Mechanism of Focal Adhesion Kinase Mechanosensing

Focal adhesion kinase (FAK) perspectives in mechanobiology: implications for cell behaviour

(2014) Pascal Tomakidi et al.   CELL AND TISSUE RESEARCH

Stressing the limits of focal adhesion mechanosensitivity

(2014) Patrick W Oakes et al.   CURRENT OPINION IN CELL BIOLOGY

FAK dimerization controls its kinase-dependent functions at focal adhesions

(2014) K. Brami-Cherrier et al.   EMBO JOURNAL

Conformational Dynamics of the Focal Adhesion Targeting Domain Control Specific Functions of Focal Adhesion Kinase in Cells

(2014) Gress Kadaré et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphatidylinositol 4,5-bisphosphate triggers activation of focal adhesion kinase by inducing clustering and conformational changes

(2014) G. M. Goni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanotransduction of fluid stresses governs 3D cell migration

(2014) W. J. Polacheck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Theory of rapid force spectroscopy

(2014) Jakob T. Bullerjahn et al.   Nature Communications

GROMACS 4.5: a high-throughput and highly parallel open source molecular simulation toolkit

(2013) Sander Pronk et al.   BIOINFORMATICS

Mechanosensitivity and compositional dynamics of cell–matrix adhesions

(2013) Herbert B Schiller et al.   EMBO REPORTS

Visualizing and Manipulating Focal Adhesion Kinase Regulation in Live Cells

(2013) Michael Ritt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct biophysical mechanisms of focal adhesion kinase mechanoactivation by different extracellular matrix proteins

(2013) J. Seong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Defining Single Molecular Forces Required to Activate Integrin and Notch Signaling

(2013) X. Wang et al.   SCIENCE

Time-resolved force distribution analysis

(2013) Bogdan I Costescu et al.   BMC Biophysics

Partial Least-Squares Functional Mode Analysis: Application to the Membrane Proteins AQP1, Aqy1, and CLC-ec1

(2012) Tatyana Krivobokova et al.   BIOPHYSICAL JOURNAL

Identification of an N-terminal inhibitory extension as the primary mechanosensory regulator of twitchin kinase

(2012) E. von Castelmur et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Divalent Cation-Dependent Formation of Electrostatic PIP2 Clusters in Lipid Monolayers

(2011) Wouter G. Ellenbroek et al.   BIOPHYSICAL JOURNAL

Focal Adhesion Kinase (FAK) Binds RET Kinase via Its FERM Domain, Priming a Direct and Reciprocal RET-FAK Transactivation Mechanism

(2011) Iván Plaza-Menacho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane protein sequestering by ionic protein–lipid interactions

(2011) Geert van den Bogaart et al.   NATURE

A Molecular Dynamics Investigation of Vinculin Activation

(2010) Javad Golji et al.   BIOPHYSICAL JOURNAL

Cellular functions of FAK kinases: insight into molecular mechanisms and novel functions

(2010) M. D. Schaller   JOURNAL OF CELL SCIENCE

Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics

(2010) Carsten Grashoff et al.   NATURE

Nanoscale architecture of integrin-based cell adhesions

(2010) Pakorn Kanchanawong et al.   NATURE

Signal transduction by focal adhesion kinase in cancer

(2009) Jihe Zhao et al.   CANCER AND METASTASIS REVIEWS

Stretching Single Talin Rod Molecules Activates Vinculin Binding

(2009) A. del Rio et al.   SCIENCE

Giant Unilamellar Vesicles Containing Phosphatidylinositol(4,5)bisphosphate: Characterization and Functionality

(2008) Kévin Carvalho et al.   BIOPHYSICAL JOURNAL

Phosphatidylinositol 4,5-bisphosphate regulates SNARE-dependent membrane fusion

(2008) Declan J. James et al.   JOURNAL OF CELL BIOLOGY

Structure of a Complete Integrin Ectodomain in a Physiologic Resting State and Activation and Deactivation by Applied Forces

(2008) Jianghai Zhu et al.   MOLECULAR CELL

How Force Might Activate Talin's Vinculin Binding Sites: SMD Reveals a Structural Mechanism

(2008) Vesa P. Hytönen et al.   PLoS Computational Biology

Mechanoenzymatics of titin kinase

(2008) E. M. Puchner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA