Article
Oncology
Gamze Tanriover, Sayra Dilmac, Gunes Aytac, Ammad Ahmad Farooqi, Muzaffer Sindel
Summary: The combination therapy of melatonin and doxorubicin can reduce primary tumor growth and distant metastasis in breast cancer. Melatonin can also reduce the expression of myeloid-derived suppressor cells, improving the off-target effects of doxorubicin in breast cancer patients.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Frank H. T. Nelissen, Wenny J. M. Peeters, Timo P. Roelofs, Anika Nagelkerke, Paul N. Span, Hans A. Heus
Summary: The study used 3D Cell-SELEX to generate aptamers for specific binding and treatment of breast cancer cells, identifying ten abundant aptamer families with specific structures that selectively bind to SKBR3 cells. The aptamer polymers showed specific binding and efficient internalization into SKBR3 spheroids, and drug-loaded polymers were effective in killing SKBR3 breast cancer cells. This innovative approach holds promise for diagnosing and treating breast cancer.
Article
Pharmacology & Pharmacy
Wenyan Hao, Zengjuan Zheng, Lin Zhu, Lulu Pang, Jinqiu Ma, Siqing Zhu, Lina Du, Yiguang Jin
Summary: The study utilized 3D printing technology to create a prosthesis with drug-loaded microspheres, capable of sustained drug release and effectively inhibiting breast cancer recurrence and metastasis.
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Engineering, Biomedical
Xiao Zheng, Yawei Zhao, Yong Jia, Dan Shao, Fan Zhang, Madi Sun, Jianati Dawulieti, Hanze Hu, Lianzhi Cui, Yue Pan, Chao Yang, Wen Sun, Shuang Zhang, Kan He, Jing Li, Jinzhi Du, Ming Zhang, Li Chen
Summary: Chemotherapy is a double-edged sword in treating breast cancer, as it can induce cancer progression; Berberine has shown potential as a regulator for Dox-exacerbated breast cancer metastasis by targeting the HMGB1-TLR4 axis; The combination of Dox and Ber in a self-assembled nanodrug can effectively inhibit tumor growth and metastasis.
Article
Pharmacology & Pharmacy
Zheng-Hong Peng, Chinmay M. Jogdeo, Jing Li, Ying Xie, Yazhe Wang, Yuri M. Sheinin, Jindrich Kopecek, David Oupicky
Summary: Significant progress has been made in nanomedicine for cancer treatment, but there is relatively less research on managing tumor metastasis. This study introduces a polymeric conjugate P-DOX-iRGD that not only inhibits primary tumor growth but also substantially inhibits pulmonary metastasis in a breast cancer mouse model. Furthermore, treatment with P-DOX-iRGD reduces splenomegaly and liver hematopoiesis caused by breast cancer.
Article
Chemistry, Multidisciplinary
Qiang Chen, Xiaoyu Huang, Geyi Zhang, Jiangnan Li, Yang Liu, Xu Yan
Summary: The development of novel nanoparticle-based drug delivery systems is urgent and important for the treatment of breast cancer. In this study, novel BC-targeted nano-DDSs based on bimetallic Prussian blue analogs were developed for intracellular doxorubicin delivery and pH-responsive release. The results showed that these novel PBA-DDSs can be used as secure and effective drug nano-DDSs for BC chemotherapy.
Article
Materials Science, Biomaterials
Jiatao Yang, Qiuyi Li, Rui Zhou, Minglu Zhou, Xi Lin, Yucheng Xiang, Dandan Xie, Yuan Huang, Zhou Zhou
Summary: The study demonstrated that a combination therapy using targeted drug delivery to mitochondria and a Bcl-2 function-converting peptide distributed in mitochondria effectively inhibited tumor growth and metastasis by enhancing apoptosis and damaging mitochondria. The treatment significantly decreased lung metastasis by increasing cytochrome C expression and decreasing Bcl-2, MMP-9, and VEGF expression, providing a promising strategy for metastatic cancer treatment.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Materials Science, Multidisciplinary
Qingxin Mu, Guanyou Lin, Mike Jeon, Hui Wang, Fei-Chien Chang, Richard A. Revia, John Yu, Miqin Zhang
Summary: This study presents a multifunctional nanoparticle formulation targeting TNBC cells and dendritic cells, inducing tumor apoptosis through multiple mechanisms and significantly inhibiting tumor growth and metastasis while extending survival in a drug-resistant mouse model of TNBC. The promising platform may substantially improve therapeutic efficacy for treating metastatic TNBC.
Article
Pharmacology & Pharmacy
Sahar Taghavi, Hamed Tabasi, Mahsa Zahiri, Khalil Abnous, Seyed Mohammad Taghdisi, Sirous Nekooei, Negar Nekooei, Mohammad Ramezani, Mona Alibolandi
Summary: We fabricated and decorated MSCM-coated biomimetic doxorubicin-loaded hollow gold nanoparticles with MUC1 aptamer to create a smart theranostic platform. The platform exhibited a spherical morphology with a diameter of 118 nm. In vitro release experiments showed that the platform could respond to acidic environments, releasing 50% of encapsulated doxorubicin in 48 hours, while only 14% was released in physiological conditions. The targeted formulation demonstrated increased cytotoxicity against MUC1 positive cell line and effective tumor growth suppression in vivo.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Yu Gao, Jiahui Wang, Hao Han, Huaxin Xiao, Wei-kui Jin, Siyu Wang, Shengpei Shao, Zhixuan Wang, Wenjing Yang, Lianhui Wang, Lixing Weng
Summary: The use of implantable drug-containing polymeric scaffolds shows promise in delivering chemotherapy directly to post-resection sites and inhibiting local recurrence of residual tumors. This strategy offers a potential alternative to systemic chemotherapy with lower side effects and may be useful in combating post-resection breast cancer recurrence in clinics.
Article
Oncology
Zhiyong Mi, Marissa C. Kuo, Paul C. Kuo
Summary: An RNA aptamer was developed to target and inhibit the extracellular sheddase domain of Adam8 in both in vitro and in vivo studies. This aptamer effectively blocked the activities of extracellular Adam8, leading to the reversal of myofibroblast cancer-associated fibroblast phenotype induced by cancer-derived osteopontin. The findings suggest that the signal pathways involved in the development and maintenance of the myCAF phenotype may differ, and that targeting extracellular Adam8 sheddase activity could be a potential therapeutic approach.
Article
Materials Science, Multidisciplinary
Sijie Wu, Shuang Du, Yucheng Guan, Quanshi Lin, Yan Liu, Runlin Lv, Zhenlin Zhang, Yong Xia, Tongkai Chen, Honghai Hong
Summary: The nanocomposite V2C-Dox, loaded with the chemotherapeutic drug doxorubicin, showed advantages in the treatment of triple-negative breast cancer (TNBC) through photothermal therapy and drug release, inhibiting the growth and migration of breast cancer cells. Compared to conventional therapies, this novel nanodelivery system has potential clinical applications in the treatment of TNBC.
ACS MATERIALS LETTERS
(2023)
Article
Oncology
Xuewei Bai, Yanmei Zhou, Qiushi Lin, Chiung-Kuei Huang, Songhua Zhang, Rolf Carlson, Hossein Ghanbari, Bei Sun, Jack R. Wands, Xiaoqun Dong
Summary: Triple negative breast cancer (TNBC) is a more aggressive subtype with a poorer prognosis than others. This study shows that targeting the aspartate beta-hydroxylase (ASPH) network may enhance the efficacy of Doxorubicin (DOX) therapy in TNBC by promoting immunogenic cell death and suppressing tumor growth and metastases.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Man Luo, Afu Fu, Renfei Wu, Na Wei, Kai Song, Sierin Lim, Kathy Qian
Summary: Resistance to doxorubicin remains a challenge in breast cancer treatment, especially for triple negative breast cancer. A study found that high levels of glucose-6-phosphate dehydrogenase (G6PD) may contribute to the resistance of breast cancer cells to doxorubicin-induced oxidative stress. Inhibiting G6PD could be a potential strategy to treat doxorubicin-resistant breast cancer.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Layth Jasim Mohammed, Asghar Taheri-Kafrani
Summary: Proteins have been utilized to create a targeted nanoscale drug delivery system. A novel cationic protein based nanocarrier, AS1411 aptamer-conjugated poly-L-lysine/beta-lactogolubolin nanoparticles (BNP/PLL/Apt), was developed, which combined the advantages of protein nanocarriers and aptamer as a targeting agent. The loaded nanocarrier demonstrated high drug encapsulation efficiency and controlled drug release profile, resulting in enhanced therapeutic efficiency in cancerous cells.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Oncology
Sayra Dilmac, Nuray Erin, Necdet Demir, Gamze Tanriover
PATHOLOGY & ONCOLOGY RESEARCH
(2018)
Article
Medicine, Research & Experimental
Nuray Erin, Sema Turker, Ozlem Elpek, Bulent Yildirim
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2018)
Article
Oncology
Nuray Erin, Nur Ogan, Azmi Yerlikaya
BREAST CANCER RESEARCH AND TREATMENT
(2018)
Correction
Oncology
Nuray Erin, Nur Ogan, Azmi Yerlikaya
BREAST CANCER RESEARCH AND TREATMENT
(2018)
Article
Medicine, Research & Experimental
Esra Nizam, Nuray Erin
BIOMEDICINE & PHARMACOTHERAPY
(2018)
Article
Otorhinolaryngology
Hulya Eyigor, Mete Eyigor, Bekir Erol, Omer Tarik Selcuk, Levent Renda, Mustafa Deniz Yilmaz, Ustun Osma, Cansu Demirkiran, Meral Gultekin, Nuray Erin
BRAZILIAN JOURNAL OF OTORHINOLARYNGOLOGY
(2020)
Article
Pharmacology & Pharmacy
Sule Kale, Aylin F. Korcum, Ertugrul Dundar, Nuray Erin
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2020)
Review
Oncology
Nuray Erin
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2020)
Article
Oncology
Esra Nizam, Sadi Koksoy, Nuray Erin
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2020)
Review
Pharmacology & Pharmacy
Nuray Erin, Jelena Grahovac, Anamaria Brozovic, Thomas Efferth
DRUG RESISTANCE UPDATES
(2020)
Article
Clinical Neurology
Mehmet Akif Kaya, Nuray Erin, Oznur Bozkurt, Nilgun Erkek, Ozgur Duman, Senay Haspolat
Summary: The study found that HMGB1 levels were significantly elevated in the cerebrospinal fluid of children with febrile seizures, while changes in sTLR4 levels were not statistically significant. This suggests that the HMGB1 network may play a role in the occurrence of febrile seizures in children.
Article
Biochemistry & Molecular Biology
Nuray Erin, Esra Tavsan, Ozlem Akdeniz, Vera M. S. Isca, Patricia Rijo
Summary: Activation of CXCR2 by chemokines promotes breast cancer aggressiveness and chemoresistance, but CXCR2 antagonists are being tested in clinical trials. Inhibition of CXCR2 may lead to increased secretion of MIP-2 and KC, which can be prevented by PKC activators. Different PKC activators have varying effects on chemokine secretion and cell proliferation, with PKC delta and PKC epsilon activators showing the most effectiveness in preventing chemoresistance.
Review
Oncology
Christiana M. Neophytou, Ioannis P. Trougakos, Nuray Erin, Panagiotis Papageorgis
Summary: This review discusses the deregulation of apoptotic pathways as a key factor leading to multidrug resistance (MDR) in cancer cells, along with the impact of the tumor microenvironment on apoptosis in MDR tumors. Therapeutic approaches targeting Bcl-2 family members, IAPs, and AKT, as well as the potential of epigenetic modifications in reversing MDR, are highlighted as important strategies against drug resistance.
Article
Surgery
Osman Tolga Harorli, Mukerrem Hatipoglu, Nuray Erin
PHOTOBIOMODULATION PHOTOMEDICINE AND LASER SURGERY
(2019)