Human Cerebrospinal Fluid Monoclonal LGI1 Autoantibodies Increase Neuronal Excitability

NMDA receptor dysfunction via unmutated human antibodies against the NR1 subunit

(2019) Nina Kerstin Wenke et al.   ANNALS OF NEUROLOGY

Hippocampal epileptogenesis in autoimmune encephalitis

(2019) Michele Romoli et al.   Annals of Clinical and Translational Neurology

Genetic predisposition in anti-LGI1 and anti-NMDA receptor encephalitis

(2018) Stefanie H. Mueller et al.   ANNALS OF NEUROLOGY

Distinct HLA associations of LGI1 and CASPR2-antibody diseases

(2018) Sophie Binks et al.   BRAIN

Antibody-Mediated Encephalitis

(2018) Josep Dalmau et al.   NEW ENGLAND JOURNAL OF MEDICINE

Structural basis of epilepsy-related ligand–receptor complex LGI1–ADAM22

(2018) Atsushi Yamagata et al.   Nature Communications

Elevated LGI1-IgG CSF index predicts worse neurological outcome

(2018) Avi Gadoth et al.   Annals of Clinical and Translational Neurology

The value of LGI1, Caspr2 and voltage-gated potassium channel antibodies in encephalitis

(2017) Agnes van Sonderen et al.   Nature Reviews Neurology

Autoantibodies to Synaptic Receptors and Neuronal Cell Surface Proteins in Autoimmune Diseases of the Central Nervous System

(2017) Josep Dalmau et al.   PHYSIOLOGICAL REVIEWS

LGI1 tunes intrinsic excitability by regulating the density of axonal Kv1 channels

(2017) Michael Seagar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NMDAR encephalitis: passive transfer from man to mouse by a recombinant antibody

(2017) Manish Malviya et al.   Annals of Clinical and Translational Neurology

Human cerebrospinal fluid monoclonalN-methyl-D-aspartate receptor autoantibodies are sufficient for encephalitis pathogenesis

(2016) Jakob Kreye et al.   BRAIN

Slowly progressive LGI1 encephalitis with isolated late-onset cognitive dysfunction: a treatable mimic of Alzheimer's disease

(2016) J. Marquetand et al.   EUROPEAN JOURNAL OF NEUROLOGY

Autoimmune synaptopathies

(2016) Sarah J. Crisp et al.   NATURE REVIEWS NEUROSCIENCE

Anti-LGI1–associated cognitive impairment

(2016) Helena Ariño et al.   NEUROLOGY

LGI1 acts presynaptically to regulate excitatory synaptic transmission during early postnatal development

(2016) Morgane Boillot et al.   Scientific Reports

The brain as immunoprecipitator of serum autoantibodies against N-Methyl-D-aspartate receptor subunit NR1

(2015) Esther Castillo-Gomez et al.   ANNALS OF NEUROLOGY

Reversible Dementia: Two Nursing Home Patients With Voltage-Gated Potassium Channel Antibody-Associated Limbic Encephalitis

(2015) Wesley Reintjes et al.   Journal of the American Medical Directors Association

Optogenetic acidification of synaptic vesicles and lysosomes

(2015) Benjamin R Rost et al.   NATURE NEUROSCIENCE

The LGI1–ADAM22 protein complex directs synapse maturation through regulation of PSD-95 function

(2015) Kathryn L. Lovero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autoantibodies to Epilepsy-Related LGI1 in Limbic Encephalitis Neutralize LGI1-ADAM22 Interaction and Reduce Synaptic AMPA Receptors

(2013) T. Ohkawa et al.   JOURNAL OF NEUROSCIENCE

Morvan syndrome: Clinical and serological observations in 29 cases

(2012) Sarosh R. Irani et al.   ANNALS OF NEUROLOGY

Faciobrachial dystonic seizures precede Lgi1 antibody limbic encephalitis

(2010) Sarosh R. Irani et al.   ANNALS OF NEUROLOGY

Electroclinical characterization of epileptic seizures in leucine-rich, glioma-inactivated 1-deficient mice

(2010) Elodie Chabrol et al.   BRAIN

Antibodies to Kv1 potassium channel-complex proteins leucine-rich, glioma inactivated 1 protein and contactin-associated protein-2 in limbic encephalitis, Morvan’s syndrome and acquired neuromyotonia

(2010) Sarosh R. Irani et al.   BRAIN

Human limbic encephalitis serum enhances hippocampal mossy fiber-CA3 pyramidal cell synaptic transmission

(2010) Tatjana Lalic et al.   EPILEPSIA

Lgi1 null mutant mice exhibit myoclonic seizures and CA1 neuronal hyperexcitability

(2010) Y. Eugene Yu et al.   HUMAN MOLECULAR GENETICS

Cellular and Synaptic Mechanisms of Anti-NMDA Receptor Encephalitis

(2010) E. G. Hughes et al.   JOURNAL OF NEUROSCIENCE

Investigation of LGI1 as the antigen in limbic encephalitis previously attributed to potassium channels: a case series

(2010) Meizan Lai et al.   LANCET NEUROLOGY

Disruption of LGI1–linked synaptic complex causes abnormal synaptic transmission and epilepsy

(2010) Yuko Fukata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AMPA receptor antibodies in limbic encephalitis alter synaptic receptor location

(2009) Meizan Lai et al.   ANNALS OF NEUROLOGY

Efficient generation of monoclonal antibodies from single human B cells by single cell RT-PCR and expression vector cloning

(2007) Thomas Tiller et al.   JOURNAL OF IMMUNOLOGICAL METHODS