Design and synthesis of diazine-based panobinostat analogues for HDAC8 inhibition

The HDAC6/8/10 inhibitor TH34 induces DNA damage-mediated cell death in human high-grade neuroblastoma cell lines

(2018) Fiona R. Kolbinger et al.   ARCHIVES OF TOXICOLOGY

Design of Potent Panobinostat Histone Deacetylase Inhibitor Derivatives: Molecular Considerations for Enhanced Isozyme Selectivity between HDAC2 and HDAC8

(2018) Shana V. Stoddard et al.   Molecular Informatics

Histone deacetylase 8 (HDAC8) and its inhibitors with selectivity to other isoforms: An overview

(2018) Suvankar Banerjee et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

3-Aroylindoles display antitumor activity in vitro and in vivo: Effects of N1-substituents on biological activity

(2017) Hsueh-Yun Lee et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of Some New Pyridazine Derivatives for Anti-HAV Evaluation

(2017) Eman Flefel et al.   MOLECULES

The modification of natural products for medical use

(2017) Zongru Guo   Acta Pharmaceutica Sinica B

Inhibitors of histone deacetylase as antitumor agents: A critical review

(2016) Mohammed Manal et al.   BIOORGANIC CHEMISTRY

Inhibition of Interleukin 1β (IL-1β) Expression by Anthrax Lethal Toxin (LeTx) Is Reversed by Histone Deacetylase 8 (HDAC8) Inhibition in Murine Macrophages

(2016) Soon-Duck Ha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Development of Purine-Based Hydroxamic Acid Derivatives: Potent Histone Deacetylase Inhibitors with Marked in Vitro and in Vivo Antitumor Activities

(2016) Yong Chen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Zinc–Metalloproteinase Inhibitors: Evaluation of the Complex Role Played by the Zinc-Binding Group on Potency and Selectivity

(2016) Cecile Rouanet-Mehouas et al.   JOURNAL OF MEDICINAL CHEMISTRY

Development of a Potent and Selective HDAC8 Inhibitor

(2016) Oscar J. Ingham et al.   ACS Medicinal Chemistry Letters

Panobinostat: First Global Approval

(2015) Karly P. Garnock-Jones   DRUGS

Heterocyclic Anticancer Compounds: Recent Advances and the Paradigm Shift towards the Use of Nanomedicine’s Tool Box

(2015) Pedro Martins et al.   MOLECULES

HDAC8: a multifaceted target for therapeutic interventions

(2015) Alokta Chakrabarti et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Selective inhibition of HDAC8 decreases neuroblastoma growth in vitro and in vivo and enhances retinoic acid-mediated differentiation

(2015) I Rettig et al.   Cell Death & Disease

Self-Replication and Amplification of Enantiomeric Excess of Chiral Multifunctionalized Large Molecules by Asymmetric Autocatalysis

(2014) Tsuneomi Kawasaki et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structure based design of novel 6,5 heterobicyclic mitogen-activated protein kinase kinase (MEK) inhibitors leading to the discovery of imidazo[1,5- a ] pyrazine G-479

(2014) Kirk D. Robarge et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

New and emerging HDAC inhibitors for cancer treatment

(2014) Alison C. West et al.   JOURNAL OF CLINICAL INVESTIGATION

Structural basis for the design and synthesis of selective HDAC inhibitors

(2013) Simone Di Micco et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Histone Deacetylase (HDAC) Inhibitor Kinetic Rate Constants Correlate with Cellular Histone Acetylation but Not Transcription and Cell Viability

(2013) Benjamin E. L. Lauffer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HDAC8 substrates: Histones and beyond

(2012) Noah A. Wolfson et al.   BIOPOLYMERS

Histone deacetylases and cancer

(2012) Bruna Barneda-Zahonero et al.   Molecular Oncology

Design, synthesis and primary activity assay of tripeptidomimetics as histone deacetylase inhibitors with linear linker and branched cap group

(2011) Yingjie Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of (2E)-3-{2-Butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl}-N-hydroxyacrylamide (SB939), an Orally Active Histone Deacetylase Inhibitor with a Superior Preclinical Profile

(2011) Haishan Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Development of the pan-DAC inhibitor panobinostat (LBH589): Successes and challenges

(2009) Peter Atadja   CANCER LETTERS

Panobinostat (LBH589): a potent pan-deacetylase inhibitor with promising activity against hematologic and solid tumors

(2009) H Miles Prince et al.   Future Oncology

Histone Deacetylase 8 in Neuroblastoma Tumorigenesis

(2008) I. Oehme et al.   CLINICAL CANCER RESEARCH