Distinctive binding properties of human monoclonal LGI1 autoantibodies determine pathogenic mechanisms

Human Cerebrospinal Fluid Monoclonal LGI1 Autoantibodies Increase Neuronal Excitability

(2020) Hans‐Christian Kornau et al.   ANNALS OF NEUROLOGY

Analysis of a Therapeutic Antibody Cocktail Reveals Determinants for Cooperative and Broad Ebolavirus Neutralization

(2020) Pavlo Gilchuk et al.   IMMUNITY

NMDA receptor dysfunction via unmutated human antibodies against the NR1 subunit

(2019) Nina Kerstin Wenke et al.   ANNALS OF NEUROLOGY

Human gestational NMDAR autoantibodies impair neonatal murine brain function

(2019) Betty Jurek et al.   ANNALS OF NEUROLOGY

Genetic predisposition in anti-LGI1 and anti-NMDA receptor encephalitis

(2018) Stefanie H. Mueller et al.   ANNALS OF NEUROLOGY

N-methyl-D-aspartate receptor antibody production from germinal center reactions: Therapeutic implications

(2018) Mateusz Makuch et al.   ANNALS OF NEUROLOGY

Condition-dependent generation of aquaporin-4 antibodies from circulating B cells in neuromyelitis optica

(2018) Robert Wilson et al.   BRAIN

Distinct HLA associations of LGI1 and CASPR2-antibody diseases

(2018) Sophie Binks et al.   BRAIN

Structural basis of epilepsy-related ligand–receptor complex LGI1–ADAM22

(2018) Atsushi Yamagata et al.   Nature Communications

Dysregulation of B Cell Repertoire Formation in Myasthenia Gravis Patients Revealed through Deep Sequencing

(2017) Jason A. Vander Heiden et al.   JOURNAL OF IMMUNOLOGY

Activity-Dependent Exocytosis of Lysosomes Regulates the Structural Plasticity of Dendritic Spines

(2017) Zahid Padamsey et al.   NEURON

A Brief History of Long-Term Potentiation

(2017) Roger A. Nicoll   NEURON

LGI1 tunes intrinsic excitability by regulating the density of axonal Kv1 channels

(2017) Michael Seagar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human cerebrospinal fluid monoclonalN-methyl-D-aspartate receptor autoantibodies are sufficient for encephalitis pathogenesis

(2016) Jakob Kreye et al.   BRAIN

Anti-LGI1 encephalitis

(2016) Agnes van Sonderen et al.   NEUROLOGY

Broadly Neutralizing Anti-Influenza Virus Antibodies: Enhancement of Neutralizing Potency in Polyclonal Mixtures and IgA Backbones

(2015) Wenqian He et al.   JOURNAL OF VIROLOGY

Faciobrachial dystonic seizures: the influence of immunotherapy on seizure control and prevention of cognitive impairment in a broadening phenotype

(2013) Sarosh R. Irani et al.   BRAIN

Autoantibodies to Epilepsy-Related LGI1 in Limbic Encephalitis Neutralize LGI1-ADAM22 Interaction and Reduce Synaptic AMPA Receptors

(2013) T. Ohkawa et al.   JOURNAL OF NEUROSCIENCE

The rapid generation of recombinant functional monoclonal antibodies from individual, antigen-specific bone marrow-derived plasma cells isolated using a novel fluorescence-based method

(2013) Alison M Clargo et al.   mAbs

Faciobrachial dystonic seizures precede Lgi1 antibody limbic encephalitis

(2010) Sarosh R. Irani et al.   ANNALS OF NEUROLOGY

Electroclinical characterization of epileptic seizures in leucine-rich, glioma-inactivated 1-deficient mice

(2010) Elodie Chabrol et al.   BRAIN

Antibodies to Kv1 potassium channel-complex proteins leucine-rich, glioma inactivated 1 protein and contactin-associated protein-2 in limbic encephalitis, Morvan’s syndrome and acquired neuromyotonia

(2010) Sarosh R. Irani et al.   BRAIN

Cellular and Synaptic Mechanisms of Anti-NMDA Receptor Encephalitis

(2010) E. G. Hughes et al.   JOURNAL OF NEUROSCIENCE

Investigation of LGI1 as the antigen in limbic encephalitis previously attributed to potassium channels: a case series

(2010) Meizan Lai et al.   LANCET NEUROLOGY