标题
Human germline genome editing
作者
关键词
-
出版物
NATURE CELL BIOLOGY
Volume 21, Issue 12, Pages 1479-1489
出版商
Springer Science and Business Media LLC
发表日期
2019-12-03
DOI
10.1038/s41556-019-0424-0
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Base-Editing-Mediated R17H Substitution in Histone H3 Reveals Methylation-Dependent Regulation of Yap Signaling and Early Mouse Embryo Development
- (2019) Guang Yang et al. Cell Reports
- World Health Organization panel weighs in on CRISPR-babies debate
- (2019) Sara Reardon NATURE
- Adopt a moratorium on heritable genome editing
- (2019) Eric S. Lander et al. NATURE
- Academies’ action plan for germline editing
- (2019) Victor J. Dzau et al. NATURE
- China set to introduce gene-editing regulation following CRISPR-baby furore
- (2019) David Cyranoski NATURE
- CRISPR babies: when will the world be ready?
- (2019) Heidi Ledford NATURE
- Russian biologist plans more CRISPR-edited babies
- (2019) David Cyranoski NATURE
- Search-and-replace genome editing without double-strand breaks or donor DNA
- (2019) Andrew V. Anzalone et al. NATURE
- Could Failure in Preimplantation Genetic Diagnosis Justify Editing the Human Embryo Genome?
- (2018) Julie Steffann et al. Cell Stem Cell
- New Developments in CRISPR Technology: Improvements in Specificity and Efficiency
- (2018) Fatemeh Safari et al. CURRENT PHARMACEUTICAL BIOTECHNOLOGY
- Efficient generation of targeted large insertions by microinjection into two-cell-stage mouse embryos
- (2018) Bin Gu et al. NATURE BIOTECHNOLOGY
- Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements
- (2018) Michael Kosicki et al. NATURE BIOTECHNOLOGY
- The CRISPR tool kit for genome editing and beyond
- (2018) Mazhar Adli Nature Communications
- Embryonic POU5F1 is Required for Expanded Bovine Blastocyst Formation
- (2018) Bradford W. Daigneault et al. Scientific Reports
- CRISPR-Cas immunity, DNA repair and genome stability
- (2018) Andrew Cubbon et al. BIOSCIENCE REPORTS
- Correction of the Marfan Syndrome Pathogenic FBN1 Mutation by Base Editing in Human Cells and Heterozygous Embryos
- (2018) Yanting Zeng et al. MOLECULAR THERAPY
- Ma et al. reply
- (2018) Hong Ma et al. NATURE
- Inter-homologue repair in fertilized human eggs?
- (2018) Dieter Egli et al. NATURE
- Large deletions induced by Cas9 cleavage
- (2018) Fatwa Adikusuma et al. NATURE
- Acute and rapid degradation of endogenous proteins by Trim-Away
- (2018) Dean Clift et al. Nature Protocols
- Dual-spindle formation in zygotes keeps parental genomes apart in early mammalian embryos
- (2018) Judith Reichmann et al. SCIENCE
- DIG-seq: a genome-wide CRISPR off-target profiling method using chromatin DNA
- (2018) Daesik Kim et al. GENOME RESEARCH
- Target-Specific Precision of CRISPR-Mediated Genome Editing
- (2018) Anob M. Chakrabarti et al. MOLECULAR CELL
- Japan set to allow gene editing in human embryos
- (2018) David Cyranoski NATURE
- Predictable and precise template-free CRISPR editing of pathogenic variants
- (2018) Max W. Shen et al. NATURE
- Predicting the mutations generated by repair of Cas9-induced double-strand breaks
- (2018) Felicity Allen et al. NATURE BIOTECHNOLOGY
- Base editing: precision chemistry on the genome and transcriptome of living cells
- (2018) Holly A. Rees et al. NATURE REVIEWS GENETICS
- Wake-up call from Hong Kong
- (2018) Victor J. Dzau et al. SCIENCE
- Mosaicism diminishes the value of pre-implantation embryo biopsies for detecting CRISPR/Cas9 induced mutations in sheep
- (2018) Marcela Vilarino et al. TRANSGENIC RESEARCH
- ESHRE PGD Consortium data collection XIV–XV: cycles from January 2011 to December 2012 with pregnancy follow-up to October 2013†
- (2017) M De Rycke et al. HUMAN REPRODUCTION
- CRISPR/Cas9-mediated gene editing in human zygotes using Cas9 protein
- (2017) Lichun Tang et al. MOLECULAR GENETICS AND GENOMICS
- Correction of a pathogenic gene mutation in human embryos
- (2017) Hong Ma et al. NATURE
- Genome editing reveals a role for OCT4 in human embryogenesis
- (2017) Norah M. E. Fogarty et al. NATURE
- Inhibition of 53BP1 favors homology-dependent DNA repair and increases CRISPR–Cas9 genome-editing efficiency
- (2017) Marella D Canny et al. NATURE BIOTECHNOLOGY
- Mapping the genomic landscape of CRISPR–Cas9 cleavage
- (2017) Peter Cameron et al. NATURE METHODS
- CIRCLE-seq: a highly sensitive in vitro screen for genome-wide CRISPR–Cas9 nuclease off-targets
- (2017) Shengdar Q Tsai et al. NATURE METHODS
- Highly efficient biallelic genome editing of human ES/iPS cells using a CRISPR/Cas9 or TALEN system
- (2017) Kazuo Takayama et al. NUCLEIC ACIDS RESEARCH
- Highly efficient base editing in human tripronuclear zygotes
- (2017) Changyang Zhou et al. Protein & Cell
- Highly efficient and precise base editing in discarded human tripronuclear embryos
- (2017) Guanglei Li et al. Protein & Cell
- Correction of β-thalassemia mutant by base editor in human embryos
- (2017) Puping Liang et al. Protein & Cell
- Early human embryos are naturally aneuploid—can that be corrected?
- (2016) Amy Lee et al. JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
- Introducing precise genetic modifications into human 3PN embryos by CRISPR/Cas-mediated genome editing
- (2016) Xiangjin Kang et al. JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
- Towards clinical application of pronuclear transfer to prevent mitochondrial DNA disease
- (2016) Louise A. Hyslop et al. NATURE
- Self-organization of the in vitro attached human embryo
- (2016) Alessia Deglincerti et al. NATURE
- Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage
- (2016) Alexis C. Komor et al. NATURE
- Self-organization of the human embryo in the absence of maternal tissues
- (2016) Marta N. Shahbazi et al. NATURE CELL BIOLOGY
- Finding an ethical path forward for mitochondrial replacement
- (2016) A. B. Claiborne et al. SCIENCE
- Rapid Protein Depletion in Human Cells by Auxin-Inducible Degron Tagging with Short Homology Donors
- (2016) Toyoaki Natsume et al. Cell Reports
- Post-translational Regulation of Cas9 during G1 Enhances Homology-Directed Repair
- (2016) Tony Gutschner et al. Cell Reports
- Nucleosome breathing and remodeling constrain CRISPR-Cas9 function
- (2016) R Stefan Isaac et al. eLife
- Nucleosomes impede Cas9 access to DNA in vivo and in vitro
- (2016) Max A Horlbeck et al. eLife
- Reverse Genetic Screening Reveals Poor Correlation between Morpholino-Induced and Mutant Phenotypes in Zebrafish
- (2015) Fatma O. Kok et al. DEVELOPMENTAL CELL
- Risk of Misdiagnosis Due to Allele Dropout and False-Positive PCR Artifacts in Molecular Diagnostics
- (2015) Jonatan Blais et al. JOURNAL OF MOLECULAR DIAGNOSTICS
- Don’t edit the human germ line
- (2015) Edward Lanphier et al. NATURE
- Genetic compensation induced by deleterious mutations but not gene knockdowns
- (2015) Andrea Rossi et al. NATURE
- Digenome-seq: genome-wide profiling of CRISPR-Cas9 off-target effects in human cells
- (2015) Daesik Kim et al. NATURE METHODS
- G&T-seq: parallel sequencing of single-cell genomes and transcriptomes
- (2015) Iain C Macaulay et al. NATURE METHODS
- A prudent path forward for genomic engineering and germline gene modification
- (2015) D. Baltimore et al. SCIENCE
- The moral imperative to continue gene editing research on human embryos
- (2015) Julian Savulescu et al. Protein & Cell
- CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes
- (2015) Puping Liang et al. Protein & Cell
- Low Incidence of Off-Target Mutations in Individual CRISPR-Cas9 and TALEN Targeted Human Stem Cell Clones Detected by Whole-Genome Sequencing
- (2014) Adrian Veres et al. Cell Stem Cell
- Whole-Genome Sequencing Analysis Reveals High Specificity of CRISPR/Cas9 and TALEN-Based Genome Editing in Human iPSCs
- (2014) Cory Smith et al. Cell Stem Cell
- DNA repair signalling pathway genes are overexpressed in poor-quality pre-implantation human embryos with complex aneuploidy
- (2014) Masood Bazrgar et al. European Journal of Obstetrics & Gynecology and Reproductive Biology
- Highly efficient RNA-guided genome editing in human cells via delivery of purified Cas9 ribonucleoproteins
- (2014) S. Kim et al. GENOME RESEARCH
- Altered cleavage patterns in human tripronuclear embryos and their association to fertilization method: A time-lapse study
- (2014) Mette Warming Joergensen et al. JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
- Mitochondrial replacement: from basic research to assisted reproductive technology portfolio tool—technicalities and possible risks
- (2014) Lynsey Cree et al. MOLECULAR HUMAN REPRODUCTION
- GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases
- (2014) Shengdar Q Tsai et al. NATURE BIOTECHNOLOGY
- Morphokinetic parameters of ICSI tripronucleated embryos observed using time lapse
- (2014) Jenna Lammers et al. REPRODUCTIVE BIOMEDICINE ONLINE
- Oct4 Cell-Autonomously Promotes Primitive Endoderm Development in the Mouse Blastocyst
- (2013) Tristan Frum et al. DEVELOPMENTAL CELL
- Blastocyst biopsy with comprehensive chromosome screening and fresh embryo transfer significantly increases in vitro fertilization implantation and delivery rates: a randomized controlled trial
- (2013) Richard T. Scott et al. FERTILITY AND STERILITY
- Emergent Complications of Assisted Reproduction: Expecting the Unexpected
- (2013) Keren Tuvia Baron et al. RADIOGRAPHICS
- Blastocyst culture selects for euploid embryos: comparison of blastomere and trophectoderm biopsies
- (2013) Alexis Adler et al. REPRODUCTIVE BIOMEDICINE ONLINE
- RNA-Guided Human Genome Engineering via Cas9
- (2013) P. Mali et al. SCIENCE
- Multiplex Genome Engineering Using CRISPR/Cas Systems
- (2013) L. Cong et al. SCIENCE
- RNA-programmed genome editing in human cells
- (2013) Martin Jinek et al. eLife
- Molecular aspects of implantation failure
- (2012) Y.E.M. Koot et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Molecular origin of mitotic aneuploidies in preimplantation embryos
- (2012) Eleni Mantikou et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Maternal Cdx2 is dispensable for mouse development
- (2012) S. Blij et al. DEVELOPMENT
- Visualization of cell cycle in mouse embryos with Fucci2 reporter directed by Rosa26 promoter
- (2012) T. Abe et al. DEVELOPMENT
- TALENs: a widely applicable technology for targeted genome editing
- (2012) J. Keith Joung et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria
- (2012) G. Gasiunas et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity
- (2012) M. Jinek et al. SCIENCE
- SICKLE CELL ANAEMIA AND MALARIA
- (2012) Lucio Luzzatto Mediterranean Journal of Hematology and Infectious Diseases
- Drug-induced cell cycle modulation leading to cell-cycle arrest, nuclear mis-segregation, or endoreplication
- (2011) Asako Sakaue-Sawano et al. BMC CELL BIOLOGY
- Meganucleases and Other Tools for Targeted Genome Engineering: Perspectives and Challenges for Gene Therapy
- (2011) George Silva et al. CURRENT GENE THERAPY
- Waves of early transcriptional activation and pluripotency program initiation during human preimplantation development
- (2011) R. Vassena et al. DEVELOPMENT
- Genome Engineering With Zinc-Finger Nucleases
- (2011) Dana Carroll GENETICS
- Comprehensive analysis of kinase inhibitor selectivity
- (2011) Mindy I Davis et al. NATURE BIOTECHNOLOGY
- Genome-wide microarray evidence that 8-cell human blastomeres over-express cell cycle drivers and under-express checkpoints
- (2010) Ann A. Kiessling et al. JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
- Endometrial secretion analysis identifies a cytokine profile predictive of pregnancy in IVF
- (2009) C.M. Boomsma et al. HUMAN REPRODUCTION
- Evidence that human blastomere cleavage is under unique cell cycle control
- (2009) Ann A. Kiessling et al. JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
- Chromosome instability is common in human cleavage-stage embryos
- (2009) Evelyne Vanneste et al. NATURE MEDICINE
- Visualizing Spatiotemporal Dynamics of Multicellular Cell-Cycle Progression
- (2008) Asako Sakaue-Sawano et al. CELL
- Blastocyst trophectoderm biopsy and preimplantation genetic diagnosis for familial monogenic disorders and chromosomal translocations
- (2008) S. J. McArthur et al. PRENATAL DIAGNOSIS
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