HSP90A inhibition promotes anti-tumor immunity by reversing multi-modal resistance and stem-like property of immune-refractory tumors

Uncoupling protein 2 reprograms the tumor microenvironment to support the anti-tumor immune cycle

(2019) Wan-Chen Cheng et al.   NATURE IMMUNOLOGY

The molecular logic of Nanog-induced self-renewal in mouse embryonic stem cells

(2019) Victor Heurtier et al.   Nature Communications

Targeting Cyclin D-CDK4/6 Sensitizes Immune-Refractory Cancer by Blocking the SCP3–NANOG Axis

(2018) Se Jin Oh et al.   CANCER RESEARCH

Interferon Gamma Messenger RNA Signature in Tumor Biopsies Predicts Outcomes in Patients with Non–Small Cell Lung Carcinoma or Urothelial Cancer Treated with Durvalumab

(2018) Brandon W. Higgs et al.   CLINICAL CANCER RESEARCH

Oncolytic Virotherapy Promotes Intratumoral T Cell Infiltration and Improves Anti-PD-1 Immunotherapy

(2018) Antoni Ribas et al.   CELL

Mitochondrial reprogramming via ATP5H loss promotes multimodal cancer therapy resistance

(2018) Kwon-Ho Song et al.   JOURNAL OF CLINICAL INVESTIGATION

TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells

(2018) Sanjeev Mariathasan et al.   NATURE

Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-γ and IL-12

(2018) Christopher S. Garris et al.   IMMUNITY

T-Cell–Inflamed Gene-Expression Profile, Programmed Death Ligand 1 Expression, and Tumor Mutational Burden Predict Efficacy in Patients Treated With Pembrolizumab Across 20 Cancers: KEYNOTE-028

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IFN-γ–related mRNA profile predicts clinical response to PD-1 blockade

(2017) Mark Ayers et al.   JOURNAL OF CLINICAL INVESTIGATION

Elements of cancer immunity and the cancer–immune set point

(2017) Daniel S. Chen et al.   NATURE

Rational combination of oncolytic vaccinia virus and PD-L1 blockade works synergistically to enhance therapeutic efficacy

(2017) Zuqiang Liu et al.   Nature Communications

API5 confers cancer stem cell-like properties through the FGF2-NANOG axis

(2017) K-H Song et al.   Oncogenesis

Induction of Hsp70 in tumor cells treated with inhibitors of the Hsp90 activity: A predictive marker and promising target for radiosensitization

(2017) Vladimir A. Kudryavtsev et al.   PLoS One

Immune escape to PD-L1/PD-1 blockade: seven steps to success (or failure)

(2016) J. M. Kim et al.   ANNALS OF ONCOLOGY

Loss of IFN-γ Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy

(2016) Jianjun Gao et al.   CELL

Expression of fibroblast growth factor receptor family members is associated with prognosis in early stage cervical cancer patients

(2016) Chel Hun Choi et al.   Journal of Translational Medicine

Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma

(2016) Jesse M. Zaretsky et al.   NEW ENGLAND JOURNAL OF MEDICINE

Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

(2016) Maxim V. Kuleshov et al.   NUCLEIC ACIDS RESEARCH

Melanoma Cell-Intrinsic PD-1 Receptor Functions Promote Tumor Growth

(2015) Sonja Kleffel et al.   CELL

Gain of HIF-1  under Normoxia in Cancer Mediates Immune Adaptation through the AKT/ERK and VEGFA Axes

(2015) Y.-H. Lee et al.   CLINICAL CANCER RESEARCH

Regulation and function of the human HSP90AA1 gene

(2015) Abbey D. Zuehlke et al.   GENE

Cancer immunotherapy: harnessing the immune system to battle cancer

(2015) Yiping Yang   JOURNAL OF CLINICAL INVESTIGATION

Transcription factor binding dynamics during human ES cell differentiation

(2015) Alexander M. Tsankov et al.   NATURE

Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity

(2015) Stefani Spranger et al.   NATURE

Loss of PTEN Promotes Resistance to T Cell-Mediated Immunotherapy

(2015) W. Peng et al.   Cancer Discovery

Targeting Heat-Shock Protein 90 (HSP90) as a Complementary Strategy to Immune Checkpoint Blockade for Cancer Therapy

(2015) D. A. Proia et al.   Cancer Immunology Research

Immune Cell-Poor Melanomas Benefit from PD-1 Blockade after Targeted Type I IFN Activation

(2014) T. Bald et al.   Cancer Discovery

Immune-mediated tumor evolution: Nanog links the emergence of a stem like cancer cell state and immune evasion

(2014) Chih-Ping Mao et al.   OncoImmunology

Oncology Meets Immunology: The Cancer-Immunity Cycle

(2013) Daniel S. Chen et al.   IMMUNITY

Cytotoxic T cells induce proliferation of chronic myeloid leukemia stem cells by secreting interferon-γ

(2013) Christian Schürch et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Complex Function of Hsp70 in Metastatic Cancer

(2013) Kata Juhasz et al.   Cancers

Cancer Vaccination Drives Nanog-Dependent Evolution of Tumor Cells toward an Immune-Resistant and Stem-like Phenotype

(2012) K. H. Noh et al.   CANCER RESEARCH

Esrrb Is a Direct Nanog Target Gene that Can Substitute for Nanog Function in Pluripotent Cells

(2012) Nicola Festuccia et al.   Cell Stem Cell

BRAF Inhibition Increases Tumor Infiltration by T cells and Enhances the Antitumor Activity of Adoptive Immunotherapy in Mice

(2012) C. Liu et al.   CLINICAL CANCER RESEARCH

Nanog signaling in cancer promotes stem-like phenotype and immune evasion

(2012) Kyung Hee Noh et al.   JOURNAL OF CLINICAL INVESTIGATION

Cancer Immunoediting: Integrating Immunity's Roles in Cancer Suppression and Promotion

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Pan-histone deacetylase inhibitor panobinostat depletes CXCR4 levels and signaling and exerts synergistic antimyeloid activity in combination with CXCR4 antagonists

(2010) A. Mandawat et al.   BLOOD

Monoclonal antibody 4C5 prevents activation of MMP2 and MMP9 by disrupting their interaction with extracellular HSP90 and inhibits formation of metastatic breast cancer cell deposits

(2010) Dimitris Stellas et al.   BMC CELL BIOLOGY

MapSplice: Accurate mapping of RNA-seq reads for splice junction discovery

(2010) Kai Wang et al.   NUCLEIC ACIDS RESEARCH

Uncovering Early Response of Gene Regulatory Networks in ESCs by Systematic Induction of Transcription Factors

(2009) Akira Nishiyama et al.   Cell Stem Cell

Identification of novel hub genes associated with liver metastasis of gastric cancer

(2009) Wenjun Chang et al.   INTERNATIONAL JOURNAL OF CANCER

ELDA: Extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays

(2009) Yifang Hu et al.   JOURNAL OF IMMUNOLOGICAL METHODS

The regulatory mechanism of Hsp90α secretion and its function in tumor malignancy

(2009) Xiaofeng Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Highly tumorigenic lung cancer CD133+ cells display stem-like features and are spared by cisplatin treatment

(2009) G. Bertolini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Structure ofClostridium perfringensNanI Sialidase and Its Catalytic Intermediates

(2008) Simon L. Newstead et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of Akt as a Mechanism for Tumor Immune Evasion

(2008) Kyung Hee Noh et al.   MOLECULAR THERAPY