A Review of FoxO1-Regulated Metabolic Diseases and Related Drug Discoveries

Identification of entacapone as a chemical inhibitor of FTO mediating metabolic regulation through FOXO1

(2019) Shiming Peng et al.   Science Translational Medicine

Forkhead Domains of FOXO Transcription Factors Differ in both Overall Conformation and Dynamics

(2019) Katarina Psenakova et al.   Cells

Suppression of Activated FOXO Transcription Factors in the Heart Prolongs Survival in a Mouse Model of LaminopathiesNovelty and Significance

(2018) Gaelle Auguste et al.   CIRCULATION RESEARCH

The regulation of FOXO1 and its role in disease progression

(2018) Ya-qi Xing et al.   LIFE SCIENCES

Novel Mechanism of Foxo1 Phosphorylation in Glucagon Signaling in Control of Glucose Homeostasis

(2018) Yuxin Wu et al.   DIABETES

The functions of FoxO transcription factors in epithelial wound healing

(2018) Chaoyang Miao et al.   AUSTRALASIAN JOURNAL OF DERMATOLOGY

FoxO Transcription Factors are Critical Regulators of Diabetes-Related Muscle Atrophy

(2018) Brian T. O’Neill et al.   DIABETES

FOXO transcription factors at the interface of metabolism and cancer

(2017) Wolfgang Link et al.   INTERNATIONAL JOURNAL OF CANCER

Transcriptional and epigenetic control of brown and beige adipose cell fate and function

(2016) Takeshi Inagaki et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

FoxO Transcription Factors and Regenerative Pathways in Diabetes Mellitus

(2015) Kenneth Maiese   CURRENT NEUROVASCULAR RESEARCH

Effects of ageing on expression of the muscle-specific E3 ubiquitin ligases and Akt-dependent regulation of Foxo transcription factors in skeletal muscle

(2015) Akira Wagatsuma et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

JNK-dependent downregulation of FoxO1 is required to promote the survival of fibroblast-like synoviocytes in rheumatoid arthritis

(2014) Aleksander M Grabiec et al.   ANNALS OF THE RHEUMATIC DISEASES

Targeting FoxO1 with AS1842856 Suppresses Adipogenesis

(2014) Peng Zou et al.   CELL CYCLE

CBP-Mediated FOXO-1 Acetylation Inhibits Pancreatic Tumor Growth by Targeting SirT

(2014) K. C. Pramanik et al.   MOLECULAR CANCER THERAPEUTICS

Transcription Factor Binding Site Analysis Identifies FOXO Transcription Factors as Regulators of the Cutaneous Wound Healing Process

(2014) Karl Markus Roupé et al.   PLoS One

Integrated control of hepatic lipogenesis versus glucose production requires FoxO transcription factors

(2014) Rebecca A. Haeusler et al.   Nature Communications

FOXO Transcription Factors: Their Clinical Significance and Regulation

(2014) Yu Wang et al.   Biomed Research International

Adaptive thermogenesis in adipocytes: Is beige the new brown?

(2013) J. Wu et al.   GENES & DEVELOPMENT

Brown and beige fat: development, function and therapeutic potential

(2013) Matthew Harms et al.   NATURE MEDICINE

FOXOs: signalling integrators for homeostasis maintenance

(2013) Astrid Eijkelenboom et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons

(2012) Kate D. Meyer et al.   CELL

Leptin and insulin pathways in POMC and AgRP neurons that modulate energy balance and glucose homeostasis

(2012) Luis Varela et al.   EMBO REPORTS

PAX3/FOXO1Fusion Gene Status Is the Key Prognostic Molecular Marker in Rhabdomyosarcoma and Significantly Improves Current Risk Stratification

(2012) Edoardo Missiaglia et al.   JOURNAL OF CLINICAL ONCOLOGY

Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq

(2012) Dan Dominissini et al.   NATURE

Regulation of FOXO protein stability via ubiquitination and proteasome degradation

(2011) Haojie Huang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

PDK1-Foxo1 in Agouti-Related Peptide Neurons Regulates Energy Homeostasis by Modulating Food Intake and Energy Expenditure

(2011) Yongheng Cao et al.   PLoS One

PDK-1/FoxO1 pathway in POMC neurons regulates Pomc expression and food intake

(2010) Kristy Iskandar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Effects of the novel Foxo1 inhibitor AS1708727 on plasma glucose and triglyceride levels in diabetic db/db mice

(2010) Hirotsugu Tanaka et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Discovery of Novel Forkhead Box O1 Inhibitors for Treating Type 2 Diabetes: Improvement of Fasting Glycemia in Diabetic db/db Mice

(2010) T. Nagashima et al.   MOLECULAR PHARMACOLOGY

Metabolism of Very-Low-Density Lipoprotein and Low-Density Lipoprotein Containing Apolipoprotein C-III and Not Other Small Apolipoproteins

(2009) Carlos O. Mendivil et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Regulation of Neuronal Cell Death by MST1-FOXO1 Signaling

(2009) Zengqiang Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MDM2 Acts Downstream of p53 as an E3 Ligase to Promote FOXO Ubiquitination and Degradation

(2009) Wei Fu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hormone and glucose signalling in POMC and AgRP neurons

(2009) Bengt F. Belgardt et al.   JOURNAL OF PHYSIOLOGY-LONDON

Inhibition of hypothalamic Foxo1 expression reduced food intake in diet-induced obesity rats

(2009) Eduardo R. Ropelle et al.   JOURNAL OF PHYSIOLOGY-LONDON

PAX3–FOXO1 fusion gene in rhabdomyosarcoma

(2008) Corinne M. Linardic   CANCER LETTERS

PDK1 Deficiency in POMC-Expressing Cells Reveals FOXO1-Dependent and -Independent Pathways in Control of Energy Homeostasis and Stress Response

(2008) Bengt F. Belgardt et al.   Cell Metabolism

Apolipoprotein CIII and Atherosclerosis

(2008) Alex Bobik   CIRCULATION

Arginine Methylation of FOXO Transcription Factors Inhibits Their Phosphorylation by Akt

(2008) Kazuyuki Yamagata et al.   MOLECULAR CELL

Structural Basis for DNA Recognition by FoxO1 and Its Regulation by Posttranslational Modification

(2008) Michael M. Brent et al.   STRUCTURE