Ataxia Telangiectasia-Mutated (ATM) Kinase Activity Is Regulated by ATP-driven Conformational Changes in the Mre11/Rad50/Nbs1 (MRN) Complex

Rad50 Zinc Hook Is Important for the Mre11 Complex to Bind Chromosomal DNA Double-stranded Breaks and Initiate Various DNA Damage Responses

(2012) Jing He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Mre11:Rad50 Structure Shows an ATP-Dependent Molecular Clamp in DNA Double-Strand Break Repair

(2011) Katja Lammens et al.   CELL

Crystal structure of the Mre11-Rad50-ATP S complex: understanding the interplay between Mre11 and Rad50

(2011) H. S. Lim et al.   GENES & DEVELOPMENT

The MRE11 complex: starting from the ends

(2011) Travis H. Stracker et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Rad50 coiled-coil domain is indispensable for Mre11 complex functions

(2011) Marcel Hohl et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

ATP driven structural changes of the bacterial Mre11:Rad50 catalytic head complex

(2011) Carolin Möckel et al.   NUCLEIC ACIDS RESEARCH

Mre11–Rad50–Nbs1 conformations and the control of sensing, signaling, and effector responses at DNA double-strand breaks

(2010) Gareth J. Williams et al.   DNA REPAIR

Requirement of ATM for Rapid p53 Phosphorylation at Ser46 without Ser/Thr-Gln Sequences

(2010) M. Kodama et al.   MOLECULAR AND CELLULAR BIOLOGY

Mre11–Rad50–Xrs2 and Sae2 promote 5′ strand resection of DNA double-strand breaks

(2010) Matthew L Nicolette et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

ATM Activation by Oxidative Stress

(2010) Z. Guo et al.   SCIENCE

RAD50, an SMC family member with multiple roles in DNA break repair: how does ATP affect function?

(2009) Eri Kinoshita et al.   CHROMOSOME RESEARCH

Single-Stranded DNA Orchestrates an ATM-to-ATR Switch at DNA Breaks

(2009) Bunsyo Shiotani et al.   MOLECULAR CELL

The P. furiosus Mre11/Rad50 Complex Promotes 5′ Strand Resection at a DNA Double-Strand Break

(2008) Ben B. Hopkins et al.   CELL

Mre11 Dimers Coordinate DNA End Bridging and Nuclease Processing in Double-Strand-Break Repair

(2008) R. Scott Williams et al.   CELL

Mre11 Nuclease Activity Has Essential Roles in DNA Repair and Genomic Stability Distinct from ATM Activation

(2008) Jeffrey Buis et al.   CELL

Mre11–Rad50–Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity

(2008) Ali Jazayeri et al.   EMBO JOURNAL

A forward chemical genetic screen reveals an inhibitor of the Mre11–Rad50–Nbs1 complex

(2008) Aude Dupré et al.   Nature Chemical Biology