkumar Sachidanandan, Corina Danciu, Mitesh Patel
Summary: The saponin-derived silver nanoparticles obtained from Ajwa dates showed strong antibacterial, antibiofilm, and anti-quorum-sensing activities. They inhibited bacterial growth by disrupting the bacterial cell membranes and leakage of nucleic acid and protein contents, and prevented biofilm formation and quorum-sensing activity by interfering with signaling molecules. Additionally, the nanoparticles exhibited antioxidant activity and cytotoxicity against lung cancer cells.
Article
Multidisciplinary Sciences
Hassan H. Alhassan, Lamya Ahmed Al-Keridis, Huma Ayub, Fawaz O. Alenazy, Yasir Alruwaili, Muhammad Rashid Khan, Mehreen Fatima, Mitesh Patel, Nawaf Alshammari, Mohd Adnan, Sumaira Sahreen
Summary: The study evaluated the metabolic profile and antioxidant potential of Carissa opaca fruit against carbon tetrachloride-induced cardiotoxicity and testicular toxicity. Gas Chromatography-Mass Spectrometry (GC-MS) analysis revealed the presence of bioactive metabolites in the fruit, and the derived fractions of the fruit showed antioxidant activity. The study supports the use of Carissa opaca fruit as an alternative medicine for cardiac dysfunction and highlights its antioxidant role in testicular tissues.
Article
Chemistry, Medicinal
Walid Sabri Hamadou, Nouha Bouali, Elham Bader Alhejaili, Zohra Soua, Mitesh Patel, Mohd Adnan, Arif Jamal Siddiqui, Abdel-Muhsin Abdel-Gadir, Abdel Moneim Elhadi Sulieman, Mejdi Snoussi, Riadh Badraoui
Summary: This study assessed the interaction between bioactive compounds derived from honey and the apoptotic protein p53, which could trigger apoptosis. The results showed that certain compounds in honey have a strong binding ability to p53 and may possess anti-cancer activity, potentially serving as alternative therapy for breast cancer.
PHARMACOGNOSY MAGAZINE
(2023)
Article
Microbiology
Mohd Adnan, Arif Jamal Siddiqui, Syed Amir Ashraf, Fevzi Bardakci, Mousa Alreshidi, Riadh Badraoui, Emira Noumi, Bektas Tepe, Manojkumar Sachidanandan, Mitesh Patel
Summary: This study explores the anti-fungal potential of phytochemicals from Ajwa dates using network pharmacology, molecular docking, and dynamics simulations, revealing the molecular mechanisms underlying their activity and providing a rational basis for developing new therapeutic strategies against candidiasis in humans.
Article
Medicine, Research & Experimental
Mohd Adnan, Arif Jamal Siddiqui, Emira Noumi, Syed Amir Ashraf, Amir Mahgoub Awadelkareem, Sibte Hadi, Mejdi Snoussi, Riadh Badraoui, Fevzi Bardakci, Manojkumar Sachidanandan, Mitesh Patel
Summary: The study demonstrates that a biosurfactant derived from L. acidophilus can effectively inhibit virulence factors, biofilm formation, and quorum sensing in Gram-negative pathogenic bacteria. This provides a promising approach for tackling antimicrobial resistance.
BIOMOLECULES AND BIOMEDICINE
(2023)
