Delta-secretase (AEP) mediates tau-splicing imbalance and accelerates cognitive decline in tauopathies
出版年份 2018 全文链接
标题
Delta-secretase (AEP) mediates tau-splicing imbalance and accelerates cognitive decline in tauopathies
作者
关键词
-
出版物
JOURNAL OF EXPERIMENTAL MEDICINE
Volume 215, Issue 12, Pages 3038-3056
出版商
Rockefeller University Press
发表日期
2018-10-29
DOI
10.1084/jem.20180539
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Delta-Secretase Phosphorylation by SRPK2 Enhances Its Enzymatic Activity, Provoking Pathogenesis in Alzheimer’s Disease
- (2017) Zhi-Hao Wang et al. MOLECULAR CELL
- Asparagine endopeptidase cleaves α-synuclein and mediates pathologic activities in Parkinson's disease
- (2017) Zhentao Zhang et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer’s disease
- (2017) Zhentao Zhang et al. Nature Communications
- Asparagine endopeptidase cleaves α-synuclein and mediates pathologic activities in Parkinson's disease
- (2017) Zhentao Zhang et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Differential Incorporation of Tau Isoforms in Alzheimer's Disease
- (2017) Marisol Espinoza et al. JOURNAL OF ALZHEIMERS DISEASE
- Asparagine endopeptidase is an innovative therapeutic target for neurodegenerative diseases
- (2016) Zhentao Zhang et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Tau Isoforms Imbalance Impairs the Axonal Transport of the Amyloid Precursor Protein in Human Neurons
- (2016) Valentina Lacovich et al. JOURNAL OF NEUROSCIENCE
- Increased 4R-Tau Induces Pathological Changes in a Human-Tau Mouse Model
- (2016) Kathleen M. Schoch et al. NEURON
- Invited review: Frontotemporal dementia caused bymicrotubule-associated protein taugene (MAPT) mutations: a chameleon for neuropathology and neuroimaging
- (2015) Bernardino Ghetti et al. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
- Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer’s disease
- (2015) Zhentao Zhang et al. Nature Communications
- Aggregates of Small Nuclear Ribonucleic Acids (snRNAs) in Alzheimer's Disease
- (2014) Chadwick M. Hales et al. BRAIN PATHOLOGY
- Integrated Approaches for Analyzing U1-70K Cleavage in Alzheimer’s Disease
- (2014) Bing Bai et al. JOURNAL OF PROTEOME RESEARCH
- Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease
- (2014) Zhentao Zhang et al. NATURE MEDICINE
- Clinicopathologic assessment and imaging of tauopathies in neurodegenerative dementias
- (2014) Melissa E Murray et al. Alzheimers Research & Therapy
- Neurodegenerative Disorder FTDP-17–Related Tau Intron 10 +16C→T Mutation Increases Tau Exon 10 Splicing and Causes Tauopathy in Transgenic Mice
- (2013) Tomohiro Umeda et al. AMERICAN JOURNAL OF PATHOLOGY
- Activation of Asparaginyl Endopeptidase Leads to Tau Hyperphosphorylation in Alzheimer Disease
- (2013) Gustavo Basurto-Islas et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cyclic AMP-Dependent Protein Kinase Enhances SC35-Promoted Tau Exon 10 Inclusion
- (2013) Caoyi Chen et al. MOLECULAR NEUROBIOLOGY
- Alternative splicing: a pivotal step between eukaryotic transcription and translation
- (2013) Alberto R. Kornblihtt et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- U1 small nuclear ribonucleoprotein complex and RNA splicing alterations in Alzheimer's disease
- (2013) B. Bai et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Serine-arginine protein kinases: new players in neurodegenerative diseases?
- (2013) Chi Bun Chan et al. REVIEWS IN THE NEUROSCIENCES
- Cyclic AMP-dependent protein kinase regulates 9G8-mediated alternative splicing of tau exon 10
- (2012) Jianlan Gu et al. FEBS LETTERS
- SRPK2 Phosphorylates Tau and Mediates the Cognitive Defects in Alzheimer's Disease
- (2012) Y. Hong et al. JOURNAL OF NEUROSCIENCE
- Cyclic AMP-dependent Protein Kinase Regulates the Alternative Splicing of Tau Exon 10
- (2011) Jianhua Shi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Tau splicing and the intricacies of dementia
- (2011) Athena Andreadis JOURNAL OF CELLULAR PHYSIOLOGY
- Regulation of alternative splicing of tau exon 10 by 9G8 and Dyrk1A
- (2011) Shaohong Ding et al. NEUROBIOLOGY OF AGING
- Regulation of the alternative splicing of tau exon 10 by SC35 and Dyrk1A
- (2011) W. Qian et al. NUCLEIC ACIDS RESEARCH
- Serine-arginine protein kinases: a small protein kinase family with a large cellular presence
- (2010) Thomas Giannakouros et al. FEBS Journal
- A rational nomenclature for serine/arginine-rich protein splicing factors (SR proteins)
- (2010) J. L. Manley et al. GENES & DEVELOPMENT
- The N-terminal Fragment from Caspase-cleaved Serine/Arginine Protein-specific Kinase2 (SRPK2) Translocates into the Nucleus and Promotes Apoptosis
- (2010) Yi Hong et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Interaction of Akt-phosphorylated SRPK2 with 14-3-3 Mediates Cell Cycle and Cell Death in Neurons
- (2009) Sung-Wuk Jang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- SR Proteins in Vertical Integration of Gene Expression from Transcription to RNA Processing to Translation
- (2009) Xiang-Yang Zhong et al. MOLECULAR CELL
- Serine/Arginine Protein-Specific Kinase 2 Promotes Leukemia Cell Proliferation by Phosphorylating Acinus and Regulating Cyclin A1
- (2008) S.-W. Jang et al. CANCER RESEARCH
- Increased Dosage of Dyrk1A Alters Alternative Splicing Factor (ASF)-regulated Alternative Splicing of Tau in Down Syndrome
- (2008) Jianhua Shi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Tau exon 10 alternative splicing and tauopathies
- (2008) Fei Liu et al. Molecular Neurodegeneration
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreDiscover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversation