Article
Biochemistry & Molecular Biology
Nobuyuki Tanahashi, Moeko Komiyama, Mina Tanaka, Yuta Yokobori, Shigeo Murata, Keiji Tanaka
Summary: This study reveals the regulatory mechanisms of proteasome activity in response to the nutritional state and identifies the important role of assembly protein Ump1 during this regulation.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Neurosciences
Jarno J. Steenhorst, Alexander Hirsch, Annemarie Verzijl, Piotr Wielopolski, Daphne De Wijs-Meijler, Dirk J. Duncker, Irwin K. M. Reiss, Daphne Merkus
Summary: Prematurely born young adults who experienced neonatal oxidative injury (NOI) of the lungs have increased incidence of cardiovascular disease. This study investigated the long-term effects of NOI on cardiopulmonary function in piglets at the age of 10-12 weeks. It was found that the duration of neonatal hypoxia is an important determinant of alterations in cardiopulmonary function that persist further into life.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Environmental Sciences
Maryam Momayez Sefat, Pejman Mortazavi, Saeed Motesaddi Zarandi, Akram Eidi
Summary: This study evaluated the effects of PM2.5 exposure on neonatal rat cerebral tissue. The results showed significant increases in the expression of S100 and GFAP genes, as well as their associated proteins, in response to PM2.5 exposure. Pathological examination revealed severe tissue damage in the cerebral tissues of rats exposed to PM2.5. Changes in oxidative stress activity were also observed. These findings provide valuable insights for identifying therapeutic targets to reduce cerebral disorders caused by PM2.5 or other air pollutants.
WATER AIR AND SOIL POLLUTION
(2023)
Article
Agriculture, Dairy & Animal Science
Austin M. Stiewert, Brian Wooming, Gregory S. Archer
Summary: The study compared the impact of various methods of euthanasia on turkey hens, including captive bolt devices, mechanical cervical dislocation, and manual cervical dislocation. Differences were found in terms of reflex cessation and skin tearing among the different methods.
Article
Environmental Sciences
Hyo-Seon Yang, Mijin Yang, Mihyun Kang, Bumseok Kim, Kyuhong Lee
Summary: Humidifier disinfectant (HD) is a causative agent of atypical lung injury reported in South Korea in 2011. Limited research has been conducted on the association between reported diseases and HD exposure, as well as the progression of diseases caused by HD exposure. In this study, the effects of HD inhalation on rats were investigated.
Article
Agriculture, Dairy & Animal Science
Juan P. Caldas-Cueva, A. Mauromoustakos, X. Sun, Casey M. Owens
Summary: This study investigated the use of image analysis to identify Woody Breast (WB) condition in broiler carcasses. The measurements of M4 and M3, as well as the ratios M9 and M11, showed high correlation with WB severity and compression force. The best model for predicting WB included M1, M2, and M3, with an 84% accuracy rate for classification of affected samples.
Article
Cardiac & Cardiovascular Systems
Ian M. Graham, Emanuele Di Angelantonio, Frank Visseren, Dirk De Bacquer, Brian A. Ference, Adam Timmis, Martin Halle, Panos Vardas, Radu Huculeci, Marie-Therese Cooney
Summary: Clinical estimation of combined risk factors is unreliable, leading to the development of risk estimation systems like SCORE. The ESC outlines the evolution of their risk estimation system and suggests future directions, including personalized lifetime risk estimation.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Leonie Dopavogui, Florence Cadoret, Gaspard Loison, Sara El Fouikar, Francois-Xavier Frenois, Frank Giton, Sandrine Ellero-Simatos, Frederic Lasserre, Arnaud Polizzi, Clemence Rives, Nicolas Loiseau, Roger D. Leandri, Nicolas Gatimel, Laurence Gamet-Payrastre
Summary: Female infertility has a multifactorial origin, and exposure to contaminants, including pesticides, is considered to be involved in this reproductive disorder. This study found that exposure to a common pesticide mixture can disrupt folliculogenesis in mice, leading to abnormal ovarian structure and changes in hormone levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Tammy Ying, Thea Golden, Lan Cheng, Jeff Ishibashi, Patrick Seale, Rebecca A. Simmons
Summary: The study revealed that exposure to IL-4 during the neonatal period induces acute beige adipogenesis while reducing adipogenic differentiation capacity long term. Adult adipocyte precursors also show persistently decreased adipogenesis without increased browning after neonatal IL-4 treatment, indicating long-lasting effects of IL-4.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Review
Cardiac & Cardiovascular Systems
Phillip G. Rowse, Hartzell V. Schaff
Summary: The selection of the most appropriate type of aortic valve prosthesis (mechanical or biologic) for patients aged 50-70 is a contentious issue. This study found that patients who received a mechanical prosthesis had better long-term survival rates compared to those who received a biologic substitute. Additionally, the rate of valve-related thromboembolism and hemorrhage was acceptably low among patients with mechanical prostheses. These findings suggest that considering a mechanical heart valve substitute over a biologic valve may be beneficial for patients aged 50-70.
PROGRESS IN CARDIOVASCULAR DISEASES
(2022)
Article
Immunology
Qiu-bo Wang, Yun-ting Du, Fei Liu, Xiao-dan Sun, Xun Sun, Guang Chen, Wei Pang, Ya-Ming Cao
Summary: The study found that 8-week-old mice showed greater resistance to malaria and had increased immune cell proportion and function. Additionally, specific antibody levels were significantly higher in 8-week-old mice, and the exhaustion marker PD-1 was up-regulated in CD4(+) T cells.
Article
Agriculture, Dairy & Animal Science
Anna Neusa Eduarda Ferreira de Brito, Isabelle Naemi Kaneko, Danilo Teixeira Cavalcante, Anilma Sampaio Cardoso, Naiara Simarro Fagundes, Garros Fontinhas-Netto, Matheus Ramalho de Lima, Jose Humberto Vilar da Silva, Patricia Emilia Naves Givisiez, Fernando Guilherme Perazzo Costa
Summary: Supplementing feeds with 0.3 ppm of OH-SeMet improves antioxidant capacity, egg quality, and productivity in 50-70 week-old Dekalb Brown laying hens.
Article
Environmental Sciences
Abeer El-Said Abdrabouh
Summary: Mosquito coil smoke causes toxic effects on the heart of young and adult male rats, leading to inflammation, dysfunction, cell apoptosis, and histopathological alterations. This highlights the significant health concerns of mosquito coil repellents.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biophysics
R. Anna Oeur, Maduran Palaniswamy, Matthew Ha, Mariano Fernandez-Corazza, Susan S. Margulies
Summary: This study aimed to investigate the feasibility of obtaining evoked potentials (EP) in healthy piglets in response to auditory and visual stimuli, and to localize the brain sources related to processing using a computational model. The results showed that different stimuli elicited specific cognitive responses, with auditory processing localized in the temporal region and visual processing in the occipital regions. The findings suggest that EPs can serve as a diagnostic assessment for traumatic brain injury (TBI).
PHYSIOLOGICAL MEASUREMENT
(2023)
Letter
Otorhinolaryngology
Christine J. Colasacco, Katrina Stidham, Gillian Graifman, Jose F. Dominguez, Sabrina Zeller, George Kleinman, Michael Tobias
Summary: This case report presents a rare occurrence of kaposiform hemangioendothelioma found in the internal auditory canal of a 4-week-old newborn.
JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Annelieke H. J. Petrus, Laurens F. Tops, Eduard R. Holman, Nina A. Marsan, Jeroen J. Bax, Martin J. Schalij, Paul Steendijk, Robert J. M. Klautz, Jerry Braun
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2020)
Review
Education, Scientific Disciplines
Marjolein Versteeg, Renee A. Hendriks, Aliki Thomas, Belinda W. C. Ommering, Paul Steendijk
Article
Neurosciences
Jan-Christian Reil, Gert-Hinrich Reil, Arpad Kovacs, Vasco Sequeira, Mark T. Waddingham, Maria Lodi, Melissa Herwig, Shahrooz Ghaderi, Michael M. Kreusser, Zoltan Papp, Niels Voigt, Dobromir Dobrev, Svenja Meyhoefer, Harald F. Langer, Lars S. Maier, Dominik Linz, Andreas Muegge, Mathias Hohl, Paul Steendijk, Nazha Hamdani
JOURNAL OF PHYSIOLOGY-LONDON
(2020)
Article
Biochemistry & Molecular Biology
Marjanne D. van der Hoek, Arie G. Nieuwenhuizen, Ondrej Kuda, Paul Bos, Veronika Paluchova, Lars Verschuren, Anita M. van den Hoek, Robert Kleemann, Nic J. G. M. Veeger, Feike R. van der Leij, Jaap Keijer
Article
Education & Educational Research
M. Versteeg, M. H. van Loon, M. Wijnen-Meijer, P. Steendijk
BMC MEDICAL EDUCATION
(2020)
Article
Physiology
Jeroen Wink, Paul Steendijk, Roula Tsonaka, Rob B. P. de Wilde, Hans J. Friedericy, Jerry Braun, Bernadette Th. Veering, Leon P. H. J. Aarts, Patrick F. Wouters
Summary: The study showed that thoracic epidural anesthesia can reduce systolic function of both left and right ventricles, as well as heart rate, stroke volume, cardiac output, and mean arterial pressure, but has minimal effect on diastolic function. Exercise can increase both systolic and diastolic biventricular function, resulting in higher heart rate, stroke volume, cardiac output, and mean arterial pressure, while decreasing systemic vascular resistance.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Education, Scientific Disciplines
Marjolein Versteeg, Guusje Bressers, Marjo Wijnen-Meijer, Belinda W. C. Ommering, Arnout Jan de Beaufort, Paul Steendijk
Summary: Medical students show differences in their use of metacognitive skills, with a focus on monitoring and to a lesser extent on planning and evaluation. Some students feel no need to develop self-regulated learning skills while others emphasize the need for more insight into their own level of knowledge and competence.
TEACHING AND LEARNING IN MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Alexander Schmeisser, Thomas Rauwolf, Thomas Groscheck, Katharina Fischbach, Siegfried Kropf, Blerim Luani, Ivan Tanev, Michael Hansen, Saskia Meissler, Kerstin Schaefer, Paul Steendijk, Ruediger C. Braun-Dullaeus
Summary: This study aimed to explore the coupling ratio of right ventricular and pulmonary artery function in patients with pulmonary hypertension (PH) to predict overall survival. The results showed that an appropriate coupling ratio was associated with higher mid-term survival rates, while an unfavorable coupling ratio was linked to higher mortality rates.
Article
Education & Educational Research
Floris M. van Blankenstein, John F. O'Sullivan, Nadira Saab, Paul Steendijk
Summary: Before the training, there were no significant differences between the groups in feedback functions and aspects. After the training, the group with peer modelling plus discussion gave significantly more positive feedback compared to the group with non-peer modelled examples. However, no other functions or aspects showed significant differences, likely due to large variations in effort put into giving peer feedback by different students.
BMC MEDICAL EDUCATION
(2021)
Review
Food Science & Technology
Johan Diepeveen, Tanja C. W. Moerdijk-Poortvliet, Feike R. van der Leij
Summary: Understanding taste is crucial for improving the palatability of protein-rich non-animal-based foods like seaweeds. Different taste receptors in the mouth detect sweet, bitter, umami, sour, and salty tastes. The taste of amino acids is influenced by various factors, and umami ingredients enhance the overall flavor of food, potentially reducing salt and fat consumption.
JOURNAL OF FOOD SCIENCE
(2022)
Article
Cardiac & Cardiovascular Systems
Alexander Schmeisser, Thomas Rauwolf, Thomas Groscheck, Siegfried Kropf, Blerim Luani, Ivan Tanev, Michael Hansen, Saskia Meissler, Paul Steendijk, Ruediger C. Braun-Dullaeus
Summary: This study validated the association between TAPSE/PASP and Ees/Ea in HFREF patients, finding TAPSE to be closely related to Ees/Ea. TAPSE and TAPSE/PASP were independently prognostically relevant in patients with PH.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2021)
Article
Education & Educational Research
Marjolein Versteeg, Anne Hafkemeijer, Arnout Jan de Beaufort, Paul Steendijk
Summary: This study did not confirm the involvement of cognitive inhibition in overcoming misconceptions, but instead found significant activation of the putamen in those holding misconceptions, suggesting a role for episodic memory in learners with misconceptions.
MIND BRAIN AND EDUCATION
(2021)
Article
Education, Scientific Disciplines
Marnix C. J. Timmer, Paul Steendijk, Sandra M. Arend, Marjolein Versteeg
MEDICAL SCIENCE EDUCATOR
(2020)
Meeting Abstract
Cardiac & Cardiovascular Systems
A. Schmeisser, T. Rauwolf, T. Groscheck, I Tanev, M. Hansen, S. Meissler, P. Steendijk, R. C. Braun-Dullaeus
EUROPEAN HEART JOURNAL
(2020)
Article
Education, Scientific Disciplines
Marjolein Versteeg, Paul Steendijk
PERSPECTIVES ON MEDICAL EDUCATION
(2019)
