δ-secretase in neurodegenerative diseases: mechanisms, regulators and therapeutic opportunities

Longitudinal tau and metabolic PET imaging in relation to novel CSF tau measures in Alzheimer’s disease

(2019) Antoine Leuzy et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Acidification of tumor at stromal boundaries drives transcriptome alterations associated with aggressive phenotypes

(2019) Nazanin Rohani et al.   CANCER RESEARCH

Acidosis and proteolysis in the tumor microenvironment

(2019) Kyungmin Ji et al.   CANCER AND METASTASIS REVIEWS

Randomized Trial of Verubecestat for Prodromal Alzheimer’s Disease

(2019) Michael F. Egan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Delta-secretase-cleaved Tau antagonizes TrkB neurotrophic signalings, mediating Alzheimer’s disease pathologies

(2019) Jie Xiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plant Vacuolar Processing Enzymes

(2019) Barend Juan Vorster et al.   Frontiers in Plant Science

Brain-derived neurotrophic factor (BDNF) and TrkB hippocampal gene expression are putative predictors of neuritic plaque and neurofibrillary tangle pathology

(2019) Stephen D. Ginsberg et al.   NEUROBIOLOGY OF DISEASE

Deficiency in BDNF/TrkB Neurotrophic Activity Stimulates δ-Secretase by Upregulating C/EBPβ in Alzheimer’s Disease

(2019) Zhi-Hao Wang et al.   Cell Reports

Affective symptoms and AT(N) biomarkers in mild cognitive impairment and Alzheimer’s disease: A systematic literature review

(2019) Leonie C.P. Banning et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

α‐Synuclein stimulation of monoamine oxidase‐B and legumain protease mediates the pathology of Parkinson's disease

(2018) Seong Su Kang et al.   EMBO JOURNAL

Mechanism of Tau Hyperphosphorylation Involving Lysosomal Enzyme Asparagine Endopeptidase in a Mouse Model of Brain Ischemia

(2018) Gustavo Basurto-Islas et al.   JOURNAL OF ALZHEIMERS DISEASE

Involvement of Activation of Asparaginyl Endopeptidase in Tau Hyperphosphorylation in Repetitive Mild Traumatic Brain Injury

(2018) Wen Hu et al.   JOURNAL OF ALZHEIMERS DISEASE

Structural and functional analysis of cystatin E reveals enzymologically relevant dimer and amyloid fibril states

(2018) Elfriede Dall et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Imaging tau and amyloid-β proteinopathies in Alzheimer disease and other conditions

(2018) Victor L. Villemagne et al.   Nature Reviews Neurology

Randomized Trial of Verubecestat for Mild-to-Moderate Alzheimer’s Disease

(2018) Michael F. Egan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Trial of Solanezumab for Mild Dementia Due to Alzheimer’s Disease

(2018) Lawrence S. Honig et al.   NEW ENGLAND JOURNAL OF MEDICINE

The prodrug of 7,8-dihydroxyflavone development and therapeutic efficacy for treating Alzheimer’s disease

(2018) Chun Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

C/EBPβ regulates delta-secretase expression and mediates pathogenesis in mouse models of Alzheimer’s disease

(2018) Zhi-Hao Wang et al.   Nature Communications

How it all Started: Tau and Protein Phosphatase 2A

(2018) Chang Liu et al.   JOURNAL OF ALZHEIMERS DISEASE

Selective vulnerability in neurodegenerative diseases

(2018) Hongjun Fu et al.   NATURE NEUROSCIENCE

Delta-secretase (AEP) mediates tau-splicing imbalance and accelerates cognitive decline in tauopathies

(2018) Zhi-Hao Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

δ-Secretase-cleaved Tau stimulates Aβ production via upregulating STAT1-BACE1 signaling in Alzheimer’s disease

(2018) Zhentao Zhang et al.   MOLECULAR PSYCHIATRY

Spatiotemporal activation of the C/EBPβ/δ-secretase axis regulates the pathogenesis of Alzheimer’s disease

(2018) Hualong Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Calpain-mediated tau fragmentation is altered in Alzheimer’s disease progression

(2018) Hsu-Hsin Chen et al.   Scientific Reports

Low-level internalization of cystatin E/M affects legumain activity and migration of melanoma cells

(2017) Hanna Wallin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Delta-Secretase Phosphorylation by SRPK2 Enhances Its Enzymatic Activity, Provoking Pathogenesis in Alzheimer’s Disease

(2017) Zhi-Hao Wang et al.   MOLECULAR CELL

Not just amyloid: physiological functions of the amyloid precursor protein family

(2017) Ulrike C. Müller et al.   NATURE REVIEWS NEUROSCIENCE

Animal models of α-synucleinopathy for Parkinson disease drug development

(2017) James B. Koprich et al.   NATURE REVIEWS NEUROSCIENCE

Asparagine endopeptidase cleaves α-synuclein and mediates pathologic activities in Parkinson's disease

(2017) Zhentao Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer’s disease

(2017) Zhentao Zhang et al.   Nature Communications

Asparagine endopeptidase cleaves α-synuclein and mediates pathologic activities in Parkinson's disease

(2017) Zhentao Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Parkinson disease

(2017) Werner Poewe et al.   Nature Reviews Disease Primers

Structure and function of legumain in health and disease

(2016) Elfriede Dall et al.   BIOCHIMIE

Calpastatin inhibits motor neuron death and increases survival of hSOD1G93Amice

(2016) Mala V. Rao et al.   JOURNAL OF NEUROCHEMISTRY

Mammalian prions and their wider relevance in neurodegenerative diseases

(2016) John Collinge   NATURE

Caspase-2 cleavage of tau reversibly impairs memory

(2016) Xiaohui Zhao et al.   NATURE MEDICINE

Structure and Mechanism of an Aspartimide-Dependent Peptide Ligase in Human Legumain

(2015) Elfriede Dall et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Expression and protease activity of mouse legumain are regulated by the oncogene/transcription co-activator, DJ-1 through p53 and cleavage of annexin A2 is increased in DJ-1-knockout cells

(2015) Takuya Yamane et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Development of a potent and selective cell penetrant Legumain inhibitor

(2015) Kerry A. Ness et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

η-Secretase processing of APP inhibits neuronal activity in the hippocampus

(2015) Michael Willem et al.   NATURE

Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer’s disease

(2015) Zhentao Zhang et al.   Nature Communications

Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stage

(2014) Lixia Zhao et al.   CELL RESEARCH

Dysregulation of TrkB Receptors and BDNF Function by Amyloid-β Peptide is Mediated by Calpain

(2014) André Jerónimo-Santos et al.   CEREBRAL CORTEX

Functional Role of Asparaginyl Endopeptidase Ubiquitination by TRAF6 in Tumor Invasion and Metastasis

(2014) Yingying Lin et al.   JNCI-Journal of the National Cancer Institute

Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease

(2014) Zhentao Zhang et al.   NATURE MEDICINE

Two Phase 3 Trials of Bapineuzumab in Mild-to-Moderate Alzheimer's Disease

(2014) Stephen Salloway et al.   NEW ENGLAND JOURNAL OF MEDICINE

Transcriptional regulation of the legumain gene by p53 in HCT116 cells

(2013) Takuya Yamane et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Activation of Asparaginyl Endopeptidase Leads to Tau Hyperphosphorylation in Alzheimer Disease

(2013) Gustavo Basurto-Islas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers

(2013) Clifford R Jack et al.   LANCET NEUROLOGY

Mechanistic and structural studies on legumain explain its zymogenicity, distinct activation pathways, and regulation

(2013) E. Dall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autoactivation of prolegumain is accelerated by glycosaminoglycans

(2012) Lise Berven et al.   BIOCHIMIE

SRPK2 Phosphorylates Tau and Mediates the Cognitive Defects in Alzheimer's Disease

(2012) Y. Hong et al.   JOURNAL OF NEUROSCIENCE

Asparaginyl endopeptidase cleaves TDP-43 in brain

(2012) Jeremy H. Herskowitz et al.   PROTEOMICS

A role for calpain-dependent cleavage of TDP-43 in amyotrophic lateral sclerosis pathology

(2012) Takenari Yamashita et al.   Nature Communications

Activation of legumain involves proteolytic and conformational events, resulting in a context- and substrate-dependent activity profile

(2011) Elfriede Dall et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

An experimental rat model of sporadic Alzheimer’s disease and rescue of cognitive impairment with a neurotrophic peptide

(2011) Silvia Bolognin et al.   ACTA NEUROPATHOLOGICA

Asparagine endopeptidase is required for normal kidney physiology and homeostasis

(2011) Gail Miller et al.   FASEB JOURNAL

Nucleoplasmic calcium regulates cell proliferation through legumain

(2011) Viviane Andrade et al.   JOURNAL OF HEPATOLOGY

Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

(2010) Lars M. Ittner et al.   CELL

Distinct Protease Requirements for Antigen Presentation In Vitro and In Vivo

(2010) Stephen P. Matthews et al.   JOURNAL OF IMMUNOLOGY

TDP-43 and FUS in amyotrophic lateral sclerosis and frontotemporal dementia

(2010) Ian RA Mackenzie et al.   LANCET NEUROLOGY

Caspase activation precedes and leads to tangles

(2010) Alix de Calignon et al.   NATURE

BlastocystisLegumain Is Localized on the Cell Surface, and Specific Inhibition of Its Activity Implicates a Pro-survival Role for the Enzyme

(2009) Binhui Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity

(2009) Y.-J. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CCAAT/enhancer binding protein   deficiency provides cerebral protection following excitotoxic injury

(2008) M. Cortes-Canteli et al.   JOURNAL OF CELL SCIENCE

Neuroprotective Actions of PIKE-L by Inhibition of SET Proteolytic Degradation by Asparagine Endopeptidase

(2008) Zhixue Liu et al.   MOLECULAR CELL

Mice lacking asparaginyl endopeptidase develop disorders resembling hemophagocytic syndrome

(2008) C.-B. Chan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA