Review
Nanoscience & Nanotechnology
Naveneet Dubey, Sukhvinder Dhiman, Apurba Lal Koner
Summary: Carbon Dots (CDs) are zero-dimensional nanostructures with high quantum yield, low cytotoxicity, high water solubility, good photostability, and tunable excitation wavelength-dependent emission properties, making them promising for targeted chemotherapy.
ACS APPLIED NANO MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Shivanand H. Nannuri, Abhijeet Pandey, Sanjay Kulkarni, Prashant K. Deshmukh, Srinivas Mutalik
Summary: Metal-organic frameworks (MOFs) have been used as nanocarriers for targeted drug delivery. This study focuses on the synthesis and characterization of carbon dots (C-dots) loaded MOFs for neuroblastoma imaging and therapy. The C-dots exhibited unique structural and optical properties, with pH and temperature-responsive behaviors. The drug release and cell uptake studies suggest the potential of these nanocomposites for drug delivery and targeted cancer therapy.
MATERIALS TODAY COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Suman Nayak, Prakash Kumar, Ravi Shankar, Asish Kumar Mukhopadhyay, Debabrata Mandal, Prolay Das
Summary: In this study, onion derived biomass DNA was transformed into DNA-dots and used as crosslinkers to create a DNA hydrogel. The hydrogel can sustainably release antibiotics and produce reactive oxygen species with visible light, showing remarkable antibacterial effects against drug-resistant strains.
Article
Chemistry, Applied
Harpreet Singh, Shalini Singh, Sanjeev K. Bhardwaj, Gurjeet Kaur, Madhu Khatri, Akash Deep, Neha Bhardwaj
Summary: In this research, a novel fluorescent immunosensor based on nitrogen-doped carbon quantum dots has been developed for the analysis of aflatoxin M1 in dairy products. The sensor exhibited high sensitivity and low limit of detection, and was further developed as a lateral flow design for on-site detection.
Article
Chemistry, Analytical
Nobuhle Ndebele, Pinar Sen, Tebello Nyokong
Summary: Two cobalt phthalocyanine molecules were synthesized and used as electro-catalytic probes in the electrochemical oxidation of dopamine, showing improved sensitivity and limit of detection when conjugated with nitrogen-doped graphene quantum dots.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Elahehnaz Parhizkar, Parivash Rafieipour, Alireza Sepasian, Effat Alemzadeh, Ali Dehshahri, Fatemeh Ahmadi
Summary: Gemcitabine, a nucleoside analogue drug, has limitations due to rapid body clearance, but chemical conjugation with Tobacco Mosaic Virus shows potential for drug delivery with minimal toxicity. In vitro studies suggest improved cytotoxicity and drug release from the conjugate, indicating potential for better pharmacokinetics and reduced toxicity in vivo.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Chemistry, Analytical
Yeling Yang, Jingzhao Yang, Yixia Yang, Xinghu Ji, Wenhua Li, Fubing Wang, Conghua Xie, Zhike He
Summary: We developed a novel detection system based on CRISPR-Cas-catalyzed formation of quantum dot-DNA (QD-DNA) hydrogel for sensitive miRNA assay. This assay, termed CRISPR-Cas-catalyzed TMSD based QD-DNA hydrogel (Cas-TMSD-QDH), showed an accurate detection of miR-17 levels in different cell lines and serum samples, revealing great potential for miRNAs assay in clinical molecular diagnostics.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Multidisciplinary
Shuai Zhang, Yan Tian, Ming Liu, Tie Hong-Meng, Chun-Rong Li, Xi Zeng, Xin Xiao, Carl Redshaw
Summary: A novel cucurbit[6]uril (Q[6])/carbon quantum dots (CQDs) material was reported, which was prepared by solvothermal and nitrogen doped methods. The obtained m-Q[6]-CQDs exhibited good water dispersibility, photostability, and strong blue fluorescence emission. The m-Q[6]-CQDs also showed good selectivity for metal ions, with fluorescence quenched by Hg2+ but enhanced by Al3+. The fluorescence of the m-Q[6]-CQDs could resist interference from other metal ions and high ionic strength environments, and they demonstrated low cytotoxicity and excellent biocompatibility for optical bioimaging of human prostate cancer (PC-3) cells.
MATERIALS CHEMISTRY FRONTIERS
(2022)
Review
Chemistry, Multidisciplinary
Yijie Wang, Tingjie Lv, Keyang Yin, Ning Feng, Xiaofeng Sun, Jin Zhou, Hongguang Li
Summary: Hydrogels with high moisture content are soft and biocompatible, making them important in various fields like biomedicine, bionic smart material, and electrochemistry. Carbon dot-based hydrogels, formed by carbon dots and auxiliary substances, have unique properties and applications in biomedicine, sensing, adsorption, energy storage, and catalysis.
Article
Chemistry, Multidisciplinary
Hongxin Liu, Zhigang Xie, Min Zheng
Summary: Cancer immunotherapy is a popular area of research, and carbon dots have shown potential as nanovectors to enhance its efficacy.
Article
Chemistry, Analytical
Kaory Barrientos, Juan Pablo Arango, Manuel Santiago Moncada, Jersson Placido, Juliana Patino, Sara Legny Macias, Camilo Maldonado, Sandra Torijano, Sandra Bustamante, Martha Elena Londono, Marisol Jaramillo
Summary: Due to their exceptional properties, carbon dots, carbon quantum dots, and graphene quantum dots have garnered attention in biosensing. This review provides an overview of the synthesis methods, properties, and applications of these carbonaceous nanomaterials in the detection of infectious and non-communicable diseases.
Article
Chemistry, Multidisciplinary
Xue Chen, Yu Wang, Chenxi Peng, Wenbo Hu, Zhongbin Wu, Weidong Xu, Suli Wu, Zhi Luo, Yung Doug Suh, Timur Sh. Atabaev, Xiyan Li, Xiaowang Liu, Wei Huang
Summary: This paper reports a novel method for synthesizing CD-doped SiO(2) MPs with tunable afterglow properties and size distributions. The pseudomorphic transformation of SiO(2) MPs enables CD doping, providing a hydrogen bond-enriched environment for triplet state stabilization, resulting in green afterglow while maintaining uniformity in size and morphology. Furthermore, the utility of CD-doped SiO(2) MPs in the fabrication of PC patterns is demonstrated, exhibiting multiple optical responses under different lighting conditions.
ADVANCED MATERIALS
(2023)
Article
Green & Sustainable Science & Technology
Yaling Liu, John Keil, Vivian E. Ferry, Uwe R. Kortshagen
Summary: Greenhouses provide a controlled environment for plant growth and offer resilience to droughts and extreme weather. Luminescent solar concentrators (LSCs) have the potential to reduce greenhouse energy demand by generating clean electricity and transmitting enough light for plant growth.
ADVANCED SUSTAINABLE SYSTEMS
(2023)
Article
Nanoscience & Nanotechnology
Paniz Rahmani, Melissa Goodlad, Yehan Zhang, Yichen Li, Tao Ye
Summary: This study develops a one-step ligand-exchange method to produce water-soluble QD-DNA conjugates with high photoluminescence. These bioconjugates can be used for DNA-directed self assembly and demonstrated fluorescence quenching by adjacent gold nanoparticles. Such QD-AuNP dimers can serve as biosensors with improved sensitivity.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Chemistry, Multidisciplinary
Adam Truskewycz, Hong Yin, Nils Halberg, Daniel T. H. Lai, Andrew S. Ball, Vi Khanh Truong, Agata Marta Rybicka, Ivan Cole
Summary: This article discusses the therapeutic potential of carbon quantum dots (CQDs) in biomedical applications. CQDs have shown biocompatibility and have been used for drug solubility, targeting, and facilitating drug delivery. They can also be triggered by environmental conditions or external stimuli, and their fluorescence is valuable for diagnostic purposes. The article also examines the toxicity of CQDs and their compatibility with larger nanoparticle carriers. The future of CQDs in theragnostic applications looks promising due to their multifunctional attributes and biocompatibility.
Review
Fisheries
Li Lian Wong, Siti Aisyah Razali, Zulaikha Mat Deris, Muhd Danish-Daniel, Min Pau Tan, Siti Azizah Mohd Nor, Hongyu Ma, Wang Min, Liang Yantao, Md Asaduzzaman, Yeong Yik Sung, Zhanjiang Liu, Patrick Sorgeloos, Yves Van de Peer, Nor Afiqah-Aleng
Summary: High-throughput sequencing technologies have been widely applied in aquaculture research, providing important data support for disease management, breeding programs, etc.
Article
Oceanography
Meiaoxue Han, Shunan Cao, Guangfu Luo, Jianfeng He, Yantao Liang, Xuechao Chen, Chengxiang Gu, Gang Liu, Ziyue Wang, Wenjing Zhang, Yue Dong, Jun Zhao, Qiang Hao, Hongbing Shao, Yeong Yik Sung, Wen Jye Mok, Li Lian Wong, Andrew McMinn, Min Wang
Summary: The summer distribution of virio- and picoplankton in the Indian Ocean sector of East Antarctica is mainly controlled by ice melting and upwelling of the Circumpolar Deep Water (CDW). Different areas show variations in marine biological composition and abundance, with viruses exhibiting correlations with different types of plankton.
DEEP-SEA RESEARCH PART II-TOPICAL STUDIES IN OCEANOGRAPHY
(2022)
Article
Biochemistry & Molecular Biology
Pervaiz Ali Channar, Mubashir Aziz, Syeda Abida Ejaz, Gul-e-Saba Chaudhry, Amna Saeed, Rabail Ujan, Abbas Hasan, Syeda Rabia Ejaz, Aamer Saeed
Summary: The synthesis of compounds with a thiazolidinone pharmacophore was achieved, and their anticancer activities were evaluated. Compounds 2c and 2d exhibited significant cytotoxicity against MCF-7 and HeLa cell lines by inducing apoptosis. Molecular docking and dynamic simulations provided further support to these findings, and computational studies suggested the potential of these compounds as lead molecules for the development of novel drug candidates for specific cancers.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Ying-Chao Ma, Mei-Rong Gao, Huan Yang, Jun-Yao Jiang, Wei Xie, Wan-Ping Su, Bo Zhang, Yik-Sung Yeong, Wu-Yan Guo, Li-Ying Sui
Summary: This study aims to find more cost-effective and manageable ways of producing C-50 carotenoids. The results showed that using natural brine medium and adding glucose, sucrose, and lactose can enhance both biomass and carotenoid productivity. The best conditions for open fermentation were salinity 20-25%, rotation speed 150-200 rpm, and pH 7.0-8.2. The open fermentation of Halorubrum is a promising method for producing C-50 carotenoids.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Article
Ecology
Siti Zuraida Zulkipli, Chee Ping Tan, Ying Giat Seah, Hon Jung Liew, Yeong Yik Sung, Masashi Ando, Min Wang, Yantao Liang, Andrew McMinn, Wen Jye Mok
Summary: This study investigated mercury contamination in common commercial marine fish from the South China Sea. The muscle tissue mercury levels of four species were analyzed, and their trophic level was assessed. The results revealed variations in mercury concentrations among species, with Epinephelus heniochus having the highest concentration and Scomberomorus guttatus having the lowest. Factors such as size, food composition, and habitat were identified as the major influences on mercury levels in these fishes.
REGIONAL STUDIES IN MARINE SCIENCE
(2023)
Article
Environmental Sciences
Linyi Ren, Yundan Liu, Yantao Liang, Baohong Liu, Andrew McMinn, Kaiyang Zheng, Ziyue Wang, Hongmin Wang, Hongbing Shao, Yeong Yik Sung, Wen Jye Mok, Li Lian Wong, Min Wang
Summary: A new Pseudomonas phage, vB_PsaP_M1, has been discovered, which has a distant evolutionary relationship with previously isolated viruses and belongs to a new viral cluster called Psaeviridae. Additionally, two unique genes were found in this phage, confirming the proposal for a new viral family.
FRONTIERS IN MARINE SCIENCE
(2022)
Article
Environmental Sciences
Yajun Jing, Ruizhe Guo, Hongmin Wang, Yantao Liang, Yundan Liu, Yifei Feng, Qin Ma, Hongbing Shao, Yeong Yik Sung, Wen Jye Mok, Li Lian Wong, Yu-Zhong Zhang, Andrew McMinn, Min Wang, Jinyan Xing
Summary: A novel marine phage vB_VhaP_PG11 infecting Vibrio hangzhouensis was isolated from offshore waters of Qingdao, China. It is a double-stranded DNA phage and is related to two Vibrio phages with low homology. Phylogenetic analysis revealed that vB_VhaP_PG11 belongs to a new genus named Qingschitovirus in Schitoviridae. This study provides important information for understanding the interactions between Vibrio phages and their hosts and analyzing unknown viral sequences in metagenomic databases.
FRONTIERS IN MARINE SCIENCE
(2023)
Article
Pharmacology & Pharmacy
Sanggeeta Kesavan, Abdah Md Akim, Gul-e-Saba Chaudry, Yazan K. Ranneh
Summary: Polycystic Ovary Syndrome (PCOS) is a hormonal disorder that affects 5-10% of women in their reproductive age. This meta-analysis evaluates the efficacy of metformin and exenatide in reducing BMI and testosterone levels in PCOS patients. The results indicate that exenatide is effective in reducing BMI and testosterone levels in PCOS patients compared to metformin, but it has no effect on LDL-C and HDL-C levels.
Correction
Engineering, Biomedical
Uzma Yunus, Muhammad Ahsan Zulfiqar, Muhammad Ajmal, Moazzam H. Bhatti, Gul-e-Saba Chaudhry, Tengku Sifzizul Tengku Muhammad, Yeong Yik Sung
BIOMEDICAL MATERIALS
(2023)
Correction
Engineering, Biomedical
Irum Gul, Uzma Yunus, Muhammad Ajmal, Moazzam Hussain Bhatti, Gul-e-Saba Chaudhry
BIOMEDICAL MATERIALS
(2023)
Article
Virology
Fuyue Ge, Ruizhe Guo, Yantao Liang, Ying Chen, Hongbing Shao, Yeong Yik Sung, Wen Jye Mok, Li Lian Wong, Andrew Mcminn, Min Wang
Summary: A novel Stutzerimonas stutzeri phage, vB_PstS_ZQG1, was isolated from the surface seawater of Qingdao, China. It has a unique morphology and genomic sequence, and shows low similarity with previously isolated phages or uncultured viruses, suggesting it belongs to a novel viral genus.
Article
Chemistry, Multidisciplinary
Syed Muddassir Ali Mashhadi, Moazzam H. Bhatti, Erum Jabeen, Uzma Yunus, Muhammad Ashfaq, Mahjbeen Akhtar, Muhammad Nawaz Tahir, Saad M. Alshehri, Sarfraz Ahmed, Suvash Chandra Ojha
Summary: In this study, two organic salts (1 and 2) were synthesized and characterized by FTIR, UV spectroscopy, and X-ray crystallographic studies. The stability and charge transfer phenomenon of the compounds were confirmed through analysis of natural bond orbitals (NBOs), natural population, frontier molecular orbitals (FMOs), and global reactivity parameters. Molecular docking predicted that the coformer exhibited DNA intercalation reinforced by its salt formation. Antioxidant studies showed that compound 3 has a higher IC50 value than 2,4-D and the highest value among the compounds studied, while compound 2 showed the lowest value.
Article
Chemistry, Multidisciplinary
Farzana Yasmeen, Uzma Yunus, Moazzam H. Bhatti, Muhammad Sher, Muhammad Nadeem
Summary: In this study, MIL-101 (Cr), an easily activated metal-organic framework with high specific surface area, big pore size, and good stability, was modified by introducing chiral ligands (l-proline, l-thioproline, and l-tyrosine) to develop chiral metal-organic frameworks (CMOFs). The prepared CMOFs showed enantioselectivity towards various racemates, as confirmed by chiral HPLC and polarimetry.
Article
Pharmacology & Pharmacy
Gul-e-Saba Chaudhry, Abdah Md Zeenia, Abdah Md Akim, Yeong Yik Sung, Tengku Muhammad Tengku Sifzizul
Summary: Anemia is a global epidemic caused by iron deficiency. This study used anthropometric measurements and a questionnaire to investigate the correlation between iron deficiency, diet, and anemia. The results showed that both underweight and obesity were prevalent among men, and 10% of men with normal blood iron levels had mild iron deficiency. In women, underweight was more common than obesity. The study also highlighted the potential risks and benefits of iron supplements. Understanding the relationship between iron deficiency anemia and specific nutrients is important for maintaining proper nutrient levels and promoting public health.
ARCHIVES OF PHARMACY PRACTICE
(2023)
Article
Marine & Freshwater Biology
Kaiyang Zheng, Yue Dong, Yantao Liang, Yundan Liu, Xinran Zhang, Wenjing Zhang, Ziyue Wang, Hongbing Shao, Yeong Yik Sung, Wen Jye Mok, Li Lian Wong, Andrew McMinn, Min Wang
Summary: This study systematically analyzed the genomes, taxonomic features, and distribution patterns of Pseudoalteromonas phages. A total of 143 Pseudoalteromonas-associated phage genomes were identified and assigned to 47 viral clusters. The prevalence of integrated proviruses and filamentous phages suggest the viral lysogenic life cycle in Pseudoalteromonas. These phages play a role in marine biogeochemical cycles and their abundance and distribution vary across polar areas and the deep sea. This study expands our understanding of marine Pseudoalteromonas phages and their interactions with their hosts.
MARINE LIFE SCIENCE & TECHNOLOGY
(2023)