4-Hydroxyderricin Promotes Apoptosis and Cell Cycle Arrest through Regulating PI3K/AKT/mTOR Pathway in Hepatocellular Cells

Autophagy: Mechanisms and Therapeutic Potential of Flavonoids in Cancer

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Naturally occurring aesculetin coumarin exerts antiproliferative effects in gastric cancer cells mediated via apoptotic cell death, cell cycle arrest and targeting PI3K/AKT/M-TOR signalling pathway

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Xanthoangelol modulates Caspase-1-dependent pyroptotic death among hepatocellular carcinoma cells with high expression of GSDMD

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ACTR confers to Sorafenib resistance in hepatocellular carcinoma via facilitating the Warburg effect

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The PI3K-Akt-mTOR Signaling Pathway in Human Acute Myeloid Leukemia (AML) Cells

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A steroidal saponin isolated from Allium chinense simultaneously induces apoptosis and autophagy by modulating the PI3K/Akt/mTOR signaling pathway in human gastric adenocarcinoma

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Carvacrol Promotes Cell Cycle Arrest and Apoptosis through PI3K/AKT Signaling Pathway in MCF-7 Breast Cancer Cells

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The PI3K-AKT-mTOR Pathway and Prostate Cancer: At the Crossroads of AR, MAPK, and WNT Signaling

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Lycopene Inhibits Epithelial–Mesenchymal Transition and Promotes Apoptosis in Oral Cancer via PI3K/AKT/m-TOR Signal Pathway

(2020) Ran Wang et al.   Drug Design Development and Therapy

A small library of chalcones induce liver cancer cell death through Akt phosphorylation inhibition

(2020) Irem Durmaz Sahin et al.   Scientific Reports

Nobiletin selectively inhibits oral cancer cell growth by promoting apoptosis and DNA damage in vitro

(2020) Junjun Yang et al.   Oral Surgery Oral Medicine Oral Pathology Oral Radiology

Puerarin 6″‐O‐xyloside suppressed HCC via regulating proliferation, stemness, and apoptosis with inhibited PI3K/AKT/mTOR

(2020) Long Li et al.   Cancer Medicine

Tambulin Targets Histone Deacetylase 1 Inhibiting Cell Growth and Inducing Apoptosis in Human Lung Squamous Cell Carcinoma

(2020) Wuming Wang et al.   Frontiers in Pharmacology

Resveratrol, curcumin, paclitaxel and miRNAs mediated regulation of PI3K/Akt/mTOR pathway: go four better to treat bladder cancer

(2020) Khushbukhat Khan et al.   Cancer Cell International

PI3K/AKT/mTOR Signaling Pathway in Breast Cancer: From Molecular Landscape to Clinical Aspects

(2020) Daniela Miricescu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Fabrication of Pickering emulsion based on particles combining pectin and zein: Effects of pectin methylation

(2020) Wei Zhang et al.   CARBOHYDRATE POLYMERS

Unfavorable Associations Between Serum Trimethylamine N-Oxide and L-Carnitine Levels With Components of Metabolic Syndrome in the Newfoundland Population

(2019) Xiang Gao et al.   Frontiers in Endocrinology

2′,4′-Dihydroxy-6′-methoxy-3′,5′-dimethylchalcone induced apoptosis and G1 cell cycle arrest through PI3K/AKT pathway in BEL-7402/5-FU cells

(2019) Xiang Ji et al.   FOOD AND CHEMICAL TOXICOLOGY

Mechanism of Juglone-Induced Cell Cycle Arrest and Apoptosis in Ishikawa Human Endometrial Cancer Cells

(2019) Yuan-Yuan Zhang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Formulation of injectable glycyrrhizic acid-hydroxycamptothecin micelles as new generation of DNA topoisomerase I inhibitor for enhanced antitumor activity

(2019) Jieying Cai et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Simultaneous Optimization of Ultrasound-Assisted Extraction for Flavonoids and Antioxidant Activity of Angelica keiskei Using Response Surface Methodology (RSM)

(2019) Lei Zhang et al.   MOLECULES

Antifibrotic action of Yifei Sanjie formula enhanced autophagy via PI3K-AKT-mTOR signaling pathway in mouse model of pulmonary fibrosis

(2019) Jing-Ze Yu et al.   BIOMEDICINE & PHARMACOTHERAPY

Predictive and Prognostic Factors in HCC Patients Treated with Sorafenib

(2019) Oronzo Brunetti et al.   Medicina-Lithuania

A Chalcone from Ashitaba (Angelica keiskei) Stimulates Myoblast Differentiation and Inhibits Dexamethasone-Induced Muscle Atrophy

(2019) Minson Kweon et al.   Nutrients

Inhibitory Effects of Osthole on Human Breast Cancer Cell Progression via Induction of Cell Cycle Arrest, Mitochondrial Dysfunction, and ER Stress

(2019) Wonhyoung Park et al.   Nutrients

Lanatoside C Induces G2/M Cell Cycle Arrest and Suppresses Cancer Cell Growth by Attenuating MAPK, Wnt, JAK-STAT, and PI3K/AKT/mTOR Signaling Pathways

(2019) Dhanasekhar Reddy et al.   Biomolecules

The Ashitaba (Angelica keiskei) chalcones 4-hydroxyderricin and xanthoangelol suppress melanomagenesis by targeting BRAF and PI3-K

(2018) Tianshun Zhang et al.   Cancer Prevention Research

Molecular mechanism and inhibitory targets of dioscin in HepG2 cells

(2018) Ying-Shuo Zhang et al.   FOOD AND CHEMICAL TOXICOLOGY

Isolation, purification and the anti-hypertensive effect of a novel angiotensin I-converting enzyme (ACE) inhibitory peptide from Ruditapes philippinarum fermented with Bacillus natto

(2018) Yingyun Chen et al.   Food & Function

Natural product pectolinarigenin inhibits proliferation, induces apoptosis, and causes G2/M phase arrest of HCC via PI3K/AKT/mTOR/ERK signaling pathway

(2018) Tianchun Wu et al.   OncoTargets and Therapy

Anticancer effects of 10-hydroxycamptothecin induce apoptosis of human osteosarcoma through activating caspase-3, p53 and cytochrome�c pathways

(2017) Xiong Min et al.   Oncology Letters

Release of Cytochrome C from Bax Pores at the Mitochondrial Membrane

(2017) Mingzhen Zhang et al.   Scientific Reports

Epidemiology of hepatocellular carcinoma: target population for surveillance and diagnosis

(2017) An Tang et al.   Abdominal Radiology

4-Hydroxyderricin, as a PPARγ Agonist, Promotes Adipogenesis, Adiponectin Secretion, and Glucose Uptake in 3T3-L1 Cells

(2016) Yongjia Li et al.   LIPIDS

Xanthoangelol and 4-hydroxyderrcin suppress obesity-induced inflammatory responses

(2016) Yongjia Li et al.   Obesity

Juglanthraquinone C Induces Intracellular ROS Increase and Apoptosis by Activating the Akt/Foxo Signal Pathway in HCC Cells

(2016) Ya-Qin Hou et al.   Oxidative Medicine and Cellular Longevity

The Cell-Cycle Arrest and Apoptotic Functions of p53 in Tumor Initiation and Progression

(2016) Jiandong Chen   Cold Spring Harbor Perspectives in Medicine

The history and future of targeting cyclin-dependent kinases in cancer therapy

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Antitumor and antimetastatic actions of xanthoangelol and 4-hydroxyderricin isolated from Angelica keiskei roots through the inhibited activation and differentiation of M2 macrophages

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pRb/E2F-1-mediated caspase-dependent induction of Noxa amplifies the apoptotic effects of the Bcl-2/Bcl-xL inhibitor ABT-737

(2013) J Bertin-Ciftci et al.   CELL DEATH AND DIFFERENTIATION

4-Hydroxyderricin and xanthoangelol from Ashitaba (Angelica keiskei) suppress differentiation of preadiopocytes to adipocytes via AMPK and MAPK pathways

(2013) Tianshun Zhang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Ganoderic acid DM, a natural triterpenoid, induces DNA damage, G1 cell cycle arrest and apoptosis in human breast cancer cells

(2011) Guo-Sheng Wu et al.   FITOTERAPIA

4-Hydroxyderricin from Angelica keiskei Roots Induces Caspase-dependent Apoptotic Cell Death in HL60 Human Leukemia Cells

(2011) Toshihiro Akihisa et al.   Journal of Oleo Science

Modulation of anti-apoptotic and survival pathways by curcumin as a strategy to induce apoptosis in cancer cells

(2008) Simone Reuter et al.   BIOCHEMICAL PHARMACOLOGY