The Antidepressant Desipramine Is an Arrestin-biased Ligand at the α2A-Adrenergic Receptor Driving Receptor Down-regulationin Vitroandin Vivo

Linking Molecules to Mood: New Insight Into the Biology of Depression

(2010) Vaishnav Krishnan et al.   AMERICAN JOURNAL OF PSYCHIATRY

 2-Adrenoceptor Blockade Accelerates the Neurogenic, Neurotrophic, and Behavioral Effects of Chronic Antidepressant Treatment

(2010) S. U. Yanpallewar et al.   JOURNAL OF NEUROSCIENCE

Enhanced Hypotensive, Bradycardic, and Hypnotic Responses to  2-Adrenergic Agonists in Spinophilin-Null Mice Are Accompanied by Increased G Protein Coupling to the  2A-Adrenergic Receptor

(2010) R. Lu et al.   MOLECULAR PHARMACOLOGY

Teaching old receptors new tricks: biasing seven-transmembrane receptors

(2010) Sudarshan Rajagopal et al.   NATURE REVIEWS DRUG DISCOVERY

Epitope-tagged Receptor Knock-in Mice Reveal That Differential Desensitization of α2-Adrenergic Responses Is because of Ligand-selective Internalization

(2009) Roujian Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic Dissection of  2-Adrenoceptor Functions in Adrenergic versus Nonadrenergic Cells

(2009) R. Gilsbach et al.   MOLECULAR PHARMACOLOGY

α2A-adrenergic receptors heterosynaptically regulate glutamatergic transmission in the bed nucleus of the stria terminalis

(2009) A.D. Shields et al.   NEUROSCIENCE

Protein Kinase A Phosphorylation of Spinophilin Modulates Its Interaction with the α2A-Adrenergic Receptor (AR) and Alters Temporal Properties of α2AAR Internalization

(2008) Jianmin Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The molecular neurobiology of depression

(2008) Vaishnav Krishnan et al.   NATURE

Major Depressive Disorder

(2008) R.H. Belmaker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Selective Publication of Antidepressant Trials and Its Influence on Apparent Efficacy

(2008) Erick H. Turner et al.   NEW ENGLAND JOURNAL OF MEDICINE

Regulation of GPCRs by Endocytic Membrane Trafficking and Its Potential Implications

(2007) Aylin C. Hanyaloglu et al.   Annual Review of Pharmacology and Toxicology