Structure of the human lipid exporter ABCB4 in a lipid environment

Structural basis of Ca2+-dependent activation and lipid transport by a TMEM16 scramblase

(2019) Maria E Falzone et al.   eLife

Structural insight into substrate and inhibitor discrimination by human P-glycoprotein

(2019) Amer Alam et al.   SCIENCE

ABCB4/MDR3 in health and disease – at the crossroads of biochemistry and medicine

(2019) Martin Prescher et al.   BIOLOGICAL CHEMISTRY

Cryo-EM structure of human lysosomal cobalamin exporter ABCD4

(2019) Da Xu et al.   CELL RESEARCH

SWISS-MODEL: homology modelling of protein structures and complexes

(2018) Andrew Waterhouse et al.   NUCLEIC ACIDS RESEARCH

Structure of a zosuquidar and UIC2-bound human-mouse chimeric ABCB1

(2018) Amer Alam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Out-of-the-groove transport of lipids by TMEM16 and GPCR scramblases

(2018) Mattia Malvezzi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular structure of human P-glycoprotein in the ATP-bound, outward-facing conformation

(2018) Youngjin Kim et al.   SCIENCE

Cryo-EM structures of a human ABCG2 mutant trapped in ATP-bound and substrate-bound states

(2018) Ioannis Manolaridis et al.   NATURE

New tools for automated high-resolution cryo-EM structure determination in RELION-3

(2018) Jasenko Zivanov et al.   eLife

Common genetic variation and risk of gallbladder cancer in India: a case-control genome-wide association study

(2017) Sharayu Mhatre et al.   LANCET ONCOLOGY

Structural basis of MsbA-mediated lipopolysaccharide transport

(2017) Wei Mi et al.   NATURE

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

(2017) Ali Punjani et al.   NATURE METHODS

Structural basis for phospholipid scrambling in the TMEM16 family

(2016) Janine D Brunner et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Functional defect of variants in the adenosine triphosphate-binding sites of ABCB4 and their rescue by the cystic fibrosis transmembrane conductance regulator potentiator, ivacaftor (VX-770)

(2016) Jean-Louis Delaunay et al.   HEPATOLOGY

Structures of the Multidrug Transporter P-glycoprotein Reveal Asymmetric ATP Binding and the Mechanism of Polyspecificity

(2016) Lothar Esser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gctf: Real-time CTF determination and correction

(2016) Kai Zhang   JOURNAL OF STRUCTURAL BIOLOGY

Mechanistic diversity in ATP-binding cassette (ABC) transporters

(2016) Kaspar P Locher   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanistic diversity in ATP-binding cassette (ABC) transporters

(2016) Kaspar P Locher   NATURE STRUCTURAL & MOLECULAR BIOLOGY

P4-ATPases as Phospholipid Flippases—Structure, Function, and Enigmas

(2016) Jens P. Andersen et al.   Frontiers in Physiology

A functional classification ofABCB4variations causing progressive familial intrahepatic cholestasis type 3

(2015) Jean-Louis Delaunay et al.   HEPATOLOGY

Structure and mechanism of an active lipid-linked oligosaccharide flippase

(2015) Camilo Perez et al.   NATURE

Phosphorylation of ABCB4 impacts its function: Insights from disease-causing mutations

(2014) Julien Gautherot et al.   HEPATOLOGY

A Mutation within the Extended X Loop Abolished Substrate-induced ATPase Activity of the Human Liver ATP-binding Cassette (ABC) Transporter MDR3

(2014) Marianne Kluth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of an antibacterial peptide ATP-binding cassette transporter in a novel outward occluded state

(2014) H. G. Choudhury et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Mechanisms for Biliary Phospholipid and Drug Efflux Mediated by ABCB4 and Bile Salts

(2014) Shin-ya Morita et al.   Biomed Research International

ATPase activity of nucleotide binding domains of human MDR3 in the context of MDR1

(2013) Masato Ishigami et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Genotype-phenotype relationships in the low-phospholipid-associated cholelithiasis syndrome: A study of 156 consecutive patients

(2013) Raoul Poupon et al.   HEPATOLOGY

Molecular mechanistic explanation for the spectrum of cholestatic disease caused by the S320F variant of ABCB4

(2013) Edward J. Andress et al.   HEPATOLOGY

Bile salt-stimulated phospholipid efflux mediated by ABCB4 localized in nonraft membranes

(2013) Shin-ya Morita et al.   JOURNAL OF LIPID RESEARCH

Analysis of the Human Tissue-specific Expression by Genome-wide Integration of Transcriptomics and Antibody-based Proteomics

(2013) Linn Fagerberg et al.   MOLECULAR & CELLULAR PROTEOMICS

Detergent Screening and Purification of the Human Liver ABC Transporters BSEP (ABCB11) and MDR3 (ABCB4) Expressed in the Yeast Pichia pastoris

(2013) Philipp Ellinger et al.   PLoS One

ABCB4/MDR3 gene mutations and cholangiocarcinomas

(2012) David Tougeron et al.   JOURNAL OF HEPATOLOGY

RELION: Implementation of a Bayesian approach to cryo-EM structure determination

(2012) Sjors H.W. Scheres   JOURNAL OF STRUCTURAL BIOLOGY

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Aspects of liver pathology in adult patients with MDR3/ABCB4 gene mutations

(2012) Dominique Wendum et al.   VIRCHOWS ARCHIV

CAVER 3.0: A Tool for the Analysis of Transport Pathways in Dynamic Protein Structures

(2012) Eva Chovancova et al.   PLoS Computational Biology

Complementary Functions of the Flippase ATP8B1 and the Floppase ABCB4 in Maintaining Canalicular Membrane Integrity

(2011) Annemiek Groen et al.   GASTROENTEROLOGY

Drug-induced cholestasis

(2011) Manmeet S. Padda et al.   HEPATOLOGY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Itraconazole-Induced Cholestasis: Involvement of the Inhibition of Bile Canalicular Phospholipid Translocator MDR3/ABCB4

(2010) T. Yoshikado et al.   MOLECULAR PHARMACOLOGY

The Spectrum of Liver Diseases Related toABCB4Gene Mutations: Pathophysiology and Clinical Aspects

(2010) Anne Davit-Spraul et al.   SEMINARS IN LIVER DISEASE

Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding

(2009) S. G. Aller et al.   SCIENCE

Hepatobiliary phospholipid transporter ABCB4, MDR3 gene variants in a large cohort of Italian women with intrahepatic cholestasis of pregnancy

(2007) A. Floreani et al.   DIGESTIVE AND LIVER DISEASE