Phosphatidylinositol 4,5-bisphosphate triggers activation of focal adhesion kinase by inducing clustering and conformational changes

FAK dimerization controls its kinase-dependent functions at focal adhesions

(2014) K. Brami-Cherrier et al.   EMBO JOURNAL

Platelets lacking PIP5KI  have normal integrin activation but impaired cytoskeletal-membrane integrity and adhesion

(2013) Y. Wang et al.   BLOOD

Mechanosensitivity and compositional dynamics of cell–matrix adhesions

(2013) Herbert B Schiller et al.   EMBO REPORTS

Visualizing and Manipulating Focal Adhesion Kinase Regulation in Live Cells

(2013) Michael Ritt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evolution of the eukaryotic protein kinases as dynamic molecular switches

(2012) S. S. Taylor et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Focal Adhesion Kinase Stabilizes the Cytoskeleton

(2011) Ben Fabry et al.   BIOPHYSICAL JOURNAL

Integrin adhesion and force coupling are independently regulated by localized PtdIns(4,5)2synthesis

(2011) Kyle R Legate et al.   EMBO JOURNAL

Focal Adhesion Kinase (FAK) Binds RET Kinase via Its FERM Domain, Priming a Direct and Reciprocal RET-FAK Transactivation Mechanism

(2011) Iván Plaza-Menacho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Focal adhesion kinase and its signaling pathways in cell migration and angiogenesis

(2010) Xiaofeng Zhao et al.   ADVANCED DRUG DELIVERY REVIEWS

Focal Adhesion Kinase Is Required for Intestinal Regeneration and Tumorigenesis Downstream of Wnt/c-Myc Signaling

(2010) Gabrielle H. Ashton et al.   DEVELOPMENTAL CELL

Therapeutic potential and limitations of new FAK inhibitors in the treatment of cancer

(2010) Alexander Schultze et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Knock-in Mutation Reveals an Essential Role for Focal Adhesion Kinase Activity in Blood Vessel Morphogenesis and Cell Motility-Polarity but Not Cell Proliferation

(2010) Ssang-Taek Lim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cellular functions of FAK kinases: insight into molecular mechanisms and novel functions

(2010) M. D. Schaller   JOURNAL OF CELL SCIENCE

Nanoscale architecture of integrin-based cell adhesions

(2010) Pakorn Kanchanawong et al.   NATURE

The FERM domain: organizing the structure and function of FAK

(2010) Margaret C. Frame et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Phosphorylation of focal adhesion kinase on tyrosine 194 by Met leads to its activation through relief of autoinhibition

(2010) T-H Chen et al.   ONCOGENE

Signal transduction by focal adhesion kinase in cancer

(2009) Jihe Zhao et al.   CANCER AND METASTASIS REVIEWS

Focal adhesion kinase: switching between GAPs and GEFs in the regulation of cell motility

(2009) Alok Tomar et al.   CURRENT OPINION IN CELL BIOLOGY

Coarse-grained modeling of allosteric regulation in protein receptors

(2009) I. A. Balabin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Focal Adhesion Kinase: Targeting Adhesion Signaling Pathways for Therapeutic Intervention

(2008) J. T. Parsons et al.   CLINICAL CANCER RESEARCH

Lipid Binding to the Tail Domain of Vinculin

(2008) Sean M. Palmer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis for the Autoinhibition of Talin in Regulating Integrin Activation

(2008) Esen Goksoy et al.   MOLECULAR CELL

Cardiac developmental defects and eccentric right ventricular hypertrophy in cardiomyocyte focal adhesion kinase (FAK) conditional knockout mice

(2008) X. Peng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Focal adhesion kinase as a regulator of cell tension in the progression of cancer

(2007) Robert W. Tilghman et al.   SEMINARS IN CANCER BIOLOGY