Feeling Things Out: Bidirectional Signaling of the Cell–ECM Interface, Implications in the Mechanobiology of Cell Spreading, Migration, Proliferation, and Differentiation

Citrullination of fibronectin alters integrin clustering and focal adhesion stability promoting stromal cell invasion

(2019) Victoria L. Stefanelli et al.   MATRIX BIOLOGY

Cell cycle progression in confining microenvironments is regulated by a growth-responsive TRPV4-PI3K/Akt-p27Kip1 signaling axis

(2019) Sungmin Nam et al.   Science Advances

Adaptable boronate ester hydrogels with tunable viscoelastic spectra to probe timescale dependent mechanotransduction

(2019) Ian A. Marozas et al.   BIOMATERIALS

Spindle pole body component 25 homolog expressed by ECM stiffening is required for lung cancer cell proliferation

(2018) Jangho Jeong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Substrate stiffness regulated migration and invasion ability of adenoid cystic carcinoma cells via RhoA/ROCK pathway

(2018) Dan Zhao et al.   CELL PROLIFERATION

Tissue stiffening promotes keratinocyte proliferation through activation of epidermal growth factor signaling

(2018) Fiona N. Kenny et al.   JOURNAL OF CELL SCIENCE

YAP/TAZ upstream signals and downstream responses

(2018) Antonio Totaro et al.   NATURE CELL BIOLOGY

Mitotic cells generate protrusive extracellular forces to divide in three-dimensional microenvironments

(2018) Sungmin Nam et al.   Nature Physics

Tenascin-C derived signaling induces neuronal differentiation in a three-dimensional peptide nanofiber gel

(2018) Melike Sever et al.   Biomaterials Science

Deep Profiling of Mouse Splenic Architecture with CODEX Multiplexed Imaging

(2018) Yury Goltsev et al.   CELL

Secondary Photocrosslinking of Click Hydrogels To Probe Myoblast Mechanotransduction in Three Dimensions

(2018) Tobin E. Brown et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Three-Dimensional Nanostructured Architectures Enable Efficient Neural Differentiation of Mesenchymal Stem Cells via Mechanotransduction

(2018) Mahla Poudineh et al.   NANO LETTERS

Biomaterials and engineered microenvironments to control YAP/TAZ-dependent cell behaviour

(2018) Giovanna Brusatin et al.   NATURE MATERIALS

Structural and functional insights into the interaction between the Cas family scaffolding protein p130Cas and the focal adhesion-associated protein paxillin

(2017) Chi Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct focal adhesion protein modules control different aspects of mechanotransduction

(2017) Ben Stutchbury et al.   JOURNAL OF CELL SCIENCE

Talin – the master of integrin adhesions

(2017) Benjamin Klapholz et al.   JOURNAL OF CELL SCIENCE

Vinculin promotes nuclear localization of TAZ to inhibit ECM stiffness-dependent differentiation into adipocytes

(2017) Mito Kuroda et al.   JOURNAL OF CELL SCIENCE

Low Focal Adhesion Signaling Promotes Ground State Pluripotency of Mouse Embryonic Stem Cells

(2017) Sara Taleahmad et al.   JOURNAL OF PROTEOME RESEARCH

Fibronectin, the extracellular glue

(2017) Alicia J. Zollinger et al.   MATRIX BIOLOGY

A cytoskeletal clutch mediates cellular force transmission in a soft, three-dimensional extracellular matrix

(2017) Leanna M. Owen et al.   MOLECULAR BIOLOGY OF THE CELL

Effects of substrate stiffness and actomyosin contractility on coupling between force transmission and vinculin–paxillin recruitment at single focal adhesions

(2017) Dennis W. Zhou et al.   MOLECULAR BIOLOGY OF THE CELL

Hydrogels with precisely controlled integrin activation dictate vascular patterning and permeability

(2017) Shuoran Li et al.   NATURE MATERIALS

Extracellular Matrices for Bone Regeneration: A Literature Review

(2017) Alaa Mansour et al.   TISSUE ENGINEERING PART A

Biglycan expression in the melanoma microenvironment promotes invasiveness via increased tissue stiffness inducing integrin-β1 expression

(2017) Hana Andrlová et al.   Oncotarget

The role of focal adhesion anchoring domains of CAS in mechanotransduction

(2017) Jaroslav Braniš et al.   Scientific Reports

Fibroblast-Mediated Collagen Remodeling Within the Tumor Microenvironment Facilitates Progression of Thyroid Cancers Driven by BrafV600Eand Pten Loss

(2016) Lee Ann Jolly et al.   CANCER RESEARCH

Role of YAP/TAZ in cell-matrix adhesion-mediated signalling and mechanotransduction

(2016) Sirio Dupont   EXPERIMENTAL CELL RESEARCH

RhoA GTPase inhibition organizes contraction during epithelial morphogenesis

(2016) Frank M. Mason et al.   JOURNAL OF CELL BIOLOGY

Integrin-mediated mechanotransduction

(2016) Zhiqi Sun et al.   JOURNAL OF CELL BIOLOGY

The molecular clutch model for mechanotransduction evolves

(2016) Vinay Swaminathan et al.   NATURE CELL BIOLOGY

Mechanical regulation of a molecular clutch defines force transmission and transduction in response to matrix rigidity

(2016) Alberto Elosegui-Artola et al.   NATURE CELL BIOLOGY

Activation of integrin α5 mediated by flow requires its translocation to membrane lipid rafts in vascular endothelial cells

(2016) Xiaoli Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oriented collagen fibers direct tumor cell intravasation

(2016) Weijing Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The glycocalyx promotes cooperative binding and clustering of adhesion receptors

(2016) Guang-Kui Xu et al.   Soft Matter

Forcing through Tumor Metastasis: The Interplay between Tissue Rigidity and Epithelial–Mesenchymal Transition

(2016) Spencer C. Wei et al.   TRENDS IN CELL BIOLOGY

Mechanosensing by the α6-integrin confers an invasive fibroblast phenotype and mediates lung fibrosis

(2016) Huaping Chen et al.   Nature Communications

CXCR6-CXCL16 axis promotes prostate cancer by mediating cytoskeleton rearrangement via Ezrin activation and αvβ3 integrin clustering

(2016) Rajesh Singh et al.   Oncotarget

Mechanoreception at the cell membrane: More than the integrins

(2015) Alexander N. Gasparski et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Intravital Imaging Reveals How BRAF Inhibition Generates Drug-Tolerant Microenvironments with High Integrin β1/FAK Signaling

(2015) Eishu Hirata et al.   CANCER CELL

Regulation of integrin-mediated adhesions

(2015) Daniel V Iwamoto et al.   CURRENT OPINION IN CELL BIOLOGY

CXCL12/CXCR4 activation by cancer-associated fibroblasts promotes integrin β1 clustering and invasiveness in gastric cancer

(2015) Daisuke Izumi et al.   INTERNATIONAL JOURNAL OF CANCER

Conformational coupling of integrin and Thy-1 regulates Fyn priming and fibroblast mechanotransduction

(2015) Vincent F. Fiore et al.   JOURNAL OF CELL BIOLOGY

A molecular mechanotransduction pathway regulates collective migration of epithelial cells

(2015) Tamal Das et al.   NATURE CELL BIOLOGY

Molecular mechanism of vinculin activation and nanoscale spatial organization in focal adhesions

(2015) Lindsay B. Case et al.   NATURE CELL BIOLOGY

Binding of MMP-9-degraded fibronectin to β6 integrin promotes invasion via the FAK-Src-related Erk1/2 and PI3K/Akt/Smad-1/5/8 pathways in breast cancer

(2015) WENTONG LI et al.   ONCOLOGY REPORTS

Integrin β1 controls VE-cadherin localization and blood vessel stability

(2015) Hiroyuki Yamamoto et al.   Nature Communications

Tissue Stiffness Dictates Development, Homeostasis, and Disease Progression

(2015) Andrew M Handorf et al.   Organogenesis

Inhibition of STAT3, FAK and Src mediated signaling reduces cancer stem cell load, tumorigenic potential and metastasis in breast cancer

(2015) Ravi Thakur et al.   Scientific Reports

Stiff substrates increase YAP-signaling-mediated matrix metalloproteinase-7 expression

(2015) A Nukuda et al.   Oncogenesis

Overcoming EMT-associated resistance to anti-cancer drugs via Src/FAK pathway inhibition

(2015) Catherine Wilson et al.   Oncotarget

3D Collagen Alignment Limits Protrusions to Enhance Breast Cancer Cell Persistence

(2014) Kristin M. Riching et al.   BIOPHYSICAL JOURNAL

Compressive Stress Inhibits Proliferation in Tumor Spheroids through a Volume Limitation

(2014) Morgan Delarue et al.   BIOPHYSICAL JOURNAL

Force Engages Vinculin and Promotes Tumor Progression by Enhancing PI3K Activation of Phosphatidylinositol (3,4,5)-Triphosphate

(2014) Matthew G. Rubashkin et al.   CANCER RESEARCH

Integrin-Associated Complexes Form Hierarchically with Variable Stoichiometry in Nascent Adhesions

(2014) Alexia I. Bachir et al.   CURRENT BIOLOGY

Nascent Adhesions: From Fluctuations to a Hierarchical Organization

(2014) Zhiqi Sun et al.   CURRENT BIOLOGY

Post-translational modifications of integrin ligands as pathogenic mechanisms in disease

(2014) Cédric Zeltz et al.   MATRIX BIOLOGY

The cancer glycocalyx mechanically primes integrin-mediated growth and survival

(2014) Matthew J. Paszek et al.   NATURE

Extracellular matrix stiffness and composition jointly regulate the induction of malignant phenotypes in mammary epithelium

(2014) Ovijit Chaudhuri et al.   NATURE MATERIALS

The Focal Adhesion-Localized CdGAP Regulates Matrix Rigidity Sensing and Durotaxis

(2014) Duncan B. Wormer et al.   PLoS One

The small GTPase N-Ras regulates extracellular matrix synthesis, proliferation and migration in fibroblasts

(2013) Isabel Fuentes-Calvo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The effects of crosslinking of scaffolds engineered from cartilage ECM on the chondrogenic differentiation of MSCs

(2013) Christopher R. Rowland et al.   BIOMATERIALS

Mesenchymal stem cell durotaxis depends on substrate stiffness gradient strength

(2013) Ludovic G. Vincent et al.   Biotechnology Journal

A Collagen-Remodeling Gene Signature Regulated by TGF-β Signaling Is Associated with Metastasis and Poor Survival in Serous Ovarian Cancer

(2013) Dong-Joo Cheon et al.   CLINICAL CANCER RESEARCH

LPA1-induced cytoskeleton reorganization drives fibrosis through CTGF-dependent fibroblast proliferation

(2013) Norihiko Sakai et al.   FASEB JOURNAL

Vinculin–actin interaction couples actin retrograde flow to focal adhesions, but is dispensable for focal adhesion growth

(2013) Ingo Thievessen et al.   JOURNAL OF CELL BIOLOGY

Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo

(2013) Tim Lämmermann et al.   NATURE

β1- and αv-class integrins cooperate to regulate myosin II during rigidity sensing of fibronectin-based microenvironments

(2013) Herbert B. Schiller et al.   NATURE CELL BIOLOGY

Suppression of MIM by microRNA-182 activates RhoA and promotes breast cancer metastasis

(2013) R Lei et al.   ONCOGENE

How vinculin regulates force transmission

(2013) D. W. Dumbauld et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Matrix Stiffness–Induced Myofibroblast Differentiation Is Mediated by Intrinsic Mechanotransduction

(2012) Xiangwei Huang et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Fibers with Integrated Mechanochemical Switches: Minimalistic Design Principles Derived from Fibronectin

(2012) Orit Peleg et al.   BIOPHYSICAL JOURNAL

Phosphorylation Primes Vinculin for Activation

(2012) Javad Golji et al.   BIOPHYSICAL JOURNAL

Force Fluctuations within Focal Adhesions Mediate ECM-Rigidity Sensing to Guide Directed Cell Migration

(2012) Sergey V. Plotnikov et al.   CELL

Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions

(2012) D A Brafman et al.   CELL DEATH AND DIFFERENTIATION

Citrullination of TNF-α by peptidylarginine deiminases reduces its capacity to stimulate the production of inflammatory chemokines

(2012) Eva A.V. Moelants et al.   CYTOKINE

Cathepsin H Mediates the Processing of Talin and Regulates Migration of Prostate Cancer Cells

(2012) Zala Jevnikar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FAK promotes recruitment of talin to nascent adhesions to control cell motility

(2012) Christine Lawson et al.   JOURNAL OF CELL BIOLOGY

Lysyl oxidase enzymatic function increases stiffness to drive colorectal cancer progression through FAK

(2012) A-M Baker et al.   ONCOGENE

Matrix Stiffness Regulates Endothelial Cell Proliferation through Septin 9

(2012) Yi-Ting Yeh et al.   PLoS One

Post-translational modifications of the extracellular matrix are key events in cancer progression: Opportunities for biochemical marker development

(2011) D. J. Leeming et al.   BIOMARKERS

The effect of matrix stiffness on the differentiation of mesenchymal stem cells in response to TGF-β

(2011) Jennifer S. Park et al.   BIOMATERIALS

Traction Forces of Neutrophils Migrating on Compliant Substrates

(2011) Risat A. Jannat et al.   BIOPHYSICAL JOURNAL

Cell Shape and Substrate Rigidity Both Regulate Cell Stiffness

(2011) Shang-You Tee et al.   BIOPHYSICAL JOURNAL

mTORC1 and mTORC2 Regulate EMT, Motility, and Metastasis of Colorectal Cancer via RhoA and Rac1 Signaling Pathways

(2011) P. Gulhati et al.   CANCER RESEARCH

Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer

(2011) T. R. Cox et al.   Disease Models & Mechanisms

Fibronectin splice variants: Understanding their multiple roles in health and disease using engineered mouse models

(2011) Eric S. White et al.   IUBMB LIFE

Mechanical signaling through the cytoskeleton regulates cell proliferation by coordinated focal adhesion and Rho GTPase signaling

(2011) P. P. Provenzano et al.   JOURNAL OF CELL SCIENCE

Talin-1 overexpression defines high risk for aggressive oral squamous cell carcinoma and promotes cancer metastasis

(2011) Ming-Tsung Lai et al.   JOURNAL OF PATHOLOGY

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Rho-Kinase in Development and Heart Failure: Insights From Genetic Models

(2011) Jianjian Shi et al.   PEDIATRIC CARDIOLOGY

Stiffness Gradients Mimicking In Vivo Tissue Variation Regulate Mesenchymal Stem Cell Fate

(2011) Justin R. Tse et al.   PLoS One

Integrin activation and internalization on soft ECM as a mechanism of induction of stem cell differentiation by ECM elasticity

(2011) J. Du et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resveratrol suppresses human colon cancer cell proliferation and induces apoptosis via targeting the pentose phosphate and the talin-FAK signaling pathways-A proteomic approach

(2011) Jairam Vanamala et al.   Proteome Science

Novel combinations of Post-Translational Modification (PTM) neo-epitopes provide tissue-specific biochemical markers—are they the cause or the consequence of the disease?

(2010) Morten Asser Karsdal et al.   CLINICAL BIOCHEMISTRY

Hallmarks of cancer: Interactions with the tumor stroma

(2010) Kristian Pietras et al.   EXPERIMENTAL CELL RESEARCH

Matrix stiffness modulates proliferation, chemotherapeutic response, and dormancy in hepatocellular carcinoma cells

(2010) Jörg Schrader et al.   HEPATOLOGY

Matrix stiffness regulation of integrin-mediated mechanotransduction during osteogenic differentiation of human mesenchymal stem cells

(2010) Yu-Ru V Shih et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Myosin II activity regulates vinculin recruitment to focal adhesions through FAK-mediated paxillin phosphorylation

(2010) Ana M. Pasapera et al.   JOURNAL OF CELL BIOLOGY

Focal adhesions are sites of integrin extension

(2010) Janet A. Askari et al.   JOURNAL OF CELL BIOLOGY

Caveolin-1 and integrin β1 regulate embryonic stem cell proliferation via p38 MAPK and FAK in high glucose

(2010) Sang Hun Lee et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Macrophage motility requires distinct α5β1/FAK and α4β1/paxillin signaling events

(2010) Michelle Y. Abshire et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Cell adhesion: integrating cytoskeletal dynamics and cellular tension

(2010) J. Thomas Parsons et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Linking actin dynamics and gene transcription to drive cellular motile functions

(2010) Eric N. Olson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Matrix Rigidity Regulates Cancer Cell Growth and Cellular Phenotype

(2010) Robert W. Tilghman et al.   PLoS One

Guiding Epithelial Cell Phenotypes with Engineered Integrin-Specific Recombinant Fibronectin Fragments

(2010) Ashley C. Brown et al.   TISSUE ENGINEERING PART A

Controlling Stem Cell Fate with Material Design

(2009) Ross A. Marklein et al.   ADVANCED MATERIALS

Laminin-1 induces neurite outgrowth in human mesenchymal stem cells in serum/differentiation factors-free conditions through activation of FAK–MEK/ERK signaling pathways

(2009) S. Mruthyunjaya et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cell Traction Forces Direct Fibronectin Matrix Assembly

(2009) Christopher A. Lemmon et al.   BIOPHYSICAL JOURNAL

Vascular Smooth Muscle Cell Durotaxis Depends on Substrate Stiffness Gradient Strength

(2009) Brett C. Isenberg et al.   BIOPHYSICAL JOURNAL

Serum CXCL13 positively correlates with prostatic disease, prostate-specific antigen and mediates prostate cancer cell invasion, integrin clustering and cell adhesion

(2009) Shailesh Singh et al.   CANCER LETTERS

Berberine suppresses in vitro migration and invasion of human SCC-4 tongue squamous cancer cells through the inhibitions of FAK, IKK, NF-κB, u-PA and MMP-2 and -9

(2009) Yung-Tsuan Ho et al.   CANCER LETTERS

The Mechanical Rigidity of the Extracellular Matrix Regulates the Structure, Motility, and Proliferation of Glioma Cells

(2009) T. A. Ulrich et al.   CANCER RESEARCH

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

Cell-Cycle Control by Physiological Matrix Elasticity and In Vivo Tissue Stiffening

(2009) Eric A. Klein et al.   CURRENT BIOLOGY

β1 integrin/FAK/ERK signalling pathway is essential for human fetal islet cell differentiation and survival

(2009) Saira Saleem et al.   JOURNAL OF PATHOLOGY

Adaptive force transmission in amoeboid cell migration

(2009) Jörg Renkawitz et al.   NATURE CELL BIOLOGY

Overexpression of macrophage inhibitory cytokine-1 induces metastasis of human prostate cancer cells through the FAK–RhoA signaling pathway

(2009) S Senapati et al.   ONCOGENE

Non-Linear Elasticity of Extracellular Matrices Enables Contractile Cells to Communicate Local Position and Orientation

(2009) Jessamine P. Winer et al.   PLoS One

Fibronectin forms the most extensible biological fibers displaying switchable force-exposed cryptic binding sites

(2009) E. Klotzsch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clustering of  5 1 integrins determines adhesion strength whereas  v 3 and talin enable mechanotransduction

(2009) P. Roca-Cusachs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stretching Single Talin Rod Molecules Activates Vinculin Binding

(2009) A. del Rio et al.   SCIENCE

Integrin Clustering Is Driven by Mechanical Resistance from the Glycocalyx and the Substrate

(2009) Matthew J. Paszek et al.   PLoS Computational Biology

Directing osteogenic and myogenic differentiation of MSCs: interplay of stiffness and adhesive ligand presentation

(2008) Andrew S. Rowlands et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Controlling integrin specificity and stem cell differentiation in 2D and 3D environments through regulation of fibronectin domain stability

(2008) Mikaël M. Martino et al.   BIOMATERIALS

Collagen density promotes mammary tumor initiation and progression

(2008) Paolo P Provenzano et al.   BMC Medicine

Dense collagen matrix accelerates osteogenic differentiation and rescues the apoptotic response to MMP inhibition

(2008) P.G. Buxton et al.   BONE

Tube Travel: The Role of Proteases in Individual and Collective Cancer Cell Invasion

(2008) P. Friedl et al.   CANCER RESEARCH

Asymmetric focal adhesion disassembly in motile cells

(2008) Joshua A Broussard et al.   CURRENT OPINION IN CELL BIOLOGY

Adsorbed fibrinogen regulates the behavior of human dendritic cells in a CD18-dependent manner

(2008) Robert I. Thacker et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

The role of matrix stiffness in regulating cell behavior

(2008) Rebecca G. Wells   HEPATOLOGY

Prognostic significance of MMP-9 and TIMP-1 serum and tissue expression in breast cancer

(2008) Zheng-Sheng Wu et al.   INTERNATIONAL JOURNAL OF CANCER

Traction stress in focal adhesions correlates biphasically with actin retrograde flow speed

(2008) Margaret L. Gardel et al.   JOURNAL OF CELL BIOLOGY

Paxillin comes of age

(2008) N. O. Deakin et al.   JOURNAL OF CELL SCIENCE

Small applied electric fields guide migration of hippocampal neurons

(2008) Li Yao et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Progress in matrix metalloproteinase research

(2008) G MURPHY et al.   MOLECULAR ASPECTS OF MEDICINE

Actin and α-actinin orchestrate the assembly and maturation of nascent adhesions in a myosin II motor-independent manner

(2008) Colin K. Choi et al.   NATURE CELL BIOLOGY

Talin depletion reveals independence of initial cell spreading from integrin activation and traction

(2008) Xian Zhang et al.   NATURE CELL BIOLOGY

Fibronectin Unfolding Revisited: Modeling Cell Traction-Mediated Unfolding of the Tenth Type-III Repeat

(2008) Elaine P. S. Gee et al.   PLoS One

Traction Dynamics of Filopodia on Compliant Substrates

(2008) C. E. Chan et al.   SCIENCE

Traction forces and rigidity sensing regulate cell functions

(2008) Marion Ghibaudo et al.   Soft Matter

An Essential Role for Fibronectin Extra Type III Domain A in Pulmonary Fibrosis

(2007) Andrés F. Muro et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE