Discovery and development of heat shock protein 90 inhibitors as anticancer agents: a review of patented potent geldanamycin derivatives

Unprecedented deoxygenation at C-7 of the ansamitocin core during mutasynthetic biotransformations

(2012) Tobias Knobloch et al.   Beilstein Journal of Organic Chemistry

Geldanamycin and its derivatives as Hsp90 inhibitors

(2012) Magdalena Gorska   Frontiers in Bioscience-Landmark

Discovery of (2S)-1-[4-(2-{6-Amino-8-[(6-bromo-1,3-benzodioxol-5-yl)sulfanyl]-9H-purin-9-yl}ethyl)piperidin-1-yl]-2-hydroxypropan-1-one (MPC-3100), a Purine-Based Hsp90 Inhibitor

(2012) Se-Ho Kim et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Novel HSP90 Inhibitor, IPI-493, Is Highly Effective in Human Gastrostrointestinal Stromal Tumor Xenografts Carrying Heterogeneous KIT Mutations

(2011) G. Floris et al.   CLINICAL CANCER RESEARCH

Advances in the discovery and development of heat-shock protein 90 inhibitors for cancer treatment

(2011) Hardik J Patel et al.   Expert Opinion on Drug Discovery

Broad Substrate Specificity of the Amide Synthase in S. hygroscopicus—New 20-Membered Macrolactones Derived from Geldanamycin

(2011) Simone Eichner et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A phase 1 study of IPI-504 (retaspimycin hydrochloride) in patients with relapsed or relapsed and refractory multiple myeloma

(2011) David Siegel et al.   LEUKEMIA & LYMPHOMA

The Heat Shock Protein 90 Inhibitor IPI-504 Induces KIT Degradation, Tumor Shrinkage, and Cell Proliferation Arrest in Xenograft Models of Gastrointestinal Stromal Tumors

(2011) G. Floris et al.   MOLECULAR CANCER THERAPEUTICS

Select pyrimidinones inhibit the propagation of the malarial parasite, Plasmodium falciparum

(2009) Annette N. Chiang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Geldanamycin and its anti-cancer activities

(2009) Yayoi Fukuyo et al.   CANCER LETTERS

New, Highly Active Nonbenzoquinone Geldanamycin Derivatives by Using Mutasynthesis

(2009) Simone Eichner et al.   CHEMBIOCHEM

Ansamycin Inhibitors of Hsp90: Natures Prototype for Anti-Chaperone Therapy

(2009) James Porter et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Update on Hsp90 Inhibitors in Clinical Trial

(2009) Y. Kim et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Tanespimycin: the opportunities and challenges of targeting heat shock protein 90

(2009) Charles Erlichman   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Discovery and development of heat shock protein 90 inhibitors

(2008) Tony Taldone et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A Phase 1 Dose-Escalation Study of Irinotecan in Combination with 17-Allylamino-17-Demethoxygeldanamycin in Patients with Solid Tumors

(2008) A. N. Tse et al.   CLINICAL CANCER RESEARCH