Silencing of Long Non-coding RNA GAS5 Suppresses Neuron Cell Apoptosis and Nerve Injury in Ischemic Stroke Through Inhibiting DNMT3B-Dependent MAP4K4 Methylation

The Regulatory Role of Long Noncoding RNAs in Different Brain Cell Types Involved in Ischemic Stroke

(2019) Runsen Chen et al.   Frontiers in Molecular Neuroscience

MAP4K4 Inhibition Promotes Survival of Human Stem Cell-Derived Cardiomyocytes and Reduces Infarct Size In Vivo

(2019) Lorna R. Fiedler et al.   Cell Stem Cell

YY1/LncRNA GAS5 complex aggravates cerebral ischemia/reperfusion injury through enhancing neuronal glycolysis

(2019) Xin-Chun Zhang et al.   NEUROPHARMACOLOGY

Profiling neuron-autonomous lncRNA changes upon ischemia/reperfusion injury

(2018) Haiying Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

GAS5 silencing protects against hypoxia/ischemia-induced neonatal brain injury

(2018) Rui-bin Zhao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

LncRNA GAS5 regulates ischemic stroke as a competing endogenous RNA for miR-137 to regulate the Notch1 signaling pathway

(2018) Fenghui Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A novel cell-penetrating peptide protects against neuron apoptosis after cerebral ischemia by inhibiting the nuclear translocation of annexin A1

(2018) Xing Li et al.   CELL DEATH AND DIFFERENTIATION

Long non-coding RNA GAS5 aggravates hypoxia injury in PC-12 cells via down-regulating miR-124

(2018) Xiaoli Hu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Noncoding RNAs and Stroke

(2018) Xuejing Zhang et al.   NEUROSCIENTIST

Pathophysiology of Long Non-coding RNAs in Ischemic Stroke

(2018) Weimin Ren et al.   Frontiers in Molecular Neuroscience

Analysis of diet-induced differential methylation, expression, and interactions of lncRNA and protein-coding genes in mouse liver

(2018) Jose P. Silva et al.   Scientific Reports

Sonographic evaluation of atherosclerosis burden in carotid arteries of ischemic stroke patients and its relation to paraoxonase 1 and 2, MTHFR and AT1R genetic variants

(2017) Carmen Rosa Hernández-Socorro et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Targeting antioxidant enzyme expression as a therapeutic strategy for ischemic stroke

(2017) Stephanie M. Davis et al.   NEUROCHEMISTRY INTERNATIONAL

LncRNA GAS5 controls cardiac fibroblast activation and fibrosis by targeting miR-21 via PTEN/MMP-2 signaling pathway

(2017) Hui Tao et al.   TOXICOLOGY

Exosomal lncRNA GAS5 regulates the apoptosis of macrophages and vascular endothelial cells in atherosclerosis

(2017) Lei Chen et al.   PLoS One

Increased DNA methylation of Dnmt3b targets impairs leukemogenesis

(2016) I. Schulze et al.   BLOOD

Capsaicin mediates caspases activation and induces apoptosis through P38 and JNK MAPK pathways in human renal carcinoma

(2016) Tao Liu et al.   BMC CANCER

Epidemiology of Ischemic Stroke

(2016) Albert S. Favate et al.   NEUROLOGIC CLINICS

Remote ischemic conditioning for acute ischemic stroke: dawn in the darkness

(2016) Jingrui Pan et al.   REVIEWS IN THE NEUROSCIENCES

MAP4K4: an emerging therapeutic target in cancer

(2016) Xuan Gao et al.   Cell and Bioscience

Neuritogenic Militarinone-Inspired 4-Hydroxypyridones Target the Stress Pathway Kinase MAP4K4

(2015) Peter Schröder et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Genomic profiling of DNA methyltransferases reveals a role for DNMT3B in genic methylation

(2015) Tuncay Baubec et al.   NATURE

An Lnc RNA (GAS5)/SnoRNA-derived piRNA induces activation of TRAIL gene by site-specifically recruiting MLL/COMPASS-like complexes

(2015) Xin He et al.   NUCLEIC ACIDS RESEARCH

Long non-coding RNA growth arrest-specific transcript 5 is involved in ovarian cancer cell apoptosis through the mitochondria-mediated apoptosis pathway

(2015) JIAYIN GAO et al.   ONCOLOGY REPORTS

lncRNA GAS5 enhances G1 cell cycle arrest via binding to YBX1 to regulate p21 expression in stomach cancer

(2015) Yongchao Liu et al.   Scientific Reports

The role of long non-coding RNAs in genome formatting and expression

(2015) Pierre-Olivier Angrand et al.   Frontiers in Genetics

LongTarget: a tool to predict lncRNA DNA-binding motifs and binding sites via Hoogsteen base-pairing analysis

(2014) Sha He et al.   BIOINFORMATICS

Fragment-based identification and optimization of a class of potent pyrrolo[2,1- f ][1,2,4]triazine MAP4K4 inhibitors

(2014) Lan Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Identification of hypo- and hypermethylated genes related to atherosclerosis by a genome-wide analysis of DNA methylation

(2014) YOSHIJI YAMADA et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

The structure, function and evolution of proteins that bind DNA and RNA

(2014) William H. Hudson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Endovascular Treatment for Acute Ischemic Stroke — Still Unproven

(2013) Marc I. Chimowitz   NEW ENGLAND JOURNAL OF MEDICINE

Genetic Deletion of NP1 Prevents Hypoxic‐Ischemic Neuronal Death Via Reducing AMPA Receptor Synaptic Localization in Hippocampal Neurons

(2013) Md Al Rahim et al.   Journal of the American Heart Association

Predicting RNA-Protein Interactions Using Only Sequence Information

(2011) Usha K Muppirala et al.   BMC BIOINFORMATICS

Unexpected low prevalence of atrial fibrillation in cryptogenic ischemic stroke: a prospective study

(2010) Fanny Dion et al.   JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY

The Science of Stroke: Mechanisms in Search of Treatments

(2010) Michael A. Moskowitz et al.   NEURON

Expression of MAP4K4 Is Associated with Worse Prognosis in Patients with Stage II Pancreatic Ductal Adenocarcinoma

(2008) J. J. Liang et al.   CLINICAL CANCER RESEARCH