A surface proton antenna in carbonic anhydrase II supports lactate transport in cancer cells

Reduction of epileptiform activity in ketogenic mice: The role of monocarboxylate transporters

(2017) Linda S. Forero-Quintero et al.   Scientific Reports

Integration of a ‘proton antenna’ facilitates transport activity of the monocarboxylate transporter MCT4

(2016) Sina Ibne Noor et al.   FEBS Journal

Carbonic Anhydrase II Mediates Malignant Behavior of Pulmonary Neuroendocrine Tumors

(2015) Yuanxiang Zhou et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Inhibition of monocarboxylate transporter by N-cyanosulphonamide S0859

(2015) Hella Heidtmann et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Analysis of the Binding Moiety Mediating the Interaction between Monocarboxylate Transporters and Carbonic Anhydrase II

(2015) Sina Ibne Noor et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxia-induced carbonic anhydrase IX as a target for cancer therapy: From biology to clinical use

(2015) Jaromir Pastorek et al.   SEMINARS IN CANCER BIOLOGY

Hypoxia-induced carbonic anhydrase IX facilitates lactate flux in human breast cancer cells by non-catalytic function

(2015) Somayeh Jamali et al.   Scientific Reports

Intracellular and Extracellular Carbonic Anhydrases Cooperate Non-enzymatically to Enhance Activity of Monocarboxylate Transporters

(2013) Michael Klier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activity and distribution of intracellular carbonic anhydrase II and their effects on the transport activity of anion exchanger AE1/SLC4A1

(2013) Samer Al-Samir et al.   JOURNAL OF PHYSIOLOGY-LONDON

A Genetically Encoded FRET Lactate Sensor and Its Use To Detect the Warburg Effect in Single Cancer Cells

(2013) Alejandro San Martín et al.   PLoS One

Transport metabolons with carbonic anhydrases

(2013) Joachim W. Deitmer et al.   Frontiers in Physiology

Membrane transport metabolons

(2012) Trevor F. Moraes et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Reduction of CAII expression in gastric cancer: Correlation with invasion and metastasis

(2012) Xiao-jie Li et al.   Chinese Journal of Cancer Research

Lactate flux in astrocytes is enhanced by a non-catalytic action of carbonic anhydrase II

(2012) Malin H. Stridh et al.   JOURNAL OF PHYSIOLOGY-LONDON

Down regulation of CAII is associated with tumor differentiation and poor prognosis in patients with pancreatic cancer

(2012) Weiwei Sheng et al.   JOURNAL OF SURGICAL ONCOLOGY

How cancer metabolism is tuned for proliferation and vulnerable to disruption

(2012) Almut Schulze et al.   NATURE

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Functional role of a putative carbonic anhydrase II-binding domain in the electrogenic Na+-HCO3−cotransporter NBCe1 expressed in Xenopus oocytes

(2011) Hideomi Yamada et al.   Channels

Transport Activity of the High-affinity Monocarboxylate Transporter MCT2 Is Enhanced by Extracellular Carbonic Anhydrase IV but Not by Intracellular Carbonic Anhydrase II

(2011) Michael Klier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intramolecular proton shuttle supports not only catalytic but also noncatalytic function of carbonic anhydrase II

(2011) H. M. Becker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Large shifts in pKa values of lysine residues buried inside a protein

(2011) D. G. Isom et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The inhibition of monocarboxylate transporter 2 (MCT2) by AR-C155858 is modulated by the associated ancillary protein

(2010) Matthew J. Ovens et al.   BIOCHEMICAL JOURNAL

pH control mechanisms of tumor survival and growth

(2010) Scott K. Parks et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Nonenzymatic Augmentation of Lactate Transport via Monocarboxylate Transporter Isoform 4 by Carbonic Anhydrase II

(2010) Holger M. Becker et al.   JOURNAL OF MEMBRANE BIOLOGY

AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7–10

(2009) Matthew J. Ovens et al.   BIOCHEMICAL JOURNAL

The proteoglycan region of the tumor-associated carbonic anhydrase isoform IX acts as anintrinsic buffer optimizing CO2 hydration at acidic pH values characteristic of solid tumors

(2009) Alessio Innocenti et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Glucose and lactate supply to the synapse

(2009) L. Felipe Barros et al.   BRAIN RESEARCH REVIEWS

Fluorescent Indicators for Intracellular pH

(2009) Junyan Han et al.   CHEMICAL REVIEWS

Tumor metabolism of lactate: the influence and therapeutic potential for MCT and CD147 regulation

(2009) Kelly M Kennedy et al.   Future Oncology

Mapping Proton Wires in Proteins: Carbonic Anhydrase and GFP Chromophore Biosynthesis†

(2009) Ai Shinobu et al.   JOURNAL OF PHYSICAL CHEMISTRY A

Nonenzymatic Proton Handling by Carbonic Anhydrase II during H+-Lactate Cotransport via Monocarboxylate Transporter 1

(2008) Holger M. Becker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterizing proteins and their interactions in cells and tissues using the in situ proximity ligation assay

(2008) Ola Söderberg et al.   METHODS