Kat3 coactivators in somatic stem cells and cancer stem cells: biological roles, evolution, and pharmacologic manipulation

CBP/catenin antagonist safely eliminates drug-resistant leukemia-initiating cells

(2015) Y Zhao et al.   ONCOGENE

Variation in cancer risk among tissues can be explained by the number of stem cell divisions

(2015) C. Tomasetti et al.   SCIENCE

Meet Our Editorial Board Member:

(2015) Michael J Kuhar   Current Molecular Pharmacology

Circadian clock-mediated control of stem cell division and differentiation: beyond night and day

(2014) S. A. Brown   DEVELOPMENT

Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells

(2014) Johanna Flach et al.   NATURE

Intestinal crypt homeostasis revealed at single-stem-cell level by in vivo live imaging

(2014) Laila Ritsma et al.   NATURE

Young Blood

(2014) Alessandro Laviano   NEW ENGLAND JOURNAL OF MEDICINE

Induction of pluripotency by defined factors

(2014) Koji TANABE et al.   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Plasticity of epithelial stem cells in tissue regeneration

(2014) C. Blanpain et al.   SCIENCE

Restoring Systemic GDF11 Levels Reverses Age-Related Dysfunction in Mouse Skeletal Muscle

(2014) M. Sinha et al.   SCIENCE

Denervation suppresses gastric tumorigenesis

(2014) C.-M. Zhao et al.   Science Translational Medicine

Wnt/Catenin Signaling in Adult Stem Cell Physiology and Disease

(2014) Alexander Ring et al.   Stem Cell Reviews and Reports

Surviving change: the metabolic journey of hematopoietic stem cells

(2014) Latika Kohli et al.   TRENDS IN CELL BIOLOGY

Quantification of Crypt and Stem Cell Evolution in the Normal and Neoplastic Human Colon

(2014) Ann-Marie Baker et al.   Cell Reports

Genetic Activation of Hedgehog Signaling Unbalances the Rate of Neural Stem Cell Renewal by Increasing Symmetric Divisions

(2014) Julien Ferent et al.   Stem Cell Reports

Evolution of Energy Metabolism, Stem Cells and Cancer Stem Cells: How the Warburg and Barker Hypotheses Might Be Linked

(2014) James E. Trosko et al.   International Journal of Stem Cells

Hypoxia Selects for a Quiescent, CML Stem/Leukemia Initiating- Like Population Dependent on CBP/Catenin Transcription

(2014) Aiko Kida et al.   Current Molecular Pharmacology

The Intestinal Crypt, A Prototype Stem Cell Compartment

(2013) Hans Clevers   CELL

Bile Acid Look-Alike Controls Life Span in C. elegans

(2013) Albert K. Groen et al.   Cell Metabolism

Wnt signaling in stem and cancer stem cells

(2013) Jane D Holland et al.   CURRENT OPINION IN CELL BIOLOGY

Wnt/β-catenin signalling induces MLL to create epigenetic changes in salivary gland tumours

(2013) Peter Wend et al.   EMBO JOURNAL

Resilient and resourceful: Genome maintenance strategies in hematopoietic stem cells

(2013) Sietske T. Bakker et al.   EXPERIMENTAL HEMATOLOGY

Spatial organization within a niche as a determinant of stem-cell fate

(2013) Panteleimon Rompolas et al.   NATURE

Neural Stem Cells: Generating and Regenerating the Brain

(2013) Fred H. Gage et al.   NEURON

Small-molecule inhibition of CBP/catenin interactions eliminates drug-resistant clones in acute lymphoblastic leukemia

(2013) E J Gang et al.   ONCOGENE

The Small Molecule Wnt Signaling Modulator ICG-001 Improves Contractile Function in Chronically Infarcted Rat Myocardium

(2013) Tomoyo Sasaki et al.   PLoS One

Half or more of the somatic mutations in cancers of self-renewing tissues originate prior to tumor initiation

(2013) C. Tomasetti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Scientific and ethical issues related to stem cell research and interventions in neurodegenerative disorders of the brain

(2013) Roger A. Barker et al.   PROGRESS IN NEUROBIOLOGY

On the role of Wnt/β-catenin signaling in stem cells

(2012) Susanne J. Kühl et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Complement C1q Activates Canonical Wnt Signaling and Promotes Aging-Related Phenotypes

(2012) Atsuhiko T. Naito et al.   CELL

Intestinal Tumorigenesis Initiated by Dedifferentiation and Acquisition of Stem-Cell-like Properties

(2012) Sarah Schwitalla et al.   CELL

Drugging Wnt signalling in cancer

(2012) Paul Polakis   EMBO JOURNAL

Glucose-Induced β-Catenin Acetylation Enhances Wnt Signaling in Cancer

(2012) Ana Chocarro-Calvo et al.   MOLECULAR CELL

A PML–PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance

(2012) Keisuke Ito et al.   NATURE MEDICINE

The complex world of WNT receptor signalling

(2012) Christof Niehrs   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PANTHER in 2013: modeling the evolution of gene function, and other gene attributes, in the context of phylogenetic trees

(2012) Huaiyu Mi et al.   NUCLEIC ACIDS RESEARCH

Human Embryonic Stem Cells Differentiated to Lung Lineage-Specific Cells Ameliorate Pulmonary Fibrosis in a Xenograft Transplant Mouse Model

(2012) Ena Ray Banerjee et al.   PLoS One

The Evolution of the Wnt Pathway

(2012) T. W. Holstein   Cold Spring Harbor Perspectives in Biology

Wnt Signaling Orchestration with a Small Molecule DYRK Inhibitor Provides Long-Term Xeno-Free Human Pluripotent Cell Expansion

(2012) Kouichi Hasegawa et al.   Stem Cells Translational Medicine

Prostaglandin E2 and Pain—An Update

(2011) Atsufumi Kawabata   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Tumor viruses and cancer biology: Modulating signaling pathways for therapeutic intervention

(2011) Abhik Saha et al.   CANCER BIOLOGY & THERAPY

Anaerobicizing into Pluripotency

(2011) Athanasia D. Panopoulos et al.   Cell Metabolism

The Gamma Catenin/CBP Complex Maintains Survivin Transcription in β-catenin Deficient/Depleted Cancer Cells

(2011) Y.-M. Kim et al.   CURRENT CANCER DRUG TARGETS

 -catenin tyrosine 654 phosphorylation increases Wnt signalling and intestinal tumorigenesis

(2011) W. van Veelen et al.   GUT

Selective Roles for cAMP Response Element-binding Protein Binding Protein and p300 Protein as Coregulators for Androgen-regulated Gene Expression in Advanced Prostate Cancer Cells

(2011) Irina Ianculescu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prospects for pluripotent stem cell therapies: Into the clinic and back to the bench

(2011) Laura Grabel   JOURNAL OF CELLULAR BIOCHEMISTRY

Targeted Inhibition of  -Catenin/CBP Signaling Ameliorates Renal Interstitial Fibrosis

(2011) S. Hao et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

DNA damage response in adult stem cells: pathways and consequences

(2011) Pankaj K. Mandal et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

β-Catenin is required for Ron receptor-induced mammary tumorigenesis

(2011) P K Wagh et al.   ONCOGENE

Interconversion Between Intestinal Stem Cell Populations in Distinct Niches

(2011) N. Takeda et al.   SCIENCE

Concise Review: Multidimensional Regulation of the Hematopoietic Stem Cell State

(2011) Il-Hoan Oh et al.   STEM CELLS

The Wnt signaling pathway in cellular proliferation and differentiation: A tale of two coactivators

(2010) Jia-Ling Teo et al.   ADVANCED DRUG DELIVERY REVIEWS

Importance of the cell cycle phase for the choice of the appropriate DSB repair pathway, for genome stability mintenance: the trans-S double-strand break repair model

(2010) Fabien Delacôte et al.   CELL CYCLE

mTOR Activation Induces Tumor Suppressors that Inhibit Leukemogenesis and Deplete Hematopoietic Stem Cells after Pten Deletion

(2010) Jae Y. Lee et al.   Cell Stem Cell

Hematopoietic Stem Cell Quiescence Promotes Error-Prone DNA Repair and Mutagenesis

(2010) Mary Mohrin et al.   Cell Stem Cell

Targeting Hedgehog -- a Cancer Stem Cell Pathway

(2010) A. A. Merchant et al.   CLINICAL CANCER RESEARCH

The Difficulty of Targeting Cancer Stem Cell Niches

(2010) M. A. LaBarge   CLINICAL CANCER RESEARCH

Targeting Notch to Target Cancer Stem Cells

(2010) A. Pannuti et al.   CLINICAL CANCER RESEARCH

Functional Coupling between the Extracellular Matrix and Nuclear Lamina by Wnt Signaling in Progeria

(2010) Lidia Hernandez et al.   DEVELOPMENTAL CELL

Empowering self-renewal and differentiation: the role of mitochondria in stem cells

(2010) Jalees Rehman   JOURNAL OF MOLECULAR MEDICINE-JMM

Origin and evolution of the ligand-binding ability of nuclear receptors

(2010) Gabriel V. Markov et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

O2 regulates stem cells through Wnt/β-catenin signalling

(2010) Jolly Mazumdar et al.   NATURE CELL BIOLOGY

Mouse telomerase reverse transcriptase (mTert) expression marks slowly cycling intestinal stem cells

(2010) R. K. Montgomery et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of Wnt/ -catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis

(2010) W. R. Henderson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coexistence of Quiescent and Active Adult Stem Cells in Mammals

(2010) L. Li et al.   SCIENCE

Wnt signal transduction pathways

(2010) Yuko Komiya et al.   Organogenesis

Upregulation of mitochondrial function and antioxidant defense in the differentiation of stem cells

(2009) Chien-Tsun Chen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

CD44+slow-cycling tumor cell expansion is triggered by cooperative actions of Wnt and prostaglandin E2in gastric tumorigenesis

(2009) Takatsugu Ishimoto et al.   CANCER SCIENCE

The Tumor Suppressor p53 Regulates Polarity of Self-Renewing Divisions in Mammary Stem Cells

(2009) Angelo Cicalese et al.   CELL

A New Look at TCF and β-Catenin through the Lens of a Divergent C. elegans Wnt Pathway

(2009) Bryan T. Phillips et al.   DEVELOPMENTAL CELL

mTOR signaling at a glance

(2009) M. Laplante et al.   JOURNAL OF CELL SCIENCE

Association of reactive oxygen species levels and radioresistance in cancer stem cells

(2009) Maximilian Diehn et al.   NATURE

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

Regulation of Reactive Oxygen Species and Genomic Stability in Hematopoietic Stem Cells

(2008) Kazuhito Naka et al.   ANTIOXIDANTS & REDOX SIGNALING

The origins of the identification and isolation of hematopoietic stem cells, and their capability to induce donor-specific transplantation tolerance and treat autoimmune diseases

(2008) I. L. Weissman et al.   BLOOD

Tumour–stroma interactions in colorectal cancer: converging on β-catenin activation and cancer stemness

(2008) N H Le et al.   BRITISH JOURNAL OF CANCER

Loss of E-Cadherin Promotes Metastasis via Multiple Downstream Transcriptional Pathways

(2008) T. T. Onder et al.   CANCER RESEARCH

Wnt Signaling Promotes Reprogramming of Somatic Cells to Pluripotency

(2008) Alexander Marson et al.   Cell Stem Cell

The C. elegans SYS-1 Protein Is a Bona Fide β-Catenin

(2008) Jing Liu et al.   DEVELOPMENTAL CELL

Comparison of nonhomologous end joining and homologous recombination in human cells

(2008) Z MAO et al.   DNA REPAIR

The Role of ATP Binding Cassette Transporters in Tissue Defense and Organ Regeneration

(2008) M. Huls et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation

(2008) Liqin Zhu et al.   NATURE

Crypt stem cells as the cells-of-origin of intestinal cancer

(2008) Nick Barker et al.   NATURE

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE

Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells

(2008) Adlen Foudi et al.   NATURE BIOTECHNOLOGY

Bmi1 is expressed in vivo in intestinal stem cells

(2008) Eugenio Sangiorgi et al.   NATURE GENETICS

Deconstructing stem cell self-renewal: genetic insights into cell-cycle regulation

(2008) Keith W. Orford et al.   NATURE REVIEWS GENETICS