Multi-Omic Analyses Provide Links between Low-Dose Antibiotic Treatment and Induction of Secondary Metabolism in Burkholderia thailandensis

Cebulantin, a Cryptic Lanthipeptide Antibiotic Uncovered using Bioactivity-Coupled HiTES

(2019) Kyuho Moon et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bioactivity-HiTES Unveils Cryptic Antibiotics Encoded in Actinomycete Bacteria

(2019) Kyuho Moon et al.   ACS Chemical Biology

The Synthetic Phenotype of ΔbamB ΔbamE Double Mutants Results from a Lethal Jamming of the Bam Complex by the Lipoprotein RcsF

(2019) Elizabeth M. Hart et al.   mBio

Bayesian Confidence Intervals for Multiplexed Proteomics Integrate Ion-Statistics with Peptide Quantification Concordance

(2019) Leonid Peshkin et al.   MOLECULAR & CELLULAR PROTEOMICS

Accurate, Sensitive, and Precise Multiplexed Proteomics Using the Complement Reporter Ion Cluster

(2018) Matthew Sonnett et al.   ANALYTICAL CHEMISTRY

Cracking the regulatory code of biosynthetic gene clusters as a strategy for natural product discovery

(2018) Sébastien Rigali et al.   BIOCHEMICAL PHARMACOLOGY

Recent advances in activating silent biosynthetic gene clusters in bacteria

(2018) Dainan Mao et al.   CURRENT OPINION IN MICROBIOLOGY

Malleilactone Is a Burkholderia pseudomallei Virulence Factor Regulated by Antibiotics and Quorum Sensing

(2018) Jennifer R. Klaus et al.   JOURNAL OF BACTERIOLOGY

A genetics-free method for high-throughput discovery of cryptic microbial metabolites

(2018) Fei Xu et al.   Nature Chemical Biology

Discovery of a Cryptic Antifungal Compound from Streptomyces albus J1074 Using High-Throughput Elicitor Screens

(2017) Fei Xu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Progress in and promise of bacterial quorum sensing research

(2017) Marvin Whiteley et al.   NATURE

Discovery ofscmRas a global regulator of secondary metabolism and virulence inBurkholderia thailandensisE264

(2017) Dainan Mao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparative transcriptomics as a guide to natural product discovery and biosynthetic gene cluster functionality

(2017) Gregory C. A. Amos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mapping the Trimethoprim-Induced Secondary Metabolome of Burkholderia thailandensis

(2016) Bethany K. Okada et al.   ACS Chemical Biology

Natural Products as Sources of New Drugs from 1981 to 2014

(2016) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Nutrient-Sensing Mechanisms across Evolution

(2015) Lynne Chantranupong et al.   CELL

A Burkholderia thailandensis Acyl-Homoserine Lactone-Independent Orphan LuxR Homolog That Activates Production of the Cytotoxin Malleilactone

(2015) Thao T. Truong et al.   JOURNAL OF BACTERIOLOGY

eggNOG 4.5: a hierarchical orthology framework with improved functional annotations for eukaryotic, prokaryotic and viral sequences

(2015) Jaime Huerta-Cepas et al.   NUCLEIC ACIDS RESEARCH

Cross-Species Comparison of the Burkholderia pseudomallei, Burkholderia thailandensis, and Burkholderia mallei Quorum-Sensing Regulons

(2014) C. D. Majerczyk et al.   JOURNAL OF BACTERIOLOGY

Global Analysis of the Burkholderia thailandensis Quorum Sensing-Controlled Regulon

(2014) C. Majerczyk et al.   JOURNAL OF BACTERIOLOGY

Microbiological effects of sublethal levels of antibiotics

(2014) Dan I. Andersson et al.   NATURE REVIEWS MICROBIOLOGY

Gene and Protein Expression in Response to Different Growth Temperatures and Oxygen Availability in Burkholderia thailandensis

(2014) Clelia Peano et al.   PLoS One

High-throughput platform for the discovery of elicitors of silent bacterial gene clusters

(2014) M. R. Seyedsayamdost   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of the Burkholderia thailandensis SOS Response by Using Whole-Transcriptome Shotgun Sequencing

(2013) Ricky L. Ulrich et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Genome-guided discovery of diverse natural products from Burkholderia sp.

(2013) Xiangyang Liu et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Competition sensing: the social side of bacterial stress responses

(2013) Daniel M. Cornforth et al.   NATURE REVIEWS MICROBIOLOGY

Sequence-Defined Transposon Mutant Library of Burkholderia thailandensis

(2013) L. A. Gallagher et al.   mBio

Genomics-Driven Discovery of Burkholderic Acid, a Noncanonical, Cryptic Polyketide from Human PathogenicBurkholderiaSpecies

(2012) Jakob Franke et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Sizing up metatranscriptomics

(2012) Mary Ann Moran et al.   ISME Journal

Malleilactone, a Polyketide Synthase-Derived Virulence Factor Encoded by the Cryptic Secondary Metabolome of Burkholderia pseudomallei Group Pathogens

(2012) John B. Biggins et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The association of DNA damage response and nucleotide level modulation with the antibacterial mechanism of the anti-folate drug Trimethoprim

(2011) Dipen P Sangurdekar et al.   BMC GENOMICS

Antibiotics as Signal Molecules

(2011) Diego Romero et al.   CHEMICAL REVIEWS

Sources of Diversity in Bactobolin Biosynthesis byBurkholderia thailandensisE264

(2011) Gavin Carr et al.   ORGANIC LETTERS

Antifolate-Induced Depletion of Intracellular Glycine and Purines Inhibits Thymineless Death inE. coli

(2010) Yun Kyung Kwon et al.   ACS Chemical Biology

Metabolomic Analysis and Visualization Engine for LC−MS Data

(2010) Eugene Melamud et al.   ANALYTICAL CHEMISTRY

Metabolomic Analysis via Reversed-Phase Ion-Pairing Liquid Chromatography Coupled to a Stand Alone Orbitrap Mass Spectrometer

(2010) Wenyun Lu et al.   ANALYTICAL CHEMISTRY

Molecular Insights intoBurkholderia pseudomalleiandBurkholderia malleiPathogenesis

(2010) Edouard E. Galyov et al.   Annual Review of Microbiology

How antibiotics kill bacteria: from targets to networks

(2010) Michael A. Kohanski et al.   NATURE REVIEWS MICROBIOLOGY

Quorum-Sensing-Regulated Bactobolin Production byBurkholderia thailandensisE264

(2010) Mohammad R. Seyedsayamdost et al.   ORGANIC LETTERS

Quorum-Sensing Control of Antibiotic Synthesis in Burkholderia thailandensis

(2009) B. A. Duerkop et al.   JOURNAL OF BACTERIOLOGY

Genomic basis for natural product biosynthetic diversity in the actinomycetes

(2009) Markus Nett et al.   NATURAL PRODUCT REPORTS

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

(p)ppGpp: Still Magical?

(2008) Katarzyna Potrykus et al.   Annual Review of Microbiology

Targeted Mutagenesis of Burkholderia thailandensis and Burkholderia pseudomallei through Natural Transformation of PCR Fragments

(2008) M. Thongdee et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Antibiotics as signals that trigger specific bacterial responses

(2008) Alicia Fajardo et al.   CURRENT OPINION IN MICROBIOLOGY

Burkholderia pseudomallei, B. thailandensis, and B. ambifaria Produce 4-Hydroxy-2-Alkylquinoline Analogues with a Methyl Group at the 3 Position That Is Required for Quorum-Sensing Regulation

(2008) L. Vial et al.   JOURNAL OF BACTERIOLOGY

Isolation and Structural Characterization of Capistruin, a Lasso Peptide Predicted from the Genome Sequence of Burkholderia thailandensis E264

(2008) Thomas A. Knappe et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Exploiting the mosaic structure of trans-acyltransferase polyketide synthases for natural product discovery and pathway dissection

(2008) TuAnh Nguyen et al.   NATURE BIOTECHNOLOGY

A domino effect in antifolate drug action in Escherichia coli

(2008) Yun Kyung Kwon et al.   Nature Chemical Biology