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Biochemistry & Molecular Biology
Jonas Weisse, Julia Rosemann, Lisa Muller, Matthias Kappler, Alexander W. Eckert, Markus Glass, Danny Misiak, Stefan Huttelmaier, Wolfgang G. Ballhausen, Mechthild Hatzfeld, Monika Haemmerle, Tony Gutschner
Summary: Cancer metastasis is the main cause of mortality, with the identification of new therapeutic targets being crucial for survival improvement. Through the study of intratumoral heterogeneity, Lymphocyte cell-specific protein-tyrosine kinase (LCK) was discovered as a significant regulator of motility in oral cancer cells, suggesting that inhibition of LCK could be a promising anti-metastasis therapy option for oral cancer patients.
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Oncology
Md Faqrul Hasan, Kavya Ganapathy, Jiao Sun, Ayman Khatib, Thomas Andl, Julia N. Soulakova, Domenico Coppola, Wei Zhang, Ratna Chakrabarti
Summary: The long noncoding RNA PAINT plays a promotive role in prostate cancer progression, with its inhibition reducing cell proliferation and migration while improving drug sensitivity. This study establishes a novel oncogenic function of PAINT in prostate cancer, providing new insights for potential therapeutic strategies.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Review
Cell Biology
Naaziyah Abdulla, C. Theresa Vincent, Mandeep Kaur
Summary: This review explores the role of cholesterol in promoting multi-drug resistance in cancer, focusing on signaling pathways, epithelial-mesenchymal transition (EMT), and the influence of hypoxia on cellular cholesterol content. A proposed model delineates the crucial role of cholesterol in EMT and discusses the potential of targeting cholesterol as a novel means of combating drug resistance in cancer progression and metastasis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Yuan Li, Zhenning Wang, Jaffer A. Ajani, Shumei Song
Summary: Therapy resistance is a significant challenge in treating cancer patients, with intrinsic and acquired factors contributing to the development of resistance. CSCs play a key role in therapy resistance, as they are inherently resistant to anticancer treatments and can easily adapt to changes in the tumor microenvironment.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Multidisciplinary Sciences
Lena Wiedmann, Francesca De Angelis Rigotti, Nuria Vaquero-Siguero, Elisa Donato, Elisa Espinet, Iris Moll, Elisenda Alsina-Sanchis, Hanibal Bohnenberger, Elena Fernandez-Florido, Ronja Muelfarth, Margherita Vacca, Jennifer Gerwing, Lena-Christin Conradi, Philipp Stroebel, Andreas Trumpp, Carolin Mogler, Andreas Fischer, Juan Rodriguez-Vita
Summary: The presence of peritoneal metastasis in pancreatic cancers is associated with poor prognosis. The authors found that HAPLN1 promotes tumor cell plasticity and pro-tumoral immune microenvironment to facilitate peritoneal dissemination in pancreatic cancers.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Miwa Fujihara, Tadahiko Shien, Kazuhiko Shien, Ken Suzawa, Tatsuaki Takeda, Yidan Zhu, Tomoka Mamori, Yusuke Otani, Ryo Yoshioka, Maya Uno, Yoko Suzuki, Yuko Abe, Minami Hatono, Takahiro Tsukioki, Yuko Takahashi, Mariko Kochi, Takayuki Iwamoto, Naruto Taira, Hiroyoshi Doihara, Shinichi Toyooka
Summary: YES1 plays a significant role in resistance to T-DM1 after acquired resistance to trastuzumab, and continuous inhibition of YES1 is crucial for overcoming resistance to T-DM1.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Munmun Panda, Surya Kant Tripathi, Bijesh K. Biswal
Summary: SOX9 plays a critical role in cancer progression and drug resistance, with its regulation affected by factors such as miRNA, methylation, phosphorylation, and acetylation, showing proto-oncogenic or tumor suppressor gene characteristics. Its importance lies in regulating the tumor microenvironment, inducing epithelial-mesenchymal transition, influencing drug resistance, and potentially serving as a biomarker for tumor prognosis and progression.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Review
Environmental Sciences
Peng He, Qiang Dai, Xiaojun Wu
Summary: The high number of cancer-related deaths is mainly caused by metastasis, which refers to the formation of new tumor colonies in secondary sites. Epithelial-mesenchymal transition (EMT) is a common characteristic of malignant tumors and plays a crucial role in promoting invasion and metastasis. In urological tumors, EMT induction enhances the invasive and metastatic behaviors of tumor cells, leading to therapy resistance and patient death. Various modulators, such as lncRNAs, microRNAs, eIF5A2, Notch-4, and hypoxia, are involved in regulating the EMT mechanism in urological tumors.
ENVIRONMENTAL RESEARCH
(2023)
Article
Cell Biology
Xinyu Shao, Yibin Sun, Kaiqiang Zhong, Jinrong Gu, Yang Yu, Tong Hu, Xiaoyi Kuai, Yechen Xing
Summary: This study finds that TYRO3 is aberrantly increased in colorectal cancer tissues and is associated with prognosis. A prediction model for prognosis is constructed based on TYRO3 expression, indicating its crucial role. Knockdown of TYRO3 inhibits proliferation, migration, and drug resistance in CRC cells, which is confirmed by in vivo experiments. Furthermore, TYRO3 inhibits EMT by down-regulating ENO1, which provides a theoretical basis for TYRO3 in drug-resistance and highlights a new strategy for CRC-targeted therapy.
Review
Medicine, Research & Experimental
Mehrdad Hashemi, Hamid Zaferani Arani, Sima Orouei, Shayan Fallah, Amin Ghorbani, Maryam Khaledabadi, Amirabbas Kakavand, Alireza Tavakolpournegari, Hamidreza Saebfar, Hajar Heidari, Shokooh Salimimoghadam, Maliheh Entezari, Afshin Taheriazam, Kiavash Hushmandi
Summary: This article highlights the function of EMT in breast tumor malignancy and drug resistance. It discusses how EMT induction leads to increased migration, invasion, chemoresistance, and radioresistance of breast tumor cells. The reversal of EMT is crucial in preventing chemotherapy or radiotherapy failure and improving the survival time of breast cancer patients.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Salman Ul Islam, Muhammad Bilal Ahmed, Jong-Kyung Sonn, Eun-Jung Jin, Young-Sup Lee
Summary: PRP4 promotes pre-mRNA splicing and signal transduction. It induces drug resistance and EMT by binding to p53 and activating miR-210 and HIF-1α. Inhibition of PRP4 could benefit patients with colon cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Esther Arnaiz, Ana Miar, Esther Bridges, Naveen Prasad, Stephanie B. Hatch, Daniel Ebner, Charles H. Lawrie, Adrian L. Harris
Summary: In clear cell renal cell carcinoma, HIF2 alpha drives tumor growth and metastasis, leading to drug resistance. The study found that PT2385 can inhibit HIF2 alpha and reduce cell invasion, but does not affect cell proliferation or clonogenicity. Key differences between targeting a specific protein versus gene silencing were identified, potentially offering new drug targets.
Review
Oncology
Qianyang Ni, Meng Li, Suyang Yu
Summary: Colorectal cancer is a common malignancy that seriously affects human health. EMT, which is essential for cell metastasis and participates in various biological processes associated with CRC, plays a role in therapeutic resistance observed in some CRC patients.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2022)
Article
Cell Biology
Zhiyu Li, Chenyuan Li, Qi Wu, Yi Tu, Changhua Wang, Xin Yu, Bei Li, Zhong Wang, Si Sun, Shengrong Sun
Summary: MEDAG is highly expressed in breast cancer and is associated with poor survival in patients. It influences cell growth, invasion, and migration by regulating the AKT/AMPK/mTOR pathway. MEDAG functions as an oncogene in breast cancer.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Minghui Peng, Zhuifeng Zheng, Shaoyang Chen, Le Fang, Rongxiu Feng, Lijun Zhang, Qingnan Tang, Xuewen Liu
Summary: This study found that AE can enhance the sensitivity of PC9-GR cells to gefitinib and reverse EMT. AE achieves these effects by blocking the PI3K/Akt/TWIS1 signaling pathway.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemical Research Methods
Steffan Vartanian, Taylur P. Ma, James Lee, Peter M. Haverty, Donald S. Kirkpatrick, Kebing Yu, David Stokoe
MOLECULAR & CELLULAR PROTEOMICS
(2016)
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Biochemistry & Molecular Biology
M. Cristina de Almagro, Tatiana Goncharov, Anita Izrael-Tomasevic, Stefanie Duttler, Matthias Kist, Eugene Varfolomeev, Xiumin Wu, Wyne P. Lee, Jeremy Murray, Joshua D. Webster, Kebing Yu, Donald S. Kirkpatrick, Kim Newton, Domagoj Vucic
CELL DEATH AND DIFFERENTIATION
(2017)
Review
Biochemical Research Methods
Corey E. Bakalarski, Donald S. Kirkpatrick
MOLECULAR & CELLULAR PROTEOMICS
(2016)
Article
Biochemistry & Molecular Biology
Taner Dogan, Florian Gnad, Jocelyn Chan, Lilian Phu, Amy Young, Mark J. Chen, Sophia Doll, Matthew P. Stokes, Marcia Belvin, Lori S. Friedman, Donald S. Kirkpatrick, Klaus P. Hoeflich, Georgia Hatzivassiliou
JOURNAL OF BIOLOGICAL CHEMISTRY
(2017)
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Multidisciplinary Sciences
Zhen Zhang, Kim Newton, Sarah K. Kummerfeld, Joshua Webster, Donald S. Kirkpatrick, Lilian Phu, Jeffrey Eastham-Anderson, Jinfeng Liu, Wyne P. Lee, Jiansheng Wu, Hong Li, Melissa R. Junttila, Vishva M. Dixit
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
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Biology
Alexander M. Whiteley, Miguel A. Prado, Ivan Peng, Alexander R. Abbas, Benjamin Haley, Joao A. Paulo, Mike Reichelt, Anand Katakam, Meredith Sagolla, Zora Modrusan, Dong Yun Lee, Merone Roose-Girma, Donald S. Kirkpatrick, Brent S. McKenzie, Steven P. Gygi, Daniel Finley, Eric J. Brown
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Biochemistry & Molecular Biology
Tatiana Goncharov, Stefanie Hedayati, Melinda M. Mulvihill, Anita Izrael-Tomasevic, Kerry Zobel, Surinder Jeet, Anna V. Fedorova, Celine Eidenschenk, Jason deVoss, Kebing Yu, Andrey S. Shaw, Donald S. Kirkpatrick, Wayne J. Fairbrother, Kurt Deshayes, Domagoj Vucic
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Immunology
Mohammad Samie, Junghyun Lim, Erik Verschueren, Joshua M. Baughman, Ivan Peng, Aaron Wong, Youngsu Kwon, Yasin Senbabaoglu, Jason A. Hackney, Mary Keir, Brent Mckenzie, Donald S. Kirkpatrick, Menno van Lookeren Campagne, Aditya Murthy
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Multidisciplinary Sciences
Klaus Heger, Katherine E. Wickliffe, Ada Ndoja, Juan Zhang, Aditya Murthy, Debra L. Dugger, Allie Maltzman, Felipe de Sousa e Melo, Jeffrey Hung, Yi Zeng, Erik Verschueren, Donald S. Kirkpatrick, Domagoj Vucic, Wyne P. Lee, Merone Roose-Girma, Robert J. Newman, Soren Warming, Yi-Chun Hsiao, Laszlo G. Komuves, Joshua D. Webster, Kim Newton, Vishva M. Dixit
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Biochemistry & Molecular Biology
Kurt M. Reichermeier, Ronny Straube, Justin M. Reitsma, Michael J. Sweredoski, Christopher M. Rose, Annie Moradian, Willem den Besten, Trent Hinkle, Erik Verschueren, Georg Petzold, Nicolas H. Thomae, Ingrid E. Wertz, Raymond J. Deshaies, Donald S. Kirkpatrick
Review
Biotechnology & Applied Microbiology
Hanna G. Budayeva, Donald S. Kirkpatrick
NATURE REVIEWS DRUG DISCOVERY
(2020)
Article
Biochemistry & Molecular Biology
Annette M. Vogl, Lilian Phu, Raquel Becerra, Sebastian A. Giusti, Erik Verschueren, Trent B. Hinkle, Martin D. Bordenave, Max Adrian, Amy Heidersbach, Patricio Yankilevich, Fernando D. Stefani, Wolfgang Wurst, Casper C. Hoogenraad, Donald S. Kirkpatrick, Damian Refojo, Morgan Sheng
NATURE STRUCTURAL & MOLECULAR BIOLOGY
(2020)
Article
Multidisciplinary Sciences
Kelvin F. Cho, P. Taylur, Christopher M. Rose, Donald S. Kirkpatrick, Kebing Yu, Robert A. Blake
NATURE COMMUNICATIONS
(2020)
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Biochemistry & Molecular Biology
Lilian Phu, Christopher M. Rose, Joy S. Tea, Christopher E. Wall, Erik Verschueren, Tommy K. Cheung, Donald S. Kirkpatrick, Baris Bingol
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Biochemical Research Methods
Hanna G. Budayeva, Arundhati Sengupta-Ghosh, Lilian Phu, John G. Moffat, Gai Ayalon, Donald S. Kirkpatrick
Summary: This study compared the site-specific phosphorylation downstream of two muscle-specific receptor tyrosine kinase (MuSK) agonists and found that they elicited similar intracellular responses. The study also identified a new MuSK inhibitor and revealed phosphorylation of Rab GTPases downstream of receptor tyrosine kinase activation.
MOLECULAR & CELLULAR PROTEOMICS
(2022)