期刊
ONCOIMMUNOLOGY
卷 3, 期 7, 页码 -出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/21624011.2014.947871
关键词
cytotoxic T lymphocytes; immune-resistant; immune surveillance; Nanog; stem-like phenotype
资金
- NIAID NIH HHS [T32 AI007247] Funding Source: Medline
- NIGMS NIH HHS [T32 GM007309] Funding Source: Medline
Tumor cells undergo molecular evolution under immune pressure. Using a murine metastatic lung cancer model, we recently reported that evolutionary pressure enforced through vaccination incites gain of Nanog, a master transcription factor that mediates both emergence of a stem-like cancer cell state and immune evasion. Thus, therapeutic strategies aiming to blunt NANOG's expression in patient tumors may improve the clinical management of cancer.
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