Farrerol Directly Targets GSK-3β to Activate Nrf2-ARE Pathway and Protect EA.hy926 Cells against Oxidative Stress-Induced Injuries

Farrerol Ameliorates TNBS-Induced Colonic Inflammation by Inhibiting ERK1/2, JNK1/2, and NF-κB Signaling Pathway

(2018) Xin Ran et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Crystal structure of GSK3β in complex with the flavonoid, morin

(2018) Kuglae Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Farrerol attenuates β-amyloid-induced oxidative stress and inflammation through Nrf2/Keap1 pathway in a microglia cell line

(2018) Bei Cui et al.   BIOMEDICINE & PHARMACOTHERAPY

Protective effect of butin against ischemia/reperfusion-induced myocardial injury in diabetic mice: involvement of the AMPK/GSK-3β/Nrf2 signaling pathway

(2017) Jialin Duan et al.   Scientific Reports

Sustained ERK activation-mediated proliferation inhibition of farrerol on human gastric carcinoma cell line by G0/G1-phase cell-cycle arrest

(2016) Enli Liu et al.   EUROPEAN JOURNAL OF CANCER PREVENTION

Nrf2-mediated liver protection by esculentoside A against acetaminophen toxicity through the AMPK/Akt/GSK3β pathway

(2016) Lidong Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Apigenin and naringenin ameliorate PKCβII-associated endothelial dysfunction via regulating ROS/caspase-3 and NO pathway in endothelial cells exposed to high glucose

(2016) Weiwei Qin et al.   VASCULAR PHARMACOLOGY

Dual regulation of transcription factor Nrf2 by Keap1 and by the combined actions of β-TrCP and GSK-3

(2015) John D. Hayes et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The antioxidative potential of farrerol occurs via the activation of Nrf2 mediated HO-1 signaling in RAW 264.7 cells

(2015) Xinxin Ci et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Global and Regional Patterns in Cardiovascular Mortality From 1990 to 2013

(2015) Gregory A. Roth et al.   CIRCULATION

Farrerol can attenuate the aortic lesion in spontaneously hypertensive rats via the upregulation of eNOS and reduction of NAD(P)H oxidase activity

(2015) Xiaojiang Qin et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Eriodictyol Protects Endothelial Cells against Oxidative Stress-Induced Cell Death through Modulating ERK/Nrf2/ARE-Dependent Heme Oxygenase-1 Expression

(2015) Seung Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Stringent Control of NFE2L3 (Nuclear Factor, Erythroid 2-Like 3; NRF3) Protein Degradation by FBW7 (F-box/WD Repeat-containing Protein 7) and Glycogen Synthase Kinase 3 (GSK3)

(2015) Meenakshi B. Kannan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Cytoprotective Effect of Hyperoside against Oxidative Stress Is Mediated by the Nrf2-ARE Signaling Pathway through GSK-3β Inactivation

(2015) Hai-Yan Xing et al.   PLoS One

Farrerol regulates occludin expression in hydrogen peroxide-induced EA.hy926 cells by modulating ERK1/2 activity

(2014) Jiankuan Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

g_mmpbsa—A GROMACS Tool for High-Throughput MM-PBSA Calculations

(2014) Rashmi Kumari et al.   Journal of Chemical Information and Modeling

Puerarin induces the upregulation of glutathione levels and nuclear translocation of Nrf2 through PI3K/Akt/GSK-3β signaling events in PC12 cells exposed to lead

(2014) Chengchong Li et al.   NEUROTOXICOLOGY AND TERATOLOGY

Protective effects of farrerol against hydrogen-peroxide-induced apoptosis in human endothelium-derived EA.hy926 cells

(2013) Jian-Kuan Li et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Farrerol regulates antimicrobial peptide expression and reduces Staphylococcus aureus internalization into bovine mammary epithelial cells

(2013) Zhengtao Yang et al.   MICROBIAL PATHOGENESIS

Citrus Flavanones: What Is Their Role in Cardiovascular Protection?

(2012) Audrey Chanet et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

In silico prediction of inhibitory effects of pyrazol-5-one and indazole derivatives on GSK3β kinase enzyme

(2012) Fangfang Wang et al.   JOURNAL OF MOLECULAR STRUCTURE

Dietary Flavonoids and Risk of Stroke in Women

(2012) Aedín Cassidy et al.   STROKE

Involvement of estrogen receptor-β in farrerol inhibition of rat thoracic aorta vascular smooth muscle cell proliferation

(2011) Qun-yi Li et al.   ACTA PHARMACOLOGICA SINICA

Signaling pathways activated by the phytochemical nordihydroguaiaretic acid contribute to a Keap1-independent regulation of Nrf2 stability: Role of glycogen synthase kinase-3

(2011) Ana I. Rojo et al.   FREE RADICAL BIOLOGY AND MEDICINE

Citrus Polyphenol Hesperidin Stimulates Production of Nitric Oxide in Endothelial Cells while Improving Endothelial Function and Reducing Inflammatory Markers in Patients with Metabolic Syndrome

(2011) Stefano Rizza et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Cardiovascular effects of flavonoids are not caused only by direct antioxidant activity

(2010) Přemysl Mladěnka et al.   FREE RADICAL BIOLOGY AND MEDICINE

Improved side-chain torsion potentials for the Amber ff99SB protein force field

(2010) Kresten Lindorff-Larsen et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Endothelial Function and Oxidative Stress in Cardiovascular Diseases

(2009) Yukihito Higashi et al.   CIRCULATION JOURNAL

Nrf2:INrf2 (Keap1) signaling in oxidative stress

(2009) James W. Kaspar et al.   FREE RADICAL BIOLOGY AND MEDICINE

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Molecular mechanisms of Nrf2-mediated antioxidant response

(2008) Wenge Li et al.   MOLECULAR CARCINOGENESIS

Phosphorylation by p38 MAPK as an Alternative Pathway for GSK3  Inactivation

(2008) T. M. Thornton et al.   SCIENCE