Emerging Mechanisms of Cardiovascular Protection for the Omega-3 Fatty Acid Eicosapentaenoic Acid

New Insights into Mechanisms of Action for Omega-3 Fatty Acids in Atherothrombotic Cardiovascular Disease

(2019) R. Preston Mason   Current Atherosclerosis Reports

Effects of Icosapent Ethyl on Total Ischemic Events: From REDUCE-IT

(2019) Deepak L. Bhatt et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Generalizability of the REDUCE-IT Trial in Patients With Stable Coronary Artery Disease

(2019) Fabien Picard et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Intercepting the Lipid-Induced Integrated Stress Response Reduces Atherosclerosis

(2019) Umut I. Onat et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

REDUCE-IT

(2019) Deepak L Bhatt   EUROPEAN HEART JOURNAL

Targeting RNA to lower triglycerides: long strides from short molecules

(2019) Arman Qamar et al.   EUROPEAN HEART JOURNAL

An omega-3 fatty acid plasma index ≥4% prevents progression of coronary artery plaque in patients with coronary artery disease on statin treatment

(2019) Abdulhamied Alfaddagh et al.   ATHEROSCLEROSIS

Biomarkers of Dietary Omega-6 Fatty Acids and Incident Cardiovascular Disease and Mortality

(2019) Matti Marklund et al.   CIRCULATION

Preferential Incorporation of Administered Eicosapentaenoic Acid Into Thin-Cap Atherosclerotic Plaques

(2019) Tomohito Sato et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Reduction in First and Total Ischemic Events With Icosapent Ethyl Across Baseline Triglyceride Tertiles

(2019) Deepak L. Bhatt et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

REDUCE-IT USA: Results from the 3,146 Patients Randomized in the United States

(2019) Deepak L. Bhatt et al.   CIRCULATION

Cardiovascular risk reduction with icosapent ethyl

(2019) Parth N. Patel et al.   CURRENT OPINION IN CARDIOLOGY

Reply

(2019) Deepak L. Bhatt et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Efficacy and Safety of Low-Dose Colchicine after Myocardial Infarction

(2019) Jean-Claude Tardif et al.   NEW ENGLAND JOURNAL OF MEDICINE

Profound reductions in first and total cardiovascular events with icosapent ethyl in the REDUCE-IT trial: why these results usher in a new era in dyslipidaemia therapeutics

(2019) William E Boden et al.   EUROPEAN HEART JOURNAL

Eicosapentaenoic acid inhibits oxidation of high density lipoprotein particles in a manner distinct from docosahexaenoic acid

(2018) Samuel C.R. Sherratt et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Eicosapentaenoic acid improves endothelial function and nitric oxide bioavailability in a manner that is enhanced in combination with a statin

(2018) R. Preston Mason et al.   BIOMEDICINE & PHARMACOTHERAPY

Eicosanoids, prostacyclin and cyclooxygenase in the cardiovascular system

(2018) Jane A Mitchell et al.   BRITISH JOURNAL OF PHARMACOLOGY

Eicosapentaenoic acid and docosahexaenoic acid have distinct membrane locations and lipid interactions as determined by X-ray diffraction

(2018) Samuel C.R. Sherratt et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Eicosapentaenoic Acid-Enriched High-Density Lipoproteins Exhibit Anti-Atherogenic Properties

(2018) Nobuaki Tanaka et al.   CIRCULATION JOURNAL

Effect of Vascepa (icosapent ethyl) on progression of coronary atherosclerosis in patients with elevated triglycerides (200-499 mg/dL) on statin therapy: Rationale and design of the EVAPORATE study

(2018) Matthew Budoff et al.   CLINICAL CARDIOLOGY

Unmet Need for Adjunctive Dyslipidemia Therapy in Hypertriglyceridemia Management

(2018) Om P. Ganda et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Eicosapentaenoic Acid Improves Polycystic Ovary Syndrome in Rats via Sterol Regulatory Element-Binding Protein 1 (SREBP-1)/Toll-Like Receptor 4 (TLR4) Pathway

(2018) Yanting Wang et al.   MEDICAL SCIENCE MONITOR

Associations of Omega-3 Fatty Acid Supplement Use With Cardiovascular Disease Risks

(2018) Theingi Aung et al.   JAMA Cardiology

Assessment of omega-3 carboxylic acids in statin-treated patients with high levels of triglycerides and low levels of high-density lipoprotein cholesterol: Rationale and design of the STRENGTH trial

(2018) Stephen J. Nicholls et al.   CLINICAL CARDIOLOGY

Effects of n−3 Fatty Acid Supplements in Diabetes Mellitus

(2018)   NEW ENGLAND JOURNAL OF MEDICINE

Rationale and design of the Pemafibrate to Reduce Cardiovascular Outcomes by Reducing Triglycerides in Patients with Diabetes (PROMINENT) study

(2018) Aruna D. Pradhan et al.   AMERICAN HEART JOURNAL

Marine n−3 Fatty Acids and Prevention of Cardiovascular Disease and Cancer

(2018) JoAnn E. Manson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia

(2018) Deepak L. Bhatt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Early initiation of eicosapentaenoic acid and statin treatment is associated with better clinical outcomes than statin alone in patients with acute coronary syndromes: 1-year outcomes of a randomized controlled study

(2017) Kazumasa Nosaka et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Role of NLRP3 Inflammasomes in Atherosclerosis

(2017) Tadayoshi Karasawa et al.   Journal of Atherosclerosis and Thrombosis

A randomized controlled trial of eicosapentaenoic acid in patients with coronary heart disease on statins

(2017) Tetsu Watanabe et al.   Journal of Cardiology

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

(2017) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Eicosapentaenoic acid shows anti-inflammatory effect via GPR120 in 3T3-L1 adipocytes and attenuates adipose tissue inflammation in diet-induced obese mice

(2017) Hodaka Yamada et al.   Nutrition & Metabolism

Effect of Eicosapentaenoic and Docosahexaenoic Acids Added to Statin Therapy on Coronary Artery Plaque in Patients With Coronary Artery Disease: A Randomized Clinical Trial

(2017) Abdulhamied Alfaddagh et al.   Journal of the American Heart Association

A randomized, crossover, head-to-head comparison of eicosapentaenoic acid and docosahexaenoic acid supplementation to reduce inflammation markers in men and women: the Comparing EPA to DHA (ComparED) Study

(2016) Janie Allaire et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Icosapent ethyl (eicosapentaenoic acid ethyl ester): Effects on remnant-like particle cholesterol from the MARINE and ANCHOR studies

(2016) Christie M. Ballantyne et al.   ATHEROSCLEROSIS

Eicosapentaenoic acid reduces membrane fluidity, inhibits cholesterol domain formation, and normalizes bilayer width in atherosclerotic-like model membranes

(2016) R. Preston Mason et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Adaptive Response of T and B Cells in Atherosclerosis

(2016) Daniel F.J. Ketelhuth et al.   CIRCULATION RESEARCH

Omega-3 fatty acids, lipid rafts, and T cell signaling

(2016) Tim Y. Hou et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Eicosapentaenoic Acid Inhibits Oxidation of ApoB-containing Lipoprotein Particles of Different Size In Vitro When Administered Alone or in Combination With Atorvastatin Active Metabolite Compared With Other Triglyceride-lowering Agents

(2016) R. Preston Mason et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Icosapent ethyl (eicosapentaenoic acid ethyl ester): Effects on plasma apolipoprotein C-III levels in patients from the MARINE and ANCHOR studies

(2016) Christie M. Ballantyne et al.   Journal of Clinical Lipidology

Proresolving lipid mediators resolvin D1, resolvin D2, and maresin 1 are critical in modulating T cell responses

(2016) Valerio Chiurchiù et al.   Science Translational Medicine

ω-3 Polyunsaturated Fatty Acid Biomarkers and Coronary Heart Disease

(2016) Liana C. Del Gobbo et al.   JAMA Internal Medicine

Biologic plausibility, cellular effects, and molecular mechanisms of eicosapentaenoic acid (EPA) in atherosclerosis

(2015) Kenneth M. Borow et al.   ATHEROSCLEROSIS

Eicosapentaenoic acid inhibits glucose-induced membrane cholesterol crystalline domain formation through a potent antioxidant mechanism

(2015) R. Preston Mason et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

How polyunsaturated fatty acids modify molecular organization in membranes: Insight from NMR studies of model systems

(2015) Saame Raza Shaikh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Effects of omega-3 carboxylic acids on lipoprotein particles and other cardiovascular risk markers in high-risk statin-treated patients with residual hypertriglyceridemia: a randomized, controlled, double-blind trial

(2015) Richard L. Dunbar et al.   Lipids in Health and Disease

Association of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk

(2014) Rajiv Chowdhury et al.   ANNALS OF INTERNAL MEDICINE

Effects of Fenofibric Acid on Carotid Intima-Media Thickness in Patients With Mixed Dyslipidemia on Atorvastatin Therapy

(2014) Michael H. Davidson et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Stabilizing effect of combined eicosapentaenoic acid and statin therapy on coronary thin-cap fibroatheroma

(2014) Ryo Nishio et al.   ATHEROSCLEROSIS

Administration of high dose eicosapentaenoic acid enhances anti-inflammatory properties of high-density lipoprotein in Japanese patients with dyslipidemia

(2014) Nobuaki Tanaka et al.   ATHEROSCLEROSIS

Triglycerides on the rise: should we swap seats on the seesaw?

(2014) Peter Libby   EUROPEAN HEART JOURNAL

Effects of Extended-Release Niacin with Laropiprant in High-Risk Patients

(2014)   NEW ENGLAND JOURNAL OF MEDICINE

Icosapent Ethyl, a Pure Ethyl Ester of Eicosapentaenoic Acid: Effects on Circulating Markers of Inflammation from the MARINE and ANCHOR Studies

(2013) Harold E. Bays et al.   American Journal of Cardiovascular Drugs

An Increase in the EPA/AA Ratio is Associated with Improved Arterial Stiffness in Obese Patients with Dyslipidemia

(2013) Ryo Ito et al.   Journal of Atherosclerosis and Thrombosis

Effects of Icosapent Ethyl on Lipoprotein Particle Concentration and the Fatty Acid Desaturation Index in Statin-treated Patients With Persistent High Triglycerides (the ANCHOR Study)

(2013) Christie M. Ballantyne et al.   Journal of Clinical Lipidology

n3 PUFAs Reduce Mouse CD4+ T-Cell Ex Vivo Polarization into Th17 Cells

(2013) Jennifer M. Monk et al.   JOURNAL OF NUTRITION

Mechanisms of Acute Coronary Syndromes and Their Implications for Therapy

(2013) Peter Libby   NEW ENGLAND JOURNAL OF MEDICINE

The Eicosapentaenoic Acid Metabolite 15-Deoxy-δ12,14-Prostaglandin J3 Increases Adiponectin Secretion by Adipocytes Partly via a PPARγ-Dependent Mechanism

(2013) Jennifer Lefils-Lacourtablaise et al.   PLoS One

Icosapent ethyl, a pure EPA omega-3 fatty acid: Effects on plasma and red blood cell fatty acids in patients with very high triglyceride levels (results from the MARINE study)

(2013) Rene A. Braeckman et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Cholesterol Crystals and Inflammation

(2013) Alena Grebe et al.   Current Rheumatology Reports

Efficacy and Safety of Eicosapentaenoic Acid Ethyl Ester (AMR101) Therapy in Statin-Treated Patients With Persistent High Triglycerides (from the ANCHOR Study)

(2012) Christie M. Ballantyne et al.   AMERICAN JOURNAL OF CARDIOLOGY

Effects of n-6 PUFAs compared with SFAs on liver fat, lipoproteins, and inflammation in abdominal obesity: a randomized controlled trial

(2012) Helena Bjermo et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Docosahexaenoic and Eicosapentaenoic Acids Segregate Differently between Raft and Nonraft Domains

(2012) Justin A. Williams et al.   BIOPHYSICAL JOURNAL

Highly Purified Eicosapentaenoic Acid Increases Interleukin-10 Levels of Peripheral Blood Monocytes in Obese Patients With Dyslipidemia

(2012) N. Satoh-Asahara et al.   DIABETES CARE

Administration of highly purified eicosapentaenoic acid to statin-treated diabetic patients further improves vascular function

(2012) Junko Sasaki et al.   ENDOCRINE JOURNAL

Icosapent ethyl, a pure EPA omega-3 fatty acid: Effects on lipoprotein particle concentration and size in patients with very high triglyceride levels (the MARINE study)

(2012) Harold E. Bays et al.   Journal of Clinical Lipidology

(n-3) Fatty Acids and Cardiovascular Health: Are Effects of EPA and DHA Shared or Complementary?

(2012) Dariush Mozaffarian et al.   JOURNAL OF NUTRITION

Dietary n-3 Polyunsaturated Fatty Acids (PUFA) Decrease Obesity-Associated Th17 Cell-Mediated Inflammation during Colitis

(2012) Jennifer M. Monk et al.   PLoS One

Eicosapentaenoic Acid Ethyl Ester (AMR101) Therapy in Patients With Very High Triglyceride Levels (from the Multi-center, plAcebo-controlled, Randomized, double-blINd, 12-week study with an open-label Extension [MARINE] Trial)

(2011) Harold E. Bays et al.   AMERICAN JOURNAL OF CARDIOLOGY

Add-on Therapy of EPA Reduces Oxidative Stress and Inhibits the Progression of Aortic Stiffness in Patients with Coronary Artery Disease and Statin Therapy: A Randomized Controlled Study

(2011) Akira Takaki et al.   Journal of Atherosclerosis and Thrombosis

Biophysical and biochemical mechanisms by which dietary N-3 polyunsaturated fatty acids from fish oil disrupt membrane lipid rafts

(2011) Saame Raza Shaikh   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Niacin in Patients with Low HDL Cholesterol Levels Receiving Intensive Statin Therapy

(2011)   NEW ENGLAND JOURNAL OF MEDICINE

Eicosapentaenoic acid (EPA) from highly concentrated n−3 fatty acid ethyl esters is incorporated into advanced atherosclerotic plaques and higher plaque EPA is associated with decreased plaque inflammation and increased stability

(2010) Abbie L. Cawood et al.   ATHEROSCLEROSIS

GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects

(2010) Da Young Oh et al.   CELL

Prediction of Cardiovascular Events and All-Cause Mortality With Arterial Stiffness

(2010) Charalambos Vlachopoulos et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Effects of Combination Lipid Therapy in Type 2 Diabetes Mellitus

(2010)   NEW ENGLAND JOURNAL OF MEDICINE

Glucose promotes membrane cholesterol crystalline domain formation by lipid peroxidation

(2009) Yehudi Self-Medlin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Omega-3 Polyunsaturated Fatty Acids: Their Potential Role in Blood Pressure Prevention and Management

(2009) Arrigo Cicero et al.   Current Vascular Pharmacology

The effects of pitavastatin, eicosapentaenoic acid and combined therapy on platelet-derived microparticles and adiponectin in hyperlipidemic, diabetic patients

(2009) Shosaku Nomura et al.   PLATELETS

In Vivo and In Vitro Inhibition of Monocyte Adhesion to Endothelial Cells and Endothelial Adhesion Molecules by Eicosapentaenoic Acid

(2008) Hideto Yamada et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Effects of EPA on coronary artery disease in hypercholesterolemic patients with multiple risk factors: Sub-analysis of primary prevention cases from the Japan EPA Lipid Intervention Study (JELIS)

(2008) Yasushi Saito et al.   ATHEROSCLEROSIS

Docosahexaenoic Acid Enhances Segregation of Lipids between Raft and Nonraft Domains: 2H-NMR Study

(2008) Smita P. Soni et al.   BIOPHYSICAL JOURNAL

Docosahexaenoic acid domains: the ultimate non-raft membrane domain

(2008) Stephen R. Wassall et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Circulating Lipid Hydroperoxides Predict Cardiovascular Events in Patients With Stable Coronary Artery Disease

(2008) Mary F. Walter et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY