Y-632 inhibits heat shock protein 90 (Hsp90) function by disrupting the interaction between Hsp90 and Hsp70/Hsp90 organizing protein, and exerts antitumor activityin vitroandin vivo

Disruption of Heat Shock Protein 90 (Hsp90)-Protein Kinase Cδ (PKCδ) Interaction by (−)-Maackiain Suppresses Histamine H1Receptor Gene Transcription in HeLa Cells

(2015) Yuki Nariai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HS-133, a novel fluorescent phosphatidylinositol 3-kinase inhibitor as a potential imaging and anticancer agent for targeted therapy

(2015) Ju-Hee Lee et al.   Oncotarget

Progress in the Discovery and Development of Heat Shock Protein 90 (Hsp90) Inhibitors

(2014) Rohit Bhat et al.   JOURNAL OF MEDICINAL CHEMISTRY

FW-04-806 inhibits proliferation and induces apoptosis in human breast cancer cells by binding to N-terminus of Hsp90 and disrupting Hsp90-Cdc37 complex formation

(2014) Wei Huang et al.   Molecular Cancer

RON confers lapatinib resistance in HER2-positive breast cancer cells

(2013) Quanren Wang et al.   CANCER LETTERS

Flumatinib, a selective inhibitor of BCR-ABL/PDGFR/KIT, effectively overcomes drug resistance of certain KIT mutants

(2013) Jie Zhao et al.   CANCER SCIENCE

Gambogic Acid Induces Apoptosis in Imatinib-Resistant Chronic Myeloid Leukemia Cells via Inducing Proteasome Inhibition and Caspase-Dependent Bcr-Abl Downregulation

(2013) X. Shi et al.   CLINICAL CANCER RESEARCH

Discovery and development of heat shock protein 90 inhibitors as anticancer agents: a review of patented potent geldanamycin derivatives

(2013) TaeHun Kim et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Contributions of co-chaperones and post-translational modifications towards Hsp90 drug sensitivity

(2013) Annerleim Walton-Diaz et al.   Future Medicinal Chemistry

HSP90 Inhibitors: Current Development and Potential in Cancer Therapy

(2013) Katerina Sidera et al.   Recent Patents on Anti-Cancer Drug Discovery

Targeting the molecular chaperone heat shock protein 90 (HSP90): Lessons learned and future directions

(2012) David S. Hong et al.   CANCER TREATMENT REVIEWS

Tumor-Intrinsic and Tumor-Extrinsic Factors Impacting Hsp90- Targeted Therapy

(2012) S.V. Alarcon et al.   CURRENT MOLECULAR MEDICINE

The architecture of functional modules in the Hsp90 co-chaperone Sti1/Hop

(2012) Andreas B Schmid et al.   EMBO JOURNAL

Oxidative inhibition of Hsp90 disrupts the super-chaperone complex and attenuates pancreatic adenocarcinomain vitroandin vivo

(2012) Sayantani Sarkar et al.   INTERNATIONAL JOURNAL OF CANCER

BCR-ABL/GATA1/miR-138 mini circuitry contributes to the leukemogenesis of chronic myeloid leukemia

(2012) C Xu et al.   ONCOGENE

Advances in the clinical development of heat shock protein 90 (Hsp90) inhibitors in cancers

(2011) Komal Jhaveri et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Post-translational modifications of Hsp90 and their contributions to chaperone regulation

(2011) Mehdi Mollapour et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Designed hybrid TPR peptide targeting Hsp90 as a novel anticancer agent

(2011) Tomohisa Horibe et al.   Journal of Translational Medicine

Curcumin inhibits metastatic progression of breast cancer cell through suppression of urokinase-type plasminogen activator by NF-kappa B signaling pathways

(2011) Hong Zong et al.   MOLECULAR BIOLOGY REPORTS

A Compound That Inhibits the HOP–Hsp90 Complex Formation and Has Unique Killing Effects in Breast Cancer Cell Lines

(2011) Genaro Pimienta et al.   MOLECULAR PHARMACEUTICS

Extracellular Heat Shock Protein (Hsp)70 and Hsp90α Assist in Matrix Metalloproteinase-2 Activation and Breast Cancer Cell Migration and Invasion

(2011) Jessica D. Sims et al.   PLoS One

Novel pyrrolo-1,5-benzoxazepine compounds display significant activity against resistant chronic myeloid leukaemia cells in vitro, in ex vivo patient samples and in vivo

(2010) S A Bright et al.   BRITISH JOURNAL OF CANCER

Stress-induced Phosphoprotein 1 as a Secreted Biomarker for Human Ovarian Cancer Promotes Cancer Cell Proliferation

(2010) Tzu-Hao Wang et al.   MOLECULAR & CELLULAR PROTEOMICS

1,4-Diamino-2,3-dicyano-1,4-bis(methylthio)butadiene (U0126) Enhances the Cytotoxicity of Combretastatin A4 Independently of Mitogen-Activated Protein Kinase Kinase

(2009) H. Quan et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

A Novel Class of Small Molecule Inhibitors of Hsp90

(2008) Fang Yi et al.   ACS Chemical Biology

Targeting Hsp90: small-molecule inhibitors and their clinical development

(2008) Tony Taldone et al.   CURRENT OPINION IN PHARMACOLOGY

Tubocapsenolide A, a Novel Withanolide, Inhibits Proliferation and Induces Apoptosis in MDA-MB-231 Cells by Thiol Oxidation of Heat Shock Proteins

(2008) Wen-Ying Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY