How do cells sense DNA lesions?

Quantitative sensing and signalling of single-stranded DNA during the DNA damage response

(2019) Susanne C. S. Bantele et al.   Nature Communications

Stepwise 5′ DNA end-specific resection of DNA breaks by the Mre11-Rad50-Xrs2 and Sae2 nuclease ensemble

(2019) Elda Cannavo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The ATP-bound conformation of the Mre11–Rad50 complex is essential for Tel1/ATM activation

(2019) Corinne Cassani et al.   NUCLEIC ACIDS RESEARCH

Quantitative phosphoproteomics reveals mitotic function of the ATR activator ETAA1

(2019) Thomas E. Bass et al.   JOURNAL OF CELL BIOLOGY

Activation of Tel1ATM kinase requires Rad50 ATPase and long nucleosome-free DNA, but no DNA ends

(2019) Sarem Hailemariam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Common motifs in ETAA1 and TOPBP1 required for ATR kinase activation

(2019) Vaughn Thada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Emerging Roles of DNA Glycosylases and the Base Excision Repair Pathway

(2019) Elwood A. Mullins et al.   TRENDS IN BIOCHEMICAL SCIENCES

Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint

(2019) Nicolas Bigot et al.   eLife

RNases H: Structure and mechanism

(2019) Malwina Hyjek et al.   DNA REPAIR

Ddc2ATRIP promotes Mec1ATR activation at RPA-ssDNA tracts

(2019) Himadri Biswas et al.   PLoS Genetics

Mechanism of DNA End Sensing and Processing by the Mre11-Rad50 Complex

(2019) Lisa Käshammer et al.   MOLECULAR CELL

Chromosome instability syndromes

(2019) A. Malcolm R. Taylor et al.   Nature Reviews Disease Primers

Activation of ATR-related protein kinase upon DNA damage recognition

(2019) Minh Ma et al.   CURRENT GENETICS

Near-Complete Structure and Model of Tel1ATM from Chaetomium thermophilum Reveals a Robust Autoinhibited ATP State

(2019) Marijke Jansma et al.   STRUCTURE

Cryo-EM Structure of Nucleotide-Bound Tel1ATM Unravels the Molecular Basis of Inhibition and Structural Rationale for Disease-Associated Mutations

(2019) Luke A. Yates et al.   STRUCTURE

Molecular and physiological consequences of faulty eukaryotic ribonucleotide excision repair

(2019) Vanessa Kellner et al.   EMBO JOURNAL

The MRE11–RAD50–NBS1 Complex Conducts the Orchestration of Damage Signaling and Outcomes to Stress in DNA Replication and Repair

(2018) Aleem Syed et al.   Annual Review of Biochemistry

Mre11-Rad50–dependent activity of ATM/Tel1 at DNA breaks and telomeres in the absence of Nbs1

(2018) Oliver Limbo et al.   MOLECULAR BIOLOGY OF THE CELL

Ataxia-Telangiectasia Mutated Kinase in the Control of Oxidative Stress, Mitochondria, and Autophagy in Cancer: A Maestro With a Large Orchestra

(2018) Venturina Stagni et al.   Frontiers in Oncology

Molecular basis for damage recognition and verification by XPC-RAD23B and TFIIH in nucleotide excision repair

(2018) Hong Mu et al.   DNA REPAIR

An intrinsic S/G2 checkpoint enforced by ATR

(2018) Joshua C. Saldivar et al.   SCIENCE

Plasticity of the Mre11–Rad50–Xrs2–Sae2 nuclease ensemble in the processing of DNA-bound obstacles

(2017) Weibin Wang et al.   GENES & DEVELOPMENT

Physiological protein blocks direct the Mre11–Rad50–Xrs2 and Sae2 nuclease complex to initiate DNA end resection

(2017) Giordano Reginato et al.   GENES & DEVELOPMENT

TOPBP1Dpb11plays a conserved role in homologous recombination DNA repair through the coordinated recruitment of 53BP1Rad9

(2017) Yi Liu et al.   JOURNAL OF CELL BIOLOGY

ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response

(2017) Andrew N. Blackford et al.   MOLECULAR CELL

The essential kinase ATR: ensuring faithful duplication of a challenging genome

(2017) Joshua C. Saldivar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Non-homologous DNA end joining and alternative pathways to double-strand break repair

(2017) Howard H. Y. Chang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Eukaryotic Rad50 functions as a rod-shaped dimer

(2017) Young Bong Park et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Eukaryotic Rad50 functions as a rod-shaped dimer

(2017) Young Bong Park et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Targeting of the Fun30 nucleosome remodeller by the Dpb11 scaffold facilitates cell cycle-regulated DNA end resection

(2017) Susanne CS Bantele et al.   eLife

RPA-Binding Protein ETAA1 Is an ATR Activator Involved in DNA Replication Stress Response

(2016) Yuan-Cho Lee et al.   CURRENT BIOLOGY

Structural mechanism of ATP‐dependent DNA binding and DNA end bridging by eukaryotic Rad50

(2016) Florian Ulrich Seifert et al.   EMBO JOURNAL

Single-Molecule Imaging Reveals that Rad4 Employs a Dynamic DNA Damage Recognition Process

(2016) Muwen Kong et al.   MOLECULAR CELL

Nbs1 Converts the Human Mre11/Rad50 Nuclease Complex into an Endo/Exonuclease Machine Specific for Protein-DNA Adducts

(2016) Rajashree A. Deshpande et al.   MOLECULAR CELL

Phosphorylated CtIP Functions as a Co-factor of the MRE11-RAD50-NBS1 Endonuclease in DNA End Resection

(2016) Roopesh Anand et al.   MOLECULAR CELL

ETAA1 acts at stalled replication forks to maintain genome integrity

(2016) Thomas E. Bass et al.   NATURE CELL BIOLOGY

Activation of the ATR kinase by the RPA-binding protein ETAA1

(2016) Peter Haahr et al.   NATURE CELL BIOLOGY

Human BRCA1–BARD1 ubiquitin ligase activity counteracts chromatin barriers to DNA resection

(2016) Ruth M Densham et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Ataxia telangiectasia: a review

(2016) Cynthia Rothblum-Oviatt et al.   Orphanet Journal of Rare Diseases

Twist-open mechanism of DNA damage recognition by the Rad4/XPC nucleotide excision repair complex

(2016) Yogambigai Velmurugu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coordinated nuclease activities counteract Ku at single-ended DNA double-strand breaks

(2016) Pauline Chanut et al.   Nature Communications

Human BRCA1–BARD1 ubiquitin ligase activity counteracts chromatin barriers to DNA resection

(2016) Ruth M Densham et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Tel1 and Rif2 Regulate MRX Functions in End-Tethering and Repair of DNA Double-Strand Breaks

(2016) Corinne Cassani et al.   PLOS BIOLOGY

Dampening DNA damage checkpoint signalling via coordinated BRCT domain interactions

(2015) J. R. Cussiol et al.   EMBO JOURNAL

ATP‐dependent DNA binding, unwinding, and resection by the Mre11/Rad50 complex

(2015) Yaqi Liu et al.   EMBO JOURNAL

Escape of Sgs1 from Rad9 inhibition reduces the requirement for Sae2 and functional MRX in DNA end resection

(2015) D. Bonetti et al.   EMBO REPORTS

Mismatch Repair

(2015) Richard Fishel   JOURNAL OF BIOLOGICAL CHEMISTRY

Slx4 and Rtt107 control checkpoint signalling and DNA resection at double-strand breaks

(2015) Diego Dibitetto et al.   NUCLEIC ACIDS RESEARCH

An Overview of the Molecular Mechanisms of Recombinational DNA Repair

(2015) Stephen C. Kowalczykowski   Cold Spring Harbor Perspectives in Biology

Kinetic gating mechanism of DNA damage recognition by Rad4/XPC

(2015) Xuejing Chen et al.   Nature Communications

Functional Interplay between the 53BP1-Ortholog Rad9 and the Mre11 Complex Regulates Resection, End-Tethering and Repair of a Double-Strand Break

(2015) Matteo Ferrari et al.   PLoS Genetics

Base excision repair: A critical player in many games

(2014) Susan S. Wallace   DNA REPAIR

ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling

(2014) R. A. Deshpande et al.   EMBO JOURNAL

Sae2 promotes dsDNA endonuclease activity within Mre11–Rad50–Xrs2 to resect DNA breaks

(2014) Elda Cannavo et al.   NATURE

Sources of DNA Double-Strand Breaks and Models of Recombinational DNA Repair

(2014) A. Mehta et al.   Cold Spring Harbor Perspectives in Biology

Interplays between ATM/Tel1 and ATR/Mec1 in sensing and signaling DNA double-strand breaks

(2013) Elisa Gobbini et al.   DNA REPAIR

Mec1/ATR regulates the generation of single-stranded DNA that attenuates Tel1/ATM signaling at DNA ends

(2013) Michela Clerici et al.   EMBO JOURNAL

Lagging strand maturation factor Dna2 is a component of the replication checkpoint initiation machinery

(2013) S. Kumar et al.   GENES & DEVELOPMENT

Ataxia Telangiectasia-Mutated (ATM) Kinase Activity Is Regulated by ATP-driven Conformational Changes in the Mre11/Rad50/Nbs1 (MRN) Complex

(2013) Ji-Hoon Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Cell Cycle-Dependent Regulatory Circuit Composed of 53BP1-RIF1 and BRCA1-CtIP Controls DNA Repair Pathway Choice

(2013) Cristina Escribano-Díaz et al.   MOLECULAR CELL

DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities

(2013) Atsushi Shibata et al.   MOLECULAR CELL

The ATM protein kinase: regulating the cellular response to genotoxic stress and more

(2013) Yosef Shiloh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Nucleosome dynamics regulates DNA processing

(2013) Nicholas L Adkins et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Relationship of DNA degradation by Saccharomyces cerevisiae Exonuclease 1 and its stimulation by RPA and Mre11-Rad50-Xrs2 to DNA end resection

(2013) E. Cannavo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Postreplicative Mismatch Repair

(2013) J. Jiricny   Cold Spring Harbor Perspectives in Biology

Nucleotide Excision Repair in Eukaryotes

(2013) O. D. Scharer   Cold Spring Harbor Perspectives in Biology

The ATM signaling network in development and disease

(2013) Travis H. Stracker et al.   Frontiers in Genetics

The Saccharomyces cerevisiae Chromatin Remodeler Fun30 Regulates DNA End Resection and Checkpoint Deactivation

(2012) V. V. Eapen et al.   MOLECULAR AND CELLULAR BIOLOGY

RNase H2-Initiated Ribonucleotide Excision Repair

(2012) Justin L. Sparks et al.   MOLECULAR CELL

DNA-repair scaffolds dampen checkpoint signalling by counteracting the adaptor Rad9

(2012) Patrice Y. Ohouo et al.   NATURE

The yeast Fun30 and human SMARCAD1 chromatin remodellers promote DNA end resection

(2012) Thomas Costelloe et al.   NATURE

The Fun30 nucleosome remodeller promotes resection of DNA double-strand break ends

(2012) Xuefeng Chen et al.   NATURE

The DNA damage response and cancer therapy

(2012) Christopher J. Lord et al.   NATURE

Identification of the First ATRIP–Deficient Patient and Novel Mutations in ATR Define a Clinical Spectrum for ATR–ATRIP Seckel Syndrome

(2012) Tomoo Ogi et al.   PLoS Genetics

The Mre11:Rad50 Structure Shows an ATP-Dependent Molecular Clamp in DNA Double-Strand Break Repair

(2011) Katja Lammens et al.   CELL

Dpb11 coordinates Mec1 kinase activation with cell cycle-regulated Rad9 recruitment

(2011) Boris Pfander et al.   EMBO JOURNAL

Crystal structure of the Mre11-Rad50-ATP S complex: understanding the interplay between Mre11 and Rad50

(2011) H. S. Lim et al.   GENES & DEVELOPMENT

The Unstructured C-terminal Tail of Yeast Dpb11 (Human TopBP1) Protein Is Dispensable for DNA Replication and the S Phase Checkpoint but Required for the G2/M Checkpoint

(2011) Vasundhara M. Navadgi-Patil et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bidirectional resection of DNA double-strand breaks by Mre11 and Exo1

(2011) Valerie Garcia et al.   NATURE

ABC ATPase signature helices in Rad50 link nucleotide state to Mre11 interface for DNA repair

(2011) Gareth J Williams et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

ATP driven structural changes of the bacterial Mre11:Rad50 catalytic head complex

(2011) Carolin Möckel et al.   NUCLEIC ACIDS RESEARCH

Human exonuclease 1 connects nucleotide excision repair (NER) processing with checkpoint activation in response to UV irradiation

(2011) S. Sertic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct Cdk1 Requirements during Single-Strand Annealing, Noncrossover, and Crossover Recombination

(2011) Camilla Trovesi et al.   PLoS Genetics

Release of Ku and MRN from DNA Ends by Mre11 Nuclease Activity and Ctp1 Is Required for Homologous Recombination Repair of Double-Strand Breaks

(2011) Petra Langerak et al.   PLoS Genetics

53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks

(2010) Samuel F. Bunting et al.   CELL

Ku prevents Exo1 and Sgs1-dependent resection of DNA ends in the absence of a functional MRX complex or Sae2

(2010) Eleni P Mimitou et al.   EMBO JOURNAL

53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination

(2010) Anne Bothmer et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Crystal Structures of RNase H2 in Complex with Nucleic Acid Reveal the Mechanism of RNA-DNA Junction Recognition and Cleavage

(2010) Monika P. Rychlik et al.   MOLECULAR CELL

Exo1 Competes with Repair Synthesis, Converts NER Intermediates to Long ssDNA Gaps, and Promotes Checkpoint Activation

(2010) Michele Giannattasio et al.   MOLECULAR CELL

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

Mechanism of the ATP-dependent DNA end-resection machinery from Saccharomyces cerevisiae

(2010) Hengyao Niu et al.   NATURE

DNA end resection by Dna2–Sgs1–RPA and its stimulation by Top3–Rmi1 and Mre11–Rad50–Xrs2

(2010) Petr Cejka et al.   NATURE

Genomic instability — an evolving hallmark of cancer

(2010) Simona Negrini et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mre11–Rad50–Xrs2 and Sae2 promote 5′ strand resection of DNA double-strand breaks

(2010) Matthew L Nicolette et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

PCNA function in the activation and strand direction of MutL  endonuclease in mismatch repair

(2010) A. Pluciennik et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamics of Rad9 Chromatin Binding and Checkpoint Function Are Mediated by Its Dimerization and Are Cell Cycle–Regulated by CDK1 Activity

(2010) Magda Granata et al.   PLoS Genetics

Reconstitution of Rad53 Activation by Mec1 through Adaptor Protein Mrc1

(2009) Sheng-hong Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Csm3, Tof1, and Mrc1 Form a Heterotrimeric Mediator Complex That Associates with DNA Replication Forks

(2009) Masashige Bando et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Unstructured C-Terminal Tail of the 9-1-1 Clamp Subunit Ddc1 Activates Mec1/ATR via Two Distinct Mechanisms

(2009) Vasundhara M. Navadgi-Patil et al.   MOLECULAR CELL

Formation of Dynamic γ-H2AX Domains along Broken DNA Strands Is Distinctly Regulated by ATM and MDC1 and Dependent upon H2AX Densities in Chromatin

(2009) Velibor Savic et al.   MOLECULAR CELL

Single-Stranded DNA Orchestrates an ATM-to-ATR Switch at DNA Breaks

(2009) Bunsyo Shiotani et al.   MOLECULAR CELL

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

DNA Damage, Aging, and Cancer

(2009) Jan H.J. Hoeijmakers   NEW ENGLAND JOURNAL OF MEDICINE

Mre11 Dimers Coordinate DNA End Bridging and Nuclease Processing in Double-Strand-Break Repair

(2008) R. Scott Williams et al.   CELL

Sgs1 Helicase and Two Nucleases Dna2 and Exo1 Resect DNA Double-Strand Break Ends

(2008) Zhu Zhu et al.   CELL

Histone methyltransferase Dot1 and Rad9 inhibit single-stranded DNA accumulation at DSBs and uncapped telomeres

(2008) Federico Lazzaro et al.   EMBO JOURNAL

Checkpoint-dependent phosphorylation of Exo1 modulates the DNA damage response

(2008) Isabelle Morin et al.   EMBO JOURNAL

TopBP1 activates ATR through ATRIP and a PIKK regulatory domain

(2008) D. A. Mordes et al.   GENES & DEVELOPMENT

Yeast DNA Replication Protein Dpb11 Activates the Mec1/ATR Checkpoint Kinase

(2008) Vasundhara M. Navadgi-Patil et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation of the Budding Yeast 9-1-1 Complex Is Required for Dpb11 Function in the Full Activation of the UV-Induced DNA Damage Checkpoint

(2008) F. Puddu et al.   MOLECULAR AND CELLULAR BIOLOGY

Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing

(2008) Eleni P. Mimitou et al.   NATURE

Dpb11 activates the Mec1-Ddc2 complex

(2008) D. A. Mordes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA