Review
Oncology
Jiaxun Song, Xiaofeng Yuan, Lianhua Piao, Jiawen Wang, Pu Wang, Ming Zhuang, Jie Liu, Zhiwei Liu
Summary: Surgical resection remains the mainstream treatment for osteosarcoma, and early diagnosis and distal metastasis are difficult issues in the treatment of this disease. Ubiquitination, as an emerging posttranslational modification, has been found to be closely related to the development of osteosarcoma. This review describes the cellular functions and molecular mechanisms of ubiquitination in osteosarcoma.
FRONTIERS IN ONCOLOGY
(2022)
Review
Immunology
Chenxiao Zheng, Jiayi Chen, Yurui Wu, Xiaochao Wang, Yongan Lin, Lilu Shu, Wenjun Liu, Peter Wang
Summary: Osteoarthritis is a non-inflammatory degenerative joint arthritis that worsens disability in the elderly. Ubiquitination, a type of post-translational modification, has been shown to impact the development and progression of osteoarthritis by targeting specific proteins for ubiquitination and influencing protein stability and localization. This review summarizes the multifaceted role of E3 ubiquitin ligases and deubiquitinases in the pathogenesis of osteoarthritis, as well as highlighting compounds that target these proteins to influence disease progression. The modulation of ubiquitination and deubiquitination may hold promise for improving treatment outcomes in osteoarthritis patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Cell Biology
Hyeon-Ah Do, Kwang-Hyun Baek
Summary: Neurodegenerative diseases are common in humans, but their exact pathogenesis is still poorly understood. The ubiquitin-proteasome system (UPS) plays a vital role in protein degradation and maintaining homeostasis, with enzymes like E1, E2, E3 ligases, and deubiquitinating enzymes (DUBs) regulating disease-inducing proteins by controlling ubiquitination. Targeting these enzymes for treatments is emerging as a promising perspective.
AGEING RESEARCH REVIEWS
(2021)
Article
Multidisciplinary Sciences
Yuka Takehara, Hideki Yashiroda, Yoshitaka Matsuo, Xian Zhao, Akane Kamigaki, Tetsuo Matsuzaki, Hidetaka Kosako, Toshifumi Inada, Shigeo Murata
Summary: Ubiquitination and deubiquitination cycle of ribosomal proteins play a crucial role in efficient protein translation. Ubiquitination at lysine 83 of eS7 is important for translation efficiency, with Otu2 and Ubp3 identified as the deubiquitinating enzymes. Ubp3 inhibits polyubiquitination to maintain eS7 in a mono-ubiquitinated form, while Otu2 promotes mRNA dissociation from 40S ribosomes in the recycling step.
Review
Oncology
Yiyang Sun, Ping He, Li Li, Xue Ding
Summary: Non-small cell lung cancer (NSCLC) is a critical type of lung cancer with early metastasis, late clinical symptoms, limited early screening methods, and poor treatment outcomes. Non-coding RNAs (ncRNAs) and ubiquitination (or deubiquitination) play important roles in NSCLC by regulating cell proliferation, metastasis, and chemoresistance.
FRONTIERS IN ONCOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Sang-Soo Park, Kwang-Hyun Baek
Summary: "Translation: Proteins associated with protein ubiquitination and modifications by Ubls in acute myeloid leukemia" This review discusses the roles of protein ubiquitination and modifications by Ubls in acute myeloid leukemia (AML). It highlights the association between AML-related mutated proteins and Ub and Ubls, as well as the potential of Ubls as therapeutic targets in AML.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Luiz Gustavo Almeida de Carvalho, Tatiana Takahasi Komoto, Daniel Antunes Moreno, Joao Vitor Caetano Goes, Roberta Taiane Germano de Oliveira, Mayara Magna de Lima Melo, Mariela Estefany Gislene Vera Roa, Paola Gyuliane Goncalves, Carlos Victor Montefusco-Pereira, Ronald Feitosa Pinheiro, Howard Lopes Ribeiro Jr
Summary: The aim of this study was to evaluate the expression of USP7, USP15, UBE2O, and UBE2T genes in Myelodysplastic neoplasm (MDS) and identify their roles in MDS pathobiology. Through analyzing eight datasets from the GEO database, the expression relationship of these genes was analyzed in 1092 MDS patients and healthy controls. The results showed differential expression patterns of these genes in MDS patients, suggesting their potential involvement in controlling genomic instability and chromosomal abnormalities in MDS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Xiaoming Zhou, Chengxiao Fu, Xisha Chen
Summary: With the increasing understanding of the relationship between tumor cells and the tumor immune microenvironment, immunotherapy based on immune checkpoint blockade has made significant progress in recent years. However, resistance to immunotherapy has limited its efficacy, with an overall response rate of only 20% to 40%. Therefore, further research on the regulation of the tumor microenvironment and antitumor immunity is urgently needed.
Review
Biochemistry & Molecular Biology
Shengjian Jin, Yasusei Kudo, Taigo Horiguchi
Summary: Ubiquitination and deubiquitination are two common post-translational modifications of proteins, affecting their intracellular localization, stability, and function. Deubiquitination is involved in various cellular processes, including histone modification, cell cycle regulation, apoptosis, and cancer development. This review focuses on the understanding of the function of deubiquitinating enzymes in head and neck squamous cell carcinoma (HNSCC) and discusses potential therapeutic strategies for HNSCC patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Seung-Cheol Jee, Heesun Cheong
Summary: Autophagy and mitophagy play important roles in regulating cancer progression. The regulation of autophagy and mitophagy through ubiquitination and deubiquitination of related proteins is crucial for exploiting their potential in cancer development. Understanding the mechanistic association between cancer and autophagy/mitophagy activities regulated by ubiquitin modification of autophagic proteins can lead to potential therapeutic targets for cancer treatment.
Review
Dermatology
Shuaishuai Hu, Lu Wang
Summary: Melanogenesis is a crucial process for coat coloration in mammals, and the mechanisms of ubiquitination and deubiquitination play important roles in regulating this process. However, the exact regulatory mechanisms are still not well understood.
EXPERIMENTAL DERMATOLOGY
(2023)
Review
Endocrinology & Metabolism
Zhen Ye, Jingru Yang, Hanming Jiang, Xianquan Zhan
Summary: Malignant lung cancer has a high incidence and poor prognosis, while the ubiquitination enzyme pathway plays a crucial role in protein degradation. Ubiquitination of proteins has different effects, and multiple short chains of ubiquitination residues are favorable for protein degradation. The balance between protein ubiquitination and deubiquitination is beneficial to the health of the organism, and imbalances in these pathways are associated with diseases such as lung cancer.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Immunology
Min Zou, Qi-Shan Zeng, Jiao Nie, Jia-Hui Yang, Zhen-Yi Luo, Hua-Tian Gan
Summary: Inflammatory bowel disease (IBD) is a complex disorder involving genetic susceptibility, gut microbiota imbalance, mucosal immune disorder, and environmental factors. Recent studies have shown associations between ubiquitination and deubiquitination in the pathogenesis of IBD, highlighting the importance of these post-translational modifications in inflammation development and potential targeted therapeutics for IBD.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Medicine, Research & Experimental
Yao Xie, Mu Wang, Min Xia, Yinping Guo, Xuyu Zu, Jing Zhong
Summary: This review discusses the roles of ubiquitination and deubiquitination in regulating glycolysis, and their involvement in regulating important signaling pathways, enzymes, and transcription factors. Focusing on potential mechanisms may provide novel strategies for cancer treatment.
Review
Biochemistry & Molecular Biology
Hong-Beom Park, Kwang-Hyun Baek
Summary: This review summarizes the role and mechanisms of MAPK signaling pathways in cancer, as well as the functions of E3 ligases and DUBs targeting MAPK signaling components.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2022)
Article
Multidisciplinary Sciences
Woo Seung Lee, Junwon Lee, Jun Jeong Choi, Hyun Goo Kang, Sung Chul Lee, Ju Han Kim
Summary: The study found that the genetic mutations in Asian UM are similar to those in Western populations, but there are differences before and after brachytherapy, with DICER1 and LRP1B genes newly mutated after brachytherapy, potentially related to resistance to brachytherapy.
SCIENTIFIC REPORTS
(2021)
Article
Ophthalmology
Dong Hyun Lee, Hyuna Cho, Junwon Lee, Eun Young Choi, Sung Chul Lee, Min Kim
Summary: The clinical features and treatment outcomes of patients with choroidal tuberculoma were investigated. The study found that choroidal tuberculoma can develop and recur without evidence of systemic tuberculosis. Early detection and management, as well as positive results on immunological tests to initiate antitubercular therapy, are important.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Hyo Jin Seong, Yong Joon Kim, Eun Young Choi, Junwon Lee, Suk Ho Byeon, Sung Soo Kim, Hyoung Jun Koh, Sung Chul Lee, Christopher Seungkyu Lee
Summary: This retrospective study on choroidal osteoma aimed to report complications, treatments, and visual prognosis. Findings revealed that choroidal neovascularization (CNV) and subretinal fluid were the main visually significant complications, with intravitreal anti-VEGF injection being the common treatment choice. Results showed that the presence of CNV and outer retinal tubulation (ORT) were independent risk factors for vision loss, emphasizing the importance of regular check-ups and appropriate treatment options for better visual outcomes.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Article
Multidisciplinary Sciences
Junwon Lee, Hyun Goo Kang, Hae Rang Kim, Christopher Seungkyu Lee, Min Kim, Sung Soo Kim, Suk Ho Byeon
Summary: This study investigated the occurrence and risk factors of late age-related macular degeneration (AMD) in the fellow eye (FE) without significant drusen in patients with unilateral exudative macular neovascularization (MNV). The findings suggest that hypopigmentation on color fundus photography (CFP) and shallow irregular RPE elevation (SIRE) on OCT might represent the same lesion. Even small hypopigmentation and small RPE elevation were found to be significant risk factors for progression to exudative MNV.
SCIENTIFIC REPORTS
(2022)
Article
Ophthalmology
Hyun Goo Kang, Jung Dong Kim, Junwon Lee, Suk Ho Byeon, Sung Soo Kim, Min Kim
Summary: This study evaluated the clinical features, treatment factors, and long-term outcomes of optic disc pit maculopathy in Korean patients. Two peak incidence groups were identified, and the primary treatment choice did not significantly impact anatomical outcomes. However, delayed vitrectomy was associated with poorer visual outcomes.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Hyun Goo Kang, Tae Young Kim, Junwon Lee, Suk Ho Byeon, Sung Soo Kim, Min Kim
Summary: Among patients with choroidal osteoma undergoing anti-VEGF therapy, tumor thickness may be an important factor for predicting long-term visual prognoses.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Junwon Lee, Han Jeong, Dongju Won, Saeam Shin, Seung-Tae Lee, Jong Rak Choi, Suk Ho Byeon, Helen J. Kuht, Mervyn G. Thomas, Jinu Han
Summary: This study reports the discovery of noncoding pathogenic variants in patients with FRMD7-related infantile nystagmus (FIN). By using genome sequencing and targeted next-generation sequencing analysis, intronic variants in the FRMD7 gene were identified in patients with FIN. Through deep learning-based annotation and in vitro functional study, the impact of these variants on eye movements was confirmed, demonstrating the effectiveness of deep learning-based splicing tools in identifying hidden pathogenic variants in previously unsolved patients with infantile nystagmus.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2022)
Article
Medicine, General & Internal
Donghyun Lee, Junwon Lee, Ji-Hae Nahm, Min Kim
Summary: Vitreous cytology has a lower detection rate for VRL compared to other tests, especially in patients who received steroid pretreatment. Even if vitreous cytology findings are negative, other tests and characteristic fundus findings should be evaluated to confirm VRL diagnosis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Chul Hee Lee, Hansang Lee, Seung Min Lee, Eun Young Choi, Junwon Lee, Min Kim
Summary: This study analyzed the clinical characteristics and multimodal imaging findings of choroidal nevi in the Korean population. It revealed that choroidal nevi in women were often larger and those with associated subretinal fluid were diagnosed at a younger age.
JOURNAL OF CLINICAL MEDICINE
(2022)
Letter
Ophthalmology
Jay Jiyong Kwak, Seung Jae Lee, Junwon Lee, Suk Ho Byeon
ACTA OPHTHALMOLOGICA
(2023)
Article
Multidisciplinary Sciences
Jinkyu Park, Gang Cui, Hyundong Lee, Han Jeong, Jay Jiyong Kwak, Junwon Lee, Suk Ho Byeon
Summary: The CRISPR/Cas9 system is used to easily edit target genes and treat human diseases. By developing a retinal pigment epithelium (RPE)-specific CRISPR/Cas9 system, we demonstrated its effectiveness in human retinal organoids and mouse models. This specific gene editing approach has potential applications in targeted therapy for specific diseases.
SCIENTIFIC REPORTS
(2023)
Article
Biology
Jung Hwa Seo, Jeong Hong Shin, Junwon Lee, Daesik Kim, Hye-Yeon Hwang, Bae-Geun Nam, Jinu Lee, Hyongbum Henry Kim, Sung-Rae Cho
Summary: The use of CRISPR interference (CRISPRi) can repress the expression of mutant huntingtin while preserving wild-type huntingtin, potentially delaying disease progression in Huntington's disease, which is caused by a CAG repeat expansion in the huntingtin gene.
COMMUNICATIONS BIOLOGY
(2023)
Article
Genetics & Heredity
Young Hoon Jung, Jay Jiyong Kwak, Kwangsic Joo, Hyuk Jun Lee, Kyu Hyung Park, Min Seok Kim, Eun Kyoung Lee, Suk Ho Byeon, Christopher Seungkyu Lee, Jinu Han, Junwon Lee, Chang Ki Yoon, Se Joon Woo
Summary: This study investigated the clinical features, natural course, and genetic characteristics of Koreans with rhodopsin-associated retinitis pigmentosa (RHO-associated RP). The study found that the generalized RP group had a higher rate of visual field impairment progression to late-stage RP compared to the sector RP group. Best-corrected visual acuity deterioration was observed only in the generalized RP group. The study also identified several RHO gene mutations, including some that presented with both generalized and sector RP phenotypes.
FRONTIERS IN GENETICS
(2023)
Article
Ophthalmology
Chul Hee Lee, Jinsuk Chun, Seung Min Lee, Hyun Goo Kang, Junwon Lee, Min Kim
Summary: This study describes the clinical course and anatomical features of focal scleral nodules (FSNs) and suggests a potential association between age and phenotype of FSNs. Young patients tend to have protruded lesions, while older patients tend to have dome-shaped lesions.
OPHTHALMOLOGY RETINA
(2022)
Article
Medicine, General & Internal
Jae Yong Han, Yong Joon Kim, Eun Young Choi, Junwon Lee, Ji Hwan Lee, Min Kim, Suk Ho Byeon, Sung Soo Kim, Christopher Seungkyu Lee
Summary: Oral spironolactone therapy showed therapeutic benefits in improving subretinal fluid and subfoveal choroidal thickness in patients with central serous chorioretinopathy, but frequent recurrence should be noted.
YONSEI MEDICAL JOURNAL
(2022)