HDAC8 substrates: Histones and beyond

ZntR-mediated transcription of zntA responds to nanomolar intracellular free zinc

(2012) Da Wang et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

NMR Profiling of Histone Deacetylase and Acetyl-transferase Activities in Real Time

(2011) Alexander Dose et al.   ACS Chemical Biology

Structure of Prokaryotic Polyamine Deacetylase Reveals Evolutionary Functional Relationships with Eukaryotic Histone Deacetylases,

(2011) Patrick M. Lombardi et al.   BIOCHEMISTRY

The Moderately Efficient Enzyme: Evolutionary and Physicochemical Trends Shaping Enzyme Parameters

(2011) Arren Bar-Even et al.   BIOCHEMISTRY

Human HDAC isoform selectivity achieved via exploitation of the acetate release channel with structurally unique small molecule inhibitors

(2011) Lewis Whitehead et al.   BIOORGANIC & MEDICINAL CHEMISTRY

On the function of the internal cavity of histone deacetylase protein 8: R37 is a crucial residue for catalysis

(2011) Shozeb Haider et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Acetylation of Heat Shock Protein 20 (Hsp20) Regulates Human Myometrial Activity

(2011) Magdalena Karolczak-Bayatti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis of the Antiproliferative Activity of Largazole, a Depsipeptide Inhibitor of the Histone Deacetylases

(2011) Kathryn E. Cole et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Proteome-wide post-translational modification statistics: frequency analysis and curation of the swiss-prot database

(2011) George A. Khoury et al.   Scientific Reports

Peptide Arrays Identify Isoform-Selective Substrates for Profiling Endogenous Lysine Deacetylase Activity

(2010) Zachary A. Gurard-Levin et al.   ACS Chemical Biology

Structures of Metal-Substituted Human Histone Deacetylase 8 Provide Mechanistic Inferences on Biological Function,

(2010) Daniel P. Dowling et al.   BIOCHEMISTRY

HSP90 modulates actin dynamics: Inhibition of HSP90 leads to decreased cell motility and impairs invasion

(2010) Aftab Taiyab et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Exploration of the HDAC2 foot pocket: Synthesis and SAR of substituted N-(2-aminophenyl)benzamides

(2010) Jerome C. Bressi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Deacetylase Inhibitors Dissociate the Histone-Targeting ING2 Subunit from the Sin3 Complex

(2010) Karen T. Smith et al.   CHEMISTRY & BIOLOGY

Physiological Roles of Class I HDAC Complex and Histone Demethylase

(2010) Tomohiro Hayakawa et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

A Proton-Shuttle Reaction Mechanism for Histone Deacetylase 8 and the Catalytic Role of Metal Ions

(2010) Ruibo Wu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nuclear Import of Histone Deacetylase 5 by Requisite Nuclear Localization Signal Phosphorylation

(2010) Todd M. Greco et al.   MOLECULAR & CELLULAR PROTEOMICS

An Acetylation Switch Modulates the Transcriptional Activity of Estrogen-Related Receptor α

(2010) Brian J. Wilson et al.   MOLECULAR ENDOCRINOLOGY

CCDC6 represses CREB1 activity by recruiting histone deacetylase 1 and protein phosphatase 1

(2010) V Leone et al.   ONCOGENE

Regulation of Cellular Metabolism by Protein Lysine Acetylation

(2010) S. Zhao et al.   SCIENCE

Histone deacetylases: salesmen and customers in the post-translational modification market

(2009) André Brandl et al.   BIOLOGY OF THE CELL

Combining Mass Spectrometry and Peptide Arrays to Profile the Specificities of Histone Deacetylases

(2009) Zachary A. Gurard-Levin et al.   CHEMBIOCHEM

Epigenetic control of skull morphogenesis by histone deacetylase 8

(2009) M. Haberland et al.   GENES & DEVELOPMENT

Activation and Inhibition of Histone Deacetylase 8 by Monovalent Cations

(2009) Stephanie L. Gantt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein promiscuity and its implications for biotechnology

(2009) Irene Nobeli et al.   NATURE BIOTECHNOLOGY

Non-muscle myosin II takes centre stage in cell adhesion and migration

(2009) Miguel Vicente-Manzanares et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

(2009) C. Choudhary et al.   SCIENCE

Inactivation of CREB mediated gene transcription by HDAC8 bound protein phosphatase

(2008) Jingxia Gao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Activity of HDAC8 Depends on Local and Distal Sequences of Its Peptide Substrates†

(2008) Zachary A. Gurard-Levin et al.   BIOCHEMISTRY

Structural Studies of Human Histone Deacetylase 8 and Its Site-Specific Variants Complexed with Substrate and Inhibitors†,‡

(2008) Daniel P. Dowling et al.   BIOCHEMISTRY

The Sirtuin family: therapeutic targets to treat diseases of aging

(2008) Jill C Milne et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Structural and Functional Analysis of the Human HDAC4 Catalytic Domain Reveals a Regulatory Structural Zinc-binding Domain

(2008) Matthew J. Bottomley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human HDAC7 Harbors a Class IIa Histone Deacetylase-specific Zinc Binding Motif and Cryptic Deacetylase Activity

(2008) Anja Schuetz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Maintenance of cardiac energy metabolism by histone deacetylase 3 in mice

(2008) Rusty L. Montgomery et al.   JOURNAL OF CLINICAL INVESTIGATION

Therapeutic application of histone deacetylase inhibitors for central nervous system disorders

(2008) Aleksey G. Kazantsev et al.   NATURE REVIEWS DRUG DISCOVERY

The many roles of histone deacetylases in development and physiology: implications for disease and therapy

(2008) Michael Haberland et al.   NATURE REVIEWS GENETICS

The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men

(2008) Xiang-Jiao Yang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Selected-fit versus induced-fit protein binding: Kinetic differences and mutational analysis

(2008) Thomas R. Weikl et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

ERRα: a metabolic function for the oldest orphan

(2008) Josep A. Villena et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM