Ddc2ATRIP promotes Mec1ATR activation at RPA-ssDNA tracts

Dynamics and selective remodeling of the DNA-binding domains of RPA

(2019) Nilisha Pokhrel et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Separable roles for Mec1/ATR in genome maintenance, DNA replication, and checkpoint signaling

(2018) Michael Charles Lanz et al.   GENES & DEVELOPMENT

The Initial Response of a Eukaryotic Replisome to DNA Damage

(2018) Martin R.G. Taylor et al.   MOLECULAR CELL

A structural and dynamic model for the assembly of Replication Protein A on single-stranded DNA

(2018) Luke A. Yates et al.   Nature Communications

Structural Basis of Mec1-Ddc2-RPA Assembly and Activation on Single-Stranded DNA at Sites of Damage

(2017) Ishan Deshpande et al.   MOLECULAR CELL

ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response

(2017) Andrew N. Blackford et al.   MOLECULAR CELL

The essential kinase ATR: ensuring faithful duplication of a challenging genome

(2017) Joshua C. Saldivar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

3.9 Å structure of the yeast Mec1-Ddc2 complex, a homolog of human ATR-ATRIP

(2017) Xuejuan Wang et al.   SCIENCE

Two separate pathways regulate protein stability of ATM/ATR-related protein kinases Mec1 and Tel1 in budding yeast

(2017) Greicy H. Goto et al.   PLoS Genetics

Functions, Regulation, and Therapeutic Implications of the ATR Checkpoint Pathway

(2016) Stephanie A. Yazinski et al.   Annual Review of Genetics

RPA-Binding Protein ETAA1 Is an ATR Activator Involved in DNA Replication Stress Response

(2016) Yuan-Cho Lee et al.   CURRENT BIOLOGY

Direct Binding to Replication Protein A (RPA)-coated Single-stranded DNA Allows Recruitment of the ATR Activator TopBP1 to Sites of DNA Damage

(2016) Julyana Acevedo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ETAA1 acts at stalled replication forks to maintain genome integrity

(2016) Thomas E. Bass et al.   NATURE CELL BIOLOGY

Activation of the ATR kinase by the RPA-binding protein ETAA1

(2016) Peter Haahr et al.   NATURE CELL BIOLOGY

Dampening DNA damage checkpoint signalling via coordinated BRCT domain interactions

(2015) J. R. Cussiol et al.   EMBO JOURNAL

Phosphoproteomics Reveals Distinct Modes of Mec1/ATR Signaling during DNA Replication

(2015) Francisco Meirelles Bastos de Oliveira et al.   MOLECULAR CELL

Functional Interplay between the 53BP1-Ortholog Rad9 and the Mre11 Complex Regulates Resection, End-Tethering and Repair of a Double-Strand Break

(2015) Matteo Ferrari et al.   PLoS Genetics

TopBP1: A BRCT-scaffold protein functioning in multiple cellular pathways

(2014) Christopher P. Wardlaw et al.   DNA REPAIR

Ddc2 Mediates Mec1 Activation through a Ddc1- or Dpb11-Independent Mechanism

(2014) Amitava Bandhu et al.   PLoS Genetics

Lagging strand maturation factor Dna2 is a component of the replication checkpoint initiation machinery

(2013) S. Kumar et al.   GENES & DEVELOPMENT

RPA Coordinates DNA End Resection and Prevents Formation of DNA Hairpins

(2013) Huan Chen et al.   MOLECULAR CELL

Dynamics of yeast histone H2A and H2B phosphorylation in response to a double-strand break

(2013) Cheng-Sheng Lee et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Relationship of DNA degradation by Saccharomyces cerevisiae Exonuclease 1 and its stimulation by RPA and Mre11-Rad50-Xrs2 to DNA end resection

(2013) E. Cannavo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In VitroAnalysis of the Role of Replication Protein A (RPA) and RPA Phosphorylation in ATR-mediated Checkpoint Signaling

(2012) Laura A. Lindsey-Boltz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Colocalization of Mec1 and Mrc1 is sufficient for Rad53 phosphorylation in vivo

(2012) Theresa J. Berens et al.   MOLECULAR BIOLOGY OF THE CELL

Dpb11 coordinates Mec1 kinase activation with cell cycle-regulated Rad9 recruitment

(2011) Boris Pfander et al.   EMBO JOURNAL

The diverse functions of Dot1 and H3K79 methylation

(2011) A. T. Nguyen et al.   GENES & DEVELOPMENT

The Unstructured C-terminal Tail of Yeast Dpb11 (Human TopBP1) Protein Is Dispensable for DNA Replication and the S Phase Checkpoint but Required for the G2/M Checkpoint

(2011) Vasundhara M. Navadgi-Patil et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Subtelomere-binding protein Tbf1 and telomere-binding protein Rap1 collaborate to inhibit localization of the Mre11 complex to DNA ends in budding yeast

(2011) Kenzo Fukunaga et al.   MOLECULAR BIOLOGY OF THE CELL

Cell cycle regulation of DNA double-strand break end resection by Cdk1-dependent Dna2 phosphorylation

(2011) Xuefeng Chen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dpb11/TopBP1 plays distinct roles in DNA replication, checkpoint response and homologous recombination

(2010) Susanne M. Germann et al.   DNA REPAIR

DNA Damage Signaling Recruits the Rtt107-Slx4 Scaffolds via Dpb11 to Mediate Replication Stress Response

(2010) Patrice Y. Ohouo et al.   MOLECULAR CELL

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

Mechanism of the ATP-dependent DNA end-resection machinery from Saccharomyces cerevisiae

(2010) Hengyao Niu et al.   NATURE

DNA end resection by Dna2–Sgs1–RPA and its stimulation by Top3–Rmi1 and Mre11–Rad50–Xrs2

(2010) Petr Cejka et al.   NATURE

Reconstitution of RPA-covered single-stranded DNA-activated ATR-Chk1 signaling

(2010) J.-H. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamics of Rad9 Chromatin Binding and Checkpoint Function Are Mediated by Its Dimerization and Are Cell Cycle–Regulated by CDK1 Activity

(2010) Magda Granata et al.   PLoS Genetics

Reconstitution of Rad53 Activation by Mec1 through Adaptor Protein Mrc1

(2009) Sheng-hong Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Csm3, Tof1, and Mrc1 Form a Heterotrimeric Mediator Complex That Associates with DNA Replication Forks

(2009) Masashige Bando et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Unstructured C-Terminal Tail of the 9-1-1 Clamp Subunit Ddc1 Activates Mec1/ATR via Two Distinct Mechanisms

(2009) Vasundhara M. Navadgi-Patil et al.   MOLECULAR CELL

Break dosage, cell cycle stage and DNA replication influence DNA double strand break response

(2008) Christian Zierhut et al.   EMBO JOURNAL

TopBP1 activates ATR through ATRIP and a PIKK regulatory domain

(2008) D. A. Mordes et al.   GENES & DEVELOPMENT

Yeast DNA Replication Protein Dpb11 Activates the Mec1/ATR Checkpoint Kinase

(2008) Vasundhara M. Navadgi-Patil et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation of the Budding Yeast 9-1-1 Complex Is Required for Dpb11 Function in the Full Activation of the UV-Induced DNA Damage Checkpoint

(2008) F. Puddu et al.   MOLECULAR AND CELLULAR BIOLOGY

Mrc1 and DNA Polymerase ɛ Function Together in Linking DNA Replication and the S Phase Checkpoint

(2008) Huiqiang Lou et al.   MOLECULAR CELL

Dpb11 activates the Mec1-Ddc2 complex

(2008) D. A. Mordes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA