Article
Oncology
Qiaoxi Xia, Zepeng Du, Mantong Chen, Xiao Zhou, Wenjing Bai, Xiaoqi Zheng, Ling Lin, Yan Zhao, Jiyu Ding, Zhisheng Wu, Haiying Zou, Shaohong Wang, Liyan Xu, Enmin Li, Bingli Wu
Summary: During malignant tumour development, the LCN2/LOXL2/MMP9 ternary complex promotes migration, invasion, and malignant progression of cancer cells through multiple mechanisms, making it a potential therapeutic target.
MOLECULAR ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Asif Amin, Asif Lone, Faizah Farooq, Umer Majeed Wani, Fizallah Kawoosa, Raies A. A. Qadri
Summary: The interaction between Tetranectin and plasminogen is crucial for extracellular matrix degradation, enabling tumor cell invasion and metastasis. This study aimed to target the carbohydrate recognition domain (CRD) of Tetranectin using natural bioactive compounds to inhibit its interaction with the Kringle-4 domain of plasminogen. Diosgenin and scytonemin exhibited favorable interactions with CRD, but diosgenin showed increased stability in the CRD binding pocket compared to scytonemin. Diosgenin was found to exert a pronounced anti-proliferative effect on breast cancer cells and reduce their migration and invasiveness.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Multidisciplinary Sciences
Hui Sun, Yufeng Wang, Shentao Wang, Yikui Xie, Kun Sun, Shuai Li, Weitong Cui, Kai Wang
Summary: This article investigated the correlation between the expression patterns of collagen family genes and gastric cancer progression using bioinformatics analyses. It was found that many collagen family genes were overexpressed in gastric cancer tissues, especially in the early T stages, highlighting the significance of collagens in tumor enlargement of gastric cancer.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Fateme Eidizade, Mohammad Soukhtanloo, Rahele Zhiani, Jamshid Mehrzad, Farshad Mirzavi
Summary: This research investigates the effects of urolithin-B on glioblastoma multiforme (GBM) U87 cells. The results suggest that urolithin-B can decrease cell viability, induce necrosis and cell cycle arrest, increase reactive oxygen species production, and reduce cell migration in U87 cells. These findings indicate that urolithin-B may be a promising compound for GBM treatment.
Article
Multidisciplinary Sciences
Chang Liu, Michael Mak
Summary: Research shows that fibroblasts can increase the motility of tumor cells and facilitate the transition of tumor cells from confined to diffusive motion. When coexisting with fibroblasts, the ECM undergoes substantial global and local remodeling. These phenomena are partly dependent on matrix metalloproteinases.
SCIENTIFIC REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Lokender Kumar, Monish Bisen, Azhar Khan, Pradeep Kumar, Sanjay Kumar Singh Patel
Summary: This review discusses the role of MMPs in skeletal muscle function, muscle injury and repair, as well as the potential applications of MMPs in the treatment of musculoskeletal disorders.
Article
Pharmacology & Pharmacy
Sanu K. Shaji, G. Drishya, Damu Sunilkumar, Nanjan Pandurangan, Geetha B. Kumar, Bipin G. Nair
Summary: Less-studied flavonoid Tamarixetin demonstrated significant dose-dependent inhibition of MMP-9 expression and cancer cell migration and invasion potential, indicating its potential as an anti-cancer agent. The compound also inhibits crucial functions necessary for MMP-9 activation and modulates endogenous regulators of MMP-9 activity, suggesting it could be a template for novel therapeutic applications.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Katarzyna Ratajczak-Wielgomas, Alicja Kmiecik, Piotr Dziegiel
Summary: The expression of POSTN is significantly increased in NSCLC and may serve as an independent prognostic factor. POSTN knockdown inhibits the migration and invasion of lung cancer cells, potentially through modulating the expression of MMP-2.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemical Research Methods
Marco Ruscone, Arnau Montagud, Philippe Chavrier, Olivier Destaing, Isabelle Bonnet, Andrei Zinovyev, Emmanuel Barillot, Vincent Noël, Laurence Calzone
Summary: In this study, a multiscale model is used to investigate the invasion process of tumor cells. The model combines agent-based modeling and continuous time Markov processes applied on Boolean network models. By considering both spatial information from the agent-based simulation and intracellular regulation from the Boolean model, the model aims to study different modes of cell migration and predict means to block it. The multiscale model successfully reproduces single and collective migration processes and is validated on published experiments on cell invasion, suggesting possible targets to block invasive tumor phenotypes through in silico experiments.
Article
Chemistry, Analytical
Xintong Lu, Luoyu Ding, Haohan Song, Wenxin Yu, Chaoqing Dong, Jicun Ren
Summary: A novel in situ single molecule spectroscopy method based on fluorescent correlation spectroscopy (FCS) technique was proposed for measuring MMP-9 activity in single living cells. The method utilizes a fluorescent specific peptide and a reference dye as dual probes, and ratiometric translational diffusion time as the measurement parameter.
Article
Biochemistry & Molecular Biology
Yang Liu, Fei Wang, Zhe Li, Yanling Mu, Voon Wee Yong, Mengzhou Xue
Summary: This study found that chlorogenic acid (CGA) can provide neuroprotection in intracerebral hemorrhage (ICH) by inhibiting the expression of EMMPRIN and MMP-2/9, alleviating neuroinflammation, blood-brain barrier disruption, cell death, and brain injury.
Review
Oncology
Ananya Mukherjee, Jose Javier Bravo-Cordero
Summary: The study of the metastatic cascade has revealed the complexity of the process and the multiple cellular states that disseminated cancer cells must go through. The tumor microenvironment, especially the extracellular matrix (ECM), plays a crucial role in regulating the transition from invasion, dormancy to proliferation during the metastatic cascade. Identifying dormant cells, their niches, and the transition to the proliferative state are active areas of investigation, and novel approaches have been developed to track dormant cells during dissemination. This review highlights the latest research on the invasive nature of disseminated tumor cells, their link to dormancy programs, and the role of the ECM in sustaining dormant niches at distant sites.
CANCER AND METASTASIS REVIEWS
(2023)
Article
Medicine, Research & Experimental
Jiao Ge, Yan Liu
Summary: This study investigated the serum expression of HSP-70 in children with ITP and healthy controls, and found that the expression of HSP-70 is associated with the progression and severity of childhood ITP.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2022)
Article
Medicine, Research & Experimental
Yanbin Song, Lei Bai, Feiping Yan, Chen Chen
Summary: This study revealed the crucial role of miR-124 in glioma by targeting EMMPRIN, which led to inhibition of cell proliferation, promotion of apoptosis, and reduction of cell migration and invasion. Additionally, tumor growth was halted by miR-124 in mice, suggesting its potential as a tumor suppressor in the treatment of glioma.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Ziqiang Liu, Jiacheng Lai, Heng Jiang, Chengyuan Ma, Haiyan Huang
Summary: COL11A1 is upregulated in various cancers and is associated with tumor progression, poor prognosis, angiogenesis, invasion, and drug resistance. While the specific mechanism by which COL11A1 regulates tumor progression remains unclear, it shows potential as a target for cancer treatment.