Neuritogenic Militarinone-Inspired 4-Hydroxypyridones Target the Stress Pathway Kinase MAP4K4

Fragment-based identification and optimization of a class of potent pyrrolo[2,1- f ][1,2,4]triazine MAP4K4 inhibitors

(2014) Lan Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of Selective 4-Amino-pyridopyrimidine Inhibitors of MAP4K4 Using Fragment-Based Lead Identification and Optimization

(2014) Terry D. Crawford et al.   JOURNAL OF MEDICINAL CHEMISTRY

Biology-Oriented Synthesis: Harnessing the Power of Evolution

(2014) Hilde van Hattum et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemical Interrogation of the Neuronal Kinome Using a Primary Cell-Based Screening Assay

(2013) Hassan Al-Ali et al.   ACS Chemical Biology

Discovery of Neuritogenic Compound Classes Inspired by Natural Products

(2013) Pierre-Yves Dakas et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Neurotrophic Natural Products: Chemistry and Biology

(2013) Jing Xu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Small Molecule Screen in Stem-Cell-Derived Motor Neurons Identifies a Kinase Inhibitor as a Candidate Therapeutic for ALS

(2013) Yin M. Yang et al.   Cell Stem Cell

Highly Enantioselective Catalytic Synthesis of Neurite Growth-Promoting Secoyohimbanes

(2013) Andrey P. Antonchick et al.   CHEMISTRY & BIOLOGY

Current and Emerging Therapies for Alzheimer’s Disease

(2013) Haakon B. Nygaard   CLINICAL THERAPEUTICS

Intercellular transfer of tau aggregates and spreading of tau pathology: Implications for therapeutic strategies

(2013) Florence Clavaguera et al.   NEUROPHARMACOLOGY

Drug repositioning for Alzheimer's disease

(2012) Anne Corbett et al.   NATURE REVIEWS DRUG DISCOVERY

Truncated militarinone fragments identified by total chemical synthesis induce neurite outgrowth

(2012) Fabian Schmid et al.   MedChemComm

A Unified Approach for the Stereoselective Total Synthesis of Pyridone Alkaloids and Their Neuritogenic Activity

(2011) Henning Jacob Jessen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Biology-Oriented Synthesis

(2011) Stefan Wetzel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Understanding the Impact of the P-loop Conformation on Kinase Selectivity

(2011) Cristiano R. W. Guimarães et al.   Journal of Chemical Information and Modeling

Molecular pathways of motor neuron injury in amyotrophic lateral sclerosis

(2011) Laura Ferraiuolo et al.   Nature Reviews Neurology

Bioactivity-Guided Navigation of Chemical Space

(2010) Robin S. Bon et al.   ACCOUNTS OF CHEMICAL RESEARCH

JNK: A Stress-Activated Protein Kinase Therapeutic Strategies and Involvement in Alzheimer’s and Various Neurodegenerative Abnormalities

(2010) Sidharth Mehan et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Fluorophore Labeling of the Glycine-Rich Loop as a Method of Identifying Inhibitors That Bind to Active and Inactive Kinase Conformations†

(2010) Jeffrey R. Simard et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

4-Hydroxy-2-pyridone alkaloids: Structures and synthetic approaches

(2010) Henning Jacob Jessen et al.   NATURAL PRODUCT REPORTS

Alzheimer's Disease: From Pathology to Therapeutic Approaches

(2009) Roland Jakob-Roetne et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Principles, implementation, and application of biology-oriented synthesis (BIOS)

(2009) Wolfram Wilk et al.   BIOLOGICAL CHEMISTRY

Analogues of Y27632 increase gap junction communication and suppress the formation of transformed NIH3T3 colonies

(2009) L Hampson et al.   BRITISH JOURNAL OF CANCER

Combined inhibition of Cdk5 and ROCK additively increase cell survival, but not the regenerative response in regenerating retinal ganglion cells

(2009) Christina Bermel et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Neuroprotective effects of SB-415286 on hydrogen peroxide-induced cell death in B65 rat neuroblastoma cells and neurons

(2008) Javier G. Pizarro et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Assessment of Chemical Effects on Neurite Outgrowth in PC12 cells Using High Content Screening

(2008) Nicholas M. Radio et al.   TOXICOLOGICAL SCIENCES