Article
Food Science & Technology
Xiangsheng Zhang, Huan Kan, Yun Liu, Wu Ding
Summary: Plumbagin shows potential medicinal properties, including anticancer activities. It inhibits cell proliferation, blocks cell cycle, induces apoptosis and autophagy in endometrial cancer cells. The anticancer effects of PLB may be mediated by abrogating the PI3K/Akt pathway.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Food Science & Technology
Xiang Gao, Yuhuan Jiang, Qi Xu, Feng Liu, Xuening Pang, Mingji Wang, Qun Li, Zichao Li
Summary: The natural flavonoid compound 4-hydroxyderricin (4-HD) derived from Angelica keiskei shows significant inhibitory effects on hepatocellular carcinoma (HCC) cells, by promoting apoptosis and cell cycle arrest through the PI3K/AKT/mTOR signaling pathway.
Article
Biochemistry & Molecular Biology
Xueyuan Zhang, Naiyi Zou, Wenzhao Deng, Chunyang Song, Ke Yan, Wenbin Shen, Shuchai Zhu
Summary: This study found that down-regulation of HMGB1 can promote the radiosensitivity of esophageal cancer cells through regulating the PI3K/Akt/ATM pathway, leading to improved prognosis for patients.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Oncology
Shailima Rampogu, Seong Min Kim, Baji Shaik, Gihwan Lee, Ju Hyun Kim, Gon Sup Kim, Keun Woo Lee, Myeong Ok Kim
Summary: The study successfully designed and synthesized three compounds, showing anticancer properties in breast cancer cell lines.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Chunyu Hou, Yunjia Lei, Na Li, Mingjun Wei, Shujun Wang, Saeed Ur Rahman, Chunling Bao, Bin Bao, Jeevithan Elango, Wenhui Wu
Summary: This study characterized and modified collagens from marine sources and investigated their molecular signaling pathways in L-929 fibroblast cells. The results showed that these modified collagens can promote cell proliferation and inhibit apoptosis. This study revealed the significant role of these modified collagens in promoting cell proliferation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pharmacology & Pharmacy
Jian Chen, Xian Lin, Kangdi Liu, Juan He, Xin Li, Chuchu Zhang, Yongxing Deng, Lianxiang Luo, Cheng Tao, Qingwen Wang
Summary: This study demonstrated that a novel compound CT2-3 inhibits the abnormal functions of RA-fibroblastlike synoviocytes (RA-FLSs) by inducing cell cycle arrest and apoptosis through modulating the PI3K/AKT pathway, offering a potential lead compound for the development of novel anti-RA drugs.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ying Zhang, Shan Li, Xiangguo Cui, Yiliang Wang
Summary: This study explored the molecular mechanism of miR-944 mediated SPP1 in breast cancer progression and its regulatory effect on the PI3K/Akt pathway. The expression of miR-944 was decreased while that of SPP1 was increased in breast cancer tissues and cells. miR-944 negatively regulated the expression of SPP1 and inhibited breast cancer cell proliferation by blocking the PI3K/Akt pathway.
Article
Oncology
Xiaochun Qin, Mingyue Liu, Chang Xu, Bo Xing, Xiangbo Xu, Yuting Wu, Huaiwei Ding, Qingchun Zhao
Summary: The study found that ZDQ-0620 inhibits the proliferation, migration, and invasion of CRC cells by targeting the PI3K/AKT pathway. It induces apoptosis in CRC cells by causing cell cycle arrest and activating the mitochondrial pathway. Additionally, ZDQ-0620 inhibits angiogenesis. These findings suggest that ZDQ-0620 has potential as an effective treatment candidate against CRC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Hao Wang, Zhinan Liu, Zhuo Sun, Dong Zhou, Hanyan Mao, Guohua Deng
Summary: In retinoblastoma, USP33 is upregulated and its downregulation leads to increased cell apoptosis, enhanced G1 phase arrest, and decreased tumorigenesis. Through modulation of the SP1/PI3K/AKT pathway, USP33 promotes the progression of retinoblastoma.
Article
Cell Biology
Hong-Zhu Yan, Hua-Feng Wang, Yueling Yin, Jue Zou, Feng Xiao, Li-Na Yi, Ying He, Bo-Sheng He
Summary: The study found that GHR regulates the growth and apoptosis of gastric cancer cells by mediating the G1 cell cycle progression via the PI3K/AKT signaling pathway.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Multidisciplinary Sciences
Shijie Wei, Yubao Zhang, Xiaoran Ma, Yan Yao, Qinqin Zhou, Wenfeng Zhang, Chao Zhou, Jing Zhuang
Summary: This study reveals that matrine, an alkaloid from the medicinal plant Sophora flavescens, has strong anticancer effects and can be explored as a new therapeutic agent for triple-negative breast cancer (TNBC). Through bioinformatics analysis and network pharmacology, researchers found that matrine inhibits the PI3K/AKT pathway, suppresses cell proliferation and invasion, induces apoptosis and autophagy, effectively inhibiting the growth and spread of TNBC.
SCIENTIFIC REPORTS
(2023)
Article
Cell Biology
Nan Tang, Kai Zhu, Cheng Jiang, Zhiyong Xiong, Qiangping Wang, Junjun Li, Weiming Xu
Summary: This study revealed the important role of RNF7 in the development of glioma. It was found that RNF7 promotes cell proliferation and inhibits apoptosis through activating the PI3K/AKT signaling pathway. Targeting the RNF7/PI3K/AKT axis may provide a new perspective on the prevention or treatment of glioma.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Oncology
Lingying Zhang, Chengyu Li, Marhaba Aziz, Rongxin Zhu, Zeyidan Jiapaer
Summary: ITF2357, an HDAC inhibitor, has been shown to inhibit proliferation and colonization ability, induce apoptosis and cell cycle arrest in meningioma cells. Mechanistically, ITF2357 affects the PI3K-Akt signaling pathway and cell cycle progression.
Article
Biochemistry & Molecular Biology
Wenyue Zhang, Kai Yin, Jiahui Shi, Xu Shi, Xue Qi, Hongjin Lin
Summary: The study found that Selenoprotein K (SELK) is crucial for the normal development of chickens, regulating various physiological functions. The deficiency of SELK in chicken liver led to apoptosis and differential expression of the PTEN/PI3K/AKT pathway, calcium homeostasis, endoplasmic reticulum health, and cell cycle progression. The study also showed that adding selenium to the diet can alleviate the deficiency.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Oncology
Xi Yu, Shenglan Li, Mingrui Pang, Yang Du, Tao Xu, Tao Bai, Kang Yang, Juncheng Hu, Shaoming Zhu, Lei Wang, Xiuheng Liu
Summary: This study revealed that downregulation of TSPAN7 in bladder cancer is associated with tumor progression and poor prognosis, and demonstrated the inhibitory effects of TSPAN7 on cancer cell proliferation and migration through multiple experiments. TSPAN7 inhibits bladder cancer cell growth by activating Bax, cleaved caspase-3, and PTEN pathways.
FRONTIERS IN ONCOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Mengliang Ye, Chunhui Zhang, Lingyu Zhu, Wei Jia, Qingshan Shen
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2020)
Article
Microbiology
Miao Chen, Bei Fan, Shujun Liu, Khandaker Md Sharif Uddin Imam, Yingying Xie, Boting Wen, Fengjiao Xin
FRONTIERS IN MICROBIOLOGY
(2020)
Article
Environmental Sciences
Mengliang Ye, Wei Jia, Chunhui Zhang, Si Mi, Qingshan Shen, Xiaojie Qin, Lingyu Zhu, Lisha Wang
Summary: This study focused on valorizing yak bone biowastes to functional ingredients with osteogenic activity, providing a feasible strategy for resource utilization and sustainable development in the Qinghai-Tibetan Plateau animal husbandry industry.
WASTE AND BIOMASS VALORIZATION
(2021)
Article
Microbiology
Miao Chen, Shujun Liu, Khandaker Md. Sharif Uddin Imam, Lichao Sun, Yulu Wang, Tianyi Gu, Boting Wen, Fengjiao Xin
FRONTIERS IN MICROBIOLOGY
(2020)
Article
Food Science & Technology
Xiaojie Qin, Qingshan Shen, Yujie Guo, Xia Li, Jiqian Liu, Mengliang Ye, Hang Wang, Wei Jia, Chunhui Zhang
Summary: The study showed that smaller particle sizes of YBP significantly increased water holding capacity and protein solubility, promoting protein digestion. However, different particle sizes had a weak effect on the anti-osteoporosis activity of YBP.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Haowen Zhang, Boting Wen, Yusi Liu, Guoming Du, Xue Wei, Khandaker Md Sharif Uddin Imam, Huan Zhou, Shilong Fan, Fengzhong Wang, Yulu Wang, Fengjiao Xin
Summary: This study revealed the high activity substrate and crystal structure of LP_0796, demonstrating the importance of certain key residues to its catalytic activity, while also identifying mutation sites that can enhance catalytic efficiency.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Food Science & Technology
Mengliang Ye, Chuanjing An, Hong Liu, Lijing Zheng
Summary: The study found that combined ultrasonic and formic acid pretreatment of yak bone collagen was the optimal condition for extracting osteogenic activity peptides, which could significantly accelerate peptide release, improve secondary structure, microstructure, and soluble peptide content.
FOOD AND BIOPROCESS TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Khandaker Md Sharif Uddin Imam, Yu Tian, Fengjiao Xin, Yingying Xie, Boting Wen
Summary: Lactucin inhibits the proliferation of lung adenocarcinoma cells and induces apoptosis. It regulates multiple proteins and pathways to limit cancer cell growth.
Article
Immunology
Marianne Burbage, Ares Rocarn-Arjo, Blandine Baudon, Yago A. Arribas, Antonela Merlotti, Derek C. Rookhuizen, Sandrine Heurtebise-Chretien, Mengliang Ye, Alexandre Houy, Nina Burgdorf, Guadalupe Suarez, Marine Gros, Benjamin Sadacca, Montserrat Carrascal, Andrea Garmilla, Mylene Bohec, Sylvain Baulande, Berangere Lombard, Damarys Loew, Joshua J. Waterfall, Marc-Henri Stern, Christel Goudot, Sebastian Amigorena
Summary: The noncanonical splice junctions between exons and transposable elements (TEs) have been identified as a source of tumor-specific antigens, and immunization with peptides derived from these junctions can delay tumor growth in mice. Inactivation of TE-silencing genes can result in overexpression of immunogenic junctions.
SCIENCE IMMUNOLOGY
(2023)
Article
Nutrition & Dietetics
Xiaobing Xian, Chunyuan Wang, Rong Yu, Mengliang Ye
Summary: This article explored the relationship between breakfast frequency and sleep quality, finding that sleep chronotypes and depressive symptoms mediate this relationship. Regular breakfast can improve sleep quality through adjusting sleep chronotypes and reducing depressive symptoms.
Article
Food Science & Technology
Khandaker Md Sharif Uddin Imam, Yingying Xie, Yusi Liu, Fengzhong Wang, Fengjiao Xin
Summary: Lentinula edodes, commonly known as shiitake mushroom, is a popular edible mushroom species with various medicinal values such as immunomodulatory, antioxidant, and anticancer properties. Research has shown that the aqueous extract of L. edodes contains potential anticancer metabolites, including indole-3-lactic acid, which may have prospective use in cancer treatment.
ACS FOOD SCIENCE & TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mengliang Ye, Chunhui Zhang, Wei Jia, Qingshan Shen, Xiaojie Qin, Hongru Zhang, Lingyu Zhu
Article
Nutrition & Dietetics
Mengliang Ye, Si Mi, Chunhui Zhang, Jianying Yue, Wei Jia, Simonetti German
CURRENT TOPICS IN NUTRACEUTICAL RESEARCH
(2020)