Dyrk1a regulates the cardiomyocyte cell cycle via D-cyclin-dependent Rb/E2f-signalling

DYRK1A controls the transition from proliferation to quiescence during lymphoid development by destabilizing Cyclin D3

(2015) Benjamin J. Thompson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication

(2015) Peng Wang et al.   NATURE MEDICINE

DYRK1A-mediated Cyclin D1 Degradation in Neural Stem Cells Contributes to the Neurogenic Cortical Defects in Down Syndrome

(2015) Sònia Najas et al.   EBioMedicine

The Down syndrome-related protein kinase DYRK1A phosphorylates p27Kip1and Cyclin D1 and induces cell cycle exit and neuronal differentiation

(2014) Ulf Soppa et al.   CELL CYCLE

Dysbindin is a potent inducer of RhoA–SRF-mediated cardiomyocyte hypertrophy

(2014) Ashraf Yusuf Rangrez et al.   JOURNAL OF CELL BIOLOGY

Tumor Suppressor DYRK1A Effects on Proliferation and Chemoresistance of AML Cells by Downregulating c-Myc

(2014) Qiang Liu et al.   PLoS One

Binucleation of cardiomyocytes: the transition from a proliferative to a terminally differentiated state

(2013) Alexandra N. Paradis et al.   DRUG DISCOVERY TODAY

Dosage of Dyrk1a Shifts Cells within a p21-Cyclin D1 Signaling Map to Control the Decision to Enter the Cell Cycle

(2013) Jia-Yun Chen et al.   MOLECULAR CELL

Control of cell cycle transcription during G1 and S phases

(2013) Cosetta Bertoli et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structures of Down Syndrome Kinases, DYRKs, Reveal Mechanisms of Kinase Activation and Substrate Recognition

(2013) Meera Soundararajan et al.   STRUCTURE

Enhanced expression of DYRK1A in cardiomyocytes inhibits acute NFAT activation but does not prevent hypertrophy in vivo

(2011) Cornelia Grebe et al.   CARDIOVASCULAR RESEARCH

Transient expression of Mnb/Dyrk1a couples cell cycle exit and differentiation of neuronal precursors by inducing p27KIP1 expression and suppressing NOTCH signaling

(2011) B. Hammerle et al.   DEVELOPMENT

DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly

(2011) L. Litovchick et al.   GENES & DEVELOPMENT

Adenovirus E1A Directly Targets the E2F/DP-1 Complex

(2011) P. Pelka et al.   JOURNAL OF VIROLOGY

DYRK family of protein kinases: evolutionary relationships, biochemical properties, and functional roles

(2010) Sergi Aranda et al.   FASEB JOURNAL

Dyrk1A Overexpression Inhibits Proliferation and Induces Premature Neuronal Differentiation of Neural Progenitor Cells

(2010) O. Yabut et al.   JOURNAL OF NEUROSCIENCE

MicroRNA-199b targets the nuclear kinase Dyrk1a in an auto-amplification loop promoting calcineurin/NFAT signalling

(2010) Paula A. da Costa Martins et al.   NATURE CELL BIOLOGY

Regulation of the cardiomyocyte population in the developing heart

(2010) Kent Thornburg et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Function and regulation of Dyrk1A: towards understanding Down syndrome

(2009) Joongkyu Park et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Ethnicity, sex, and the incidence of congenital heart defects: a report from the National Down Syndrome Project

(2009) Sallie B Freeman et al.   GENETICS IN MEDICINE

DYRK1A Is a Novel Negative Regulator of Cardiomyocyte Hypertrophy

(2009) Christian Kuhn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histopathological Changes of the Heart After Neonatal Dexamethasone Treatment: Studies in 4-, 8-, and 50-Week-Old Rats

(2009) Miriam P Bal et al.   PEDIATRIC RESEARCH

Phosphorylation of pRb by cyclin D kinase is necessary for development of cardiac hypertrophy

(2008) R. Hinrichsen et al.   CELL PROLIFERATION

A Cyclin D2–Rb Pathway Regulates Cardiac Myocyte Size and RNA Polymerase III After Biomechanical Stress in Adult Myocardium

(2008) Ekaterini Angelis et al.   CIRCULATION RESEARCH

Impaired Spatial Learning Strategies and Novel Object Recognition in Mice Haploinsufficient for the Dual Specificity Tyrosine-Regulated Kinase-1A (Dyrk1A)

(2008) Glòria Arqué et al.   PLoS One

Long-term cardiovascular effects of neonatal dexamethasone treatment: hemodynamic follow-up by left ventricular pressure-volume loops in rats

(2007) Miriam P. Bal et al.   JOURNAL OF APPLIED PHYSIOLOGY