Cholesterol Crystals and Inflammation

Autophagy Links Inflammasomes to Atherosclerotic Progression

(2012) Babak Razani et al.   Cell Metabolism

Rationale for cholesteryl ester transfer protein inhibition

(2012) Bernd Hewing et al.   CURRENT OPINION IN LIPIDOLOGY

Effects of Dalcetrapib in Patients with a Recent Acute Coronary Syndrome

(2012) Gregory G. Schwartz et al.   NEW ENGLAND JOURNAL OF MEDICINE

Interleukin-1β inhibition and the prevention of recurrent cardiovascular events: Rationale and Design of the Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS)

(2011) Paul M Ridker et al.   AMERICAN HEART JOURNAL

Genetic inactivation of IL-1 signaling enhances atherosclerotic plaque instability and reduces outward vessel remodeling in advanced atherosclerosis in mice

(2011) Matthew R. Alexander et al.   JOURNAL OF CLINICAL INVESTIGATION

Emerging therapeutic strategies to enhance HDL function

(2011) Santiago Redondo et al.   Lipids in Health and Disease

Atherosclerosis in ApoE-deficient mice progresses independently of the NLRP3 inflammasome

(2011) P Menu et al.   Cell Death & Disease

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Cholesterol crystals piercing the arterial plaque and intima trigger local and systemic inflammation

(2010) George S. Abela   Journal of Clinical Lipidology

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

Cholesterol Crystals Activate the NLRP3 Inflammasome in Human Macrophages: A Novel Link between Cholesterol Metabolism and Inflammation

(2010) Kristiina Rajamäki et al.   PLoS One

Effect of Cholesterol Crystals on Plaques and Intima in Arteries of Patients With Acute Coronary and Cerebrovascular Syndromes

(2009) George S. Abela et al.   AMERICAN JOURNAL OF CARDIOLOGY

ACAT Inhibition and Progression of Carotid Atherosclerosis in Patients With Familial Hypercholesterolemia

(2009) Marijn C. Meuwese et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Inflammasomes: too big to miss

(2009) Andrea Stutz et al.   JOURNAL OF CLINICAL INVESTIGATION

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY

Lysosomal membrane permeabilization in cell death

(2008) P Boya et al.   ONCOGENE

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE