Article
Oncology
Adriana de Souza Sergio Ferreira, Jane Rocha Duarte Cintra, Vivian Assis Fayer, Mario Cirio Nogueira, Cassimiro Baesso Junior, Maria Teresa Bustamante-Teixeira, Alfredo Chaoubah, Arthur Duarte Cintra, Caroline Montes Simao, Maximiliano Ribeiro Guerra
Summary: In a cancer care center in the Brazilian southeast region, the 5- and 10-year survival rates for breast cancer patients with private healthcare insurance were higher compared to those with public healthcare insurance. The survival rate disparities in breast cancer can be attributed to differences in the stage of the disease at the time of diagnosis, indicating inequalities in access to early detection of breast cancer.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Chi-Son Chang, Jung In Shim, Sun-Ju Byeon, Eun Jin Lee, Yoo-Young Lee, Tae-Joong Kim, Jeong-Won Lee, Byoung-Gie Kim, Chel Hun Choi
Summary: This study investigated the prognostic significance of HER3 expression in cervical cancer. Immunohistochemistry analysis revealed that HER3 protein expression was associated with poor survival in cervical cancer patients and could serve as an independent prognostic factor. This finding could provide insights for individualized management of cervical cancer patients.
Review
Obstetrics & Gynecology
Antonio Raffone, Antonio Travaglino, Diego Raimondo, Manuela Maletta, Valentino De Vivo, Umberto Visiello, Paolo Casadio, Renato Seracchioli, Fulvio Zullo, Luigi Insabato, Antonio Mollo
Summary: A systematic review and meta-analysis showed that compared to SC and CCC, UCS has a significantly worse prognosis with a 1.5-1.6-fold increased risk of death. This suggests the need for more aggressive treatment for UCS compared to SC and CCC. Further studies are necessary to define the prognostic impact of different molecular subgroups.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2022)
Article
Oncology
Ayumi Saito, Tadaaki Nishikawa, Hiroshi Yoshida, Chiharu Mizoguchi, Rui Kitadai, Kasumi Yamamoto, Shu Yazaki, Yuki Kojima, Mitsuya Ishikawa, Tomoyasu Kato, Kan Yonemori
Summary: This study investigated the expression and clinical significance of folate receptor alpha (FRα) in uterine carcinosarcoma (UCS) and ovarian carcinosarcoma (OCS). The results showed that FRα was universally expressed in all patients, but it was not significantly associated with clinicopathological features or prognosis. However, FRα-targeted therapies may have potential therapeutic effects for gynecologic carcinosarcoma.
GYNECOLOGIC ONCOLOGY
(2023)
Article
Oncology
Shiyu Cao, Xianzhen Liao, Kekui Xu, Haifan Xiao, Zhaohui Shi, Yanhua Zou, Can Li, Yingyun Hu, Shipeng Yan
Summary: This study aimed to establish tumor-size-stratified nomograms for predicting the overall survival of patients with uterine sarcoma. The study found that the significant prognostic factors differed between the two tumor size groups. The nomograms constructed and validated in this study could be useful for predicting the probability of survival for patients with uterine sarcoma.
Article
Oncology
Fang Zhang, Yali Wang, Hongjuan Li, Li Li, Xiaofeng Yang, Xiaoyan You, Lina Tang
Summary: Using various bioinformatic tools, we comprehensively analyzed the expression profile and prognostic value of LIFR, as well as its correlations with immune cell infiltration and clinicopathological parameters across different tumor types. Our results demonstrate that aberrant expression of LIFR is associated with prognosis, particularly in uterine corpus endometrial carcinoma. The expression level of LIFR is positively correlated with the abundance of cancer-associated fibroblasts and endothelial cells in the tumor microenvironment, and is strongly associated with the presence of immune modulators and checkpoint genes.
FRONTIERS IN ONCOLOGY
(2023)
Review
Oncology
Mayumi Kobayashi Kato, Yasuhito Tanase, Masaya Uno, Mitsuya Ishikawa, Tomoyasu Kato
Summary: This study investigated the clinical characteristics, diagnosis, treatment, and prognosis of brain metastases from uterine cervical carcinoma and uterine endometrial carcinoma. The findings highlight factors influencing treatment selection and prognosis, with specific high-risk factors and poor prognostic indicators identified for each type of carcinoma. Despite limited evidence, further research is needed to better understand brain metastases from uterine cancer.
Article
Oncology
Xiang Fan, Yifei Wang, Ni Yang, Pengfeng Zhu
Summary: This study aimed to analyze the prognostic factors in patients with stage IIIC1p cervical cancer treated by surgery. Through a retrospective analysis of clinical data from 102 patients who underwent surgical treatment, it was found that no postoperative adjuvant therapy, LNR > 0.3, and NLR > 3.8 were independent risk factors for poor prognosis in patients with stage IIIC1p cervical cancer.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Akiyo Takada, Hajime Yokota, Miho Watanabe Nemoto, Takuro Horikoshi, Koji Matsumoto, Yuji Habu, Hirokazu Usui, Katsuhiro Nasu, Makio Shozu, Takashi Uno
Summary: We investigated the predictive value of ADC histogram and texture parameters, as well as their change rates during concurrent chemoradiotherapy treatment of cervical cancer. We found that the change rate in ADC kurtosis between the first and second MRIs was the most reliable predictor of prognosis.
Article
Medicine, General & Internal
Justin Couetil, Ziyu Liu, Kun Huang, Jie Zhang, Ahmed K. K. Alomari
Summary: In this study, machine learning approaches were used to analyze melanoma histopathological images, resulting in a set of image features that can help clinicians identify high-risk-of-metastasis patients for increased clinical follow-up and precision treatment. The results show that survival and metastasis can be predicted using simple models and cell morphological features.
FRONTIERS IN MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Aleksandra Salagacka-Kubiak, Dawid Zawada, Lias Saed, Radzislaw Kordek, Agnieszka Jelen, Ewa Balcerczak
Summary: ABCG2 is a cell membrane pump encoded by the ABCG2 gene, which can protect cells against compounds initiating and/or intensifying neoplasia and is considered a marker of cancer stem cells. Its prognostic significance in colorectal cancer remains unclear. Using publicly available data, ABCG2 was shown to be underexpressed in colon and rectum adenocarcinomas, and this downregulation could result from the methylation level of some sites of the ABCG2 gene. However, no association was found between ABCG2 expression level and survival of colorectal cancer patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Ming-Wen Wang, Zhong Li, Li-Hong Chen, Ning Wang, Jian-Ming Hu, Jin Du, Li-Juan Pang, Yan Qi
Summary: Overexpression of PLK-1 in various malignant neoplasms is significantly associated with poor overall survival and disease-free survival. It is also linked with clinical parameters such as lymph node metastasis, tumor grade, and clinical stages.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Hui Sun, Xin Wang, Xiaoyan Zhang, Xu Wang, Cong Tan, Weiwei Weng, Meng Zhang, Shujuan Ni, Lei Wang, Dan Huang, Midie Xu, Weiqi Sheng
Summary: This study explored the expression and clinical relevance of CAF-associated markers EZH2 and FOXM1 in gastric samples. The results showed that EZH2 and FOXM1 expression were positively associated with CAFs abundance and correlated with clinicopathological parameters and prognosis.
Article
Medicine, General & Internal
Li-Na Wang, Ke-Jin Huang, Le Wang, Hai-Yan Cheng
Summary: This study found that UBQLN4 is overexpressed in cervical cancer and is associated with poor prognosis. This finding provides new insights into the pathogenesis of cervical cancer.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Article
Oncology
Youngji Kwak, Sung Yoon Jang, Joon Young Choi, Hyunjun Lee, Dong Seung Shin, Yeon Hee Park, Ji-Yeon Kim, Jin-Seok Ahn, Byung Joo Chae, Jonghan Yu, Jeong Eon Lee, Seok Won Kim, Seok Jin Nam, Jai Min Ryu
Summary: Although ER expression levels affect the prognosis of breast cancer, studies about PR expression levels are insufficient. This study found that low PR expression is associated with worse clinicopathologic features and increased risk of recurrence, metastasis, and death. Therefore, low PR may be a prognostic factor of ER-positive/HER2-negative YBC breast cancer.
Article
Cell Biology
Kyungeun Kim, Kris Ylaya, Candice Perry, Mi-Yeon Lee, Jeong Won Kim, Joon-Yong Chung, Stephen M. Hewitt
Summary: Water is a crucial factor for protein and RNA degradation in stored tissue sections, and storage conditions can affect the expression of certain key proteins and RNA integrity in breast tissue.
BIOPRESERVATION AND BIOBANKING
(2023)
Article
Surgery
Kapil K. Saharia, Sabrina C. Ramelli, Sydney R. Stein, Allison E. Roder, Allie Kreitman, Stephanie Banakis, Joon-Yong Chung, Peter D. Burbelo, Manmeet Singh, Robert M. Reed, Vipul Patel, Joseph Rabin, Alexander S. Krupnick, Jeffrey I. Cohen, Emmie de Wit, Elodie Ghedin, Stephen M. Hewitt, Kevin M. Vannella, Daniel S. Chertow, Alison Grazioli
Summary: Although the risk of SARS-CoV-2 transmission through lung transplantation from acutely infected donors is high, using lungs from COVID-19-recovered donors does not significantly increase the risks of virus transmission and long-term lung allograft outcomes.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Biochemistry & Molecular Biology
Jung-A Choi, Elizabeth Hyeji Lee, Hanbyoul Cho, Jae-Hoon Kim
Summary: This study found that high-dose sodium selenite (SS) can inhibit the proliferation and induce cell death of ovarian cancer cells through increased reactive oxygen species (ROS) generation. High-dose SS also reduced the levels of glutathione peroxidase (GPx) and triggered lipid peroxidation and ferroptosis via dysregulated GPx4 pathways. In mouse models, high-dose SS significantly reduced tumor growth and weight, and decreased GPx4 expression in tumors. Therefore, high-dose SS is considered a potential chemotherapeutic agent for ovarian cancer, utilizing ferroptotic therapy by depleting glutathione and increasing ROS generation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Joon-Yong Chung, Kyungeun Kim, Kris Ylaya, Katharine E. Walker-Bawa, Candice Perry, Robert A. Star, Stephen M. Hewitt
Summary: Neutral buffered formalin (NBF) is commonly used as a fixative in clinical applications, but it damages proteins and nucleic acids, limiting the quality of molecular analysis. Previous studies have shown that BE70, a fixative of buffered 70% ethanol, has advantages over NBF, but protein and nucleic acid degradation in archival paraffin blocks is still a challenge. With the addition of guanidinium salts, BE70G fixative improves the quality of molecular analysis, provides better protein and RNA quality at shorter fixation times, and reduces protein degradation in archival tissue blocks.
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
(2023)
Article
Oncology
Gwan Hee Han, Hee Yun, Joon-Yong Chung, Jae-Hoon Kim, Hanbyoul Cho
Summary: The study aimed to investigate the function, molecular mechanisms, and clinical significance of ATP6V1B1 in epithelial ovarian cancer (EOC). It was found that ATP6V1B1 was highly expressed in EOC tissues and was associated with clinicopathological features and prognosis. Knockdown of ATP6V1B1 inhibited cancer cell proliferation and colony-forming abilities. Therefore, ATP6V1B1 could serve as a biomarker for prognostic evaluation and chemotherapy resistance, as well as a potential therapeutic target in EOC.
Article
Multidisciplinary Sciences
Se Jin Oh, Ji Yeon Lim, Min Kyu Son, Jun Hyeok Ahn, Kwon-Ho Song, Hyo-Jung Lee, Suyeon Kim, Eun Ho Cho, Joon-Yong Chung, Hanbyoul Cho, Hyosun Kim, Jae-Hoon Kim, Jooyoung Park, Jungmin Choi, Sun Wook Hwang, Tae Woo Kim
Summary: The emergence of cisplatin resistance and side-effects are important factors in cancer treatment failure. The authors identify autophagy-mediated EGFR hyperactivation by TRPV1 promotion as a mechanism of cisplatin resistance and demonstrate the efficacy of a TRPV1 inhibitor to sensitize lung cancer to cisplatin. Future studies should provide evidence regarding the mechanisms of potential targets that can overcome the resistance as well as alleviate pain.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Soseul Sung, Youjin Hong, Byoung-Gie Kim, Ji-Yeob Choi, Jae Weon Kim, Sang-Yoon Park, Jae-Hoon Kim, Yong-man Kim, Jong-Min Lee, Tae Jin Kim, Sue K. K. Park
Summary: This study aimed to verify the association between ovarian cancer (OC) and reproductive- and lifestyle-related risk factors stratified by the subtype of OC. The results showed that smoking was positively associated with high-grade serous (HGS) OC, alcohol consumption was positively associated with mucinous type (MUC), and obesity was associated with clear cell type (CLC). Further, spontaneous abortion was negatively associated with CLC, while tubal ligation, hysterectomy, and oophorectomy were associated with decreased risk of HGS. Early menarche was strongly associated with increased risk of CLC. Additionally, childbirth, oral contraceptives, and hormone replacement therapy were negatively associated with OC.
Article
Oncology
Ha Kyun Chang, Young Hoon Park, Jung-A Choi, Jeong Won Kim, Jisup Kim, Hyo Sun Kim, Hae Nam Lee, Hanbyoul Cho, Joon-Yong Chung, Jae-Hoon Kim
Summary: The expression of Nectin-4 is significantly increased in endometrial cancer and can be used as a diagnostic marker. High Nectin-4 expression is associated with DNA mismatch repair protein deficiency and may predict short progression-free survival. This study provides clues for selecting patients for adjuvant therapy.
Article
Oncology
Ji-Won Ryu, Ha-Yeon Shin, Hyo-Sun Kim, Gwan Hee Han, Jeong Won Kim, Hae-Nam Lee, Hanbyoul Cho, Joon-Yong Chung, Jae-Hoon Kim
Summary: Hormonal factors, particularly steroid hormones, are believed to play a significant role in ovarian cancer development. The expression of glucocorticoid receptor (GR) has been associated with poor prognosis in epithelial ovarian cancer. This study investigates the clinical significance of beta-arrestin expression in ovarian cancer and the potential synergistic effect with GR as prognostic factors. The findings demonstrate a moderate correlation between beta-arrestin 1 and GR expression, suggesting a possible role in prognostication.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Razaul Haque, Jaebon Lee, Joon-Yong Chung, Ha-Yeon Shin, Hyosun Kim, Jae-Hoon Kim, Jae Won Yun, Eun-Suk Kang
Summary: This study suggests that VGLL3 is associated with tumor development and prognosis in patients with high-grade serous ovarian carcinoma, as well as with tumor-infiltrating macrophages. VGLL3 may serve as a potential prognostic marker and therapeutic target for ovarian cancer.
FRONTIERS IN ONCOLOGY
(2023)
Article
Medicine, Research & Experimental
Jordan M. White, Nicholas Ramos, Allen-Dexter Saliganan, Joon-Yong Chung, Meghan Bell, Jacob Lindquist, Kayla Conner, Wendy N. Wiesend, Michael Schopperle, Steve M. Patrick, Seongho Kim, Elisabeth I. Heath, Freddy E. Escorcia, Nerissa T. Viola
Summary: This study investigated the clinical implications of TRA expression in prostate cancer. It found that high PODXL copy number alterations were associated with poor prognosis. TRA-targeted PET imaging successfully located cancer stem cells (CSCs) and TRA-targeted RPT showed promising therapeutic effects. Ablation of TRA+ CSCs inhibited prostate cancer growth.
Article
Oncology
Takayuki Enomoto, Aikou Okamoto, Jae-Hoon Kim, Chyong-Huey Lai, Xiaohua Wu, Yong-Man Kim
Summary: There are racial and regional differences in gynecologic cancer, but most large-scale phase III studies have been conducted in Western countries, limiting data on Asians. To address this, four clinical trial groups in East Asia have established the East Asia Gynecologic Oncology Trial Group (EAGOT) to conduct international clinical trials and provide the best treatments for Asian women. EAGOT aims to establish standards of care and guidelines for gynecologic cancer in Asia.
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2023)
Article
Medical Laboratory Technology
Jaehyeok Jang, Yoonjung Kim, Jae-Hoon Kim, Sun-Mi Cho, Kyung-A Lee
Summary: This study comparatively evaluated the cost-effectiveness of several BRCA testing strategies in clinical practice in Korea and found that performing germline testing first, followed by somatic testing, may be a reasonable option.
ANNALS OF LABORATORY MEDICINE
(2023)
