Review
Immunology
Jordan W. Conway, Jorja Braden, James S. Wilmott, Richard A. Scolyer, Georgina V. Long, Ines Pires da Silva
Summary: Immunotherapy, especially immune checkpoint inhibitors, has been widely used in different cancer types. However, there are differences in response to immune checkpoint inhibitors at different metastatic sites. Understanding the tumor immune microenvironment at various organ sites can help explain the organ-specific patterns of response to immunotherapy. This review discusses the association between site of metastasis and response to immune checkpoint inhibitors and summarizes key clinical and pre-clinical findings on the immune microenvironment of specific metastatic sites. The ultimate goal is to develop personalized treatment approaches for patients with innate or acquired resistance to immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biology
Elvira Forte, Mirana Ramialison, Hieu T. Nim, Madison Mara, Jacky Y. Li, Rachel Cohn, Sandra L. Daigle, Sarah Boyd, Edouard G. Stanley, Andrew G. Elefanty, John Travis Hinson, Mauro W. Costa, Nadia A. Rosenthal, Milena B. Furtado
Summary: Organ fibroblasts exhibit transcriptomic heterogeneity and inherit embryonic gene expression signatures, which play crucial roles in shaping the extracellular matrix, sensing the microenvironment, and communicating with other cells. Understanding the tissue-specific gene signature of fibroblasts may assist in targeted treatment of fibrotic diseases.
Article
Cell Biology
Bingyun Sun, Cynthia Lorang, Shizhen Qin, Yijuan Zhang, Ken Liu, Gray Li, Zhi Sun, Ashley Francke, Angelita G. Utleg, Zhiyuan Hu, Kai Wang, Robert L. Moritz, Leroy Hood
Summary: Organ-specific proteins (OSPs) have great medical potential, but their organ specificity and influencing factors need further study. This study, using a mouse model, found significant diversity of organ specificity in panorgan proteomes, providing a new perspective for exploring organ specificity at the protein level.
Article
Oncology
Eman A. Toraih, Mohammad H. Hussein, Mourad Zerfaoui, Abdallah S. Attia, Assem Marzouk Ellythy, Arwa Mostafa, Emmanuelle M. L. Ruiz, Mohamed Ahmed Shama, Jonathon O. Russell, Gregory W. Randolph, Emad Kandil
Summary: The study examined the impact of different distant metastasis sites on the survival of PTC patients and found that metastasis to specific organs can significantly affect prognosis. Patients with brain and liver metastases had lower 5-year survival rates compared to those with bone and liver metastases, with risk factors such as male gender, multiple organ involvement, and brain metastasis influencing overall survival. Clinicians should consider these factors when developing treatment strategies.
Article
Immunology
Maria Rendina, Michele Barone, Chiara Lillo, Silvia Trapani, Lucia Masiero, Paolo Trerotoli, Francesca Puoti, Luigi Giovanni Lupo, Francesco Tandoi, Salvatore Agnes, Antonio Grieco, Enzo Andorno, Simona Marenco, Edoardo Giovanni Giannini, Umberto Baccarani, Pierluigi Toniutto, Amedeo Carraro, Antonio Colecchia, Matteo Cescon, Maria Cristina Morelli, Umberto Cillo, Patrizia Burra, Paolo Angeli, Michele Colledan, Stefano Fagiuoli, Luciano De Carlis, Luca Belli, Paolo De Simone, Paola Carrai, Fabrizio Di Benedetto, Nicola De Maria, Giuseppe Maria Ettorre, Valerio Giannelli, Salvatore Gruttadauria, Riccardo Volpes, Sveva Corsale, Vincenzo Mazzaferro, Sherrie Bhoori, Renato Romagnoli, Silvia Martini, Giorgio Rossi, Lucio Caccamo, Maria Francesca Donato, Massimo Rossi, Stefano Ginanni Corradini, Marco Spada, Giuseppe Maggiore, Giuseppe Tisone, Ilaria Lenci, Giovanni Vennarecci, Raffaella Tortora, Marco Vivarelli, Gianluca Svegliati Baroni, Fausto Zamboni, Laura Mameli, Silvio Tafuri, Simona Simone, Loreto Gesualdo, Massimo Cardillo, Alfredo Di Leo
Summary: This study evaluated the prevalence, mortality, and lethality of COVID-19 infection in liver transplant recipients (LTRs) compared to non-liver solid transplant recipients (NL-SOTRs) and the general population (GP) in Italy. The results showed that the infection, mortality, and lethality rates in LTRs were lower than NL-SOTRs and comparable to the Italian GP. The discussion suggests that LTRs may have a different immune response to SARS-CoV-2 infection compared to NL-SOTRs, possibly due to the immunotolerance induced by the grafted liver.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Endocrinology & Metabolism
Mikaela M. Mallin, Kenneth J. Pienta, Sarah R. Amend
Summary: Metastatic cancer, especially bone metastases, is highly lethal. The determinants of bone-specific metastasis have remained unknown, although the sequential steps of metastasis have been studied extensively. This study proposes a new perspective on metastatic organotropism by applying ecological principles to cancer biology models. It suggests that bone-specific metastasis is the result of habitat selection by foraging cancer cells and that only a small subset of cells in a primary tumor possess this ability.
Review
Immunology
Laura A. Huppert, Michael D. Green, Luke Kim, Christine Chow, Yan Leyfman, Adil Daud, James C. Lee
Summary: Advancements in immuno-oncology have led to the development of immunotherapies for metastatic cancer patients, providing long-term treatment responses but with infrequent cures. Recent research indicates that tumors in certain organ sites may exhibit unique response patterns to immunotherapy and could reduce antitumor immunity in distant tumors, possibly due to the activation of tissue-specific immune tolerogenic mechanisms.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Article
Oncology
Seung Geun Song, Sehui Kim, Jaemoon Koh, Jeemin Yim, Bogyeong Han, Young A. Kim, Yoon Kyung Jeon, Doo Hyun Chung
Summary: The study evaluated the immune microenvironment characteristics in brain metastases of non-small-cell lung cancer and found that tumors were clustered based on organ involvement and EGFR mutation status. Different immune-related functions and pathways were enriched in primary tumors compared to brain metastases, with upregulated immune-related pathways in EGFR-mutated brain metastases.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Medicine, Research & Experimental
Lin Zhang, Ming Fan, Francesco Napolitano, Xin Gao, Ying Xu, Lihua Li
Summary: Analyzing gene expression profiles between metastatic tumor tissues and control tissues revealed organ-specific metastasis genes and pathways. These genes and pathways interact with the molecular characteristics of cancer cells and target organs, influencing the metastasis process. Understanding organ-specific metastasis genes and pathways may identify potential drug targets and aid in the development of targeted treatment strategies.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Immunology
Akhila Balachander, Bernett Lee, Subhra K. Biswas, David C. Lye, Raymond T. P. Lin, Yee-Sin Leo, Paul Chui, Lisa F. P. Ng, Laurent Renia
Summary: In young adults without comorbidities, SARS-CoV-2 infection can lead to imbalanced immune cell populations and organ-specific dysfunction. Lung and ileal tissue show altered architecture with loss of tissue integrity, while lung and heart tissue exhibit severe hyperinflammation.
CLINICAL & TRANSLATIONAL IMMUNOLOGY
(2022)
Review
Oncology
Qian Jiang, Xiao-Ping Tan, Cai-Hua Zhang, Zhi-Yuan Li, Du Li, Yan Xu, Yu Xuan Liu, Lingzhi Wang, Zhaowu Ma
Summary: This review summarizes the underlying mechanisms and functions of EV-ncRNA-mediated metastatic organotropism in various types of cancer, and highlights the clinical applications of EV-ncRNAs as biomarkers and therapeutic targets.
Article
Cell Biology
Kaiyuan Liu, Na Jing, Deng Wang, Penghui Xu, Jinming Wang, Xinyu Chen, Chaping Cheng, Zhixiang Xin, Yuman He, Huifang Zhao, ZhongZhong Ji, Pengcheng Zhang, Wei-Qiang Gao, Helen He Zhu, Kai Zhang
Summary: This study established an immune-intact mouse model for prostate cancer liver metastasis, which recapitulates the histological and lineage features of the original tumors and reveals dynamic tumor-immune cell communication in liver metastatic foci. The results suggest that the lack of CD8(+) T cells, enrichment of CD163(+) M2-like macrophages, and PD1(+)CD4(+) T cells contribute to an immunosuppressive microenvironment in prostate cancer liver metastasis.
CELL PROLIFERATION
(2021)
Article
Oncology
Jia-Yi Deng, Qing Gou, Lingling Yang, Zhi-Hong Chen, Ming-Yi Yang, Xiao-Rong Yang, Hong-Hong Yan, Xue-Wu Wei, Jia-Qi Liu, Jian Su, Wen-Zhao Zhong, Chong-Rui Xu, Yi-Long Wu, Qing Zhou
Summary: This study aimed to analyze the different tumor responses to immunotherapy between pulmonary lesions (PL) and liver metastases (LM) in non-small cell lung cancer (NSCLC) and explore potential mechanisms through multiomics analysis. The results showed that LM presented an inferior organ-specific tumor response to immunotherapy compared to PL. Additionally, LM exhibited lower levels of immune activation and infiltration in the tumor microenvironment. These findings contribute to the development of precise immunotherapy strategies for NSCLC patients with LM.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Oncology
Chenfei Zhou, Changting Qiao, Jun Ji, Wenqi Xi, Jinling Jiang, Liting Guo, Junwei Wu, Feng Qi, Qu Cai, Steven W. M. Olde Damink, Jun Zhang
Summary: Organ-specific metastasis is a unique mode of metastasis in gastric cancer, and the role of exosomes in this process is not fully understood. This study aimed to investigate the biological functions of plasma exosome proteins and their correlation with organ-specific metastasis in gastric cancer. The results showed that ILK1 and CD14 were associated with organ-specific metastasis and played a role in regulating malignant behaviors in gastric cancer cells. These findings highlight the importance of exosome proteins in driving tumor metastasis and provide new insights into the mechanisms of organ-specific metastasis in gastric cancer.
Article
Biochemistry & Molecular Biology
Abhilash Nitin Deo, Rahul Thorat, Ajit Chandrakant Dhadve, Abhijit De, Bharat Rekhi, Pritha Ray
Summary: Recurrent metastatic epithelial ovarian cancer (EOC) poses challenges due to treatment limitations, with chemoresistance exacerbating organ-specific metastasis through the IGF1R-alpha 6 integrin-S100A4 molecular network. S100A4 may serve as a potential target for treating recurrent metastatic EOC.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Oncology
Sayra Dilmac, Nuray Erin, Necdet Demir, Gamze Tanriover
PATHOLOGY & ONCOLOGY RESEARCH
(2018)
Article
Medicine, Research & Experimental
Nuray Erin, Sema Turker, Ozlem Elpek, Bulent Yildirim
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2018)
Article
Oncology
Nuray Erin, Nur Ogan, Azmi Yerlikaya
BREAST CANCER RESEARCH AND TREATMENT
(2018)
Correction
Oncology
Nuray Erin, Nur Ogan, Azmi Yerlikaya
BREAST CANCER RESEARCH AND TREATMENT
(2018)
Article
Oncology
Reginald M. Gorczynski, Nuray Erin, Tahir Maqbool, Christopher P. Gorczynski, Laura Y. Gorczynski
Article
Otorhinolaryngology
Hulya Eyigor, Mete Eyigor, Bekir Erol, Omer Tarik Selcuk, Levent Renda, Mustafa Deniz Yilmaz, Ustun Osma, Cansu Demirkiran, Meral Gultekin, Nuray Erin
BRAZILIAN JOURNAL OF OTORHINOLARYNGOLOGY
(2020)
Article
Pharmacology & Pharmacy
Sule Kale, Aylin F. Korcum, Ertugrul Dundar, Nuray Erin
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2020)
Article
Oncology
Nuray Erin, Sayra Dilmac, Anna Curry, Ozlem Duymus, Gamze Tanriover, Aaron Prodeus, Jean Gariepy, Reginald M. Gorczynski
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2020)
Review
Oncology
Nuray Erin
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2020)
Review
Pharmacology & Pharmacy
Nuray Erin, Jelena Grahovac, Anamaria Brozovic, Thomas Efferth
DRUG RESISTANCE UPDATES
(2020)
Article
Clinical Neurology
Mehmet Akif Kaya, Nuray Erin, Oznur Bozkurt, Nilgun Erkek, Ozgur Duman, Senay Haspolat
Summary: The study found that HMGB1 levels were significantly elevated in the cerebrospinal fluid of children with febrile seizures, while changes in sTLR4 levels were not statistically significant. This suggests that the HMGB1 network may play a role in the occurrence of febrile seizures in children.
Article
Biochemistry & Molecular Biology
Nuray Erin, Esra Tavsan, Ozlem Akdeniz, Vera M. S. Isca, Patricia Rijo
Summary: Activation of CXCR2 by chemokines promotes breast cancer aggressiveness and chemoresistance, but CXCR2 antagonists are being tested in clinical trials. Inhibition of CXCR2 may lead to increased secretion of MIP-2 and KC, which can be prevented by PKC activators. Different PKC activators have varying effects on chemokine secretion and cell proliferation, with PKC delta and PKC epsilon activators showing the most effectiveness in preventing chemoresistance.
Review
Oncology
Christiana M. Neophytou, Ioannis P. Trougakos, Nuray Erin, Panagiotis Papageorgis
Summary: This review discusses the deregulation of apoptotic pathways as a key factor leading to multidrug resistance (MDR) in cancer cells, along with the impact of the tumor microenvironment on apoptosis in MDR tumors. Therapeutic approaches targeting Bcl-2 family members, IAPs, and AKT, as well as the potential of epigenetic modifications in reversing MDR, are highlighted as important strategies against drug resistance.
Article
Surgery
Osman Tolga Harorli, Mukerrem Hatipoglu, Nuray Erin
PHOTOBIOMODULATION PHOTOMEDICINE AND LASER SURGERY
(2019)