Autophagy Is a Protective Response to the Oxidative Damage to Endplate Chondrocytes in Intervertebral Disc: Implications for the Treatment of Degenerative Lumbar Disc

Mesenchymal stem cells in regenerative medicine: Focus on articular cartilage and intervertebral disc regeneration

(2016) Stephen M. Richardson et al.   METHODS

Current trends in biologics delivery to restore intervertebral disc anabolism

(2015) Gianluca Fontana et al.   ADVANCED DRUG DELIVERY REVIEWS

Autophagy in bone: Self-eating to stay in balance

(2015) Valérie Pierrefite-Carle et al.   AGEING RESEARCH REVIEWS

Autophagy exacerbates caspase-dependent apoptotic cell death after short times of starvation

(2015) Paolo Mattiolo et al.   BIOCHEMICAL PHARMACOLOGY

Hypoxia facilitates the survival of nucleus pulposus cells in serum deprivation by down-regulating excessive autophagy through restricting ROS generation

(2015) Jiang-Wei Chen et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Cell death by autophagy: emerging molecular mechanisms and implications for cancer therapy

(2015) S Fulda et al.   ONCOGENE

Oxidative/Nitrosative Stress in Patients With Modic Changes

(2015) Ergul Belge Kurutas et al.   SPINE

Establishment of intervertebral disc degeneration model induced by ischemic sub-endplate in rat tail

(2015) Wei Yuan et al.   Spine Journal

Autophagy and apoptosis: where do they meet?

(2014) Subhadip Mukhopadhyay et al.   APOPTOSIS

Autophagy protects end plate chondrocytes from intermittent cyclic mechanical tension induced calcification

(2014) Hong-guang Xu et al.   BONE

The Protective Role of Autophagy inHeterocephalus glaberHepatic Stellate Cells Exposed to H2O2or Nutritional Stress

(2014) Shanmin Zhao et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

The Responses of Autophagy and Apoptosis to Oxidative Stress in Nucleus Pulposus Cells: Implications for Disc Degeneration

(2014) Jiang-Wei Chen et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Oxidative damage to osteoblasts can be alleviated by early autophagy through the endoplasmic reticulum stress pathway—Implications for the treatment of osteoporosis

(2014) Yue-Hua Yang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Antioxidative nanofullerol prevents intervertebral disk degeneration

(2014) Xinlin Yang et al.   International Journal of Nanomedicine

Src-dependent impairment of autophagy by oxidative stress in a mouse model of Duchenne muscular dystrophy

(2014) Rituraj Pal et al.   Nature Communications

Estradiol inhibits osteoblast apoptosis via promotion of autophagy through the ER–ERK–mTOR pathway

(2013) Yue-Hua Yang et al.   APOPTOSIS

Mitochondrial-derived reactive oxygen species (ROS) play a causal role in aging-related intervertebral disc degeneration

(2013) Luigi A. Nasto et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

The evidence and the possible significance of autophagy in degeneration model of human cervical end-plate cartilage

(2013) HONGGUANG XU et al.   Experimental and Therapeutic Medicine

Rottlerin induces autophagy which leads to apoptotic cell death through inhibition of PI3K/Akt/mTOR pathway in human pancreatic cancer stem cells

(2012) Brahma N. Singh et al.   BIOCHEMICAL PHARMACOLOGY

Increased Macroautophagy in the Pathological Process of Intervertebral Disc Degeneration in Rats

(2012) Wei Ye et al.   CONNECTIVE TISSUE RESEARCH

Diversity of intervertebral disc cells: phenotype and function

(2012) Girish Pattappa et al.   JOURNAL OF ANATOMY

A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010

(2012) Stephen S Lim et al.   LANCET

Role of death receptor, mitochondrial and endoplasmic reticulum pathways in different stages of degenerative human lumbar disc

(2011) Hua Wang et al.   APOPTOSIS

Autophagy and Aging

(2011) David C. Rubinsztein et al.   CELL

Age-Related Increases of Macroautophagy and Chaperone-Mediated Autophagy in Rat Nucleus Pulposus

(2011) Wei Ye et al.   CONNECTIVE TISSUE RESEARCH

Autophagy in rat annulus fibrosus cells: evidence and possible implications

(2011) Chao Shen et al.   ARTHRITIS RESEARCH & THERAPY

Glucocorticoid-induced autophagy in osteocytes

(2010) Xuechun Xia et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The Association Between Lumbar Disc Degeneration and Low Back Pain

(2010) Evelien I. T. de Schepper et al.   SPINE

Both endoplasmic reticulum and mitochondria are involved in disc cell apoptosis and intervertebral disc degeneration in rats

(2009) Chang-Qing Zhao et al.   AGE

Biologic Solutions for Degenerative Disk Disease

(2009) Daniel R. Fassett et al.   JOURNAL OF SPINAL DISORDERS & TECHNIQUES

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Pharmacological enhancement of disc diffusion and differentiation of healthy, ageing and degenerated discs

(2008) S. Rajasekaran et al.   EUROPEAN SPINE JOURNAL

Senescence, Apoptosis or Autophagy?

(2008) José Miguel Vicencio et al.   GERONTOLOGY

IGF-1 rescues human intervertebral annulus cells fromin vitrostress-induced premature senescence

(2008) Helen E. Gruber et al.   GROWTH FACTORS

Higher Risk of Adjacent Segment Degeneration After Floating Fusions: Long-Term Outcome After Low Lumbar Spine Fusions

(2008) Alexander Carl Disch et al.   JOURNAL OF SPINAL DISORDERS & TECHNIQUES

IGF-1 regulation of type II collagen and MMP-13 expression in rat endplate chondrocytes via distinct signaling pathways

(2008) M. Zhang et al.   OSTEOARTHRITIS AND CARTILAGE