FAK Structure and Regulation by Membrane Interactions and Force in Focal Adhesions

Structural and mechanistic insights into mechanoactivation of focal adhesion kinase

(2019) Magnus Sebastian Bauer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapy

(2019) Carlos J Diaz Osterman et al.   eLife

Small molecule FAK activator promotes human intestinal epithelial monolayer wound closure and mouse ulcer healing

(2019) Qinggang Wang et al.   Scientific Reports

FAK and BMP-9 synergistically trigger osteogenic differentiation and bone formation of adipose derived stem cells through enhancing Wnt-β-catenin signaling

(2018) Cheng Yuan et al.   BIOMEDICINE & PHARMACOTHERAPY

Mechanoresponsive stem cells acquire neural crest fate in jaw regeneration

(2018) Ryan C. Ransom et al.   NATURE

Structural Insights How PIP2 Imposes Preferred Binding Orientations of FAK at Lipid Membranes

(2017) Florian A. Herzog et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition

(2017) Sang-Oh Yoon et al.   MOLECULAR CELL

Phospholipid binding to the FAK catalytic domain impacts function

(2017) Jessica E. Hall et al.   PLoS One

The Rap1-RIAM-talin axis of integrin activation and blood cell function

(2016) F. Lagarrigue et al.   BLOOD

Oncogenic Receptor Tyrosine Kinases Directly Phosphorylate Focal Adhesion Kinase (FAK) as a Resistance Mechanism to FAK-Kinase Inhibitors

(2016) Timothy A. Marlowe et al.   MOLECULAR CANCER THERAPEUTICS

TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action

(2016) Yuan Gao et al.   NATURE

Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy

(2016) Hong Jiang et al.   NATURE MEDICINE

Intravital Imaging Reveals How BRAF Inhibition Generates Drug-Tolerant Microenvironments with High Integrin β1/FAK Signaling

(2015) Eishu Hirata et al.   CANCER CELL

Definition of a consensus integrin adhesome and its dynamics during adhesion complex assembly and disassembly

(2015) Edward R. Horton et al.   NATURE CELL BIOLOGY

Molecular mechanism of vinculin activation and nanoscale spatial organization in focal adhesions

(2015) Lindsay B. Case et al.   NATURE CELL BIOLOGY

Extracellular rigidity sensing by talin isoform-specific mechanical linkages

(2015) Katharina Austen et al.   NATURE CELL BIOLOGY

How cryo-EM is revolutionizing structural biology

(2015) Xiao-chen Bai et al.   TRENDS IN BIOCHEMICAL SCIENCES

Focal adhesion kinase-dependent focal adhesion recruitment of SH2 domains directs SRC into focal adhesions to regulate cell adhesion and migration

(2015) Jui-Chung Wu et al.   Scientific Reports

Mechanism of Focal Adhesion Kinase Mechanosensing

(2015) Jing Zhou et al.   PLoS Computational Biology

FAK dimerization controls its kinase-dependent functions at focal adhesions

(2014) K. Brami-Cherrier et al.   EMBO JOURNAL

Conformational Dynamics of the Focal Adhesion Targeting Domain Control Specific Functions of Focal Adhesion Kinase in Cells

(2014) Gress Kadaré et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endothelial-cell FAK targeting sensitizes tumours to DNA-damaging therapy

(2014) Bernardo Tavora et al.   NATURE

Phosphatidylinositol 4,5-bisphosphate triggers activation of focal adhesion kinase by inducing clustering and conformational changes

(2014) G. M. Goni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Actomyosin-dependent formation of the mechanosensitive talin–vinculin complex reinforces actin anchoring

(2014) Corina Ciobanasu et al.   Nature Communications

Fragment-based discovery of focal adhesion kinase inhibitors

(2013) Ulrich Grädler et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Distinct biophysical mechanisms of focal adhesion kinase mechanoactivation by different extracellular matrix proteins

(2013) J. Seong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Defining Single Molecular Forces Required to Activate Integrin and Notch Signaling

(2013) X. Wang et al.   SCIENCE

FAK promotes recruitment of talin to nascent adhesions to control cell motility

(2012) Christine Lawson et al.   JOURNAL OF CELL BIOLOGY

Quantitative proteomics of the integrin adhesome show a myosin II-dependent recruitment of LIM domain proteins

(2011) Herbert B Schiller et al.   EMBO REPORTS

Focal Adhesion Kinase (FAK) Binds RET Kinase via Its FERM Domain, Priming a Direct and Reciprocal RET-FAK Transactivation Mechanism

(2011) Iván Plaza-Menacho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression of Focal Adhesion Proteins in the Developing Rat Kidney

(2011) Sato Matsuura et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Focal adhesion kinase links mechanical force to skin fibrosis via inflammatory signaling

(2011) Victor W Wong et al.   NATURE MEDICINE

Focal Adhesion Kinase Is Required for Intestinal Regeneration and Tumorigenesis Downstream of Wnt/c-Myc Signaling

(2010) Gabrielle H. Ashton et al.   DEVELOPMENTAL CELL

Knock-in Mutation Reveals an Essential Role for Focal Adhesion Kinase Activity in Blood Vessel Morphogenesis and Cell Motility-Polarity but Not Cell Proliferation

(2010) Ssang-Taek Lim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics

(2010) Carsten Grashoff et al.   NATURE

Nanoscale architecture of integrin-based cell adhesions

(2010) Pakorn Kanchanawong et al.   NATURE

Dissecting the molecular architecture of integrin adhesion sites by cryo-electron tomography

(2010) Israel Patla et al.   NATURE CELL BIOLOGY

The Structure of the Talin Head Reveals a Novel Extended Conformation of the FERM Domain

(2010) Paul R. Elliott et al.   STRUCTURE

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

Dynamic conformational changes in the FERM domain of FAK are involved in focal-adhesion behavior during cell spreading and motility

(2009) E. Papusheva et al.   JOURNAL OF CELL SCIENCE

The Tail of Integrins, Talin, and Kindlins

(2009) M. Moser et al.   SCIENCE

Stretching Single Talin Rod Molecules Activates Vinculin Binding

(2009) A. del Rio et al.   SCIENCE

Structural Basis for the Autoinhibition of Talin in Regulating Integrin Activation

(2008) Esen Goksoy et al.   MOLECULAR CELL

A conserved protonation-dependent switch controls drug binding in the Abl kinase

(2008) Y. Shan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA